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Search Results: 1 - 10 of 41743 matches for " Sheng-Ying Lai "
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Efficient Architecture for Spike Sorting in Reconfigurable Hardware
Wen-Jyi Hwang,Wei-Hao Lee,Shiow-Jyu Lin,Sheng-Ying Lai
Sensors , 2013, DOI: 10.3390/s131114860
Abstract: This paper presents a novel hardware architecture for fast spike sorting. The architecture is able to perform both the feature extraction and clustering in hardware. The generalized Hebbian algorithm (GHA) and fuzzy C-means (FCM) algorithm are used for feature extraction and clustering, respectively. The employment of GHA allows efficient computation of principal components for subsequent clustering operations. The FCM is able to achieve near optimal clustering for spike sorting. Its performance is insensitive to the selection of initial cluster centers. The hardware implementations of GHA and FCM feature low area costs and high throughput. In the GHA architecture, the computation of different weight vectors share the same circuit for lowering the area costs. Moreover, in the FCM hardware implementation, the usual iterative operations for updating the membership matrix and cluster centroid are merged into one single updating process to evade the large storage requirement. To show the effectiveness of the circuit, the proposed architecture is physically implemented by field programmable gate array (FPGA). It is embedded in a System-on-Chip (SOC) platform for performance measurement. Experimental results show that the proposed architecture is an efficient spike sorting design for attaining high classification correct rate and high speed computation.
In silico identification and comparative analysis of differentially expressed genes in human and mouse tissues
Sheng-Ying Pao, Win-Li Lin, Ming-Jing Hwang
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-86
Abstract: To deal with the issue of tissue source, in this work, we carefully screened and organized more than 8 million human and mouse ESTs into 157 human and 108 mouse tissue/organ categories, to which we applied an established statistic test using different thresholds of the p value to identify genes differentially expressed in different tissues. Further analysis of the tissue distribution and level of expression of human and mouse orthologous genes showed that tissue-specific orthologs tended to have more similar expression patterns than those lacking significant tissue specificity. On the other hand, a number of orthologs were found to have significant disparity in their expression profiles, hinting at novel functions, divergent regulation, or new ortholog relationships.Comprehensive statistics on the tissue-specific expression of human and mouse genes were obtained in this very large-scale, EST-based analysis. These statistical results have been organized into a database, freely accessible at our website http://gln.ibms.sinica.edu.tw/product/HMDEG/EST/index.php webcite, for easy searching of human and mouse tissue-specific genes and for investigating gene expression profiles in the context of comparative genomics. Comparative analysis showed that, although highly tissue-specific genes tend to exhibit similar expression profiles in human and mouse, there are significant exceptions, indicating that orthologous genes, while sharing basic genomic properties, could result in distinct phenotypes.High-throughput analysis of gene expression offers a powerful means of studying how genes work and of uncovering the secrets encoded in genome sequences. Differential gene expression, which plays a key role in various cellular processes, can be quantified by analyzing a large number of transcription products. To do so, several large-scale transcript detection technologies have been developed, chief among which are variants of microarray technology [1,2], expressed sequence tags (ESTs
Clinical Profile and Outcome of First Acute Myocardial Infarction with Ischemic Mitral Regurgitation
Sheng-Ying Chung,Fen-Chiung Lin,Sarah Chua,Morgan Fu
Chang Gung Medical Journal , 2008,
Abstract: Background: Ischemic mitral regurgitation indicates a poor prognosis after acute myocardialinfarction (AMI). This study addresses the clinical characteristics andcontribution of ischemic mitral regurgitation to the midterm survival rate ofpatients following first AMI in our institution.Methods: Between January 2000 and December 2002, patients who underwent 2-dimensional color Doppler echocardiographic quantitation of ischemic mitralregurgitation within 30 days after first myocardial infarction (MI) were analyzed.Results: During the study period, 519 patients were enrolled (mean age 62.7
Anisotropic intrinsic lattice thermal conductivity of phosphorene from first principles
Guangzhao Qin,Qing-Bo Yan,Zhenzhen Qin,Sheng-Ying Yue,Ming Hu,Gang Su
Physics , 2014, DOI: 10.1039/c4cp04858j
Abstract: Phosphorene, the single layer counterpart of black phosphorus, is a novel two-dimensional semiconductor with high carrier mobility and a large fundamental direct band gap, which has attracted tremendous interest recently. Its potential applications in nano-electronics and thermoelectrics call for a fundamental study of the phonon transport. Here, we calculate the intrinsic lattice thermal conductivity of phosphorene by solving the phonon Boltzmann transport equation (BTE) based on first-principles calculations. The thermal conductivity of phosphorene at $300\,\mathrm{K}$ is $30.15\,\mathrm{Wm^{-1}K^{-1}}$ (zigzag) and $13.65\,\mathrm{Wm^{-1}K^{-1}}$ (armchair), showing an obvious anisotropy along different directions. The calculated thermal conductivity fits perfectly to the inverse relation with temperature when the temperature is higher than Debye temperature ($\Theta_D = 278.66\,\mathrm{K}$). In comparison to graphene, the minor contribution around $5\%$ of the ZA mode is responsible for the low thermal conductivity of phosphorene. In addition, the representative mean free path (MFP), a critical size for phonon transport, is also obtained.
A Fast Multi-scale Feature Matching Algorithm
一种快速多尺度特征点匹配算法

SHAO Wei,ZHU Sheng-ying,CHEN Ling-zhi,
邵 巍
,朱圣英 陈灵芝

中国图象图形学报 , 2009,
Abstract: 为了快速稳定地进行特征点的跟踪,提出了一种快速多尺度特征点的提取算法.该算法首先利用快速局部窗口极值搜索算法提取出不同尺度空间特征点的局部极值,减少了局部极值搜索的冗余性,然后再利用最近邻算法对特征点进行匹配.实验结果表明,该算法的计算速度快于SIFT算法和MOPS算法,稳定性强于传统的Harris算法,可以用于实时图像配准及目标跟踪.
Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer
Xiao-Hua Zhang, Du-Ping Huang, Gui-Long Guo, Guo-Rong Chen, Hu-Xiang Zhang, Li Wan, Sheng-Ying Chen
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-4
Abstract: Tissue samples of primary tumors from 70 patients undergoing intentionally curative surgical resections for breast cancer were immunohistochemically examined for VEGF-C, COX-2, and D2-40 expressions. The association between COX-2 and VEGF-C expressions and clinicopathological parameters as well as prognosis were analysised. To demonstrate the presence of proliferating lymphatic endothelial cells, 10 random cases with high LVD counts were selected for D2-40/Ki-67 double immunostaining.A significant correlation was found between the expression of VEGF-C and COX-2 (r = 0.529, P < 0.001), and both elevated VEGF-C expression and elevated COX-2 expression were associated with higher lymph vessel density (LVD), lymph node metastasis and D2-40 positive lymphatic invasion (LVI) as well as worse disease free survival (DFS) and overall survival (OS) in a univariate analysis. In the double immunostain for the lymph vessel marker D2-40 and the proliferation marker Ki-67, the results confirmed Ki-67-positive nuclei in a proportion of lymph vessel endothelial cells.There is indeed lymphangiogenesis in breast cancer, the most compelling evidence being the presence of proliferating lymphatic endothelial cells. VEGF-C and COX-2 are coexpressed and significantly associated with lymphangiogenesis and prognosis in invasive breast cancer. Suggesting COX-2 may up-regulate VEGF-C expression and thus promote lymph node metastasis via lymphangiogenesis pathway in human breast cancer.The lymphatic vasculature is an important route for the metastatic spread of human cancer. And the presence of tumour foci in lymph nodes is the most important adverse prognostic factor in a variety of human cancers. Recently, lymphangiogenesis, the formation of new lymphatic vessels, has become a new research frontier in tumor metastasis since the discovery of the two major lymphatic vessel growth factors-C (VEGF-C) and -D (VEGF-D), as well as reliable lymphatic markers that have allowed observation and isolatio
Hinge-like structure induced unusual properties of black phosphorus and new strategies to improve the thermoelectric performance
Guangzhao Qin,Qing-Bo Yan,Zhenzhen Qin,Sheng-Ying Yue,Hui-Juan Cui,Qing-Rong Zheng,Gang Su
Physics , 2014, DOI: 10.1038/srep06946
Abstract: We systematically investigated the geometric, electronic and thermoelectric (TE) properties of bulk black phosphorus (BP) under strain. The hinge-like structure of BP brings unusual mechanical responses such as anisotropic Young's modulus and negative Poisson's ratio. A sensitive electronic structure of BP makes it transform among metal, direct and indirect semiconductors under strain. The maximal figure of merit $ZT$ of BP is found to be 0.72 at $800\,\mathrm{K}$ that could be enhanced to 0.87 by exerting an appropriate strain, revealing BP could be a potential medium-high temperature TE material. Such strain-induced enhancements of TE performance are often observed to occur at the boundary of the direct-indirect band gap transition, which can be attributed to the increase of degeneracy of energy valleys at the transition point. By comparing the structure of BP with SnSe, a family of potential TE materials with hinge-like structure are suggested. This study not only exposes various novel properties of BP under strain, but also proposes effective strategies to seek for better TE materials.
Electronic and magnetic properties of twisted graphene nanoribbon and M?bius strips: first-principles calculations
Sheng-Ying Yue,Qing-Bo Yan,Zhen-Gang Zhu,Hui-Juan Cui,Qing-Rong Zheng,Gang Su
Physics , 2013,
Abstract: The geometrical, electronic, and magnetic properties of twisted zigzag-edged graphene nanoribbons (ZGNRs) and novel graphene M\"obius strips (GMS) are systematically investigated using first-principles density functional calculations. The structures of ZGNRs and GMS are optimized, and their stabilities are examined. The molecular energy levels and the spin polarized density of states are calculated. It is found that for twisted ZGNRs, the atomic bonding energy decreases quadratically with the increase of the twisted angle, and the HOMO-LUMO gap are varying in a sine-like behavior with the twisted angle. The calculated spin densities reveal that the ZGNRs and GMS have antiferromagnetic ground states, which persist during the twisting. The spin flips on the zigzag edges of GMS are observed at some positions.
Comparison of acute versus convalescent stage high-sensitivity C-Reactive protein level in predicting clinical outcome after acute ischemic stroke and impact of erythropoietin
Kuo-Ho Yeh, Tzu-Hsien Tsai, Han-Tan Chai, Steve Leu, Sheng-Ying Chung, Sarah Chua, Yung-Lung Chen, Hung-Sheng Lin, Chun-Man Yuen, Hon-Kan Yip
Journal of Translational Medicine , 2012, DOI: 10.1186/1479-5876-10-6
Abstract: Totally 160 patients were prospectively randomized to receive either EPO therapy (group 1, n = 80) (5,000 IU each time, subcutaneously) at 48 h and 72 h after acute IS, or placebo (group 2, n = 80). Serum level of hs-CRP was determined using ELISA at 48 h and on day 21 after IS and once in 60 healthy volunteers.Serum level of hs-CRP was substantially higher in all patients with IS than in healthy controls at 48 h and day 21 after IS (all p < 0.001). Levels of hs-CRP did not differ between group 1 and 2 at 48 h and day 21 after IS (all p > 0.5). Multivariate analysis showed that hs-CRP levels (at 48 h and day 21) were independently predictive of 90-day major adverse neurological event (MANE) (defined as recurrent stroke, NIHSS≥8, or death) (all p < 0.03), whereas EPO therapy was independently predictive of reduced 90-day MANE (all p < 0.02).EPO therapy which was independently predictive of freedom from 90-day MANE did not alter the crucial role of hs-CRP levels measured at 48 h and 21-day in predicting unfavorable clinical outcome after IS.Numerous studies have already shown that inflammation plays a crucial role in the initiation of endothelial dysfunction, atherosclerosis and plaque formation, propagation of plaque burden, and finally, rupture of the vulnerable plaque and acute arterial obstructive syndrome (AOS) [1-4]. Although a myriad of inflammatory biomarkers have been reported to be useful in predicting endothelial dysfunction and the likelihood of AOS, high-sensitivity C-reactive protein (hs-CRP) remains one of the most extensively studied and widely accepted inflammatory biomarkers in our daily clinical practice [4-10].Indeed, not only is hs-CRP an inflammatory biomarker, but it has also been proved to directly participate in the inflammatory process contributing to acute AOS [3,4,7]. Besides, immense clinical observational studies have demonstrated that serum level of hs-CRP is a useful and powerful inflammatory marker in predicting future cardiovascular a
On-line Method for Measurement of the Carbon Isotope Ratio of Atmospheric Methane and Its Application to Atmosphere of Yakela Condensed Gas Field
大气甲烷碳同位素测试方法及其在雅克拉凝析气田上方大气中的应用

TANG Jun-hong,BAO Zheng-yu,XIANG Wu,QIAO Sheng-ying,LI Bing,
唐俊红
,鲍征宇,向武,乔胜英,李兵

环境科学 , 2006,
Abstract: An on-line method for measurement of the 13C/12C ratio of methane by a gas chromatography/high-temperature conversion/ isotope ratio mass spectrometry (GC/C/MS) technique was developed. This method is less laborious, more rapid (45 min), of high precision (+/- 0.4 x 10(-3)) and by using a small amount of sample (about 200 mL of atmosphere). Its application to isotopic characterization, and hence methane source identification, was demonstrated by examination of atmosphere sample collected in Yakela condensed gas field, China. The average 13C/12C ratio of atmospheric methane in Yakela field was -45.0 x 10(-3) heavier by 1.2 x 10(-3) -2.0 x 10(-3) than the global average. This is caused by seepage and diffusing of methane from Yakela condensed gas reservoir. The concentrations of atmospheric methane in daytimes are found to be lower than those in nighttimes, and the corresponding 13C/12C ratios in daytimes are lighter compared to those in nighttimes, a phenomena probably caused by the fact that a small part of methane from Yakela condensate reservoir is consumed in soil's surface under sunlight.
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