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Search Results: 1 - 10 of 54 matches for " Shekhawat Satpal "
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Zosteriform verrucous epidermal nevus
Thomas Emy,Singla Monika,Shekhawat Satpal
Indian Journal of Dermatology , 2005,
Fragile Kashmir, Costs and Hopes for Peace
Seema Shekhawat
Journal of Alternative Perspectives in the Social Sciences , 2009,
Abstract: The recent decades have proved challenging fornations due to emergence and escalation of a wide variety ofviolent conflicts around the globe. Regardless of the motives,violent conflicts prove disastrous in all aspects- political,socio-cultural and economic. Needless to add, violentconflicts create atmosphere which stunts economic growth,destroys civic life and sows seeds of distrust, frustration andmaligns future generations.
Connectivity Algorithm
Krishnendra Shekhawat
Computer Science , 2015,
Abstract: In this work, for the given adjacency matrix of a graph, we present an algorithm which checks the connectivity of a graph and computes all of its connected components. Also, it is mathematically proved that the algorithm presents all the desired results.
Improving extreme value statistics
Ashivni Shekhawat
Statistics , 2014, DOI: 10.1103/PhysRevE.90.052148
Abstract: The rate of uniform convergence in extreme value statistics is non-universal and can be arbitrarily slow. Further, the relative error can be unbounded in the tail of the approximation, leading to difficulty in extrapolating the extreme value fit beyond the available data. We show that by using simple nonlinear transformations the extreme value approximation can be rendered rapidly convergent in the bulk, and asymptotic in the tail, thus fixing both issues. The transformations are often parameterized by just one parameter which can be estimated numerically. The classical extreme value method is shown to be a special case of the proposed method. We demonstrate that vastly improved results can be obtained with almost no extra cost.
Investigation of Anti-Inflammatory, Analgesic and Antipyretic Properties of Madhuca indica GMEL
Neha Shekhawat,Rekha Vijayvergia
International Journal of Molecular Medicine and Advance Sciences , 2011, DOI: 10.3923/ijmmas.2010.26.30
Abstract: The crude methanolic extract of Madhuca indica (Sapotaceae) at 50, 100 and 200 mg kg-1 body weight were evaluated for anti-inflammatory, analgesic and antipyretic activities in male wistar rats. Anti-inflammatory activity was studied by using carrageenan induced oedema right hind paw volume while the analgesic effect was evaluated using acetic acid-induced abdominal pains i.e., nociception response. The brewer s yeast-induced pyrexia model was used for antipyretic investigation. Phytochemical screening of the alcoholic extract revealed the presence of tannins, flavonoids, steroids, terpenes, cardiac glycosides and saponins. The extract at all the doses used and the indomethacin significantly inhibited carrageenan induced inflammation in a manner that was not dose dependent. The extract reduced the acetic acid induced pain licking. While the 50 and 100 mg kg-1 body weight of the extract reduced the brewer s yeast provoked elevated body temperature in rats after 60 min that of 200 mg kg-1 body weight manifested from 30 min. The results suggest a potential benefit of M. indica methanolic extract in treating conditions associated with inflammation, pain and fever. These properties might be adduced to the presence of the phytoconstituents.
A quantitative structure-activity relationship study of novel inhibitors of cyclooxygenase-2: The 5-aryl-2,2-dialkyl-4-phenyl-3(2 H)furanone derivatives
Singh P,Shekhawat Manju
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: The cyclooxygenase-2 enzyme inhibition activity of 5-aryl-2,2-dialkyl-4-phenyl-3(2 H )furanone derivatives is quantitatively analyzed through Fujita-Ban and Hansch type of approaches. The analyses have helped to ascertain the role of different substituents in explaining the observed inhibitory activity of these congeners. From both approaches it is revealed that more hydrophobic susbtituents at 4- R1, a non-hydrogen bond acceptor substitutent, preferably a -F substituent, at 3- R1 in 4-phenyl ring of 3(2 H )furanone scaffold improve inhibitory action of a compound. The substituents exhibiting collective molecular bulk smaller than spirocyclopentyl at X and Y positions are preferred as these geminal positions seems to be involved in steric interation. Similarly, 4-aminosulfonyl in 5-aryl ring of 3(2 H )furanone moiety emerged as a better choice than 4-methylsulfonyl substitution.
Eco-friendly synthesis and potent antifungal activity of 2-substituted coumaran-3-ones
Nusantara Bioscience , 2012,
Abstract: Solanki P, Shekhawat P. 2012. Eco-friendly synthesis and potent antifungal activity of 2-substituted coumaran-3-ones. Nusantara Bioscience 4: 101-104. 3-halochromones (IIa-c and IIIa-c) have been synthesized by treating 1- (2-hydroxyphenyl)-3-methyl-1,3-propanediones (Ia-c) with bromine or sulphuryl chloride in dioxane respectively. These chromones were employed in the synthesis of 2-acetyl-coumaran-3-ones (IVa-f). These were subjected to Knoevenagel condensation to give 2-cinnamoyl coumaran-3-ones. In vitro assay and field trials of these compounds against Fusarium oxysporum were carried out to study the antifungal effect of target compounds. Compound Va was the most effective growth inhibitor of the pathogen, whereas Vc showd a little tendency and Vb, Vd, Ve and Vf hardly inhibits the growth
International Journal of Pharmaceutical Research and Bio-Science , 2013,
Abstract: Nano-biotechnology is at leading edge of research development, making an impact in all spheres of human life. The size of nanoparticles is comparable to that of most of biological molecules (e.g., proteins, DNA) and structures (e.g., viruses and bacteria) therefore; nanoparticles can be developed for diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug delivery vehicles. This review illustrates possibilities of development of reliable experimental protocols for the bio synthesis of nanomaterial’s using different plant extracts by performing analytical comparisons of characterization techniques like Ultra Violet visible spectroscopy, Scanning Electron Microscope, Transmission Electron Microscope and X-Ray Diffraction. Biological methods of synthesis have paved way for the “greener synthesis” of nanoparticles and these have proven to be better methods due to slower kinetics, being environmentally friendly, less expensive. Also they offer better manipulation and control over stabilization of nanoparticles.
Inhibition of Ion Channels and Heart Beat in Drosophila by Selective COX-2 Inhibitor SC-791
Roman V. Frolov, Satpal Singh
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038759
Abstract: Recent findings suggest that modulation of ion channels might be implicated in some of the clinical effects of coxibs, selective inhibitors of cyclooxygenase-2 (COX-2). Celecoxib and its inactive analog 2,5-dimethyl-celecoxib, but not rofecoxib, can suppress or augment ionic currents and alter functioning of neurons and myocytes. To better understand these unexpected effects, we have recently investigated the mechanism of inhibition of human Kv2.1 channels by a highly selective COX-2 inhibitor SC-791. In this study we have further explored the SC-791 action on ion channels and heartbeat in Drosophila, which lacks cyclooxygenases and thus can serve as a convenient model to study COX-2-independent mechanisms of coxibs. Using intracellular recordings in combination with a pharmacological approach and utilizing available Drosophila mutants, we found that SC-791 inhibited voltage-activated K+ and L-type Ca2+ channels in larval body-wall muscles and reduced heart rate in a concentration-dependent manner. Unlike celecoxib and several other K+ channel blockers, SC-791 did not induce arrhythmia. Instead, application of SC-791 resulted in a dramatic slowing of contractions and, at higher concentrations, in progressively weaker contractions with gradual cessation of heartbeat. Isradipine, a selective blocker of L-type Ca2+ channels, showed a similar pattern of heart arrest, though no prolongation of contractions was observed. Ryanodine was the only channel modulating compound of those tested additionally that was capable of slowing contractions. Like SC-791, ryanodine reduced heart rate without arrhythmia. However, it could not stop heartbeat completely even at 500 μM, the highest concentration used. The magnitude of heart rate reduction, when SC-791 and ryanodine were applied together, was smaller than expected for independent mechanisms, raising the possibility that SC-791 might be interfering with excitation-contraction coupling in Drosophila heart.
Optimization of Laser Transmission Joining Process Parameters on Joint Strength of PET and 316?L Stainless Steel Joint Using Response Surface Methodology
Shashi Prakash Dwivedi,Satpal Sharma
Journal of Engineering , 2014, DOI: 10.1155/2014/197060
Abstract: The objective of the present work is to study the effects of laser power, joining speed, and stand-off distance on the joint strength of PET and 316?L stainless steel joint. The process parameters were optimized using response methodology for achieving good joint strength. The central composite design (CCD) has been utilized to plan the experiments and response surface methodology (RSM) is employed to develop mathematical model between laser transmission joining parameters and desired response (joint strength). From the ANOVA (analysis of variance), it was concluded that laser power is contributing more and it is followed by joining speed and stand-off distance. In the range of process parameters, the result shows that laser power increases and joint strength increases. Whereas joining speed increases, joint strength increases. The joint strength increases with the increase of the stand-off distance until it reaches the center value; the joint strength then starts to decrease with the increase of stand-off distance beyond the center limit. Optimum values of laser power, joining speed, and stand-off distance were found to be?18 watt, 100?mm/min, and 2?mm to get the maximum joint strength (predicted: 88.48?MPa). There was approximately 3.37% error in the experimental and modeled results of joint strength. 1. Introduction Laser transmission joining has various advantages over conventional plastic joining techniques, for example, no contact, high joining speed, accuracy, flexibility, small heat affected zone, and so forth. Laser transmission joining technology has extensively promising applications in the fields of the microfluidics, microelectromechanical systems, and biomedicine [1, 2]. During laser transmission welding of overlap connections laser radiation transmits through the upper thermoplastic part and is absorbed by a lower material. Heat is developed in the laser absorbing part, which melts the thermoplastic locally. Due to heat conduction, the laser transparent part melts locally too. Thermoplastic materials are laser radiation absorbing, when the material contains, for example, carbon black, absorbing additives, and pigments or when the materials are reinforced with carbon fibers [3]. There is a continuously growing interest in the joining of dissimilar materials in manufacturing industries. Joining of PET to 316?L stainless steel is found in a number of industrial applications [4]. The advantages of laser transmission joining are as follows: (a) exact control of the energy deposition in the joining area; (b) minimization of the heat affected
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