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Search Results: 1 - 10 of 146085 matches for " Sharon B. Cantor "
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FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response
Jenny Xie,Min Peng,Shawna Guillemette,Steven Quan,Stephanie Maniatis,Yuliang Wu,Aditya Venkatesh,Scott A. Shaffer,Robert M. Brosh Jr.,Sharon B. Cantor
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002786
Abstract: BRCA1 promotes DNA repair through interactions with multiple proteins, including CtIP and FANCJ (also known as BRIP1/BACH1). While CtIP facilitates DNA end resection when de-acetylated, the function of FANCJ in repair processing is less well defined. Here, we report that FANCJ is also acetylated. Preventing FANCJ acetylation at lysine 1249 does not interfere with the ability of cells to survive DNA interstrand crosslinks (ICLs). However, resistance is achieved with reduced reliance on recombination. Mechanistically, FANCJ acetylation facilitates DNA end processing required for repair and checkpoint signaling. This conclusion was based on the finding that FANCJ and its acetylation were required for robust RPA foci formation, RPA phosphorylation, and Rad51 foci formation in response to camptothecin (CPT). Furthermore, both preventing and mimicking FANCJ acetylation at lysine 1249 disrupts FANCJ function in checkpoint maintenance. Thus, we propose that the dynamic regulation of FANCJ acetylation is critical for robust DNA damage response, recombination-based processing, and ultimately checkpoint maintenance.
Traumatic brain injury: future assessment tools and treatment prospects
Steven R Flanagan,Joshua B Cantor,Teresa A Ashman
Neuropsychiatric Disease and Treatment , 2008,
Abstract: Steven R Flanagan1, Joshua B Cantor2, Teresa A Ashman21New York University School of Medicine, The Rusk Institute of Rehabilitation, New York, NY, USA; 2Department of Rehabilitation Medicine, Mount Sinai School of Medicine, New York, NY, USAAbstract: Traumatic brain injury (TBI) is widespread and leads to death and disability in millions of individuals around the world each year. Overall incidence and prevalence of TBI are likely to increase in absolute terms in the future. Tackling the problem of treating TBI successfully will require improvements in the understanding of normal cerebral anatomy, physiology, and function throughout the lifespan, as well as the pathological and recuperative responses that result from trauma. New treatment approaches and combinations will need to be targeted to the heterogeneous needs of TBI populations. This article explores and evaluates the research evidence in areas that will likely lead to a reduction in TBI-related morbidity and improved outcomes. These include emerging assessment instruments and techniques in areas of structural/chemical and functional neuroimaging and neuropsychology, advances in the realms of cell-based therapies and genetics, promising cognitive rehabilitation techniques including cognitive remediation and the use of electronic technologies including assistive devices and virtual reality, and the emerging field of complementary and alternative medicine.Keywords: traumatic brain injury, assessments, treatments
The impact of local U.S. tobacco policies on youth tobacco use: a critical review  [PDF]
Karen B Friend, Sharon Lipper-Kreda, Joel Grube
Open Journal of Preventive Medicine (OJPM) , 2011, DOI: 10.4236/ojpm.2011.12006
Abstract: Tobacco use continues to be the leading preventable cause of premature death in the United States, killing over 430,000 people annually. To-bacco initiation and use among youth remains a significant public health concern. Despite declines in U.S. youth tobacco use in recent years, state and national survey results are still cause for alarm. Although traditional school-based curricular programs are the most common strategy to prevent or reduce youth tobacco use, their effectiveness may be limited because young people are immersed in a broader social context in which tobacco is readily available. Environmental strategies change this social context by focusing on policy, enforcement, and media. A compelling body of evidence suggests that interventions at the state and federal levels can, when implemented in combination, reduce youth tobacco use. The impact of policies implemented at the local levels is less well understood and effects of environmental strategies on smokeless tobacco consumption have been largely ignored. The purpose of this paper is to review the literature on environmental strategies implemented at the local level on youth use of both cigarettes and smokeless tobacco. We highlight results of the extant *-literature, hypothesize possible effects where research is lacking, and suggest where future studies might be warranted.
El discurso de participación ciudadana en organismos internacionales: El caso del Banco Interamericano de Desarrollo
Cantor,Guillermo;
Revista de Ciencias Sociales , 2008,
Abstract: this article examines the inter american development bank?s institutional approach regarding citizen participation through reconstruction of the concepts of participation and democracy explicitly and implicitly contained in the strategy for promoting citizen participation in bank activities, with particular emphasis on their potential and limitations to inform effective practices. the discourse analysis is based on secondary sources, such as institutional documents, and transcriptions of meetings, negotiations, and consultations with different actors intervening in the process. as a result of the research, it is argued that the idb?s prevailing idea of participation is for the most part limited - namely, one based on the notion of influence and deliberation; oriented to achieve legitimacy for the idb?s operations; and largely mediated by formally organized groups. additionally, that concept of participation is a result of antecedents of the idb?s work with civil society, the way in which the participation agenda was adopted by the idb, and the idb?s structural position in regard to member governments.
Sujeto, lenguaje y organización social en el ni o: análisis de discurso
Jackeline Cantor
Revista CS , 2013,
Abstract: El siguiente artículo presenta los resultados de una investigación sobre cómo algunas madres se refieren discursivamente a los ni os con dificultades en su organización social primaria. Basado en la aplicación de encuestas y la realización de talleres, este estudio contempla un marco analítico que parte de la visión pragmática del lenguaje y la teoría de la enunciación, para construir un modelo de análisis que articula el problema de la enunciación, el referente y los actos de habla con los indicadores de la organización social primaria. Los resultados de la investigación están relacionados con el marco simbólico a partir del cual el ni o organiza su identidad como sujeto social.
Biología y ciclo reproductivo de Praon pos. occidentale (Hymenoptera: Braconidae) parasitoide de Macrosiphum euphorbiae (Hemiptera:Aphididae)
Cantor Fernando
Agronomía Colombiana , 2009,
Abstract: Trabajos preliminares realizados en cultivos comerciales de rosa en la Sabana de Bogotá han permitido evidenciar la presencia de avispas del género Praon parasitando áfidos. Con el fin de explorar su potencial como controlador biológico, el presente estudio caracterizó la biología y el ciclo reproductivo de Praon sp. en condiciones de laboratorio bajo seis temperaturas constantes: 15, 17, 20, 25, 28 y 30°C. áfidos parasitados fueron mantenidos en incubadoras a la temperatura deseada con 12 horas luz y 12 horas de oscuridad. Diariamente se realizaron disecciones de los áfidos parasitados para determinar el estado de desarrollo del parasitoide, lo que hizo posible determinar la duración promedio en días de cada estado, desde huevo hasta adulto. A todas las temperaturas, excepto a 15°C, se observó un desarrollo completo de los diferentes estadios, para los cuales se ajustaron modelos de tasa de desarrollo en función de la temperatura. El estado de huevo presentó el mayor umbral de temperatura mínima requerida para completar su desarrollo. Tanto hembras como machos son más longevos a temperaturas bajas. A temperaturas de 17 y 20°C se encontró mayor número de machos, mientras que a 25, 28 y 30°C se halló mayor número de hembras.
Results obtained on the gladiolus amelioration
Maria CANTOR
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 1998,
Abstract: Ce travail présente les deux derniéres variétés de glaieuls (Clujana, Lucia) crées et homologuées á SCPP Cluj. Grace á leurs caractéristiques particuliéres (vigueur, qualité des fleurs, bonne capacité de multiplication, résistence aux maladies et aux ennemis etc.) celles-ci peuvent être utilisées directement dans la production ou comme matériel génétique pou obtenir des nouveaux hybrides.
Research on the heritage transmission of the Gerbera hybrida's flowers colour
Maria CANTOR
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 1998,
Abstract: La publication traite de la facon de transmission hereditaire de la couleur des fleurs chez la Gerbera hybrida pour huit combinaisons hybrides. Dans la descendance F1, on a constate une puissante segregation phenotypique du caractere. Des 100 plantes cultivees, 11,1% ressemble au genotype maternel, 8,2% au genotype paternal, 72,2% ont des caracteres intermediaires et 8,5% presentent d'autres couleurs que les geniteurs. La couleur rouge est dominate par rapport aux autres couleurs, donc on peut parler d'une heredité polygenique et elle se transmet en descendance selon le type de la dominance incomplete. La transmission hereditaire de la couleur des fleurs et puissamment influencee par les effets maternales aux couleurs rose clair cyclamen par rapport aux croisements des especes differentes sous l'aspect de la couleur (rouge x blanche).
Las diferentes posturas en relación con el infinito actual (carta de Cantor a G. Enestrí-m, 4 de noviembre de 1885)
Georg Cantor
Signos filosóficos , 2004,
Abstract:
An Introduction To Jazz Filmography
Mark Cantor
Current Research in Jazz , 2009,
Abstract: The author identifies aspects peculiar to researching and documenting jazz on film. A bibliography is included.
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