OALib Journal期刊

ISSN: 2333-9721




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匹配条件: “Sharma Shrinivas” ,找到相关结果约7990条。
Antitumour activity of ethanolic extract of leaves of Holoptelea integrifolia on Dalton′s ascitic lymphoma in Swiss albino mice
Lakshmi K,Sharma Shrinivas,Rajesh T,Chitra V
International Journal of Green Pharmacy , 2010,
Abstract: The antitumour activity of the ethanolic extract of leaves of Holoptelea integrifolia (EHI) has been evaluated against Dalton′s ascitic lymphoma (DAL) in Swiss albino mice at the dose of 250 and 500 mg/kg, body weight. The experimental parameters were evaluated like tumour volume, tumour cell count, viable tumour cell count, mean survival time and increase in life span to assess antitumour activity. The extract was administered orally for 14 consecutive days to tumour bearing group of animals. The extract increased the life span of DAL treated mice and restored the hematological parameters as compared with the DAL bearing mice in a dose-dependant manner. The study revealed that the EHI showed significant antitumour activity in tested animal models.
Studies on anti-inflammatory effect of aqueous extract of leaves of Holoptelea integrifolia, Planch. in rats
Sharma Shrinivas,Lakshmi K,Patidar Arjun,Chaudhary Abhinav
Indian Journal of Pharmacology , 2009,
Abstract: Objectives: The purpose of the present study was to investigate the anti-inflammatory properties of aqueous extract of the leaves of H. integrifolia, Planch. Materials and Methods: The hind paw edema was produced in rats by subplanter injection of carageenan. The aqueous extract of H. integrifolia, Planch. (AHI) at dose (250 and 500 mg/kg p.o) was given to observe % inhibition of paw edema which were comparable with indomethacin (10 mg/kg p.o) used as a reference drug. Results: The extract administered orally at doses of 250 and 500 mglkg p.o produced a significant (P < 0.05) dose dependent inhibition of edema formation Conclusions: A significant % inhibition of paw edema by the aqueous extract of leaves of H. integrifolia, Planch. and its almost nearby same % inhibition with indomethacin suggest its usefulness as an anti-inflammatory agent.
Analytical Stability Indicative Method Development and Validation by High Pressure Liquid Chromatography for Assay in Ciprofloxacin hydrochloride Drug Substances  [PDF]
S. Shrinivas, M. Revanasiddappa
American Journal of Analytical Chemistry (AJAC) , 2015, DOI: 10.4236/ajac.2015.69069
Abstract: Ciprofloxacin is an antibiotic generic drug that can treat a number of bacterial infections. It is a second generic fluoroquinolone. This work presents a simple, sensitive and stability indicative method for assay determination of drug substances ciprofloxacin hydrochloride by high pressure liquid chromatography (HPLC). Separation of impurities from the main drug substances and accurate assay quantification with a simple method is difficult by Spectrophotometry. The separation of co-eluents and impurities from the ciprofloxacin drug substances was archived by HPLC with simple mobile phase 0.15% orthophosphoric acid adjusted pH to 3.0 with triethylamine and acetonitrile using a gradient program, column inertsil C18, 250 mm × 4.0 mm, 5 μm. Flow rate was 0.7 mL/min, the column temperature and injection volume were 35°C and 10.0 μL. Chromato-graphic analysis was carried out at wavelength 278 nm. The developed method was validated according to the international conference on harmonization (ICH) guidelines regarding: Precision, specificity by degradation, linearity, accuracy, range and robustness. The proposed method showed good linearity (correlation coefficient and regression coefficient were not less than 0.999 and 0.998) in the range of 50% to 150% of working concentration. The recovery at 50%, 100% and 150% of working concentration level was within 98.0% to 102.0%. The range of the method is concluded that developed method is from 50% to 150% of target concentration for ciprofloxacin hydrochloride. The applicability of the proposed method was verified through the analysis of the samples and percentage recoveries in the range of 98% to 102% were obtained without any interference detected at the main peak in the chromatogram. The validated method is highly selective, simple, accurate, cost effective, and it is applicable for stability studies and routine quality-control analysis in the pharmaceutical industries.
On Hilbert polynomial of certain determinantal ideals
Shrinivas G. Udpikar
International Journal of Mathematics and Mathematical Sciences , 1991, DOI: 10.1155/s0161171291000157
Abstract: Let X=(Xij) be an m(1) by m(2) matrix whose entries Xij, 1 ¢ ‰ ¤i ¢ ‰ ¤m(1), 1 ¢ ‰ ¤j ¢ ‰ ¤m(2); are indeterminates over a field K. Let K[X] be the polynomial ring in these m(1)m(2) variables over K. A part of the second fundamental theorem of Invariant Theory says that the ideal I[p+1] in K[X], generated by (p+1) by (p+1) minors of X is prime. More generally in [1], Abhyankar defines an ideal I[p+a] in K[X], generated by different size minors of X and not only proves its primeness but also calculates the Hilbert function as well as the Hilbert polynomial of this ideal. The said Hilbert polynomial is completely determined by certain integer valued functions FD(m,p,a). In this paper we prove some important properties of these integer valued functions.
Utility of transoesophageal echocardiography during surgery on left atrial myxoma
Gadhinglajkar Shrinivas,Sreedhar Rupa
Annals of Cardiac Anaesthesia , 2008,
Intraoperative evaluation of left atrial myxoma using real-time 3D transesophageal echocardiography
Gadhinglajkar Shrinivas,Sreedhar Rupa
Annals of Cardiac Anaesthesia , 2010,
Transoesophageal echocardiography during surgery for atrial septal defect with partial anomalous pulmonary venous connection
Gadhinglajkar Shrinivas,Sreedhar Rupa
Annals of Cardiac Anaesthesia , 2008,
Transoesophageal echocardiography during Senning′s operation
Gadhinglajkar Shrinivas,Sreedhar Rupa
Annals of Cardiac Anaesthesia , 2008,
Lower Bounds on the Rate-Distortion Function of Individual LDGM Codes
Shrinivas Kudekar,Ruediger Urbanke
Mathematics , 2008,
Abstract: We consider lossy compression of a binary symmetric source by means of a low-density generator-matrix code. We derive two lower bounds on the rate distortion function which are valid for any low-density generator-matrix code with a given node degree distribution L(x) on the set of generators and for any encoding algorithm. These bounds show that, due to the sparseness of the code, the performance is strictly bounded away from the Shannon rate-distortion function. In this sense, our bounds represent a natural generalization of Gallager's bound on the maximum rate at which low-density parity-check codes can be used for reliable transmission. Our bounds are similar in spirit to the technique recently developed by Dimakis, Wainwright, and Ramchandran, but they apply to individual codes.
Algebraic gossip on Arbitrary Networks
Dinkar Vasudevan,Shrinivas Kudekar
Mathematics , 2009,
Abstract: Consider a network of nodes where each node has a message to communicate to all other nodes. For this communication problem, we analyze a gossip based protocol where coded messages are exchanged. This problem was studied by Aoyama and Shah where a bound to the dissemination time based on the spectral properties of the underlying communication graph is provided. Our contribution is a uniform bound that holds for arbitrary networks.

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