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Search Results: 1 - 10 of 27634 matches for " Sharma Hemandra Kumar "
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Development and Validation of a RP-HPLC Method For Simultaneous Determination of Amlodipine Besylate and Hydrochlorthiazide in Tablet Dosage Form
Sharma Hemandra Kumar,Vinod Sahu,Rahul Sahu
International Journal of Research in Pharmacy and Science , 2011,
Abstract: A simple, precise, rapid and reproducible reversed-phase high performance liquid chromatography (RP-HPLC) method is developed for the simultaneous estimation of amlodipine besylate (AML) and hydrochlorthiazide (HCZ) present in multicomponent dosage forms. Chromatography is carried out isocratically at 25°C ± 0.5°C on an Prontosil C-18 column (4.6 x 250mm, 5μ particle size) with a mobile phase composed of acetonitrile: methanol: phosphate buffer (pH-3) in the ratio of 48:12:40 v/v/v at a flow rate of 1.2 mL/min. Detection is carried out using a UV-PDA detector at 232 nm. Parameters such as linearity, precision, accuracy, recovery, specificity and ruggedness are studied as reported in the International Conference on Harmonization guidelines. The retention times for AML and HCZ are 3.93 ± 0.5 min and 2.61 ± 0.5 min respectively. The linearity range and percentage recoveries for AML and HCZ are 5-25μgml-1 for both drugs and 99.05, 98.73% respectively. The correlation coefficients for all components are close to 1. The relative standard deviations for three replicate measurements in three concentrations of samples in tablets are always less than 2%.
Aptamers—A Promising Approach for Sensing of Biothreats Using Different Bioinformatics Tools  [PDF]
Anamika Sharma, Rakesh Kumar Sharma
Soft Nanoscience Letters (SNL) , 2013, DOI: 10.4236/snl.2013.34A001
Abstract: Intentional release of pathogens or biotoxin against humans, plants, or animals is an impending threat all over the world. Continuous monitoring of environment is required for their detection. These signals can help to distinguish whether the bioattack has occurred or not. Biosensors utilise biological response including different biochemical reactions, antigen antibody reactions, electrochemical reactions, aptameric reactions etc. The currently available biosensors have a limit of detection, specificity and less linearity which affect their sensitivity. Aptamers are single stranded oligonucleotides binding species which are capable of tightly binding to their distinguishing targets. They are evolved from random oligonucleotides pools by using different strategies. These are capable of conscientiously distinguishing their target ligands. They have high sensitivity and a wide range of detection limit. The versatility of nucleic acid based methods allowed for the design of specific aptamer sequences, typically on the order of 10 to 30 base pairs in length, identifying the different biothreat agents in the environment. By using different bioinformatics tools we can design RNA aptamers for toxins of lectin family.
Nodal Spine Pairs Present in the Mimosoid Prosopis juliflora Are Not Stipules but Define a Distinct Class of Lateral Organs  [PDF]
Vishakha Sharma, Sushil Kumar
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.38140
Abstract: The descriptions of Prosopis juliflora of subfamily mimosoideae in the family leguminosae, given in the floras of arid and semi-arid regions of the world, including the flora of Delhi, state that the spine pairs seen in association with compound leaf on nodes are stipules. The suggestions that spines are stipules were tested by morphological and histological examination of nodes of P. juliflora plants growing in the Arawalli range at New Delhi. The nascent nodes on growing branches of P. juliflora were observed to produce a pair of knife-like free bifacial stipules together with a leaf and a pair of spines. The stipules were missing from the mature nodes of the same branches whose young nodes carried stipule pairs, suggesting that the stipules were deciduous whereas leaves and spines were persistent. Anatomically, spines were observed to be appendages to stem and located adjacent to leaf petiole away from stipules. Vasculature of stipules was independent. The observations allowed the conclusion that P. juliflora nodes form regular stipules and spines produced on them are stem-like distinct lateral organs. It is suggested that nodal spine pairs borne on plant nodes in general are lateral organs different from stipules, leaves and secondary inflorescences.
Necessary Optimality Conditions for Multi-Objective Semi-Infinite Variational Problem  [PDF]
Bharti Sharma, Promila Kumar
American Journal of Operations Research (AJOR) , 2016, DOI: 10.4236/ajor.2016.61006
Abstract:

In this paper, necessary optimality conditions for a class of Semi-infinite Variational Problems are established which are further generalized to a class of Multi-objective Semi-Infinite Variational Problems. These conditions are responsible for the development of duality theory which is an extremely important feature for any class of problems, but the literature available so far lacks these necessary optimality conditions for the stated problem. A lemma is also proved to find the topological dual of \"\"?as it is required to prove the desired result.

Remediation of Pulp and Paper Industry Effluent Using Electrocoagulation Process  [PDF]
Dushyant Kumar, Chhaya Sharma
Journal of Water Resource and Protection (JWARP) , 2019, DOI: 10.4236/jwarp.2019.113017
Abstract: Electrocoagulation of pulp and paper industry effluent with SS-304 electrode has been carried out under varying process variable such as pH, current density, time and dose of electrolyte to find out the optimum conditions. Maximum reduction efficiency of Chemical Oxygen Demand (COD) 82% and color more than 99% from pulp and paper industry wastewater at the following conditions pH = 7, current density = 24.80 mA/cm2 time = 40 min and dose of electrolytes = 1.0 g/L. Moreover, effects of electrolytes dosage on electricity consumption were observed and found to be that NaCl is better in comparison of Na2SO4 in respect of lower down the electricity consumption. But application of NaCl causes the formation of hazardous compounds as secondary pollutants within treated water. Therefore, Na2SO4 could be a potent replacement of NaCl to enhance the conductivity of paper industry effluent treated by EC process. The treated water has been compared with standard of Central Pollution control board (CPCB) and World Health organization, and found to be suitable for the reuse in irrigation.
Studies on antibacterial activity and biochemical/biophysical properties of phytocystatin purified from Catharanthus roseus (Madagascar Periwinkle): an evergreen subshrub commonly found in district bijnor (U.P.)  [PDF]
Garima Sharma, Mukesh Kumar, Sandeep Sharma
Advances in Bioscience and Biotechnology (ABB) , 2011, DOI: 10.4236/abb.2011.26057
Abstract: In the present study two phytocystatins (thiol protease inhibitors) have been isolated and purified to homogeneity form Catharanthus roseusby a simple two step procedure using ammonium sulphate fractionation and gelfiltration chromatography on Sephacryl- 100HR.The two inhibitors were named as CRCI and CRCII (Catharanthus roseuscystatin I and II). CRCI and CRCII were purified with a fold purification of 1333.3, 1348.5 and percent yield of 18.18 and 16.35% respectively. The molecular weight of purified phytocystatins were 19.1 kDa and 16.9 kDa respectively, as determined by SDS-PAGE and mass spectrometry. Effect of denaturants like ureaon CRCI and II was analysed by Fluorescence spectroscopy. Results suggest an unfolding of CRCI and II. FTIR results show that structurally CRCI is different from CRCII. Hydrophobic interactions are observed over a longer timescale (5 - 150 min). Furthermore, fluorescence spectroscopy results show quenching of fluorescence intensity of CRC I and II, although to different extent, due to perturbations of the environment of aromatic residues in the protein. Both the cystatins showed strong inhibitory/antibacterial activity against E. coliand S. aureus
Solar Cells: In Research and Applications—A Review  [PDF]
Shruti Sharma, Kamlesh Kumar Jain, Ashutosh Sharma
Materials Sciences and Applications (MSA) , 2015, DOI: 10.4236/msa.2015.612113
Abstract: The light from the Sun is a non-vanishing renewable source of energy which is free from environmental pollution and noise. It can easily compensate the energy drawn from the non-renewable sources of energy such as fossil fuels and petroleum deposits inside the earth. The fabrication of solar cells has passed through a large number of improvement steps from one generation to another. Silicon based solar cells were the first generation solar cells grown on Si wafers, mainly single crystals. Further development to thin films, dye sensitized solar cells and organic solar cells enhanced the cell efficiency. The development is basically hindered by the cost and efficiency. In order to choose the right solar cell for a specific geographic location, we are required to understand fundamental mechanisms and functions of several solar technologies that are widely studied. In this article, we have reviewed a progressive development in the solar cell research from one generation to other, and discussed about their future trends and aspects. The article also tries to emphasize the various practices and methods to promote the benefits of solar energy.
Indirect Solar Drier with Electric Back up System for Quality Hill Products  [PDF]
Rajeev Kumar Aggarwal, Madan Mohan Sharma, Ashwani Kumar Sharma
Natural Resources (NR) , 2010, DOI: 10.4236/nr.2010.12009
Abstract: An indirect solar drier of 25 kg capacity has been developed fitted with solar cell for running the fan. The bulbs are provided in the solar collector for air heating during clouds and evening & morning for faster drying reducing drying time. Various hill crops (Punica granatum L, Ginger, Turmeric and Red chili) have been dried in open sun, oven and solar drier for quality/caparison. The dried products were tested in the post harvest technology laboratory for value addition. The market value of dried products has also been compared.
Acousto-Diffusive Waves in a Piezoelectric-Semiconductor-Piezoelectric Sandwich Structure  [PDF]
Jagan Nath Sharma, Kuldeep Kumar Sharma, Ashwani Kumar
World Journal of Mechanics (WJM) , 2011, DOI: 10.4236/wjm.2011.15031
Abstract: The propagation of acoustic waves in a homogeneous isotropic semiconducting layer sandwiched between two homogeneous transversely isotropic piezoelectric halfspaces has been investigated. The mathematical model of the problem is depicted by a set of partial differential equations of motion, Gauss equation in piezoelectric material and electron diffusion equation in semiconductor along with the boundary conditions to be satisfied at the piezoelectric-semiconductor interfaces. The secular equations describing the symmetric and asymmetric modes of wave propagation have been derived in compact form after obtaining the analytical expressions for various field quantities that govern the wave motion. The complex secular equation has been solved numerically using functional interaction method along with irreducible cardano method. The computer simulated results are obtained with the help of MATLAB software for 6 mm cadmium selenide (CdSe) piezoelectric material and n-type silicon (Si) semiconductor in respect of dispersion curve, attenuation and specific loss factor of energy dissipation for symmetric (sym) and asymmetric (asym) modes of wave propagation. The study may find applications in non-destructive testing, resonators, waveguides etc.
Towards Multi-Faceted Test Cases Optimization  [PDF]
Manoj Kumar, Arun Sharma, Rajesh Kumar
Journal of Software Engineering and Applications (JSEA) , 2011, DOI: 10.4236/jsea.2011.49064
Abstract: The target of software engineering is to produce high quality software product at low cost. Software testing is labour-intensive, ambiguous and error prone activity of software development. How to provide cost-effective strategies for software test cases optimization problem such as classification, minimization, selection, and prioritization has been one of the research focuses in software testing for a long time. Many researchers and academicians have addressed the effectiveness/fitness and optimization of test cases, and obtained many interesting results. However, one issue of paramount importance in software testing i.e. the intrinsic imprecise and uncertainty of test cases fitness, fitness parameters, multi-objective optimization, is left unaddressed. Test cases fitness depends on several parameters. Vagueness of fitness of test cases and their fitness parameters have created the uncertainty in test cases optimization. Cost and adequacy values are incorporated into multi-faceted optimization of test cases. This paper argues test cases optimization requires multi-faceted optimization in order to adequately cater realistic software testing. In this paper, authors have identified several parameters for test cases fitness and multiple objectives for test cases optimization. In addition above, authors have formulated the test cases optimization problem in three different ways using multi-faceted concept. These formulations can be used in future by authors and researchers.
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