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Search Results: 1 - 10 of 25492 matches for " Shaoguang Dong "
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The Larger Grain and (111)-Orientation Planes of Poly-Ge Thin Film Grown on SiO2 Substrate by Al-Induced Crystallization  [PDF]
Shaoguang Dong, Junhuo Zhuang, Yaguang Zeng
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.62003
Abstract: Al-induced crystallization yields the larger grain and (111)-orientation planes of poly-Ge thin film grown on SiO2 substrate, the (111)-orientation planes of poly-Ge thin film grown on SiO2 substrate are very important for the superior performance electronics and solar cells. We discussed the 50 nm thickness poly-Ge thin film grown on SiO2 substrate by Alinduced crystallization focusing on the lower annealing temperature and the diffusion control interlayer between Ge and Al thin film. The (111)-orientation planes ratio of poly-Ge thin film achieve as high as 90% by merging the lower annealing temperature (325℃) and the GeOx diffusion control interlayer. Moreover, we find the lack of defects on poly-Ge thin film surface and the larger average grains size of poly-Ge thin film over 12 μm were demonstrated by electron backscatter diffraction measurement. Our results turn on the feasibility of fabricating electronic and optical device with poly-Ge thin film grown on SiO2 substrate.
A New Immunosuppressive Protein in Pig Spleen  [PDF]
Hongyan Fu, Juan Feng, Shaoguang Fan
World Journal of Vaccines (WJV) , 2014, DOI: 10.4236/wjv.2014.43013
Abstract:
Chronic stress has been the popular phenomenon in the modern society. But we have not yet resolved the problem effectively. A novel protein in pig spleen, which possesses immunosuppressive activity, has been purified in this study. Its molecular weight about 200 kDa and three subunits composition were fractionated by SDS-PAGE. The protein inhibited mouse T-lymphocyte proliferation by the induced concanavalin A (ConA) and regulatory volume decrease (RVD), which may be due to the decreased Kv1.3 expression and activity. In addition, we have raised successfully its polyclonal antibody, which could reverse the inhibited lymphocyte proliferation by the immuno-suppressive protein. And the antibody could be used to coat plate for ELISA assay. Therefore, the antibody will have the potential to provide a basis for applying to clinical stress diseases in the future.
DNA Microarray Assay Helps to Identify Functional Genes Specific for Leukemia Stem Cells
Haojian Zhang,Shaoguang Li
Dataset Papers in Science , 2013, DOI: 10.1155/2013/520285
Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative disease derived from an abnormal hematopoietic stem cell (HSC) and is consistently associated with the formation of Philadelphia (Ph) chromosome. Tyrosine kinase inhibitors (TKIs) are highly effective in treating chronic phase CML but do not eliminate leukemia stem cells (LSCs), which are believed to be related to disease relapse. Therefore, one major challenge in the current CML research is to understand the biology of LSCs and to identify the molecular difference between LSCs and its normal stem cell counterparts. Comparing the gene expression profiles between LSCs and normal HSCs by DNA microarray assay is a systematic and unbiased approach to address this issue. In this paper, we present a DNA microarray dataset for CML LSCs and normal HSCs to show that the microarray assay will benefit the current and future studies of the biology of CML stem cells. 1. Introduction Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder that originates from an abnormal hematopoietic stem cell (HSC) harboring the Philadelphia chromosome (Ph) [1–3]. The Ph is caused by a reciprocal translocation between chromosomes 9 and 22 (t(9; 22)(q34; q11)), resulting in the formation of the chimeric BCR-ABL protein [1, 4]. As a result, the BCR-ABL oncogene is formed. BCR-ABL is a constitutively active tyrosine kinase, which has provided the molecular basis for designing therapeutic drugs. Imatinib is the first tyrosine kinase inhibitor (TKI) found to be highly effective in CML treatment through inhibiting BCR-ABL kinase activity [5–7]. Targeted therapy with TKIs induces a complete hematologic and cytogenetic response in more than 90% of chronic phase CML patients [8]. However, TKIs cannot efficiently eradicate leukemia stem cells (LSCs) of CML due to the insensitivity of LSCs to TKIs [9, 10]. Therefore, developing new strategies to target LSC is necessary and critical for curing CML, and the success of this approach requires a full understanding of the biology of LSCs. Although increasing evidence demonstrated that CML stem cells utilize signaling pathways that are independent of BCR-ABL kinase activity for their maintenance and survival [11, 12], the underlying molecular mechanisms remain unclear. To address these challenging issues, we performed a DNA microarray assay to compare the gene expression profiles between LSCs and normal HSCs. Here, we present the entire microarray dataset in open access format to demonstrate the usefulness of the microarray data in studying LSCs in CML. 2. Methodology Our previous
Effective time of immuno-suppressive protein in serum
Qingjun Huang,Can Jiang,Shaoguang Fan
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02883689
Abstract: Immuno-suppressive protein was generated in spleen and lymph node and released into serum in mice and rats under stress, which had strong suppressive effects on T and B lymphocyte proliferation. The present study showed that the serum from stressed mice presented a significant decrease in lymphocyte proliferation at 1, 12, 24, and 48 h after stress. There was not significant suppressive effect at 96 h. The half life of biological effect was 21.6 h.
Effect of the extract of intestine from stressed rat on lymphocyte proliferationin vitro
Qingjun Huang,Xiansuo Zhou,Shaoguang Fan
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02884126
Abstract: Immuno-suppressive protein, with a molecular weight of 155 and 370 ku, was generated in spleen and lymph node in stressed rats. It strongly inhibited lymphocyte proliferation. The results of activity assay, molecular weight determination and histological localization all demonstrated that under stress the immuno-suppressive protein was also generated in intestinal rnucosa of rats.
Boundedness of sublinear operators on weighted Morrey spaces and applications
Zunwei Fu,Shanzhen Lu,Shaoguang Shi
Mathematics , 2012,
Abstract: We study the boundedness of some sublinear operators on weighted Morrey spaces under certain size conditions. These conditions are satisfied by most of the operators in harmonic analysis, such as the Hardy-Littlewood maximal operator, Calder\'{o}n-Zygmund singular integral operator, Bochner-Riesz means at the critical index, oscillatory singular operators, singular integral operators with oscillating kernels and so on. As applications, the regularity in weighted Morrey spaces of strong solutions to nondivergence elliptic equations with VMO coefficients are established.
Boundedness of oscillatory integral operators and their commutators on weighted Morrey spaces
Zunwei Fu,Shaoguang Shi,Shanzhen Lu
Mathematics , 2011,
Abstract: It is proved that both oscillatory integral operators and fractional oscillatory integral operators are bounded on weighted Morrey spaces. The corresponding commutators generated by $BMO$ functions are also considered.
Weighted Norm Inequalities for One-sided Oscillatory Integral Operators
Zunwei Fu,Shaoguang Shi,Shanzhen Lu
Mathematics , 2011,
Abstract: The purpose of this paper is to establish the weighted norm inequalities of one-sided oscillatory integral operators by the aid of interpolation of operators with change of measures.
Heat Shock Protein 90 and Role of Its Chemical Inhibitors in Treatment of Hematologic Malignancies
Ngoc Ho,Adam Li,Shaoguang Li,Haojian Zhang
Pharmaceuticals , 2012, DOI: 10.3390/ph5080779
Abstract: Heat shock protein 90 (Hsp90) is a conserved and constitutively expressed molecular chaperone and it has been shown to stabilize oncoproteins and facilitate cancer development. Hsp90 has been considered as a therapeutic target for cancers and three classes of Hsp90 inhibitors have been developed: (1) benzoquinone ansamycin and its derivatives, (2) radicicol and its derivates, and (3) small synthetic inhibitors. The roles of these inhibitors in cancer treatment have been studied in laboratories and clinical trials, and some encouraging results have been obtained. Interestingly, targeting of Hsp90 has been shown to be effective in inhibition of cancer stem cells responsible for leukemia initiation and progression, providing a strategy for finding a cure. Because cancer stem cells are well defined in some human leukemias, we will focus on hematologic malignancies in this review.
Antagonistic effect of 6-hydroxydopamine (6-OHDA) on generation of immunosuppressive protein of stress in the rat
Juxiang Li,Li Shao,Yifan Li,Lin Mei,Shaoguang Fan
Chinese Science Bulletin , 1999, DOI: 10.1007/BF02887122
Abstract: Neonatal rats were injected with 6-hydroxydopamine (6-OHDA) for chemical sympathectomy. The rats were treated with restraint stress when they grew up to 56 d. It has-been found that the generation of immunosuppressive protein of stress (ISPS) is significantly reduced, suggesting that peripheral sympathetic nerve plays an important role in mediating the generation of ISPS.
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