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Search Results: 1 - 10 of 28025 matches for " Shao-Qing Kuang "
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Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia
Shao-Qing Kuang, Zhihong Fang, Patrick A. Zweidler-McKay, Hui Yang, Yue Wei, Emilio A. Gonzalez-Cervantes, Yanis Boumber, Guillermo Garcia-Manero
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061807
Abstract: The Notch pathway can have both oncogenic and tumor suppressor roles, depending on cell context. For example, Notch signaling promotes T cell differentiation and is leukemogenic in T cells, whereas it inhibits early B cell differentiation and acts as a tumor suppressor in B cell leukemia where it induces growth arrest and apoptosis. The regulatory mechanisms that contribute to these opposing roles are not understood. Aberrant promoter DNA methylation and histone modifications are associated with silencing of tumor suppressor genes and have been implicated in leukemogenesis. Using methylated CpG island amplification (MCA)/DNA promoter microarray, we identified Notch3 and Hes5 as hypermethylated in human B cell acute lymphoblastic leukemia (ALL). We investigated the methylation status of other Notch pathway genes by bisulfite pyrosequencing. Notch3, JAG1, Hes2, Hes4 and Hes5 were frequently hypermethylated in B leukemia cell lines and primary B-ALL, in contrast to T-ALL cell lines and patient samples. Aberrant methylation of Notch3 and Hes5 in B-ALL was associated with gene silencing and was accompanied by decrease of H3K4 trimethylation and H3K9 acetylation and gain of H3K9 trimethylation and H3K27 trimethylation. 5-aza-2′-deoxycytidine treatment restored Hes5 expression and decreased promoter hypermethylation in most leukemia cell lines and primary B-ALL samples. Restoration of Hes5 expression by lentiviral transduction resulted in growth arrest and apoptosis in Hes5 negative B-ALL cells but not in Hes5 expressing T-ALL cells. These data suggest that epigenetic modifications are implicated in silencing of tumor suppressor of Notch/Hes pathway in B-ALL.
Manipulating Biopolymer Dynamics by Anisotropic Nanoconfinement
Shao-Qing Zhang,Margaret S. Cheung
Physics , 2007, DOI: 10.1021/nl071948v
Abstract: How the geometry of nano-sized confinement affects dynamics of biomaterials is interesting yet poorly understood. An elucidation of structural details upon nano-sized confinement may benefit manufacturing pharmaceuticals in biomaterial sciences and medicine. The behavior of biopolymers in nano-sized confinement is investigated using coarse-grained models and molecular simulations. Particularly, we address the effects of shapes of a confinement on protein folding dynamics by measuring folding rates and dissecting structural properties of the transition states in nano-sized spheres and ellipsoids. We find that when the form of a confinement resembles the geometrical properties of the transition states, the rates of folding kinetics are most enhanced. This knowledge of shape selectivity in identifying optimal conditions for reactions will have a broad impact in nanotechnology and pharmaceutical sciences.
Characterization of Ag adsorption on TiC(001) substrate: an ab initio study

Ma Shang-Yi,Wang Shao-Qing,

中国物理 B , 2008,
Abstract: Ag adsorptions at 0.25--3 monolayer (ML) coverage on a perfect TiC(001) surface and at 0.25\,ML coverage on C vacancy are separately investigated by using the pseudopotential-based density functional theory. The preferential adsorption sites and the adsorption-induced modifications of electronic structures of both the substrate and adsorbate are analysed. Through the analyses of adsorption energy, ideal work of separation, interface distance, projected local density of states, and the difference electron density, the characteristic evolution of the adatom-surface bonding as a function of the amount of deposited silver is studied. The nature of the Ag/TiC bonding changes as the coverage increases from 0.25 to 3\,MLs. Unlike physisorption in an Ag/MgO system, polar covalent component contributes to the Ag/TiC interfacial adhesion in most cases, however, for the case of 1--3\,ML coverage, an additional electrostatic interaction between the absorption layer and the substrate should be taken into account. The value of ideal work of separation, 1.55\,J/m$^{2}$, for a 3-ML-thick adlayer accords well with other calculations. The calculations predict that Ag does not wet TiC(001) surface and prefers a three-dimensional growth mode in the absence of kinetic factor. This work reports on a clear site and coverage dependence of the measurable physical parameters, which would benefit the understanding of Ag/TiC(001) interface and the analysis of experimental data.
Coalescence between Cu57 and Cu58 clusters at a room temperature: molecular dynamics simulations

Zhang Lin,Li Wei,Wang Shao-Qing,

中国物理 B , 2010,
Recurrent Chromosome 16p13.1 Duplications Are a Risk Factor for Aortic Dissections
Shao-Qing Kuang equal contributor,Dong-Chuan Guo equal contributor,Siddharth K. Prakash equal contributor,Merry-Lynn N. McDonald,Ralph J. Johnson,Min Wang,Ellen S. Regalado,Ludivine Russell,Jiu-Mei Cao,Callie Kwartler,Kurt Fraivillig,Joseph S. Coselli,Hazim J. Safi,Anthony L. Estrera,Suzanne M. Leal,Scott A. LeMaire,John W. Belmont,Dianna M. Milewicz ,GenTAC Investigators
PLOS Genetics , 2011, DOI: 10.1371/journal.pgen.1002118
Abstract: Chromosomal deletions or reciprocal duplications of the 16p13.1 region have been implicated in a variety of neuropsychiatric disorders such as autism, schizophrenia, epilepsies, and attention-deficit hyperactivity disorder (ADHD). In this study, we investigated the association of recurrent genomic copy number variants (CNVs) with thoracic aortic aneurysms and dissections (TAAD). By using SNP arrays to screen and comparative genomic hybridization microarrays to validate, we identified 16p13.1 duplications in 8 out of 765 patients of European descent with adult-onset TAAD compared with 4 of 4,569 controls matched for ethnicity (P = 5.0×10?5, OR = 12.2). The findings were replicated in an independent cohort of 467 patients of European descent with TAAD (P = 0.005, OR = 14.7). Patients with 16p13.1 duplications were more likely to harbor a second rare CNV (P = 0.012) and to present with aortic dissections (P = 0.010) than patients without duplications. Duplications of 16p13.1 were identified in 2 of 130 patients with familial TAAD, but the duplications did not segregate with TAAD in the families. MYH11, a gene known to predispose to TAAD, lies in the duplicated region of 16p13.1, and increased MYH11 expression was found in aortic tissues from TAAD patients with 16p13.1 duplications compared with control aortas. These data suggest chromosome 16p13.1 duplications confer a risk for TAAD in addition to the established risk for neuropsychiatric disorders. It also indicates that recurrent CNVs may predispose to disorders involving more than one organ system, an observation critical to the understanding of the role of recurrent CNVs in human disease and a finding that may be common to other recurrent CNVs involving multiple genes.
A 485ps 64-Bit Parallel Adder in 0.18μm CMOS
A 485ps 64-Bit Parallel Adder in 0.18$\mu$m CMOS

Dong-Yu Zheng,Yan Sun,Shao-Qing Li,Liang Fang,
Dong-Yu Zheng
,Yan Sun,Shao-Qing Li,and Liang Fang

计算机科学技术学报 , 2007,
Abstract: This paper presents an optimized 64-bit parallel adder. Sparse-tree architecture enables low carry-merge fan-outs and inter-stage wiring complexity. Single-rail and semi-dynamic circuit improves operation speed. Simulation results show that the proposed adder can operate at 485ps with power of 25.6mW in 0.18μm CMOS process. It achieves the goal of higher speed and lower power. Supported by the National Natural Science Foundation of China under Grant Nos. 60273069, 60376018, 90207011, the National High Technology Development 863 Program of China under Grant No. 2002AA110020, and the Advanced Research Foundation of NUDT under Grant No. JC03-06-007.
Quasicontinuum simulation of crack propagation in nanocrystalline Ni

Shao Yu-Fei,Wang Shao-Qing,

物理学报 , 2010,
Abstract: The propagation process of crack in the nanocrystalline Ni is simulated via the quasicontinuum method. The results show that the stress near the crack tip could prompt the disassociation of grain boundaries, and the formation of stacking faults and deformation twins. Farther from the crack tip, fewer deformation twins can be found. There are more stacking faults than deformation twins in the grains, which approximately have the same distance to the crack tip. The effect on deformation twins from the variation of local stress and generalized planar fault energies is manifested by these results. The distribution of hydrostatic stress on atomic-level around the crack tip is also calculated. It is shown that nanovoids can be easily created in grain boundaries in front of the crack tip. There exists an intense tensile stress state in the grain boundary regions around these nanovoids. As a result of the stress accumulation, the crack propagates along the grain boundaries. Our simulated results qualitatively uncover the propagation process of crack in nanocrystalline Ni, which agrees well with the relevant experimental results.
Tight-binding molecular-dynamics study of melting behaviour of small silicon clusters

Wang JianWang,Shao-Qing,

物理学报 , 2003,
Abstract: 利用紧束缚分子动力学方法研究了硅团簇Sin(n=5—10)的熔化行为.给出了团簇 熔化潜热 和熔点随团簇尺寸的变化关系,表明团簇熔化潜热和熔点强烈依赖于团簇的原子数.计算结 果表明硅团簇熔化机理与金属团簇熔化有很大不同,金属小团簇的熔化是一个从低温类固态 向高温类固态转变的过程,在转变温区,类固态和类液态处于动力学共存,而硅团簇在转变 温区则是处于一种中间态,这种中间态既不是类固态又不是类液态.比较了用不同计算方法 和定义方法所得硅团簇熔点.
Molecular dynamics studies on vacancy-interstitial annihilation in silicon

Qiao Yong-Hong,Wang Shao-Qing,

物理学报 , 2005,
Abstract: Molecular dynamics (MD) simulation is performed to study the vacancy-interstitial annihilation in crystalline silicon. We choose the Stillinger-Weber potential , which is commonly used for silicon, to describe the interaction between atoms. The system is relaxed under 300K and 1400K respectively. We have found that <111 > is the preferred recombination direction and propose the presence of an energy barrier in the <110>direction. From the calculated value of energy barrier alon g <110> we give a reasonable explanation for the difference between Tang's and Z awadzki's data.
Two practical methods of phase space reconstruction

Yang Shao-Qing,Jia Chuan-Ying,

物理学报 , 2002,
Abstract: In this paper, several prevalent methods of phase space reconstruction are studied and their disadvantages are discussed. Based on the previous work, two practical methods of phase space reconstruction under different conditions are presented and the qualities of reconstruction are analyzed. In simulation, by using wavelet denoising approach, the two methods have good results in phase space reconstruction from noisy signals and the first method is better than the second. But the second method is suitable to solve the engineering problems.
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