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Search Results: 1 - 10 of 28426 matches for " Shanliang SUN "
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The Recovery Process of Murine Tracheal Epithelium Injured by 5-FU and Its Microarray Analysis
Jingru ZHANG,Nan SONG,Xinshan JIA,Shanliang SUN
Chinese Journal of Lung Cancer , 2009,
Abstract: Background and objective Although there are increasing reports on localization of tracheal stem cells, the mechanism of proliferation and differentiation of tracheal stem cells remains unclear. Methods In this study, we developed an ex vivo model of murine tracheal epithelial injury and regeneration induced by 5-FU. The regenerationprocess of murine tracheal epithelium was observed and analyzed by morphological, immunofluorescence and microarray methods. Results After treatment with 5-FU, the differentiated mature cells were dead and desquamated. Only a few cells remained in G0 phase and located on the basement membrane. After being put back in normal culture media, the cells became flat, cubic and restored as pseudostratified epithelium at last. These G0 phase cells were ABCG2 positive. We detected the differences of stem cell genes between normal tracheal epithelial cells and regenerated epithelial cells at 24 h and 48 h after injured by 5-FU using stem cell differentiation gene microarray. At 24 h, 8 genes were up-regulated and 31 genes were down-regulated. At 48 h, 5 genes were up-regulated and 42 genes were down-regulated. Conclusion The differently expressed genes were mainly associated with cell cycle regulation, intercellular junction, FGF, BMP, Notch and Wnt signaling pathways, which suggested these alterations might be closely associated with the proliferation and differentiation of tracheal stem cells.
Existence of Nonoscillatory Solutions of a Class of Nonlinear Dynamic Equations with a Forced Term  [PDF]
Shanliang Zhu, Xinli Zhang
Open Journal of Discrete Mathematics (OJDM) , 2012, DOI: 10.4236/ojdm.2012.24035
Abstract: In this paper, we consider the following forced higher-order nonlinear neutral dynamic equation on time scales. By using Banach contraction principle, we obtain sufficient conditions for the existence of nonoscillatory solutions for general and which means that we allow oscillatory and . We give some examples to illustrate the obtained results.
The Dynamic Multi-Task Supply Chain Principal-Agent Analysis  [PDF]
Shanliang LI, Chunhua WANG, Daoli ZHU
Journal of Service Science and Management (JSSM) , 2009, DOI: 10.4236/jssm.2009.24039
Abstract: In the supply chain by the composition of the supplier and the retailer, the supplier offers products to the retailer for sales while the retailer affects the sales outcome by his effort which is divided into two dimensions. One is for the short-term sales task and the other is for the long-term sales task. For the long-term development of the enterprise, the supplier wants to inspire the retailer to make more effort for the long-term task. However, due to the asymmetric information, the supplier can’t observe the retailer’s action and the moral hazard will come into being. To deal with this problem, we construct the dynamic multi-task supply chain principal-agent model, by which we analyze the impact of the information asymmetry to the supply chain contract. Furthermore, by comparing the contracts between the single-term multi-task and two-term multi-task, we have analyzed their different effect on the commission rate.
Oscillation and Nonoscillation Criteria for Nonlinear Dynamic Systems on Time Scales
Shanliang Zhu,Chunyun Sheng
Discrete Dynamics in Nature and Society , 2012, DOI: 10.1155/2012/137471
Abstract: We consider the nonlinear dynamic system Δ()=()(()),Δ()=?(,()). We establish some necessary and sufficient conditions for the existence of oscillatory and nonoscillatory solutions with special asymptotic properties for the system. We generalize the known results in the literature. Some examples are included to illustrate the results.
Life cycle of Craspedacusta sowerbyi xinyangensis
Shanliang XU,Danli WANG
Current Zoology , 2009,
Abstract: To explore the life cycle of Craspedacusta, the authors collected male and female specimens of the Craspedacusta sowerbyi xinyangensis in a small fire-fighting pond in Ningbo, Zhejiang Province in July, 2005 and 2006. The development of C.sowerbyi xinyangensis was studied from zygote to medusa by means of light microscopy and digital camera. The zygotes of C.sowerbyi xinyangensis are globular and smooth (90–105 μm diameter) and have an equal, total cleavage to the two-cell stage 15 min after fertilization. The embryos enter the four-cell stage after another 15 min and become multicellular embryos after 3h 15min. At this stage the embryos have a diameter similar to fertilized eggs but have uneven surfaces that are distinct from the smooth surfaces of the uncleaved zygotes. Solid gastrulae are formed 7 h after fertilization. These are spherical planulae with short surface cilia that begin to swim in slow clockwise circles. After 12 h, they lose their cilia, cease swimming and become elongated planulae with one end larger than the other. Rod-like planulae, similar in thickness at both ends, are formed after an additional 7 h. After 4 days, the planulae develop into tiny polyps having two germ layers and a gastrovascular cavity. The polyp mouth is 50–62 μm in diameter, lacking tentacles but having nematocysts around the mouth. Planulae become mature polyps after 10 days (15 days after fertilization). Medusa buds (45–88 μm diameter) are formed by polyp budding, which soon become free-living medusae with 8 tentacles (380–620 μm diameters). Sometimes, the movement of frustules, which are formed by the polyps and similar to planulae in morphology can also be observed [Current Zoology 55(3):227–234, 2009].
Oscillation of Two-Dimensional Neutral Delay Dynamic Systems
Xinli Zhang,Shanliang Zhu
Advances in Mathematical Physics , 2013, DOI: 10.1155/2013/871961
Abstract: We consider a class of nonlinear two-dimensional dynamic systems of the neutral type We obtain sufficient conditions for all solutions of the system to be oscillatory. Our oscillation results when improve the oscillation results for dynamic systems on time scales that have been established by Fu and Lin (2010), since our results do not restrict to the case where . Also, as a special case when , our results do not require to be a positive real sequence. Some examples are given to illustrate the main results. 1. Introduction In this paper, we are concerned with oscillation of the two-dimensional nonlinear neutral dynamic systems on time scales. Since we are interested in the oscillatory behavior of the solution of system (1) near infinity, we will assume throughout this paper that the time scales are unbounded. We assume that , and it is convenient to let , and define the time scale interval by . For system (1), we assume that? , and ;? , where , ;? and are real valued positive and rd-continuous functions defined on , and ;? are continuous, nondecreasing with for , . There exists continuous function such that for all , and for all . , where is a positive constant. The theory of time scales, which has recently a lot of attention, was introduced by Hilger in his Ph.D. degree thesis in 1988 in order to unify continuous and discrete analysis (see [1]). Not only can this theory of the so-called “dynamic equations” unify the theories of differential equations and difference equations, but also extend these classical cases to cases “in between,” for example, to the so-called -difference equations and can be applied on other different types of time scales. Since Hilger formed the definition of derivatives and integrals on time scales, several authors have expounded on various aspects of the new theory; see the paper in [2] and the references cited therein. A book on the subject of time scales in [3] summarizes and organizes much of time scale calculus. The reader is referred to [3], Chapter 1, for the necessary time scale definitions and notations used throughout this paper. Our main interest in this paper is to establish some oscillation results for system (1). We will relate our results to some earlier work for system (1). In the special case when , system (1) becomes the two-dimensional difference system If is a positive real sequence, the oscillatory property of system (2) has been receiving attention. We refer the reader to the papers [4, 5] and the references cited therein. However, system (1) have been restricted to the case when in paper [4]. On the other
Hardness estimation for covalent crystals using empirical electron theory
XiaoGuang Luo,JinPing Li,Ping Hu,ShanLiang Dong
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-010-3176-6
Abstract: Covalent electrons substantially determine the intrinsic hardness of inorganic crystals. A hardness model is presented on the basis of the Empirical Electron Theory generated from Pauling’s covalent bond length equation and the bond length difference method. The calculated hardness values of inorganic crystals are in good agreement with experimental and other theoretical values. Covalent bond energy with polarity correction can be used as an intrinsic indicator linking microscopic electronic structure to macroscopic hardness. A simple mathematical processing of bond energy is performed to extend the model to multi-bonding or multi-component systems. It is also found that spatial distribution of covalent bonds has a great influence on the hardness of inorganic crystals.
Family structure and phylogenetic analysis of odorant receptor genes in the large yellow croaker (Larimichthys crocea)
Yingsong Zhou, Xiaojun Yan, Shanliang Xu, Peng Zhu, Xianxing He, Jianxin Liu
BMC Evolutionary Biology , 2011, DOI: 10.1186/1471-2148-11-237
Abstract: Eighty-nine full-length and 22 partial OR cDNA sequences were isolated from the olfactory epithelium of the large yellow croaker, Larimichthys crocea. Bayesian phylogenetic analysis classified the vertebrate OR genes into two types, with several clades within each type, and showed that the L. crocea OR genes of each type are more closely related to those of fugu, pufferfish and stickleback than they are to those of medaka, zebrafish and frog. The reconciled tree showed 178 duplications and 129 losses. The evolutionary relationships among OR genes in these fishes accords with their evolutionary history. The fish OR genes have experienced functional divergence, and the different clades of OR genes have evolved different functions. The result of real-time PCR shows that different clades of ORs have distinct expression levels.We have shown about 100 OR genes to be expressed in the olfactory epithelial tissues of L. crocea. The OR genes of modern fishes duplicated from their common ancestor, and were expanded over evolutionary time. The OR genes of L. crocea are closely related to those of fugu, pufferfish and stickleback, which is consistent with its evolutionary position. The different expression levels of OR genes of large yellow croaker may suggest varying roles of ORs in olfactory function.Vertebrates can distinguish numerous odorants in the environment using chemosensory receptors that are expressed in the olfactory epithelium [1-3]. Four types of chemosensory receptors have been found in the vertebrate olfactory epithelium, including the main odorant receptors (ORs) [4], vomeronasal receptors (VRs) [5-7], trace-amine associated receptors (TAARs) [8] and formyl peptide receptor-like proteins [9]. The OR genes were initially identified in mouse olfactory organ by Linda Buck and Richard Axel [4], who found that each olfactory sensory neuron expressed a single OR allele [4,10,11]. The ORs, located on the surface of dendrites of sensory neurons on the olfactory epithel
Functional IL-23R rs10889677 Genetic Polymorphism and Risk of Multiple Solid Tumors: a Meta-Analysis
Shanliang Zhou, Yueqin Ruan, Hongchen Yu, Yunzhi Chen, Yongjun Yao, Yanhui Ma, Yan Gao
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080627
Abstract: Interleukin-23 receptor (IL23R) can interact with IL-23 and, thus, is involved in the T-helper 17 (Th17) cell-mediated inflammatory process as well as tumorigenesis. Recently, a functional single nucleotide polymorphism (SNP) rs10889677 has been identified in the 3’-untranslated region of IL-23R. It has been showed that the rs10889677AC SNP could increase the binding affinity of microRNA let-7f and downregulate IL-23R expression. Several case-control studies have examined the association between this SNP and genetic susceptibility of multiple solid tumors. However, the conclusions are conflicting. Therefore, we conducted this meta-analysis to systematically study the role of this functional IL-23R SNP in development of multiple solid tumors. There are a total of 5 studies are eligible (6731 cases and 7296 healthy controls). Either fixed-effect model or random-effect model was used to calculate pooled odds ratios (ORs) and the 95% confidence interval (95% CI). Significant association between this functional rs10889677 genetic variant and risk of multiple solid tumors were observed (CC genotype vs. AA genotype: OR = 0.59, 95% CI = 0.53-0.66, P < 0.001). These findings demonstrated that the IL-23R rs10889677 genetic variant might play an important part during malignant transformation of multiple solid tumors.
Status of non-destructive bunch length measurement based on coherent Cherenkov radiation
Jianbing Zhang,Shanliang Lu,Tiemin Yu,Haixiao Deng,Dmitry Shkitov,Mikhail Shevelev,Gennady Naumenko,Alexander Potylitsyn
Physics , 2013,
Abstract: As a novel non-destructive bunch length diagnostic of the electron beam, an experimental observation of the coherent Cherenkov radiation generated from a dielectric caesium iodide crystal with large spectral dispersion was proposed for the 30MeV femtosecond linear accelerator at Shanghai Institute of Applied Physics (SINAP). In this paper, the theoretical design, the experimental setup, the terahertz optics, the first angular distribution observations of the coherent Cherenkov radiation, and the future plans are presented.
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