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Search Results: 1 - 10 of 81802 matches for " Shan-Yu Su "
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Bi-Directional Regulation by Chinese Herbal Formulae to Host and Parasite for Multi-Drug Resistant Staphylococcus aureus in Humans and Rodents  [PDF]
Nobuo Yamaguchi, Takanao Ueyama, Nurmuhamamt Amat, Dilxat Yimit, Parida Hoxur, Daisuke Sakamoto, Yuma Katoh, Ikkan Watanabe, Shan-Yu Su
Open Journal of Immunology (OJI) , 2015, DOI: 10.4236/oji.2015.51003
Abstract: A decline in the immunopotential of the host plays acritical factor(s) in the occurrence of infections with methicillin-resistant Staphylococcus aureus (MRSA) or microorganisms by opportunistic infection. In such an infection, no way out for therapeutic concept, therefore bi-directional trial was the final choice. So we selected aformula, Dang Gui Liu Huang Tang (dLHT), which could both augmentimmune factorsin host and exert bacteriostatic effect. We sought to break through the epidemic by MRSA especially in elderly patient, by the fundamental and clinical trial by employing minor TCM, characterizing bidirectional ability of the decoction by western methods. Animal Experiment: Mitomycin-C (MMC)-treated mice with or without the infection of MRSA were made. The experimental design was made up to examine the bacteriostatic action as well as the immunopo-tentiating bias of the promising Chinese herbal medicine, dLHT, which was first proved for its immune potentiating activities as well as their sensitivity to antibiotics, but not direct aseptic effect was clear for MRSA. Both basic and clinical data showed that this formula was effective on repelling from the infectious focus after the treatment of MRSA infection. After the administration of dLHT, the number of white blood cells in MMC-treated mice recovered to 80% of the normal level. In addition, the phagocytic activity of macrophages increased to 70% in the dLHT-treated group, while that of the non-treated group was only 20%. The bactericidal activity also recovered to the level close to the normal value by dLHT. The ratio of neutrophils in the dLHT-administered group increased to 2.2% (normal mice, 2.6%), whereas that in the non-terated group was only 0.5%. The bacterial count in the liver of MRSA-challenged mice reached the peak at six hours after the challenge in both dLHT-treated and non-treated mice. However, the number of bacteria in dLHT group was much greater than that in the non-treated group. The bacterial count in the blood showed an increase 12 and 24 hours after the challenge. Even 24 hours after the challenge, a significant number of bacteria existed in the blood of dLHT-administered group, whereas only a small number of bacteria detectable 6 hours after the challenge and the number gradually decreased thereafter in the dLHT-administered group. MRSA-challenged MMC-treated mice were treated by dLHT, vancomycin, or dLHT and vancomycin. All of non-treated mice died 8 days after the MRSA challenge, whereas the survival rates were 60% after dLHT treatment, 40% after vancomycin treatment, and 80%
Hemopoietic Formulae Rearranged Leukocyte Subsets and Implication for Use against the Type of Constitution and Infectious Agent for Further Modification to Future  [PDF]
Nobuo Yamaguchi, Wataru Hiruma, Kohei Suruga, Nurmuhamamt Amat, Dilxat Yimit, Parida Hoxur, Daisuke Sakamoto, Kazuhiro Okamoto, Shan-Yu Su
Open Journal of Immunology (OJI) , 2015, DOI: 10.4236/oji.2015.53015
Abstract: A hemopoietic formula (HF) in traditional Chinese medicine (TCM) usually consists of more than six single herbs. We seek to look into changes of immune-competent cells by two commonly utilized HF, including Shi-Quan-Da-Bu-Tang (SDT) and Bu-Zong-Ye-Qi-Tang (BYT). However, the effects of both formulae on levels of leukocyte subsets are not yet defied. After administration of immno-suppressant to animals, the effects by HFs on the augmentation for subsets of leukocytes, CD positive cell counts of lymphocytes, and the cytokine-producing cells are measured. Our results show that SDT augments the level of lymphocytes, while BYT increases the level of granulocytes. In our clinical study with 15 healthy volunteers, positive cells for CD2, CD11b, CD14, IL-4, IL-1β and IFN-γ in peripheral blood are increased significantly 15 days after the ingestion of HFs. In rodents, compromised host as well as normal animal is administered with cancer chemotherapeutic agent (Mytomycin-C). Our observations show that SDT regulates phagocyte activities of the immune system, introducing it against intracellular parasite, and that BYT augments intercellular pathogen through humoral immunity. We discuss the significance and mechanism of HFs on the level of leukocyte subsets in number and function that are considered to be potential indicators for the evaluation of TCM modalities. We also propose an idea that TCM exhibits tonic effects via enhancing the ability to fight against infection and bacteria, as well as turning the multi-drug resistant bacteria to the sensitive ones. Together with these evidences, we suggest an ideal remedy for the compromised to fight host against pathogens. Moreover, we try to modify these hemopoietic formulae to more digestive forms. This modification brings to the significant lifted up for antibody producing cells and anti-oxidative activity for phagocytic cells.
Multiple Comparisons of Traditional Acupuncture Therapies of Japan, Korea and China—A Preliminary Report of Three Countries’ Acupuncture (TCA) Project  [PDF]
Kenji Kawakita, Yong-Suk Kim, Nobuo Yamaguchi, Xiao-Pin Lin, Matsuo Arai, Naomi Takazawa, Shan-Yu Su
Open Journal of Immunology (OJI) , 2015, DOI: 10.4236/oji.2015.53009
Abstract: Acupuncture therapy had established in China and it distributed among Asian countries and developed in each country as traditional medicine. In this project we compared the procedures and effects of traditional acupuncture therapies in China, Korea and Japan by using 10 healthy young male volunteers with written informed consent. Total white cell counts, leukocyte subsets and noradrenalin contents were used as outcomes. Three well trained traditional acupuncture therapists were chosen and they treated the same subjects at random order with intervals of at least two months. Each acupuncturist made his diagnosis and points selection for potentiate vital conditions. Clearly different procedures and point selections were used among three traditional acupuncture therapies on the same subject and the obtained changes of outcome measures also differed. Although variations of data were quite large, these results clearly demonstrated that acupuncture therapies have developed among three countries in unique manner.
The Association between Traditional Chinese Dietary and Herbal Therapies and Uterine Involution in Postpartum Women
Ming Ho,Tsai-Chung Li,Shan-Yu Su
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/918291
Abstract: Background. Traditional Chinese postpartum care is believed to help in the recovery of women after delivery. Objective. This study investigated the association of elements in dietary and herbal therapy with uterine involution. Methods. Indices of uterine involution were measured ultrasonographically in 127 postpartum women between 4-6 weeks after delivery. A self-reported retrospective questionnaire was used to query women about their frequencies of taking herbal medicines and consuming special diets during the first month after delivery. Correlation coefficients were calculated to identify the associations, then the regression models were used to identify the predictors. Result. Among the herbal medicines and diet, consumption of Eucommia ulmoides (E. ulmoides) negatively correlated with the AP diameter of the uterus and the cavity. E. ulmoides was also the only predictor of maximum AP diameter of the uterus, AP diameter of the uterus 5 cm from the fundus, and the maximum AP diameter of the cavity. Moreover, consumption of Sheng-hau-tang was significantly correlated with anteverted uterus and was a predictor of anteverted uterus. Conclusion. E. ulmoides and Sheng-hau-tang positively correlated with the degree of uterine involution after delivery, implying that both therapies might possess the pharmacological efficacy of uterine contraction in postpartum women.
Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia
Shan-Yu Su, Ching-Liang Hsieh
Chinese Medicine , 2011, DOI: 10.1186/1749-8546-6-26
Abstract: Activation of multiple inflammatory cascades accounts for the progressing of ischemia stroke [1]. After cerebral ischemia, energy depletion and necrotic neuron death in the local ischemic area start the inflammatory cascades. The reperfusion generates reactive oxygen species (ROS) that induce the production of cytokines and chemokines leading peripheral leukocytes to influx into the cerebral parenchyma and activate endogenous microglia. Then cellular immunity, adhesion molecules, inflammatory mediators, transcriptional factors participate in the inflammatory process.Anti-inflammatory treatment that inhibits specific steps of the inflammatory cascade is a new strategy for improving outcome after ischemia stroke [2-4]. The anti-inflammatory agents, including a variety of natural products used in Chinese medicine, have been shown to be able to prevent or treat ischemic stroke, by decreasing the infarct area and neurological deficiency [5]. These natural products are documented as anti-oxidative, anti-inflammatory, anti-apoptotic and neuro-functional regulatory agents [5]. Some active ingredients isolated from these herbs have been identified and demonstrated to have neuroprotective actions. Some of these compounds are andrographolide isolated from Andrographis paniculata (Chuan-xin-lian), oxymatrine isolated from Sophora flavescens (Ku-shen), quercetin isolated from Sophora japonica (Huai-hua), ferulic acid isolated from both Angelica sinensis (Dang-gui) and Ligusticum wallichii (Chuan-xiong), tetramethylpyrazine isolated from Ligusticum wallichii (Chuan-xiong), paeonol and paeoniflorin isolated from Paeonia lactiflora (Bai-shao), shikonin isolated from Lithospermum erythrorhizon (Zi-cao), vanillin, 4-hydroxybenzyl alcohol and 4-hydroxybenzyl aldehyde isolated from Gastrodia elata (Tain-ma), puerarin from Radix Puerariae (Pueraria lobata; Ge-gen), polydatin and emodin-8-O-β-D-glucoside isolated from Polygonum cuspidatum (Hu-zhang), tanshinone IIA isolated from Salviae
Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis
Shan-Yu Su,Chin-Yi Cheng,Tung-Hu Tsai,Ching-Liang Hsieh
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/932823
Abstract: Poststroke dementia commonly occurs following stroke, with its pathogenesis related to β-amyloid production and apoptosis. The present study evaluate the effects of paeonol, one of the phenolic phytochemicals isolated from the Chinese herb Paeonia suffruticosa Andrews (MC), on protection from memory loss after ischemic stroke in the subacute stage. Rats were subjected to transient middle cerebral artery occlusion (tMCAo) with 10 min of ischemia. The data revealed that paeonol recovered the step-through latency in the retrieval test seven days after tMCAo, but did not improve the neurological deficit induced by tMCAo. Levels of Amyloid precursor protein (APP)- and beta-site APP cleaving enzyme (BACE; β-secretase)-immunoreactive cells, and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells decreased in the paeonol-administered group. Western blotting revealed decreased levels of Bax protein in mitochondria and apoptosis-inducing factor (AIF) in cytosol following paeonol treatment. In conclusion, we speculate that paeonol protected memory after ischemic stroke via reducing APP, BACE, and apoptosis. Supression the level of Bax and blocking the release of AIF into cytosol might participate in the anti-apoptosis provided by paeonol.
Use of Chinese Medicine and Subsequent Surgery in Women with Uterine Fibroid: A Retrospective Cohort Study
Shan-Yu Su,Chih-Hsin Muo,Donald E. Morisky
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/617918
Abstract: Background. Chinese medicine (CM) has been used to relieve symptoms relevant to uterine fibroids. Objective. This study investigated the association between the use of CM and the incidence of uterine surgery in women with uterine fibroids. Subjects and Methods. This retrospective cohort study extracted records for 16,690 subjects diagnosed with a uterine fibroid between 2000 and 2003 from the National Health Insurance reimbursement database. The risk factors for surgery were examined via Cox proportional hazard analysis, and the difference in incidence of surgery between CM users and nonusers was compared using incidence rate ratios (IRRs) derived from Poisson's models. Results. After an average follow-up period of 4.5 years, the cumulative incidence of uterine surgery was significantly lower in CM users than CM nonusers (). Compared to CM nonusers, CM users were more unlikely to undergo uterine surgery (adjusted hazard ratio = 0.18, 95% confidence interval (CI) = 0.17, 0.19). The incidence of surgery in CM users was dramatically different from that for CM nonusers (IRR = 0.17, 95% CI = 0.16, 0.18). Conclusion. The risk of uterine surgery among fibroid patients who used CM was significantly decreased, implying an effective treatment of fibroid-related symptoms provided by CM.
Assessment by meta-analysis of interferon-gamma for the diagnosis of tuberculous peritonitis
Si-Biao Su,Shan-Yu Qin,Xiao-Yun Guo,Wei Luo
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i10.1645
Abstract: AIM: To investigate the performance and diagnostic accuracy of interferon-gamma (IFN-γ) for tuberculous peritonitis (TBP) by meta-analysis. METHODS: A systematic search of English language studies was performed. We searched the following electronic databases: MEDLINE, EMBASE, Web of Science, BIOSIS, LILACS and the Cochrane Library. The Standards for Reporting Diagnostic Accuracy initiative and Quality Assessment for Studies of Diagnostic Accuracy tool were used to assess the methodological quality of the studies. Sensitivity, specificity, and other measures of the accuracy of IFN-γ concentration in the diagnosis of peritoneal effusion were pooled using random-effects models. Receiver operating characteristic (ROC) curves were applied to summarize overall test performance. Two reviewers independently judged study eligibility while screening the citations. RESULTS: Six studies met the inclusion criteria. The average inter-rater agreement between the two reviewers for items in the quality checklist was 0.92. Analysis of IFN-γ level for TBP diagnosis yielded a summary estimate: sensitivity, 0.93 (95%CI, 0.87-0.97); specificity, 0.99 (95%CI, 0.97-1.00); positive likelihood ratio (PLR), 41.49 (95%CI, 18.80-91.55); negative likelihood ratio (NLR), 0.11 (95%CI, 0.06-0.19); and diagnostic odds ratio (DOR), 678.02 (95%CI, 209.91-2190.09). χ2 values of the sensitivity, specificity, PLR, NLR and DOR were 5.66 (P = 0.3407), 6.37 (P = 0.2715), 1.38 (P = 0.9265), 5.46 (P = 0.3621) and 1.42 (P = 0.9220), respectively. The summary receiver ROC curve was positioned near the desirable upper left corner and the maximum joint sensitivity and specificity was 0.97. The area under the curve was 0.99. The evaluation of publication bias was not significant (P = 0.922). CONCLUSION: IFN-γ may be a sensitive and specific marker for the accurate diagnosis of TBP. The level of IFN-γ may contribute to the accurate differentiation of tuberculosis (TB) ascites from non-TB ascites.
Unripe Fruit Extracts of Mangifera indica L. Protect against AGEs Formation, Melanogenesis and UVA-Induced Cell Damage  [PDF]
Chin-Hsiu Yu, Yu-Ting Lin, Hsiang-Ling Su, Kai-Wen Kan, Fu-Chen Liu, Shan-Yu Lin, Yu-Ming Chung, Hsin-Fen Hsu, Yung-Hsiang Lin
Food and Nutrition Sciences (FNS) , 2019, DOI: 10.4236/fns.2019.102014
Abstract: In this study, we explored the effects of unripe fruit extracts of Mangifera indica L. on the anti-aging activity in skin cells. Mangifera indica L. is a popular economical and medicinal plant with numerous health-beneficial properties. The aqueous extracts of unripe fruit of Mangifera indica L. were obtained and subjected to HPLC and NMR analyses for the identification of bioactive compounds. The anti-glycation effect of Mango unripe fruit extracts was monitored by in vitro model system of AGEs (Advanced glycation end products) formation. Mango unripe fruit extracts significantly inhibited the AGEs formation in a dose-dependent manner. Meanwhile, Mango unripe fruit extracts possessed a comparable efficiency to commercialized Kojic acids in the inhibition of melanogenesis in B16-F10 melanoma cells. The UVA-induced cell damages can be prevented and repaired by Mango unripe fruit extracts in skin fibroblast CCD-966SK. Compared to the untreated control, Mango unripe fruit extracts significantly increased the cell viability while being applied before (36%) or after (43%) UVA irradiation. These results verified the potential application of Mango unripe fruit extracts in the skin protection and recovery from UVA irradiation, as well as the suppression of AGEs formation and melanogenesis.
Modification of Hydrophilic and Hydrophobic Surfaces Using an Ionic-Complementary Peptide
Hong Yang, Shan-Yu Fung, Mark Pritzker, P. Chen
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0001325
Abstract: Ionic-complementary peptides are novel nano-biomaterials with a variety of biomedical applications including potential biosurface engineering. This study presents evidence that a model ionic-complementary peptide EAK16-II is capable of assembling/coating on hydrophilic mica as well as hydrophobic highly ordered pyrolytic graphite (HOPG) surfaces with different nano-patterns. EAK16-II forms randomly oriented nanofibers or nanofiber networks on mica, while ordered nanofibers parallel or oriented 60° or 120° to each other on HOPG, reflecting the crystallographic symmetry of graphite (0001). The density of coated nanofibers on both surfaces can be controlled by adjusting the peptide concentration and the contact time of the peptide solution with the surface. The coated EAK16-II nanofibers alter the wettability of the two surfaces differently: the water contact angle of bare mica surface is measured to be <10°, while it increases to 20.3±2.9° upon 2 h modification of the surface using a 29 μM EAK16-II solution. In contrast, the water contact angle decreases significantly from 71.2±11.1° to 39.4±4.3° after the HOPG surface is coated with a 29 μM peptide solution for 2 h. The stability of the EAK16-II nanofibers on both surfaces is further evaluated by immersing the surface into acidic and basic solutions and analyzing the changes in the nanofiber surface coverage. The EAK16-II nanofibers on mica remain stable in acidic solution but not in alkaline solution, while they are stable on the HOPG surface regardless of the solution pH. This work demonstrates the possibility of using self-assembling peptides for surface modification applications.
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