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Search Results: 1 - 10 of 14284 matches for " Shalini Singh "
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Nanostructures: Enhancing Potential Applications in Biomedicals  [PDF]
Shalini Singh
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.41002
Abstract: Nanotechnology is defined as the study and application of 1 - 100 nm sized structures. Nanomaterials have opened avenues for the industries and scientific endeavors. These recognized for unique size, dependant physical and chemical properties (optical, magnetic, catalytic, thermodynamic, electrochemical) [1]. Most significant properties of nanoparticles is their carbon strength. It is said to be so tough that recently with a nano-sized particles i.e. carbon nanotube—a bullet proof T-shirt/vests was manufactured. Nanotechnology were firstly proposed/initiated by Nobel Prize winner Richard Feynman in 1959 [2]. This science is credited to have applications ranging from electronics, biomedicals, food, fuel cells to biosensors and even fabrics. Though every field of science progressing but still faces some lacunae and that result in development of a new technology. The thriving biomedical techniques for disorders like cancers etc. is still in developmental stage where researchers and doctors are working hard for concrete therapeutic results from such nano-techniques. On Cancers, the harmful side effects of its treatment like chemotherapy can’t be left aside which is result of one of its drug delivery methods that don’t pinpoint their intended target cells accurately rather affects whole area. Researchers in universities like Harvard and MIT have been able to attach special RNA strands, measuring about 10nm in diameter, to nanoparticles and fill the nanoparticles with a chemotherapy drug. The RNA strands get attracted to cancer cells. When the nanoparticle encounters a cancer cell it adheres to it and releases the drug into the cancer cell. This directed method of drug delivery has great potential for treating cancer patients while producing less side harmful effects than those produced by conventional chemotherapy [3]. This paper provides valuable information to the researchers, knowledge experts and policy makers regarding the application of nanotechnology and its values in science and technology. Biomedical is one of the major issues which were catered by nanotechnology.
Molecular Docking Studies of Myricetin and Its Analogues against Human PDK-1 Kinase as Candidate Drugs for Cancer  [PDF]
Shalini Singh, Pradeep Srivastava
Computational Molecular Bioscience (CMB) , 2015, DOI: 10.4236/cmb.2015.52004
Abstract: Phosphoinositide-dependent protein kinase-1 (PDK1), the class of serine threonine kinase, is a master regulator of the AGC family of kinases. It is a main component of the PI3K pathway. As it is reported that this pathway is most commonly, and this pathway is the most commonly deregulated among many cancers. So designing a selective inhibitor of PDK1 may have the efficacy as an anticancer agent. Herein, we describe our work focused on the structure based on screening of 95% similar analogues of Myricetin deposited in PubChem database as earlier studies have been suggested that myricetin acts as an anti cancer agent. Further molecular docking as well as the in silico ADMET studies are incorporated on these compounds to evaluate the binding and pharmacokinetic properties of these compounds. Due to low oral bioavailability, clinical use of myricetin is limited. Therefore this study is an attempt towards screening of structurally similar better compounds as compare with myricetin which can act as better inhibitor against PDK-1.
Enhancement in QoS for Hybrid Networks Using IEEE 802.11e HCCA with Extended AODV Routing Protocol  [PDF]
Shalini Singh, Rajeev Tripathi
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2015, DOI: 10.4236/ijcns.2015.86024
Abstract: The mobile ad hoc network (MANET) with infrastructure networks (hybrid networks) has several practical uses. The utility of hybrid network is increased in real time applications by providing some suitable quality of service. The quality thresholds are imposed on parameters like end-to-end delay (EED), jitter, packet delivery ratio (PDR) and throughput. This paper utilizes the extended ad hoc on-demand distance vector (AODV) routing protocol for communication between ad hoc network and fixed wired network. This paper also uses the IEEE 802.11e medium access control (MAC) function HCF Controlled Channel Access (HCCA) to support quality of service (QoS) in hybrid network. In this paper two simulation scenarios are analyzed for hybrid networks. The nodes in wireless ad hoc networks are mobile in one scenario and static in the other scenario. Both simulation scenarios are used to compare the performance of extended AODV with HCCA (IEEE 802.11e) and without HCCA (IEEE802.11) for real time voice over IP (VoIP) traffic. The extensive set of simulations results show that the performance of extended AODV with HCCA (IEEE 802.11e) improves QoS in hybrid network and it is unaffected whether the nodes in wireless ad hoc networks are mobile or static.
Pseudomonas stutzeri associated conjunctivitis
Malhotra Shalini,Singh Kirti
Indian Journal of Pathology and Microbiology , 2008,
Combined 3D QSAR Based Virtual Screening and Molecular Docking Study of Some Selected PDK-1 Kinase Inhibitors
Shalini Singh,Pradeep Srivastava
Journal of Computational Medicine , 2014, DOI: 10.1155/2014/563080
Abstract: Phosphoinositide-dependent kinase-1 (PDK-1) is an important therapeutic target for the treatment of cancer. In order to identify the important chemical features of PDK-1 inhibitors, a 3D QSAR pharmacophore model was developed based on 21 available PDK-1 inhibitors. The best pharmacophore model (Hypo1) exhibits all the important chemical features required for PDK-1 inhibitors. The correlation coefficient, root mean square deviation (RMSD), and cost difference were 0.96906, 1.0719, and 168.13, respectively, suggesting a good predictive ability of the model (Hypo1) among all the ten pharmacophore models that were analyzed. The best pharmacophore model (Hypo1) was further validated by Fisher’s randomization method (95%), test set method , and the decoy set with the goodness of fit (0.73). Further, this validated pharmacophore model Hypo1 was used as a 3D query to screen the molecules from databases like NCI database and Maybridge. The resultant hit compounds were subsequently subjected to filtration by Lipinski’s rule of five as well as the ADMET study. Docking study was done to refine the retrieved hits and as a result to reduce the rate of false positive. Best hits will further be subjected to in vitro study in future. 1. Introduction Protein kinases are critical components of cellular signal transduction cascades [1]. Over 500 protein kinases in the human genome have been reported till date and they are considered as the second largest group of drug targets [2, 3]. Phosphoinositide-dependent kinase-1 (PDK-1), a 63?kDa serine/threonine kinase, is a major player in the PI3-kinase signaling pathway that regulates gene expression, cell cycle, growth, and proliferation [4–11]. PDK-1 is also termed as the ‘‘master kinase’’ because it phosphorylates highly conserved serine or threonine residues in the T-loop (or activation loop) of numerous AGC kinases, including PKB/AKT, PKC, p70S6K, SGK, and PDK-1 itself [12]. Although precise regulatory mechanisms vary, in the case of PKB/AKT, activation by PDK-1 is critically dependent on prior PI3 kinase activation and the presence of phosphatidylinositol-(3,4,5)-triphosphate (PIP3). A significant proportion (40–50%) of all tumors involve mutations in PIP3-3-phosphatase (PTEN) [13–15], which result in elevated levels of PIP3 and enhanced activation of PKB/AKT, p70S6K, and SGK. The inhibitors of PDK-1 could potentially provide valuable therapeutic agents for the treatment of cancer. Recognition process between ligand and model is based on spatial distribution of certain structural features of active site being complimentary
Modeling of the Interaction of Flavanoids with GABA (A) Receptor Using PRECLAV (Property-Evaluation by Class Variables)  [PDF]
Vijay K. Agrawal, Basheerulla Shaik, Padmakar V. Khadikar, Shalini Singh
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.24035
Abstract: Quantitative Structure-Activity Relationship (2D-QSAR) models for binding affinity constants (log Ki) of 78 flavanoid ligands towards the benzodiazepine site of GABA (A) receptor complex were estimated using the PRECLAV (Property-Evaluation by Class Variables) program. The best MLR equation with nine PRECLAV descriptors has R2 = 0.843 and R2C = 0.782. Attempt is also made for obtaining 2D-QSAR model using NCSS software. The comparison of the results indicated that the PRECLAV method is very efficient in detecting structure-activity correlation with good predictive power.
Intra osseous dermoid cyst of mandible—A rare case report  [PDF]
Vibha Singh, Shalini Gupta, Ridhi Jaiswal, Laxman Malkunje
Open Journal of Stomatology (OJST) , 2012, DOI: 10.4236/ojst.2012.22028
Abstract: The present article report a rare case of intraosseous dermoid cyst in mandible which clinically and radio-graphicaly presented as mandibular cyst. The diagnosis of dermoid cyst was confirmed histologically. A 20 year old patient was admitted to our Department with the complaint of swelling in left lower jaw with occasional pain. Radiographic examination revealed a radiolucent lesion extending from left 2nd molar to right premolar region. On surgical exploration the lesion was cystic in nature full of hair and keratinized tissues. The tissue was sent for the histopathological examination and macroscopic feature reveal numerous bits of soft tissue. The tissues were creamish brown in color, firm in consistency, with largest tissue measuring 2.5 × 1.5 × 0.5 cm in dimension. Few hair follicles were also evident within it. The histopathology reveal cyst lined by stratified squamous hyperor- thokeratinized epithelium supported by a fibrous connective tissue wall. The cystic epithelium is showing melanin pigmentation in the basal cell layer. Ab-undant onion skin keratin is seen within the cyst lumen. The epithelial lining as well as cyst wall shows numerous skin appendages such as lobules of seba-ceous glands. The underlying connective tissue shows mild chronic inflammatory infiltrate mainly composed of lymphocytes.
Characterization of sequences in human TWIST required for nuclear localization
Shalini Singh, Anthony O Gramolini
BMC Cell Biology , 2009, DOI: 10.1186/1471-2121-10-47
Abstract: Using site-specific mutagenesis and immunofluorescences, we observed that altered TWISTNLS1 K38R, TWISTNLS2 K73R and K77R constructs inhibit nuclear accumulation of H-TWIST in mammalian cells, while TWISTNLS2 K76R expression was un-affected and retained to the nucleus. Subsequently, co-transfection of TWIST mutants K38R, K73R and K77R with E12 formed heterodimers and restored nuclear localization despite the NLSs mutations. Using a yeast-two-hybrid assay, we identified a novel TWIST-interacting candidate TCF-4, a basic helix-loop-helix transcription factor. The interaction of TWIST with TCF-4 confirmed using NLS rescue assays, where nuclear expression of mutant TWISTNLS1 with co-transfixed TCF-4 was observed. The interaction of TWIST with TCF-4 was also seen using standard immunoprecipitation assays.Our study demonstrates the presence of two putative NLS motifs in H-TWIST and suggests that these NLS sequences are functional. Furthermore, we identified and confirmed the interaction of TWIST with a novel protein candidate TCF-4.TWIST1 is a basic helix-loop-helix (bHLH) transcription factor [1] which forms either homo-or-heterodimers with other bHLH proteins to bind to a core E-box (CANNTG) sequence on the promoter region of target genes through the basic region [2]. Twist is necessary for the development of the mesoderm [1], cell type determination and differentiation during myogenesis [3], neurogenesis [4], cardiogenesis [5] and also required for formation of the head mesenchyme, somites and limb buds [6]. Twist loses its function as a negative modulator during the differentiation of separate mesodermal layers, myogenesis, osteogenesis or neurogenesis [7,8]. Twist has also been implicated in neural tube closure and null mice mutants are embryonic lethal at E10.5, whereas TWIST is essential for normal development and promotes autosomal dominant defects characterized by minor skull and limb anomalies in humans [6]. Mutations in TWIST1 result in Saethre-Chotzen Syndrome
A Warehouse Imperfect Fuzzified Production Model with Shortages under Inflationary Conditions
S. R. Singh,Shalini Jain,Sarla Pareek
Advances in Decision Sciences , 2012, DOI: 10.1155/2012/638060
Dothiepin dependence syndrome
Singh Gurvinder,Kaur Paramleen,Bhatia Shalini
Indian Journal of Medical Sciences , 2004,
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