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匹配条件: “Shaik Mohammad Naushad” ,找到相关结果约12976条。
Clinical utility of polymorphisms in one-carbon metabolism for breast cancer risk prediction
Shaik Mohammad Naushad,Shree Divyya,Addepalli Pavani,Yedluri Rupasree
Journal of Medical and Allied Sciences , 2011,
Abstract: This study addresses the issues in translating the laboratory derived data obtained during discovery phase of research to a clinical setting using a breast cancer model. Laboratory-based risk assessment indi-cated that a family history of breast cancer, reduced folate carrier 1 (RFC1) G80A, thymidylate synthase (TYMS) 5’-UTR 28bp tandem repeat, methylene tetrahydrofolate reductase (MTHFR) C677T and catecholamine-O-methyl transferase (COMT) genetic polymorphisms in one-carbon metabolic pathway increase the risk for breast cancer. Glutamate carboxypeptidase II (GCPII) C1561T and cytosolic serine hydroxymethyl transferase (cSHMT) C1420T polymorphisms were found to decrease breast cancer risk. In order to test the clinical validity of this information in the risk prediction of breast cancer, data was stratified based on number of protective alleles into four categories and in each category sensitivity and 1-specificity values were obtained based on the distribution of number of risk alleles in cases and controls. Receiver operating characteristic (ROC) curves were plotted and the area under ROC curve (C) was used as a measure of discriminatory ability between cases and controls. In subjects without any protective allele, aberrations in one-carbon metabolism showed perfect prediction (C=0.93) while the predictability was lost in subjects with one protective allele (C=0.60). However, predictability increased steadily with increasing number of protective alleles (C=0.63 for 2 protective alleles and C=0.71 for 3 protective alleles). The cut-off point for discrimination was >4 alleles in all predictable combinations. Models of this kind can serve as valuable tools in translational re-search, especially in identifying high-risk individuals and reducing the disease risk either by life style modification or by medical intervention.
Media Economics Study Prominence and Relevance in India  [PDF]
Shaik Mohammad Shameer
Social Networking (SN) , 2015, DOI: 10.4236/sn.2015.44013
Abstract: Evolution of economic thought propagated different theories to understand the money management and its subsequent measures so as to fill demand and supply. The economics horizon broadens to study micro and macro aspects of each industry. Now mass media emerge as industry, delivering goods and services to the consumers. As mass media have expanded and given scope to many key players to enter into this industry to take part in pivotal role like content creators, exhibitors and distributors. Media priorities and agendas are incessantly changing to the tune of the market requirements. Each media industry is working out to produce content with low investment and gain profit out of it. Any change in the regulation policy and technologies may affect the economic process of the media industry. This article laid emphasis on the importance of media industry, scope for research, prospects and challenges of micro and macro characteristics of media industry in India.
P.M. Naushad Ali,Mohammad Javeed
Trends in Information Management , 2006,
Abstract: The paper examines the use of Internet by the faculty members of Aligarh Muslim University, Aligarh, India. The study includes search behaviour and difficulties confronted by the faculty members while browsing Internet and opinion about available Infrastructure Acilities in the university etc. Printed questionnaires were administered among faculty members of all departments in AMU, Aligarh. The result of the study shows that E-mail and World Wide Web are the most used Internet services besides a good number of users facing difficulties while searching especially those accessing from respective departments. The majority of users are not satisfied with the infrastructure facilities of the university for the service. The paper presents several suggestions for the further improvement of the services.
A Reduced Latency Architecture for Obtaining High System Performance
Kareemullah shaik,Mohammad Mohiddin,Md. Zabirullah
International Journal of Recent Technology and Engineering , 2012,
Abstract: Microprocessor performance has improved rapidlythese years. In contrast, memory latencies and bandwidths haveimproved little. The result is that the memory access time has beena bottleneck which limits the system performance. As the speed offetching data from memories is not able to match up with speed ofprocessors. So there is the need for a fast memory controller. Theresponsibility of the controller is to match the speeds of theprocessor on one side and memory on the other so that thecommunication can take place seamlessly. Here we have built amemory controller which is specifically targeted for SDRAM.Certain features were included in the design which could increasethe overall efficiency of the controller, such as, searching theinternal memory of the controller for the requested data for themost recently used data, instead of going to the Memory to fetch it.The memory controller is designed which compatible withAdvanced High-performance Bus (AHB) which is a newgeneration of AMBA bus. The AHB is for high-performance, highclock frequency system modules. The AHB acts as thehigh-performance system backbone bus. AHB supports theefficient connection of processors, on-chip memories and off-chipexternal memory interfaces with low-power peripherals.
SRGM with logistic-exponential testing-effort with change-point and Analysis of Optimal release policies based on increasing the test efficiency
Shaik. Mohammad Rafi,Dr.K.Nageswara Rao
International Journal on Computer Science and Engineering , 2010,
Abstract: Reliability is the one of the important factor of software quality. Past few decades several software reliability growth models are proposed to access the quality of the software. Main challenging task of reliability growth model is predicting the reliability, totalcost at optimal time at, software released into the market. It has been observed that most of the reliability growth models predict the failure rate to be constant during the software testing, but in reality software failure rate changes with testing time. In this paper we have investigated software reliability growth model byincorporating the both change point and testing effort. We incorporated logistic-exponential TEF in software reliability growth model with change-point. We also investigated the how testing efficiency can be increased by adopting the new automated testing tools into the software testing and its effect on the total cost of the software. Experiments are done on real datasets. Parameters are estimated. Results show the better fit.
Mohammad Salahuddin,Mohd Obaid-ur-Rahman,Shaik Jaleel
International Journal of Research in Aeronautical and Mechanical Engineering , 2013,
Abstract: The main goal of the proposed paper is the numerical investigation of Wings with and without winglet designs. Thisinvestigation shows the various performance and parameters for the wings when designed with a winglet and without awinglet and thus comparing the parameters for both the designs. The discussions were focused on the aerodynamicscharacteristics which include drag coefficient CD, lift coefficient CL, and lift-to-drag ratio L/D. In this investigation twoDifferent wings are used: An Elliptical wing and a Short wing. The airfoil used in this investigation is NACA 2412 withwhich both the wings are designed. The Geometry of the models is carried out in the CATIA V5 R19 Software and isdesigned in Part and Wireframe and Surface Design. The airfoils of Different Chord length are designed with differentStations using the geometry given in the DESIGNFOIL Software. The winglet is then designed for both the wings. Theinvestigation aims to produce better aerodynamic performance with the implementation of the winglet for both wingdesigns. One of the objectives of this work is reduce the induced drag formed on wing during the fight operation, thusimproving the efficiency of the aircraft. The analysis part is done by using the ANSYS Software, flow parameters (like thelift and drag) are measured for different design configurations and are compared with the plane wing and the wing designedwith winglet.
Incorporating Generalized Modified Weibull TEF in to Software Reliability Growth Model and Analysis of Optimal Release Policy
Shaik. Mohammad Rafi,K.Nageswara Rao,Shaheda Akthar
Computer and Information Science , 2010, DOI: 10.5539/cis.v3n2p145
Abstract: Software reliability is generally a key factor in software quality. Reliability is an essential ingredient in customer satisfaction. In software development process reliability conveys the information to managers to access the testing effort and time at which software release into the market. Large numbers of papers are published in this context. In this paper we proposed a software reliability growth model with generalized modified weibull testing effort. Performance application of proposed model is demonstrated through real datasets. The experimental results shown that the model gives an excellent performance compared to other models. We also discuss the optimal release time based on reliability requirement and cost criteria.
Polymorphisms in MTHFR, MS and CBS Genes and Homocysteine Levels in a Pakistani Population
Mohsin Yakub, Naushad Moti, Siddiqa Parveen, Bushra Chaudhry, Iqbal Azam, Mohammad Perwaiz Iqbal
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033222
Abstract: Background Hyperhomocysteinemia (>15 μmol/L) is highly prevalent in South Asian populations including Pakistan. In order to investigate the genetic determinants of this condition, we studied 6 polymorphisms in genes of 3 enzymes - methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C), methionine synthase (MS; A2756G), cystathionine-β-synthase (CBS; T833C/844ins68, G919A) involved in homocysteine metabolism and investigated their interactions with nutritional and environmental factors in a Pakistani population. Methodology/Principal Findings In a cross-sectional survey, 872 healthy adults (355 males and 517 females; age 18–60 years) were recruited from a low-income urban population in Karachi. Fasting venous blood was obtained and assessed for plasma/serum homocysteine; folate, vitamin B12, pyridoxal phosphate and blood lead. DNA was isolated and genotyping was performed by PCR-RFLP (restriction-fragment-length- polymorphism) based assays. The average changes in homocysteine levels for MTHFR 677CT and TT genotypes were positive [β(SE β), 2.01(0.63) and 16.19(1.8) μmol/L, respectively]. Contrary to MTHFR C677T polymorphism, the average changes in plasma homocysteine levels for MS 2756AG and GG variants were negative [β(SE β), ?0.56(0.58) and ?0.83(0.99) μmol/L, respectively]. The average change occurring for CBS 844ins68 heterozygous genotype (ancestral/insertion) was ?1.88(0.81) μmol/L. The combined effect of MTHFR C677T, MS A2756G and CBS 844ins68 genotypes for plasma homocysteine levels was additive (p value <0.001). Odds of having hyperhomocysteinemia with MTHFR 677TT genotype was 10-fold compared to MTHFR 677CC genotype [OR (95%CI); 10.17(3.6–28.67)]. Protective effect towards hyperhomocysteinemia was observed with heterozygous (ancestral/insertion) genotype of CBS 844ins68 compared to homozygous ancestral type [OR (95% CI); 0.58 (0.34–0.99)]. Individuals with MTHFR 677CT or TT genotypes were at a greater risk of hyperhomocysteinemia in folate and vitamin B12 deficiencies and high blood lead (p value <0.05) level. Conclusions Gene polymorphism (especially MTHFR C677T transition), folate and vitamin B12 deficiencies, male gender and high blood lead level appear to be contributing towards the development of hyperhomocysteinemia in a Pakistani population.
Inorganic and Composite Ion Exchange Materials and their Applications
Mu. Naushad
Ion Exchange Letters , 2009,
Abstract: Article describes applications of several groups of inorganic and composite ion exchange materials. Zeolites, acidic salts,hydrous oxides, metal ferrocyanides, heteropolyacids and composite organic/inorganic ion exchangers are reviewed.
Condition Driven Adaptive Music Generation for Computer Games
Alamgir Naushad
Computer Science , 2013, DOI: 10.5120/10652-5416
Abstract: The video game industry has grown to a multi-billion dollar, worldwide industry. The background music tends adaptively in reference to the specific game content during the game length of the play. Adaptive music should be further explored by looking at the particular condition in the game; such condition is driven by generating a specific music in the background which best fits in with the active game content throughout the length of the gameplay. This research paper outlines the use of condition driven adaptive music generation for audio and video to dynamically incorporate adaptively.

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