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Familial Progressive Hyperpigmentation: A Case Report
Monica Yadav,Sugandha Ghonasgi,Rohit Shah,S. M. Meghana
Case Reports in Dentistry , 2012, DOI: 10.1155/2012/840167
Abstract: Familial progressive hyperpigmentation (FPH) is a rare genodermatosis characterized by hyperpigmented patches in the skin and mucous membranes, present in early infancy, and increase in size and number with age. The genetic basis for FPH remains unknown. We report an unusual case of familial progressive hypermelanosis in a 17-year-old male patient with family history, who presented with a peculiar progressive oral pigmentation disorder. Diagnosis was confirmed by a series of hematological, biochemical, and histopathological investigations. Our paper stresses the need for the dentist to be aware of the systemic conditions that can also manifest in the oral cavity.
Effect of method of preparation on pioglitazone HCl-β-cyclodextrin inclusion complexes
Beloshe Shrikant,Chougule Dhanyakumar,Shah Rohit,Ghodke Dhananjay
Asian Journal of Pharmaceutics , 2010,
Abstract: Pioglitazone HCl is an antidiabetic agent with poor aqueous solubility. Inclusion complexes of pioglitazone HCl were prepared with β-cyclodextrin using various methods (physical mixing, kneading method, co-precipitation). The main aim of the present invention is to study the effect of the method of preparation on the dissolution profiles of pioglitazone HCl-β-Cyclodextrin inclusion complexes . The phase solubility profile of pioglitazone HCl with β-cyclodextrin was classified as AL-type and stability constant with 1:1 molar ratio was 115.45, calculated from the phase solubility diagram. Formation of the inclusion complex between pioglitazone HCl and β-cyclodextrin was confirmed by the Fourier Transform Infrared (FT-IR) spectroscopy. The dissolution profile of inclusion complexes were determined and compared with those of pioglitazone HCl alone and its physical mixtures. The dissolution rate of the pioglitazone HCl-β-cyclodextrin inclusion complex prepared by the co-precipitation method was six times higher when compared with the pure drug. The method of complexation of pioglitazone HCl in β-CD increased the dissolution rate of the drug in the following order: Coppt > KM > PM >Drug.
Familial Progressive Hyperpigmentation: A Case Report
Monica Yadav,Sugandha Ghonasgi,Rohit Shah,S. M. Meghana
Case Reports in Dentistry , 2012, DOI: 10.1155/2012/840167
Abstract: Familial progressive hyperpigmentation (FPH) is a rare genodermatosis characterized by hyperpigmented patches in the skin and mucous membranes, present in early infancy, and increase in size and number with age. The genetic basis for FPH remains unknown. We report an unusual case of familial progressive hypermelanosis in a 17-year-old male patient with family history, who presented with a peculiar progressive oral pigmentation disorder. Diagnosis was confirmed by a series of hematological, biochemical, and histopathological investigations. Our paper stresses the need for the dentist to be aware of the systemic conditions that can also manifest in the oral cavity. 1. Introduction Familial progressive hyperpigmentation (FPH) is a rare genodermatosis first reported by Chernosky et al. in 1971 [1]. Melanosis universalis hereditaria, melanosis diffusa congenita, universal acquired melanosis, and familial universal or diffuse melanosis are just some of the other terms coined by various authors to describe patients with a generalized diffuse hypermelanosis without systemic symptoms, but often with a familial pattern [2]. This condition has been described mostly in blacks, Hispanics, and oriental individuals, with both the sexes being affected equally [3]. Mode of inheritance is still debated upon since a number of inheritance patterns are recognised, mainly: (1) autosomal dominant (Chernosky et al. 1971 [1], Rebora and Parodi 1989 [4], Debao and Ting 1991 [5]); (2) autosomal recessive with germ-line mosaicism (Wende and Baukus 1919, Pegum 1955) [3]. Though such cases have been previously reported in dermatology, no such case has been reported in dental literature even though there are significant oral findings in these patients. 2. Case Report A 17-yr-old male patient reported to the department with a complaint of pain in the lower right side of the arch since 2 weeks. General examination revealed the presence of abnormal spotty hyperpigmentation all over his body. The pigmentation was more pronounced over the extremities (Figures 1 and 2). The pigmentation was present since birth and eventually increased thereafter. No other systemic abnormality was observed. He also reported that his brother and maternal uncle showed similar skin changes. Intraorally, generalized pigmentation was seen over the mucous membranes and observed to be concentrated on the tongue, palate, and gingiva. The lingual papillae were seen as prominent whitish spots, which on palpation appeared to be leathery in consistency (Figure 3). A grossly decayed 46 was found and advised for
Impact of formulation and process variable on the preparation of acyclovir microspheres by spray drying using factorial design
Madhuri L.Shinde, Virag A. Shah, Dhananjay S. Ghodke, Rohit R. Shah
International Journal of Research in Pharmaceutical Sciences , 2010,
Abstract: The aim of this work is to study the impact of polymer ratio and feed flow rate (ml/min) in the preparation of acyclovir microspheres by using spray drying technique. A 32 full factorial experiment was designed to study the effects of the polymer ratio and feed flow rate (ml/min) of spray dryer on the percent yield and encapsulation efficiency of microspheres. The result of analysis of variance test for both effects indicated that the test is significant. The effect of factor X1 (polymer ratio) (SSY1=120.96; SSY2=357.38) is higher than factor X2 (feed flow rate) (SSY1=79.06; SSY2=88.94) for optimizing the percent yield and encapsulation efficiency. The optimum polymer ratio (X1) and feed flow rate (X2) was found to be 3.68 and 10.00 ml/min respectively for obtaining higher percent yield and maximum encapsulation efficiency of microspheres which was found to be 33.26% and 91.23% respectively.
Detection of Adolescent Idiopathic Scoliosis among Nepalese Children Through the School Screening Program
Rohit Kumar Pokharel,Rajesh Bahadur Lakhey,Dinesh Kafle,Lakahn Lall Shah
Nepal Orthopaedic Association Journal , 2013, DOI: 10.3126/noaj.v3i2.9514
Abstract: Introduction: Idiopathic Adolescent Scoliosis (IAS) is the commonest type of scoliosis without any known cause. There has been studies in different countries and population on IAS; and its prevalence rate varies for different population. There has been no reported study done in Nepal on prevalence of adolescent idiopathic scoliosis (AIS). The aim of this study was to detect and evaluate the prevalence of idiopathic adolescent scoliosis in school children in different parts of Nepal.
Measurement of Radioactivity of 238U, 226Ra, 232Th and 40K in Soil of Different Geological Origins in Northern India  [PDF]
Rohit Mehra, Manmohan Singh
Journal of Environmental Protection (JEP) , 2011, DOI: 10.4236/jep.2011.27110
Abstract: Radioactivity of the nuclides 238U, 226Ra, 232Th and 40K was measured in soil by γ-ray spectrometry using HPGe detector. A criterion was set in order to analyse soil samples from plain, semi-hilly and hilly areas in northern India. More than three γ-ray energy peaks were used for the determination of 226Ra and 232Th activity concentrations to obtain more accurate results. Some of these peaks have interfering energies, which was caused by the limited resolution of the detector, but they were resolved theoretically and used in the analysis because of their significance in reducing the random error to its minimum level. Relationships between the measured radionuclides have been discussed elaborately. Radionuclides 238U and 226Ra were found in disequilibrium with ratio of specific activities 238U/, 226Ra) less than unity for most of the samples. In some cases this disequilibrium may be significant enough to modify the γ-ray dose factors.
Insights on the structural characteristics of NDM-1: The journey so far  [PDF]
Avneet Saini, Rohit Bansal
Advances in Biological Chemistry (ABC) , 2012, DOI: 10.4236/abc.2012.24040
Abstract: New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first reported; as it is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy worldwide is now considered a nightmare scenario, particularly due to its rapid dissemination. An underlying theme in the majority of recent studies is structural characterization as knowledge of the three-dimensional structure of NDM-1 shall help find connections between its structure and function. Moreover, structural details are even critical in order to reveal the resistance mecha- nism to β-lactam antibiotics. In this perspective, we review structural characteristics of NDM-1 that have been delineated since its first report. We anticipate that these structure-function connections made by its characterization shall further serve as future guidelines for elucidating pathways towards de novo design of functional inhibitors.
Determinants of IPOs Initial Return: Extreme Analysis of Indian Market  [PDF]
Rohit Bansal, Ashu Khanna
Journal of Financial Risk Management (JFRM) , 2012, DOI: 10.4236/jfrm.2012.14012
Abstract: This paper attempts to design and test empirical models, which integrate theoretical, institutional, and other factors, which interact to explain ownership structure. Ex-ante information at the level of under-pricing succeeds the Indian stock market crunch. The study is based on IPO that listed at Bombay stock exchange given that April 2000 to December 2011. Multiple linear regressions are used to distinguish the relationship between various independent variables with the dependent variable, i.e. level of underpricing. The outcomes of multiple regressions reveal that, firm’s age, IPO years, book building pricing mechanism, ownership structure, issue size, & market capitalization explained 44% of the variation in issuer under-pricing, Durbin Watson’s value subsisted 1.58, which indicates that, there is a positive sequential rela-tionship between variables. Number of share offered, issue size, market capitalization, subscription offer timing, book building mechanism and IPO years 2006, 2009 & 2011 are constructed to have important effect on the level of underpricing after the Indian market crisis. Nevertheless, firm’s age, IPOs year 2008, private issuing firms, non institutional promoters, Indian promoters and non institutional non promoters contain no significant difference in the level of underpricing after-market crisis.
Anaemia in a Patient with Diffuse Systemic Scleroderma  [PDF]
Karan Grover, Rohit Peshin
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.47056
Abstract: We hereby present a case of anaemia in a 73 years old patient with known past medical history of diffuse systemic scleroderma, who presented with acute onset of dizziness and haemetemesis. Blood tests revealed sudden drop of haemoglobin and an urgent gastroscopy revealed gastric antral vascular ectasia (GAVE) or watermelon stomach. GAVE is a rare but well recognised cause of acute bleeding in systemic scleroderma patients and should be kept as a differential diagnosis in the work up of anaemia in these patients.
Plasma cell pleocytosis in HSV-2 aseptic meningitis  [PDF]
Rohit Kalia, Karen Hennessey
Open Journal of Internal Medicine (OJIM) , 2013, DOI: 10.4236/ojim.2013.34026
Abstract:

Plasma cell pleocytosis has been seen in cerebrospinal fluid (CSF) analysis of patients with multiple myeloma, multiple sclerosis, leukemia, west nile encephalitis and lymphoma. There also have been some anecdotal reports suggesting the presence of plasma cells in CSF as possible early indicator of WNV encephalitis. We describe a case of plasma cell pleocytosis in CSF due to HSV-2 meningitis, adding it to the list of possible etiologies for the same. 

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