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Search Results: 1 - 10 of 4801 matches for " Seyed Alireza Mousavi Shirazi "
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The New Methods for Purifying the Industrial Effluents by Submerged Biofilm Reactors  [PDF]
Seyed Alireza Mousavi Shirazi
Journal of Environmental Protection (JEP) , 2011, DOI: 10.4236/jep.2011.27114
Abstract: Life on the earth is dependent on dynamic interactions between its physical, chemical and biological components. In fact, all the individual processes are responsible for regulating the environmental equilibrium which can provide biosphere for multiple forms of human life. In order to overcome on shortcomings, the use of immobilized cell bioreactor technology which provides a valuable effective for treatment of waste water is discussed. An immobilized system which in this matter is applied is about absorbed or captured microorganisms in a solid substratum to retain them in a reactor or analytical system. The multiply of these immobilized cells is done when by nutrients be supplied and then migrate to the surfaces which are referred to biofilms. The biofilms can be developed on various support systems such as polypropylene pall, rocks, sands, charcoal, ceramics, and glass beads. The controllable reaction vessels which are used for these colonized surfaces are referred to bioreactors. Bioreactors in both up flows and down flows mode which use of either batch or continuous processes principle can be operated. Synchronic with development in biotechnology, there is also an extensive development in the field of bioreactors like: pumped tower loop reactor (PTLR), liquid impelled loop reactor (LILR), multipurpose tower bioreactor (MTB), fluidized-bed and packed-bed bioreactor, that in this article are discussed them.
Design and Simulation of a New Model for Treatment by NCT
Seyed Alireza Mousavi Shirazi,Dariush Sardari
Science and Technology of Nuclear Installations , 2012, DOI: 10.1155/2012/213640
Abstract: In this investigation, neutron capture therapy (NCT) through high energy neutrons using Monte Carlo method has been studied. In this study a new method of NCT for a sample liver phantom has been defined, and interaction of 12?MeV neutrons with a multilayer spherical phantom is considered. In order to reach the desirable energy range of neutrons in accord with required energy in absence of eligible clinical neutron source for NCT, this model of phantom might be utilized. The neutron flux and the deposited dose in the all components and different layers of the mentioned phantom are computed by Monte Carlo simulation. The results of Monte Carlo method are compared with analytical method results so that by using a computer program in Turbo-Pascal programming, the deposited dose in the liver phantom has been computed. 1. Introduction Neutron capture therapy (NCT) has been one of the most important methods for treatment of cancers in recent years. This method of radiation therapy is applicable in treatment of liver cancer. During clinical practice, it is always essential to stop absorption of additional dose by normal tissue. On the other hand, measurement and assessment of the absorbed dose and its calibration is an important matter [1, 2]. Thus computation and modeling of the deposited dose by Monte Carlo method before practical treatment is recommended. An appropriate software tool for this purpose is MCNP4C code. It is a particular engineering solution when BNCT facilities such as low energy neutron source are not available. In this paper for simulation by MCNP4C code, a phantom is considered so that it has been encased by polyethylene sphere with 20?cm radius. This sphere is covered with a layer of cadmium which has 100? m thickness [3, 4]. The cadmium layer has high absorption cross-section for thermal neutrons and helps to reentrance the scattered neutrons from surface of the sphere to the phantom [5]. The polyethylene sphere is surrounded by a graphite shell which has 25?cm radius and 5?mm thickness (according to moderation ratio: ). This layer serves as a reflector to reduce escaping the fast neutrons [6]. In the present work, neutrons are emitted from an external source, and after passing through polyethylene and slowing down, their deposited energy in the phantom’s materials is computed by the MCNP4C code. The F6 tally in the MCNP4C code is applied. The absorbed energy in the liver is computed through analytical computations as well. It includes generation of random numbers along with using the neutron diffusion equation [7]. The outcomes of two
Vesicoureteral Reflux in Neonates with Hydronephrosis; Role of Imaging Tools
Hamid Mohammadjafari,Alireza Alam,Mehrnoosh Kosarian,Seyed-Abdollah Mousavi
Iranian Journal of Pediatrics , 2009,
Abstract: Objective: Neonatal Hydronephrosis is a common abnormality diagnosed ante- or postnatally. The aim of this study was to determine the prevalence and severity of vesicoureteral reflux (VUR) in neonates with antenatal or postnatal hydronephrosis and the value of ultrasonography as a noninvasive tool for VUR prediction. Methods: In a prospective study, 202 infants with neonatal hydronephrosis were studied. Two successive renal ultrasound examinations were performed at 1 and 4-6 weeks after birth in neonates with antenatal hydronephrosis or immediately after presentation. Voiding cystourethrography (VCUG) was performed in all infants. Findings: The incidence of VUR was 29.7%, of which 17.8% had severe (grade IV-V) reflux. 27% of 133 neonates with unilateral and 34.8% of 69 cases with bilateral hydronephrosis had VUR. Although a significant association was observed between severity of hydronephrosis and VUR, 5.9% of normal appearing and 7.8% of grade 1 hydronephrotic neonates had high-grade reflux. Conclusion: VUR was observed significantly in hydronephrotic neonates. A normal or mildly hydronephrotic urinary tract on ultrasound scan cannot exclude presence of severe VUR. We recommend performing VCUG in all hydronephrotic newborns.
Urinary Tract and Other Associated Anomalies in Newborns With Esophageal Atresia
Fatemeh Eghbalian,Alireza Monsef,Seyed Habibollah Mousavi-Bahar
Urology Journal , 2009,
Abstract: Esophageal atresia is often associated with other anomalies. Hereditary and environmental factors may influence the incidence of associated anomalies, particularly of the urogenital system. We had 63 neonates with esophageal atresia admitted to 2 centers in Hamadan, Iran, from 2002 to 2008. They were 38 girls (60.3%) and 25 boy (39.7%). Tracheoesophageal fistula was present in 54 neonates (85.7%), and other associated anomalies in 10 (15.9%). Cardiac anomalies were found in 7 neonates; anorectal anomalies, in 4; urinary tract anomalies, in 2; and limb anomaly, in 1. Urinary tract anomalies (3.2%) were bilateral polycystic kidney in 1 neonate and unilateral hydronephrosis due to ureteropelvic junction obstruction in another. Both neonates with urinary tract anomalies were female and both had tracheoesophageal fistula, as well. Many of the associated congenital abnormalities influence the management protocol of esophageal atresia, and therefore, should be detected as soon as possible after birth.
Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines
Zahra Tayarani-Najaran,Seyed Ahmad Emami,Javad Asili,Alireza Mirzaei,Seyed Hadi Mousavi
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep214
Abstract: The Scutellaria species (Lamiaceae) is used as a source of flavonoids to treat a variety of diseases in traditional medicine. In spite of many reports about the cytotoxic and antitumor effects of some species of this genus, anticancer researches on one of the Iranian species S. litwinowii have not yet been conducted. The cytotoxic properties of total methanol extract of S. litwinowii and its fractions were investigated on different cancer cell lines including AGS, HeLa, MCF-7, PC12 and NIH 3T3. Meanwhile, the role of apoptosis in this toxicity was explored. The cells were cultured in DMEM medium and incubated with different concentrations of herb plant extracts. Cell viability was quantitated by MTT assay. Apoptotic cells were determined using propidium iodide staining of DNA fragmentation by flow cytometry (sub-G1 peak). Scutellaria litwinowii inhibited the growth of malignant cells in a dose-dependent manner. Among solvent fractions of S. litwinowii, the methylene chloride fraction was found to be more toxic compared to other fractions. The IC50 values of this fraction against AGS, HeLa, MCF-7 and PC12 cell lines after 24 h were determined, 121.2 ± 3.1, 40.9 ± 2.5, 115.9 ± 3.5 and 64.5 ± 3.4 μg/ml, respectively. Scutellaria litwinowii induced a sub-G1 peak in the flow cytometry histogram of treated cells compared to control cells indicating that apoptotic cell death is involved in S. litwinowii toxicity. Scutellaria litwinowii exerts cytotoxic and proapototic effects in a variety of malignant cell lines and could be considered as a potential chemotherapeutic agent in cancer treatment.
Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells
Tayarani-Najarani, Zahra;Asili, Javad;Parsaee, Heydar;Mousavi, Seyed Hadi;Mashhadian, Naser Vadati;Mirzaee, Alireza;Emami, Seyed Ahmad;
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/S0102-695X2011005000161
Abstract: chemical investigation on the ch2cl2 fraction of the scutellaria litwinowii bornm. & sint., lamiaceace, root extract for the first time resulted in the isolation of wogonin, and neobaicalein. these compounds were evaluated for their cytotoxicity towards hela cell lines and lymphocytes. meanwhile, the role of apoptosis was explored in this toxicity. the cells were cultured in rpmi medium and incubated with different concentrations of isolated flavonoids. cell viability was quantified by mts assay. apoptotic cells were determined using propidium iodide staining of dna fragmentation by flow cytometry (sub-g1peak). wogonin, and neobaicalein inhibited the growth of malignant cells in a dose-dependent manner. the ic50 values of 46.62 and 79.34 μm were, respectively, found for neobaicalein and wogonin against hela cells after 48 h of treatment. neobaicalein induced a sub-g1 peak in the flow cytometry histogram of treated cells compared to control cells indicating that apoptotic cell death is involved in neobaicalein toxicity. neobaicalein exerts cytotoxic and pro-apoptotic effects in hela cell lines and could be considered as a potential chemotherapeutic agent in cancer treatment.
Addressing the Younger Age at Onset in Breast Cancer Patients in Asia: An Age-Period-Cohort Analysis of Fifty Years of Quality Data from the International Agency for Research on Cancer
Seyed Houssein Mousavi-Jarrrahi,Amir Kasaeian,Kamyar Mansori,Mehdi Ranjbaran,Mahmoud Khodadost,Alireza Mosavi-Jarrahi
ISRN Oncology , 2013, DOI: 10.1155/2013/429862
Abstract: Introduction. There is an established fact that Asian breast cancer patients are, on average, younger than their European counterparts. This study aimed to utilize the data from the Cancer Incidence in Five Continents I through XIII (published by the International Agency for Research on Cancer) to examine what contributes to the younger age at onset in the Asian population. Material and Methods. Data (number of breast cancer cases and corresponding population figures) for 29 registries in Europe and 9 registries in Asia for the period of 1953–2002 was accessioned and pooled to form two distinct populations, Asia and Europe. The age specific rates were defined and analyzed cross-sectionally (period wise) and longitudinally (cohort wise). The magnitude and the pattern of age specific rates were analyzed using the age-period-cohort analysis. The constrained generalized linear model with a priority assumption of cohort effect as contributing factor to changing rates was used to analyze the data. Result. During the last 50 years, the rate of breast cancer increased for both populations with an estimated annual percent change of 1.03% (with 95% CI of 1.029, 1.031) for Asia and 1.016% (95% CI of 1.015, 1.017) for Europe. There were stronger cohort effects in the magnitude of rates among the Asian population compared to the European population. The cohort effects, expressed as the rate ratio with cohort born in 1970 as reference, ranged from 0.06 (95% CI 0.05, 0.08) to 0.94 (95% CI 0.93, 0.96) for Asians and 0.35 (95% CI 0.33, 0.36) to 1.03 (95% CI 1.02, 1.04) for Europeans. The estimated longitudinal age specific rates (adjusted for cohort and period effects) showed similar patterns between the two populations. Conclusion. It was concluded that a strong cohort effect contributes to the younger age at onset among Asian breast cancer patients. 1. Introduction Breast cancer is a leading cause of mortality and morbidity all over the world. In 2008, close to 1.4 million cases were diagnosed with breast cancer worldwide [1]. The incidence varies among different populations with high rates seen in developed countries compared to developing countries [2, 3]. In general, breast cancer rates are highest in white European and lowest in east Asian populations [1, 4, 5]. The estimated incidence rate for women living in the south-east Asia region of World Health Organization’ is 26.1 per 100000 population and this figure is 89.7 for women living in Western Europe [1]. The established risk factors of breast cancer are, mainly, early age at menarche, late age at menopause,
Nutlet Micromorphological Study on Salvia L. (Lamiaceae) from NE Iran  [PDF]
Seyed Mohammad Mousavi, Azarnoosh Jafari, Shahla Najafi
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.47178
Abstract:

In the present research, micromorphological features of 10 Salvia L. nutlets (mericarp) growing in NE Iran were studied by SEM. These species were divided into three and four groups based on the shape and ornamentation of nutlets respectively. The variation in color, size and ornamentation of mericarp helped to identify species.

Effect of Job Organization on Job Performance among Operating Staffs in Manufacturing Companies  [PDF]
Seyed Mehdi Mousavi Davoudi, Meysam Allahyari
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.32018
Abstract:

The current study was conducted in Mazandaran, a northern province of Iran, and aimed to analyze the effect of job organization on job performance of 1000 operating staffs in 50 manufacturing companies. According to Krejcie & Morgan table [1], the minimum number of sample size was determined as 278 people. A total of 333 questionnaires were distributed among respondents and 284 usable questionnaires were returned. The research method used for this study is descriptive-correlation. Further, the analysis was carried out utilizing Structural Equation Modeling (SEM) methodology by LISREL 8.8 software. The factors analysis and the findings show that job organization has a significant positive influence on job performance. Further, a number of suggestions on managerial implementation were proposed.

Application of radioprotective agents in cancer treatment
Ehsan Mihandoust,Alireza Shirazi
Iranian Journal of Nuclear Medicine , 2010,
Abstract: Radiation exposures can occur without any prior warning in the following settings: radiography, nuclear medicine, radiotherapy, radiological imaging, radionuclide production, biomedical research, military, public domain, transportation, nuclear reactors, space flights etc. patients may be exposed to ionizing radiation during radiotherapy or following exposure to radionuclides in nuclear medicine. There is, therefore, a need to protect humans against planned(e.g. radiotherapy and nuclear medicine) and unplanned (e.g. industrial nuclear accident or nuclear war)exposures is necessary. radioprotectors are compounds that have the ability to reduce the biological effects of ionizing radiation on normal tissues, including lethality, mutagenicity and carcinogenicity, and have applications in clinical oncology, space travel, radiation site clean-up, radiological terrorism and military scenarios . The radioprotectors can elicit their action by various mechanisms such as: suppressing the formation of free radicals, inducing the cellular radioprotectors such as superoxide dismutase (SOD) , enhancing the DNA repair and inducting hypoxia in the tissues. The most effective radioprotectors developed so far are aminothiols and their derivatives. Some of these compounds have been successfully used to prevent complications of radiation therapy in patients with cancer. Unfortunately, all of the aminothiols have toxic side effects that limit their use in medical practice. Results from animal experiments indicate that antioxidant nutrients, like vitamin A, C ,E and selenium compounds, are protective against lethality and other radiation effects but to a lesser degree than most synthetic protectors. a large number of plants contain antioxidant phytochemicals reported to be radioprotective in various model systems. Clinical trials have not yet been undertaken with most herbal radioprotectors. If these are performed, herbal radioprotective drugs for human use from several of plants may soon be available. Therefore, the activity of numerous investigators is directed towards finding an effective radioprotective agents that would successfully prevent development of radiation syndrome and protect cells and tissue from deleterious effects of radiation. most of the compounds failed in their transition from laboratory to clinic. Acute toxicity and their inability to differentiate between tumor and normal cells are the main reasons for their failure in clinical applications. However, Early research on radiation protection has unraveled the basic mechanisms and yielded a large number of
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