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Search Results: 1 - 10 of 35 matches for " Sevtap Hamdemir "
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Ovarian Cyst Formation Following Gonadotropin-Releasing Hormone-Agonist Administration Decreases the Oocyte Quality in IVF Cycles
?zlem Gün Ery?lmaz,Esma Sar?kaya,Fatma Nur Aksakal,Sevtap Hamdemir
Balkan Medical Journal , 2012,
Abstract: Objective: The gonadotropin-releasing hormone-agonist (GnRH-a) treatment during in vitro fertilization (IVF) sometimes causes a functional ovarian cyst during the administration period before gonadotropin stimulation, as an undesired event. The aim of this study was to analyze the effect of these cysts on the IVF outcomes.Materials and Methods: Out of 981 IVF cycles, 78 with ovarian cysts were retrospectively analyzed with respect to the demographic characteristics, hormonal outcomes, and fertilization, implantation and clinical pregnancy rates. Results: The metaphase II oocyte ratio, fertilization rate and percentage of high quality embryos (grade 1) were significantly higher in the cyst-negative group (p<0.0001; p<0.0001; p≤0.05). These same three parameters were also significantly higher in the cyst-aspirated group (p<0.01; p<0.05; p<0.05). Cyst diameters of the aspiration group were significantly higher (p<0.05). No statistically significant differences in implantation and clinical pregnancy rates were determined between the groups.Conclusion: An ovarian cyst formation during the GnRH-a suppression period negatively affects oocyte quality. Cyst aspiration before gonadotropin stimulation does not improve the IVF outcome.
Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs
Sevtap Savas, Hilmi Ozcelik
BMC Cancer , 2005, DOI: 10.1186/1471-2407-5-107
Abstract: In this study, we used the web-based NetPhos tool to predict candidate nsSNPs that either introduce or remove putative phosphorylation sites in proteins that act in DNA repair and cell cycle pathways.Our results demonstrated that a total of 15 nsSNPs (16.9%) were likely to alter the putative phosphorylation patterns of 14 proteins. Three of these SNPs (CDKN1A-S31R, OGG1-S326C, and XRCC3-T241M) have already found to be associated with altered cancer risk. We believe that this set of nsSNPs constitutes an excellent resource for further molecular and genetic analyses.The novel systematic approach used in this study will accelerate the understanding of how naturally occurring human SNPs may alter protein function through the modification of phosphorylation mechanisms and contribute to disease susceptibility.Phosphorylation is a common, reversible post-translational modification that occurs at serine (S), threonine (T), and tyrosine (Y) residues in proteins [1]. Overall, phosphorylation can alter the structure, function, interaction, stability, and the sub-cellular location of the proteins [2-4], and therefore play an indispensable role in regulation of the cellular processes such as signal transduction, gene expression, cytoskeletal regulation, apoptosis, homeostasis, cell cycle, and DNA damage recognition and repair [5-11]. The phosphorylation state of a protein is determined by the opposing actions of kinases and phosphatases [12]. Proteins may contain multiple phosphorylation sites, which may be targeted by different kinases/phosphatases [2]. The activity of kinases and phosphatases at different times and/or upon different stimuli provides a means of powerful control over the protein phosphorylation state and thus the biological processes the protein is involved in.In the post-genomic era, there is an expanding interest in identification of the single nucleotide polymorphisms (SNPs) that might affect the protein function and thus contribute to the disease susceptibil
Mucosal Immunization
Sevtap Velipasaoglu Guney,Olcay Yegin
Cocuk Enfeksiyon Dergisi , 2008,
Abstract: Immunization against infectious diseases is considered to be one of the most cost-effective public health interventions. Mucosal immunization may be defined as introducing a vaccine by the mucosal route in order to induce both mucosal and systemic immunity against a pathogen. Mucosal immune system is an integrated cross-communication pathway consisting of inductive sites where antigens are encountered and selectively taken up for the initiation of immune responses and effector sites where these immune responses are elicited. Thus the mucosal vaccines have the advantage of preventing colonization or infection of mucosal surfaces with a pathogen, as well as hindering the dissemination and systemic invasion of the pathogen. In addition to protecting the vaccinated individual, some of the mucosal vaccines may also have a herd effect through elimination of the transmission of pathogen between susceptible hosts. Further benefits of mucosal immunization are ease of administration, suitability for mass vaccinations, being more acceptable than the injection vaccines, and prevention of risky and unsafe injections. Although live oral polio vaccine, which has been widely used in Turkey for decade,s is a very good example of mucosal immunization, so far only a few mucosal vaccines have been licensed for human use. The development of new antigen delivery and adjuvant systems that can efficiently help to introduce vaccine antigens to the mucosal immune system are expected to revolutionize the field of mucosal vaccine production.
Human SNPs resulting in premature stop codons and protein truncation
Sevtap Savas, Sukru Tuzmen, Hilmi Ozcelik
Human Genomics , 2006, DOI: 10.1186/1479-7364-2-5-274
Abstract:
Plasma catalase, glutathione-s-transferase and total antioxidant activity levels of children with attention deficit and hyperactivity disorder  [PDF]
V. Kenan ?elik, Erdal Er?an, Serpil Er?an, Sevtap Bak?r, Orhan Dogan
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.42026
Abstract:
Objective: In this study, we plan to measure plasma Catalase (CAT), Antioxidant Activity (AOA) and Glu- tathione-S-Transferase (GST) levels to understand whether oxidative stress develops or not and whether or not the detoxification mechanism properly functions in children with Attention Deficit and Hyperactivity Disorder (ADHD) with unknown etiology and pathogenesis. Method and Results: Plasma CAT, AOA, and GST activities were spectrophotometrically measured in forty patients (average age 10.27 ± 2.54) and thirty-five (average age, 9.97 ± 2.59) healthy individuals as the control group. While the CAT activity showed no difference in the patient group (P > 0.05) compared to the control group, AOA and GST levels were found significantly meaningful (P = 0.001). Conclusion: In this pilot study ,the study shows that no oxidative stress develops in individuals with ADHD in high AOA and stable CAT activity, and that the de- toxification mechanism functions extremely in high GST activity. These findings need to be supported by other studies.
Are the Marketing Margins of Poor Livestock Farmsin Rural Areas adequate for the Sustainability of Livestock farming? An Example from Rural Turkey
Sevtap Guler Gumus,Akin Olgun,Hakan Adanacioglu
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2010.643.650
Abstract: Livestock has an important role in reducing rural poverty in that it provides people living in rural areas with income and employment opportunities and at the same time contributes to an improvement in the distribution of income. However, in many developed countries the structural and economic problems associated with livestock constitute a significant threat to it. It was found that this threat comes more from economic problems and is related to poor marketing efficiency by farmers. This study examines rural livestock farms in the Aegean Region of Turkey, with emphasis on distribution channels in marketing by animal breeding farms, prices in those distribution channels and on showing the trading margins, which arise in these channels. The results obtained in the study show that animal breeding farms in the rural areas of Turkey do not have an efficient marketing system, when marketing margins, which they obtain are considered. For milk, the most important product, the total intermediary s margin was calculated in the study as 64.96% and the relative margin as 185.36%. The study also makes some suggestions on increasing marketing efficiency for animal breeding farms in rural areas.
Duodenal Necrosis During Nasogastric Tube Feeding: A Case Report
Dilek MEMIS,Sevtap HEKIMOGLU SAHIN,Atakan SEZER
Trakya Universitesi Tip Fakultesi Dergisi , 2007,
Abstract: A case of duodenal necrosis during nasogastric tube feeding in a 45-year-old male patient hospitalized in intensive care unit with a diagnosis of acute respiratory distress syndrome is reported with a review of literature. Abdominal distension developed after several days of uneventful nasogastric tube feeding. At laparotomy patchy necrosis of the duedonum was found without signs of bowel obstruction or impaired mesenteric perfusion. In this case, the large doses of fentanyl, midazolam and dopamine given for sedation, were suspected to be a major contributing factor to the development of the necrosis by impairing mucosal perfusion.
Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: Potential breast cancer risk alleles and their distribution across human populations
Sevtap Savas, Steffen Schmidt, Hamdi Jarjanazi, Hilmi Ozcelik
Human Genomics , 2006, DOI: 10.1186/1479-7364-2-5-287
Abstract:
Detection of biologically active isomers of conjugated linoleic acid in kaymak
Sibel Akalin, A.,Tokusoglu, ?zlem,G?n?, Siddik,?kten, Sevtap
Grasas y Aceites , 2005,
Abstract: Numerous physiological effects are attributed to conjugated linoleic acids (CLA). Biologically active isomers of CLA ( cis -9, trans -11 (C18:2) and trans- 10, cis- 12 (C18:2)) have been reported to have anticarcinogenic, antioxidative and antiatherosclerotic properties. Relatively rich sources of CLA include milk fat-containing foods such as kaymak. Kaymak is a kind of concentrated cream which is traditionally manufactured from buffalo or cow's milk mainly in Turkey . The objective of this study was to determine CLA concentrations during kaymak production. Kaymak was manufactured from cow's milk which was enriched with unfermented cream. Biologically active isomers of CLA in raw milk, cream and kaymak were analyzed using gas chromatography. The method was quick, repeatable and sensitive for the CLA determination of samples. Significant differences were found among the concentrations of both isomer and total CLA during the production process (p<0.01). The total CLA contents of raw milk, cream and kaymak were determined as 0.08 ± 0.02, 0.234 ± 0.04 and 0.091 ± 0.08 g/ 100 g lipid, respectively. Numerosos efectos fisiológicos se atribuyen a los ácidos linoleico conjugados (CLA). Así los isómeros biológicamente activos ( cis -9, trans -11 (C18:2) y trans- 10, cis) del ácido linoleico han sido descritos con propiedades anticarcinogénicas, antioxidantes y antiarterioscleróticas. Fuentes relativamente ricas de CLA incluyen alimentos con grasas lácteas tales como el kaymak. El kaymak es una crema concentrada elaborada de leche de búfalo o vaca principalmente en Turquía. El objetivo de este estudio fue la determinación de la concentración de CLA durante la producción de kaymak. El kaymak objeto de estudio fue elaborado a partir de leche de vaca que fue enriquecida con crema no fermentada. Los isómeros biológicamente activos del CLA fueron analizados por cromatografía gaseosa en leche cruda, crema y kaymak. El método empleado fue rápido, reproducible y sensible. Se encontraron diferencias significativas en las concentraciones de ambos isómeros y de CLA total durante el proceso de producción (p < 0.01). Los contenidos totales de CLA para leche cruda, crema y kaymak fueron 0.08 ± 0.02, 0.234 ± 0.04 y 0.091 ± 0.08 g/100 g de lípido, respectivamente.
Fat Embolism Associated with Anesthesia Induction with Propofol-Lidocaine Combination: A Case Report
Sevtap HEK?MO?LU ?AH?N,Dilek MEM??,Alkin ?OLAK
Trakya Universitesi Tip Fakultesi Dergisi , 2008,
Abstract: Fat embolism syndrome has been described following traumatic, surgical, and atraumatic conditions. Long-bone fractures are probably the most common cause of this syndrome. Fat embolic events are often clinically insignificant and difficult to recognize since clinical manifestations vary and there is no routine laboratory or radiographic means of diagnosis. Propofol is widely used for the induction and maintenance of anesthesia. Addition of lidocaine to propofol may result in a coalescence of oil droplets, forming a separate layer. The risk of propofol and lidocaine combination to cause fat embolism depends on the dose of lidocaine and the duration between its preparation and administration. We presented a patient who developed fat embolism following anesthesia induction during surgery for a lower extremity fracture due to a traffic accident. The occurrence of fat embolism was attributed to propofol-lidocaine use. The diagnosis of fat embolism was based on clinical manifestations, radiographic and laboratory findings, and elimination of other causes associated with arterial hypoxemia.
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