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Search Results: 1 - 10 of 957 matches for " Serap Baydur Sahin "
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Testosterone- and Cortisol-Secreting Adrenocortical Oncocytoma: An Unusual Cause of Hirsutism
Serap Baydur Sahin,Ahmet Fikret Yucel,Recep Bedir,Sabri Ogullar,Teslime Ayaz,Ekrem Algun
Case Reports in Endocrinology , 2014, DOI: 10.1155/2014/206890
Abstract: Objective. Oncocytomas of the adrenal cortex are usually benign and nonfunctional. They are rarely seen as the cause of hirsutism. Therefore, we aimed to report a case of adrenocortical oncocytoma presenting with hirsutism. Methods. We report a testosterone- and cortisol-secreting adrenal oncocytoma in a 23-year-old female patient presenting with hirsutism. Results. The patient had the complaint of hirsutism for the last year. Laboratory tests revealed total testosterone level of 4.2?ng/mL, free testosterone of >100?pg/mL, and DHEAS level of 574?μg/dL. There was no suppression in cortisol levels with 2?mg dexamethasone suppression test (5.4?μg/dL). Adrenal MRI revealed a ?mm isointense solid mass lesion in the left adrenal gland and the patient underwent laparoscopic left adrenalectomy. Pathological examination confirmed the diagnosis of benign adrenocortical oncoyctoma. Conclusion. This well-characterized case describes a testosterone- and cortisol-secreting adrenocortical oncocytoma as a possible cause of hirsutism. To our knowledge, this is the second report in the literature. Adrenal oncocytomas should always be considered in the differential diagnosis of hirsutism. 1. Introduction Hirsutism, defined as excessive male-pattern hair growth, affects between 5 and 10% of women of reproductive age and most women with hirsutism have polycystic ovary syndrome [1, 2]. Androgen-secreting tumors are rarely seen as the cause of hirsutism. In an epidemiological study, the frequency of androgen-secreting tumors was 0.2% in 950 hirsute women [3]. Most testosterone-secreting tumors arise from the ovary and rarely origins from the adrenal gland. Oncocytic neoplasms or oncocytomas usually arise in the kidneys or thyroid, parathyroid, salivary, or pituitary glands [4]. Oncocytomas of the adrenal cortex are extremely rare and usually detected incidentally [5]. Adrenal oncocytomas are usually benign and nonfunctional in most of cases. Herein, we report a testosterone- and cortisol-secreting adrenal oncocytoma in a 23-year-old female patient presenting with hirsutism. 2. Case Report A 23-year-old female patient admitted to endocrinology outpatient clinic with the complaint of hirsutism for the last year. Excessive hair growth was identified to originate from facial and mandibular areas initially and then to spread to abdominal and thoracic regions. She had regular menstrual cycles since her first period by the age of 12. Medical background and family history were unremarkable. Physical examination revealed that body temperature was 37°C, pulse rate was 80 beats/min,
Routine Screening for Cushing's Syndrome Is Not Required in Patients Presenting with Obesity
Serap Baydur Sahin,Hacer Sezgin,Teslime Ayaz,Emine Uslu Gur,Kadir Ilkkilic
ISRN Endocrinology , 2013, DOI: 10.1155/2013/321063
Abstract: Background. Cushing’s syndrome (CS) is a relatively unusual condition that resembles many of the phenotypic features of obesity. Our aim was to evaluate the frequency of CS in obese patients. Materials and Methods. This study included 354 consecutive patients (87.9% female, age years) who presented with simple obesity. All the patients were evaluated for the clinical signs of CS. Lipid parameters, fasting glucose (FPG) and insulin, 75?gr oral glucose tolerance test, basal cortisol and ACTH were measured. 1?mg overnight DST was performed. Results. The mean weight of the patients was ?kg and BMI ?kg/m2. 34.5% of the patients were hypertensive. 36.2% of the patients had central obesity, 72% dorsocervical fat accumulation, 28.8% abdominal striae and 23.2% acne. 49.4% of the women had hirsutism. 46.5% had prediabetes and 12.0% had type 2 diabetes, 72.6% had dyslipidemia. The mean cortisol and ACTH levels were as follows: ?μg/dL and ?pg/mL. Seven patients failed to suppress plasma cortisol to less than 1.8?μg/dL. Biochemical confirmation tests were performed in these patients and 2 of them were diagnosed glucocorticoid-secreting adrenal adenoma. Conclusions. Routine screening for CS in obese patients is not required. 1. Introduction Cushing’s syndrome (CS) is considered a contributing factor to the development of obesity. On the other hand, obesity itself might share the symptoms and signs of CS such as hirsutism, menstrual abnormalities, acne, dorsocervical fat pad (buffalo hump), supraclavicular fullness, glucose intolerance, and hypertension. Physicians may be called upon to exclude CS in obese patients, who are increasingly present in the general population. Early recognition of CS can reduce the morbidity and mortality [1]. The diagnosis of CS is often a challenge for clinicians due to the variable pattern and the nonspecificity of clinical manifestations. The diagnosis can be difficult particularly in states of mild or cyclical or periodical hypercortisolism [2–4]. The suspicion of CS arises in the presence of concomitant recent weight gain, impaired glucose tolerance, and high blood pressure [3]. Several studies reported a 1–5% prevalence of unsuspected CS in patients with poorly controlled type 2 diabetes and/or hypertension [5–8]. However, there are only few studies on the prevalence of CS in obese patients [9–13]. We therefore aimed to evaluate the frequency of CS in patients who present with obesity. The 1?mg overnight dexamethasone-suppression test (DST) is the most frequently used screening tool for CS [14]. Because it is easy to perform and has
An Investigation on the Distribution of Mollusc Fauna of Lake Terkos (Istanbul/Turkey) Related with Some Environmental Parameters
Serap Kosal Sahin
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2012.3045.3049
Abstract: The aim of this study is that to investigate both ecological and numerical species assemblages of mollusc fauna of Lake Terkos (Istanbul, Turkey). In order to determine the mollusc fauna of Lake Terkos (Turkey) samples were collected from 5 stations monthly between February, 2008 to January, 2009. While a total of 11 mollusc species were found at the sampling stations, it was determined 817 individuals in per m2 at average. Six species of them (Physella acuta, Galba truncatula, Radix labiata, Lymnaee stagnalis, Planorbis planorbis and Planorbarius corneus) belong to Pulmonota, two taxa of them (Viviparus viviparus costae and Bithynia tentaculata) belong to Prosobranchia and three species of them (Unio pictorum, Dreissena polymorpha and Anodonta cygnea) belong to Bivalvia. Furthermore in each samples water temperature, dissolved oxygen, pH, Ca, Mg, NO2-N, NO3-N and NH3 measured at the sampling sites. Canonical Correspondence Analysis (CCA) explained 91.8% of the correlation between species and environmental variables. Water temperature (t), Dissolved Oxygen (DO), Ca, Mg and pH were most affective variables on the species absence.
Breathing Intolerance Index in COPD and Obesity: A Comparative Observational Study  [PDF]
Ahmet Baydur, Zhanghua Chen
Open Journal of Respiratory Diseases (OJRD) , 2013, DOI: 10.4236/ojrd.2013.33019
Abstract: Background: The breathing intolerance index, BIT, a noninvasive derivation of the tension-time index of respiratory muscles, has been recently used to evaluate patients with respect to their need for noninvasive ventilation. Comparing the BIT index in different disorders with mild to moderate respiratory impairment, such as COPD and obesity, would be useful in determining differences in threshold for respiratory muscle fatigue amongst cohorts. Objectives: The purpose of this study was to compare control of ventilation and BIT in individuals with obesity, chronic obstructive pulmonary disease (COPD), and control subjects free of cardiorespiratory disorders. Because change in posture can alter respiratory load and control of ventilation, variables were assessed in two postures. Methods: We assessed 142 subjects consisting of 81 with obesity, 42 with COPD, and 19 non-smoking healthy adults. All subjects underwent evaluation of pulmonary function, control of ventilation and BIT index [(Ti/Ttot) × (Vt/FVC)] in seated and supine postures. Findings: BIT index was significantly greater in seated posture in all 3 cohorts due primarily to an increase in Vt in this position. BIT index was similar in value amongst cohorts in both postures, but tended to be higher in patients with obesity and COPD. Conclusion: While BIT index is higher in seated posture, and tends to be higher in patients with obesity and COPD as compared to control subjects, discrimination between cohorts is not found in our study because of small inter-group variations of respiratory function amongst cohorts. Thus, in clinically stable patients whose vital capacities are mild to moderately reduced, the BIT index alone cannot be recommended as a predictive guide for initiating assisted ventilation for respiratory failure. Nevertheless, because it is easy to perform, and is comfortably tolerated by patients, its potential usefulness may be in periodic measurements to monitor its increase as respiratory reserve declines.
Bullous pemphigoid associated with prostate adenocarcinoma
?ztürkcan Serap,Ermertcan Aylin,Sahin Mustafa,Türkdogan Peyker
Indian Journal of Dermatology, Venereology and Leprology , 2004,
Abstract: Bullous pemphigoid is a common autoimmune skin disease characterized by the presence of subepidermal blisters. It has been associated with underlying neoplasia in isolated reports. A 78-year-old man with generalized blisters was diagnosed as bullous pemphigoid on clinical, histopathological and direct immunofluorescence grounds. His free and total prostate specific antigen (PSA) levels were high and histopathological examination of a prostate specimen revealed prostate adenocarcinoma. We present this rare case to discuss the possible association between bullous pemphigoid and prostate adenocarcinoma.
The Effect of Deficit Irrigation on Potato Evapotranspiration and Tuber Yield under Cool Season and Semiarid Climatic Conditions
Fatih M. Kiziloglu,Ustun Sahin,Talip Tunc,Serap Diler
Journal of Agronomy , 2006,
Abstract: Field experiments were conducted to study the effects of water deficits on potato (Solanum tuberosum L.) evapotranspiration, tuber yield and water-use efficiency. The experiments were carried out under cool season semiarid climatic conditions in Erzurum province located in the east of Turkey in the spring seasons of 2003 and 2004. The experiment included six water deficits: 0% (well-irrigation), 20, 40, 60, 80 and 100% (non-irrigation). Results indicate that deficit irrigation influenced evapotranspiration, tuber yield and water-use efficiency. Potato evapotranspiration decreased as water deficit increased. Seasonal evapotranspiration was 445.2 mm in well-irrigated treatment and 195.2 mm non-irrigated treatment. Potato yield and water-use efficiency were also found decrease as water deficit increased. Potato yield of well-irrigated treatment was 26.43 t ha-1 while 8.28 t ha-1 in non-irrigated treatment. A linear relationship was found between evapotranspiration and tuber yield. Water use efficiency was 59.56 kg/ha/mm for well-irrigated treatment and 42.13 kg/ha/mm for non-irrigated treatment. The seasonal yield response factor (ky) for potato was also found as 1.12.
Anti-inflammatory effects of montelukast on smoke-induced lung injury in rats
Ilknur Basyigit, Murat Sahin, Deniz Sahin, Fusun Yildiz, Hasim Boyaci, Serap Sirvanci, Feriha Ercan
Multidisciplinary Respiratory Medicine , 2010, DOI: 10.1186/2049-6958-5-2-92
Abstract: 28 Wistar-Albino rats were enrolled into 4 groups with 7 rats per group. The healthy control group was exposed to fresh air while all rats in the 3 experimental groups were exposed to cigarette smoke for 20 weeks for 2 hours per day. After histopathological verification of smoke induced lung injury, montelukast (0.1 mg/kg) dissolved in Na2CO3 was given in one group (MON), Na2CO3 only was given in another group (MON control) and placebo was injected in the third group (COPD control) intraperitoneally for 21 days. At the end of this period blood samples were obtained for serum TNF-α assessment and light and electron microscopy analyses were performed on the lung tissues of sacrificed rats.Serum TNF-α levels in the MON group were significantly lower than in the MON control and COPD control groups (38.84 ± 4.9 pg/ml, 77.5 ± 5.8 pg/ml and 79.2 ± 6.9 pg/ml respectively, p < 0.05). Furthermore there was no statistically significant difference between the MON group and healthy controls with respect to serum TNF-α levels (38.84 ± 4.9 pg/ml vs. 29.5 ± 3.6 pg/ml, p > 0.05). Light and electron microscopic evaluation of the lungs demonstrated that the total histopathological damage score of the lung samples was significantly lower in the MON group than in MON controls and COPD controls (5.14 ± 0.5, 8.4 ± 0.6 and 8.7 ± 0.4 respectively, p < 0.05), while there was no significant difference between the MON group and healthy controls (5.1 ± 0.6 vs 2.3 ± 0.2, p > 0.05).These findings suggest that montelukast might have a protective effect on smoke-induced lung injury in rats both from a histopathological and inflammatory point of view.Cigarette smoking induces an abnormal inflammatory response in the airways which is now increasingly acknowledged in the pathogenesis of chronic obstructive pulmonary disease (COPD) [1]. Smoking classically causes neutrophil predominant inflammation in the airways with the increase of neutrophil chemotactic cytokines such as tumor necrosis factor (TNF)-
Gender Equity in Education  [PDF]
Elmas Sahin
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.21007
Abstract: Numerous studies show that society often treats boys and girls differently. Although gender inequalities in education have changed much in recent decades thanks to the fight for womens rights, inequity between the sexes continues to flourish nowadays. This article focuses on how and why education is the key to gender equality, and the importance of gender equity in education system in order to create a better environment for girls under traditional pressures. It will also query whether a philosophy of education offering the same opportunities to young women and men, teaching the same things at the same time, in the same place, with the same methods, and under the same system is necessary or not.
Meta-Herpetic Keratitis and Therapeutic Approach: Case Report  [PDF]
Ozlem Sahin
Open Journal of Ophthalmology (OJOph) , 2014, DOI: 10.4236/ojoph.2014.43012
Abstract:

The purpose of this study is to disclose the steps in the therapeutic approach for meta-herpetic corneal ulcer. Report of a case with anterior segment photography was used. The 6 months of follow-up results of the case were disclosed. The efficacy of the therapeutic approach for meta-herpetic corneal ulcer was discussed.

Women Travel Writings: A Comparative Journey  [PDF]
Elmas Sahin
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.31008
Abstract: Since the 18th century, Turkey increasingly played a significant role for women travel writers such as Lady Marry Montague, Elizabeth Craven, Julia Pardoe, Hester Donaldson Jenkins, Eliza Cheney Abbott Schneider, Mary Mills Patrick, Grace Ellison, who were in curiosity to discover the other: their cultures, customs, literatures, social, political and historical backgrounds and improvements, emancipation movements, sexualities and so on. Whereas some women writers including Zeyneb Hanim, Melek Hanim, Demetre Vaka and Halide Edib Adivar penned impressions about both European and Turkey. In this study, the works named An Englishwoman in a Turkish Harem by Grace Ellison and A Turkish Woman’s European Impressions by Zeynep Hanim will be evaluated in regard to comparative literature and cultural studies. Additionally, I argue that comparative literature accepted as a most advantageous approach for literary and cultural studies can probably contribute much more than the other disciplines to cultural studies and cultural history, even feminist cultural history, comparative cultural perspectives to literature; and or cultural studies open a large umbrella for international cultures and literatures in the light of these two works focused on literary writings, experiments, representations of occidental and oriental women, and occidental and oriental perceptions.
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