oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 2 )

2019 ( 232 )

2018 ( 290 )

2017 ( 325 )

Custom range...

Search Results: 1 - 10 of 140266 matches for " Seong K. Mun "
All listed articles are free for downloading (OA Articles)
Page 1 /140266
Display every page Item
Lessons Learned from Implementing the Patient-Centered Medical Home
Ellen P. Green,John Wendland,M. Colette Carver,Cortney Hughes Rinker,Seong K. Mun
International Journal of Telemedicine and Applications , 2012, DOI: 10.1155/2012/103685
Abstract: The Patient-Centered Medical Home (PCMH) is a primary care model that provides coordinated and comprehensive care to patients to improve health outcomes. This paper addresses practical issues that arise when transitioning a traditional primary care practice into a PCMH recognized by the National Committee for Quality Assurance (NCQA). Individual organizations' experiences with this transition were gathered at a PCMH workshop in Alexandria, Virginia in June 2010. An analysis of their experiences has been used along with a literature review to reveal common challenges that must be addressed in ways that are responsive to the practice and patients’ needs. These are: NCQA guidance, promoting provider buy-in, leveraging electronic medical records, changing office culture, and realigning workspace in the practice to accommodate services needed to carry out the intent of PCMH. The NCQA provides a set of standards for implementing the PCMH model, but these standards lack many specifics that will be relied on in location situations. While many researchers and providers have made critiques, we see this vagueness as allowing for greater flexibility in how a practice implements PCMH. 1. Introduction In response to the increasing demand for an improved healthcare system in the United States, the American Academy of Family Physicians, the American Academy of Pediatrics, the American College of Physicians, and the American Osteopathic Association developed the Joint Principles of the Patient-Centered Medical Home (Table 1 [1]) [2]. The Patient-Centered Medical Home (PCMH) is an extension of internationally employed Edward Wagner’s Chronic Care Model (CCM). The CCM was developed to address the increasing rate of patients with chronic conditions in the United States using team-based care. The rate of chronic conditions is currently estimated to be 2.2 conditions for individuals having 60 years old and up, on average [3]. In its implementation, the CCM has proven to reduce patients’ healthcare costs and improve patient care quality, two elements directly aligned with the goals of the PCMH [3]. The PCMH model strives to provide quality, coordinated, and cost-effective care to patients and to increase access to services. In addition, it aims to increase practice efficiency and subsequently provider and patient satisfaction. Within this paper, we follow the process of implementing the PCMH Model within primary care practices and discuss the difficulties these practices have encountered in the transition as well as potential solutions. Our goal is to provide future PCMHs
Recent Advances in the Treatment of ST-Segment Elevation Myocardial Infarction
Mun K. Hong
Scientifica , 2012, DOI: 10.6064/2012/683683
Abstract:
Recent Advances in the Treatment of ST-Segment Elevation Myocardial Infarction
Mun K. Hong
Scientifica , 2012, DOI: 10.6064/2012/683683
Abstract: ST-segment elevation myocardial infarction (STEMI) represents the most urgent condition for patients with coronary artery disease. Prompt diagnosis and therapy, mainly with primary angioplasty using stents, are important in improving not only acute survival but also long-term prognosis. Recent advances in angioplasty devices, including manual aspiration catheters and drug-eluting stents, and pharmacologic therapy, such as potent antiplatelet and anticoagulant agents, have significantly enhanced the acute outcome for these patients. Continuing efforts to educate the public and to decrease the door-to-balloon time are essential to further improve the outcome for these high-risk patients. Future research to normalize the left ventricular function by autologous stem cell therapy may also contribute to the quality of life and longevity of the patients surviving STEMI. 1. Introduction ST-segment elevation myocardial infarction (STEMI) accounts for approximately 30–45% of an estimated 1.5 million hospitalizations for acute coronary syndromes annually in the USA [1]. STEMI results primarily from sudden-onset plaque rupture and complete occlusion of a coronary artery [2]. Therefore, STEMI represents the most severe form of acute coronary syndromes and requires immediate therapy. There have been many recent advances in the treatment of STEMI, ranging from pharmacologic to device therapy. These advances have resulted in improved outcomes for the patients experiencing STEMI [3, 4]. In-hospital mortality from STEMI decreased steadily in the USA in all groups between 1997 and 2006, except for men <55 years of age [4]. Thus, there is still much more work to be done, especially the prevention of its occurrence in young men due to the unpredictable timing and relatively high risk of sudden death [5]. In addition, complete myocardial perfusion to improve left ventricular function and survival is essential but may not be achieved in many patients due to multifactorial reasons [6–12] and needs continued research for better long-term outcome. 2. Reperfusion Therapies The most important therapy for STEMI patients is the prompt reestablishment of antegrade flow. The earlier and the more complete the reperfusion, the greater the myocardial salvage and preservation of left ventricular function, the most important prognostic factor for long-term survival. There are pharmacologic and mechanical reperfusion therapies. Randomized trials have conclusively established primary angioplasty with stents as the optimal therapy for these patients, as primary percutaneous coronary
Strong Coupling of a Cavity QED Architecture for a Current-biased Flux Qubit
Mun Dae Kim,K. Moon
Physics , 2010, DOI: 10.3938/jkps.58.1599
Abstract: We propose a scheme for a cavity quantum electrodynamics (QED) architecture for a current-biased superconducting flux qubit with three Josephson junctions. The qubit operation is performed by using a bias current coming from the current mode of the circuit resonator. If the phase differences of junctions are to be coupled with the bias current, the Josephson junctions should be arranged in an asymmetric way in the qubit loop. Our QED scheme provides a strong coupling between the flux qubit and the transmission line resonator of the circuit.
Readout of superconducting flux qubit state with a Cooper pair box
Mun Dae Kim,K. Moon
Physics , 2012, DOI: 10.1088/0953-8984/24/22/225305
Abstract: We study a readout scheme of superconducting flux qubit state with a Cooper pair box as a transmon. The qubit states consist of the superpositions of two degenerate states where the charge and phase degrees of freedom are entangled. Owing to the robustness of transmon against external fluctuations, our readout scheme enables the quantum non-demolition and single-shot measurement of flux qubit states. The qubit state readout can be performed by using the non-linear Josephson amplifiers after a $\pi/2$-rotation driven by an ac-electric field.
Dense RFID Reader Deployment in Europe using Synchronization
Kin Seong Leong,Mun Leng Ng,Alfio R. Grasso,Peter H. Cole
Journal of Communications , 2006, DOI: 10.4304/jcm.1.7.9-16
Abstract: For a dense RFID reader deployment, such as in a warehouse, where hundreds of readers will be positioned in a building, the interference between all these readers must be studied carefully to avoid disruption of operations. Strict RFID regulations and standards have been imposed, trying to address the problem of reader collision and also the problem of RFID devices interfering with other devices operating in the same and nearby frequency bands. However, these guidelines and regulations are not entirely friendly for dense RFID reader deployment; in some cases it is not possible to have a feasible RFID system while adhering to these regulations. Hence, this paper proposes the synchronization of RFID readers to enable successful dense RFID reader deployment. A case study targeted at European operations is presented in this paper to illustrate the actual synchronization of RFID readers in real applications. Some fine-tuning methods are also suggested to further improve the performance of readers in a high reader density population area.
Evaluation of the Effectiveness of Pregabalin in Alleviating Pain Associated with Fibromyalgia: Using Functional Magnetic Resonance Imaging Study
Seong-Ho Kim, Youngho Lee, Sunggun Lee, Chi-Woong Mun
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074099
Abstract: Purpose To assess the efficacy of pregabalin by showing differences in the neuronal activities of fibromyalgia (FM) patients before and after longitudinal treatment using functional magnetic resonance imaging (fMRI). Materials and Methods In total, 21 female patients with FM and 11 age- and gender-matched healthy controls participated. FM patients underwent fMRI at baseline and following pharmacological therapy with pregabalin to diminish their pain. Pressure-pain stimuli were delivered on the subject’s thumbnail bed during fMRI scans. Brain activation regions in fMRI were evaluated for longitudinal changes using a paired t-test. Changes in clinical features were also assessed with the Fibromyalgia Impact Questionnaire (FIQ), Brief Fatigue Inventory (BFI), Beck Depression Inventory (BDI), Widespread Pain Index (WPI), Symptom Severity Scale Score (SSS), and State-Trait Anxiety Inventory (STAI). Results Clinical scores were reduced significantly following therapy with five of the six clinical tests (FIQ, BFI, BDI, WPI, SSS; p < 0.05). Brain activation post-treatment was significantly lower than that pre-treatment in 13 regions of the brain (p < 0.001). Conclusions Our findings confirm that pregabalin influences aspects of the whole pain matrix, using fMRI, inducing longitudinal changes in neuronal activity during the pain state, and that it reduces pain and other core symptoms of FM. This method could be applied to other longitudinal clinical trials of pharmacological treatments for FM.
Unusual finding of endocervical-like mucinous epithelium in continuity with urothelium in endocervicosis of the urinary bladder
Phaik-Leng Cheah, Lai-Meng Looi, George Lee, Kean-Hooi Teoh, Kein-Seong Mun, Abdul Nazarina
Diagnostic Pathology , 2011, DOI: 10.1186/1746-1596-6-56
Abstract: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2840395525426177 webcite.Endocervicosis in the urinary bladder is a rare benign condition, first recognised by Steele and Byrne in 1982 in their report of endocervical-like glands deep in the urinary bladder wall [1]. This lesion was identified as a distinct entity by Clement and Young in 1992 [2] and the glands subsequently noted to be similar to endocervical glands in their immunohistochemical expressions [3-5]. To the best of our knowledge, there are to date less than 40 cases reported in the world literature in the two decades since this entity was first described. Usually occurring in women of reproductive age and located in the posterior bladder wall, endocervicosis is generally thought to be an embryological disorder of the secondary mullerian system [6,7] and the mucinous analogue of mullerianosis; "mullerianosis" being a term first used by Young and Clement to encompass endocervicosis, endometriosis and endosalpingiosis in the bladder [6]. Implant following pelvic surgery has also been considered an aetiological possibility as some cases were associated with earlier pelvic surgery [4,8] while others [8-10] put forth metaplasia as another possible cause of this condition. Nonetheless, the aetiogenesis of this interesting lesion still remains an enigma and largely based on circumstantial evidence. We present a case where mucinous epithelium, morphologically similar to endocervical epithelium, was detected in continuity with urothelium in addition to the characteristic endocervicosis glands, a finding that has hitherto not been reported, although Young and Clement had noted tubal epithelium replacing urothelium in mullerianosis [6]. The surface mucinous epithelium, its adjacent urothelium and the endocervicosis glands were compared for their immunohistochemical expressions of cytokeratins (AE1/AE3, CK19, CK7, CK5/6, CK20), HBME-1, estrogen receptor (ER) and p
Whole-Exome Sequencing Identifies a Novel Genotype-Phenotype Correlation in the Entactin Domain of the Known Deafness Gene TECTA
Byung Yoon Choi, Jiwoong Kim, Juyong Chung, Ah Reum Kim, Sue Jean Mun, Seong Il Kang, Sang-Heon Lee, Namshin Kim, Seung-Ha Oh
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097040
Abstract: Postlingual progressive hearing loss, affecting primarily the high frequencies, is the clinical finding in most cases of autosomal dominant nonsyndromic hearing loss (ADNSHL). The molecular genetic etiology of ADNSHL is extremely heterogeneous. We applied whole-exome sequencing to reveal the genetic etiology of high-frequency hearing loss in a mid-sized Korean family without any prior linkage data. Whole-exome sequencing of four family members (two affected and two unaffected), together with our filtering strategy based on comprehensive bioinformatics analyses, identified 21 potential pathogenic candidates. Sanger validation of an additional five family members excluded 20 variants, leaving only one novel variant, TECTA c.710C>T (p.T237I), as the strongest candidate. This variant resides in the entactin (ENT) domain and co-segregated perfectly with non-progressive high-frequency hearing loss in the family. It was absent among 700 ethnically matched control chromosomes, and the T237 residue is conserved among species, which supports its pathogenicity. Interestingly, this finding contrasted with a previously proposed genotype-phenotype correlation in which variants of the ENT domain of TECTA were associated with mid-frequency hearing loss. Based upon what we observed, we propose a novel “genotype to phenotype” correlation in the ENT domain of TECTA. Our results shed light on another important application of whole-exome sequencing: the establishment of a novel genotype-phenotype in the molecular genetic diagnosis of autosomal dominant hearing loss.
Enhancement of mouse sperm motility by trophinin-binding peptide
Park Seong,Yoon Jiwon,Wang Ling,Shibata Toshiaki K
Reproductive Biology and Endocrinology , 2012, DOI: 10.1186/1477-7827-10-101
Abstract: Background Trophinin is an intrinsic membrane protein that forms a complex in the cytoplasm with bystin and tastin, linking it microtubule-associated motor dynein (ATPase) in some cell types. Previously, we found that human sperm tails contain trophinin, bystin and tastin proteins, and that trophinin-binding GWRQ (glycine, tryptophan, arginine, glutamine) peptide enhanced motility of human sperm. Methods Immunohistochemistry was employed to determine trophinin protein in mouse spermatozoa from wild type mouse, by using spermatozoa from trophinin null mutant mice as a negative control. Multivalent 8-branched GWRQ (glycine, tryptophan, arginine, glutamine) peptide or GWRQ-MAPS, was chemically synthesized, purified by HPLC and its structure was confirmed by MALDI-TOF mass spectrometry. Effect of GWRQ-MAPS on mouse spermatozoa from wild type and trophinin null mutant was assessed by a computer-assisted semen analyzer (CASA). Results Anti-trophinin antibody stained the principal (central) piece of the tail of wild type mouse sperm, whereas the antibody showed no staining on trophinin null sperm. Phage particles displaying GWRQ bound to the principal piece of sperm tail from wild type but not trophinin null mice. GWRQ-MAPS enhanced motility of spermatozoa from wild type but not trophinin null mice. CASA showed that GWRQ-MAPS enhanced both progressive motility and rapid motility in wild type mouse sperm. Conclusions Present study established the expression of trophinin in the mouse sperm tail and trophinin-dependent effect of GWRQ-MAPS on sperm motility. GWRQ causes a significant increase in sperm motility.
Page 1 /140266
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.