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Development of a floating multiple unit controlled-release system for mosapride
Senthil Kumaran K,Manjunath S,Wamorkar Vinay
Asian Journal of Pharmaceutics , 2010,
Abstract: Floating beads are often used for controlled drug release as they have a gastroretentive property without affecting the gastric emptying rate. In the present study mosapride-controlled release beads were prepared with the help of the ionotropic gelation method, using sodium alginate containing KHCO 3 as the gas-forming agent. The physical characterization of the mosapride beads was examined by SEM. The results showed that the shape and texture of the beads were uniform before and after dissolution. The percentage of mosapride drug entrapment efficiency ranged from 97.4 ± 0.08 to 99.1 ± 0.04. The percentage of mosapride content from the beads was determined by high-performance liquid chromatography (HPLC) and ranged from 97.9 ± 0.08 to 99.6 ± 0.01. The in-vitro percentage release of mosapride from the beads at the end of 14 hours ranged from 90.0 ± 0.2 to 99.5 ± 0.12. The formulated beads in formulations 1 and 3 were sealed in vials and kept for 90 days at 40°C / 75% RH. After 90 days of exposure the percentage drug content was found to be 99.2 ± 0.04. The Floating beads designed for the gastroretentive dosage form could be suitable for controlled drug delivery.
Synthesis and Characterization of Selenium Nanowires
C. K. Senthil kumaran,S. Agilan,Dhayalan Velauthapillai,N. Muthukumarasamy
ISRN Nanotechnology , 2011, DOI: 10.5402/2011/589073
Abstract:
An Approach to Automatic Generation of Test Cases Based on Use Cases in the Requirements Phase
U.Senthil Kumaran,S. Arun Kumar,,K.Vijaya Kumar
International Journal on Computer Science and Engineering , 2011,
Abstract: The main aim of this paper is to generate test cases from the use cases. In the real-time scenario we have to face several issues like inaccuracy, ambiguity, and incompleteness in requirements this is because the requirements are not properly updated after various change requests. This will reduce the quality of test cases. To overcome these problems we develop a solution which generates test cases at the early stages of system development life cycle which captures maximum number of requirements. As requirements are best captured by use cases our focus lies on generating test cases from use case diagrams.
Batch type synthesis of high free fatty acid Jatropha Curcus oil biodiesel- India as supplying country
Sanjay Gandhi Bojan,Senthil Kumaran,Sam Chelladurai
Journal of Engineering and Applied Sciences , 2011,
Abstract: The Jatropha Curcas oil grown and extracted in the rural belts of western ghat section of South India was tested for its physical and chemical properties to determine its suitability as a feedstock for biodiesel production. A compact, simple, 4-litre biodiesel processor was developed locally. The biodiesel processor was capable of producing biodiesel sufficient in quantity for formers in village level to run the commonly used farm engine for producing electricity for agricultural and other purposes. The properties like kinematic viscosity, acid number, specific gravity, Cetane number, etc of the biodiesel produced meet the ASTM standard but the yield quantity was comparatively low (80.50%) because of the high free fatty acid content in the raw Jatropha Curcas oil. The overall efficiency of the biodiesel produced as a fuel in a four stroke diesel engine coupled with a electric generator was high (24.38%) at maximum load conditions compare to raw Jatropha Curcas oil and petro diesel as fuels which gives only 19.6% and 20.11%, respectively shows the possibilities of using biodiesel produced as a fuel in diesel engine.
Fungitoxic effects of root extracts of certain plant species on Colletotrichum capsici causing anthracnose in Capsicum annuum
RANGARAJULU SENTHIL KUMARAN, v. GOMATHI and B. KANNABIRAN
Indian Phytopathology , 2012,
Abstract:
Improved Datagram Transport Protocol over Wireless Sensor Networks- TCP Fairness
Senthil Kumaran .M,Dr. R. Rangarajan
International Journal of Computer Science Issues , 2011,
Abstract: TCP connections have small bandwidth-delay product and frequent packet loss in wireless sensor networks due to route breakages and radio interference. Datagram transport protocol provides a reliable end-to-end transport protocol over wireless sensor networks. This paper deals with improvement of TCP Fairness as Fairness in wireless sensor networks plays a major role to have maximum fair share of available bandwidth among the nodes, thus energy is consumed. A distributed adaptive max-min algorithm has been proposed in order to improve the fairness in WSNs. The proposed scheme incorporates two techniques: a fixed-size window-based flow-control algorithm and a cumulative bit-vector-based selective ACK strategy. Security has got the major impact over WSNs and that has been overcome by logical Tunneling. The simulation results show the improvement in terms of fairness, throughput and delay and packet loss using Network Simulator NS-2.
IMPACT OF PHYSICAL THERAPY ON BURDEN OF CAREGIVERS OF INDIVIDUALS WITH FUNCTIONAL DISABILITY
Anushree Narekuli,Kavitha Raja,Senthil Kumaran
Disability, CBR & Inclusive Development , 2011, DOI: 10.5463/dcid.v22i1.17
Abstract: Advances in medical science have resulted in a concomitant increase in the life span of persons with disabilities. The prevalence of chronic disease, an aging population and the ongoing shift of the site of care from institutions to the community, have resulted in a significant increase in the informal care provided by family members and friends of those living with chronic illnesses. This in turn increases the burden on the family, by way of physical and psychological stressors.The objectives of this study were to identify the burden perceived by caregivers of individuals with functional disability, and to evaluate the effects of a tailored physical therapy intervention, or caregiver education, on the caregivers’ burden. Ninety seven persons were deliberately assigned, based on their accessibility, to the control group, caregiver education group and intervention group.Although there was no statistically significant difference between the groups, among caregivers of persons affected by moderate to severe disability, there were trends showing greater reduction in caregiver stress and burden in the intervention group.These trends and comments from individual participants point to an improvement in caregiver burden with physiotherapy intervention. Hence, it can be suggested that physiotherapy management of persons with disabilities must also include caregiver health. DOI 10.5463/DCID.v22i1.17
FPGA Based Speed Control of SRM with Optimized Switching Angles by Self Tuning  [PDF]
P. Saravanan, R. Arumugam, M. Senthil Kumaran
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.78134
Abstract:

The electromagnetic torque and speed in Switched Reluctance Motor (SRM) greatly depend on the excitation parametersi.e.?turn-on angle, turn-off angle, dwell angle and magnitude of the phase currents of its phases. At lower speeds, a change in the current contributes the torque requirement which can be achieved either by voltage control (pulse width modulation) or instantaneous current control techniques. At high speeds, due to high back EMF, the regulation of current is crucial and achieved with the control of switching angles of phases. This type of control is referred as average torque control, where the torque is averaged over one stroke (2π/Nr). With constant dwell angle, advancing the phase angle influences the current into the phase winding at minimum inductance position. It has more time to get the current out of the phase winding before the rotor reaches the negative inductance slope. To maintain the speed of the motor at different load conditions, the turn-on and turn-off angles are adaptively varied. The change in dwell angle may be required where the turn-on and turn-off angle may not be sufficient to reach the required speed. In this paper, a new algorithm is proposed for self tuning of switching parameters of SRM. The proposed algorithm is simulated in MATLAB-Simulink and experimentally validated with Field Programmable Gated Array (FPGA) using MATLAB- system generator environment.

Role of Self-help Groups in Promoting Inclusion and Rights of Persons with Disabilities
K P Kumaran
Disability, CBR & Inclusive Development , 2011, DOI: 10.5463/dcid.v22i2.78
Abstract: Purpose:This study examined the role of self help groups in addressing some of the problems faced by persons with disabilities such as social exclusion, discrimination, lack of awareness about their rights and privileges, and absence of livelihood programmes. Method: One hundred persons with disabilities were randomly drawn for the study from 50 self help groups in 2 districts that were covered under a popular poverty alleviation programme implemented by the state of Andhra Pradesh in India. An interview schedule was used to collect information. Results: Before joining the group, some of the persons with disabilities were mostly confined to their houses, and viewed as less productive and incapable of leading a ‘normal’ life. After joining the groups, they came out of their seclusion and started to work together for their collective welfare and development. They gained knowledge about their rights and privileges and started income generation activities with the help of loans made available to them. They gained better acceptance within their families, but attitudes of their communities was slower to change. A feeling that “disability is not inability” seemed to have been internalized among the members of the groups. Conclusion: Self-help groups can be very effective in helping persons with disabilities to come out of their isolation and in promoting their participation and inclusion in societal mainstream. Key Words: Self-help group, persons with disabilitiesdoi 10.5463/DCID.v22i2.78
In vitro assay for human thyroid hormone receptor β agonist and antagonist effects of individual polychlorinated naphthalenes and Halowax mixtures
Na Li,Mei Ma,ZiJian Wang,Satyanarayanan Senthil Kumaran
Chinese Science Bulletin , 2011, DOI: 10.1007/s11434-010-4315-9
Abstract: Polychlorinated naphthalenes (PCNs) are dioxin-like environmental contaminants. There is growing concern over the endocrine-disrupting effects of PCNs, but very few studies have investigated the effect of PCNs on the thyroid system. This study used a yeast two-hybrid assay, which included the recombinant human thyroid receptor(TR)-β and reporter genes, to characterize the TRβ-disrupting effects of five individual PCN congeners, five PCN Halowax mixtures, and naphthalene. Their agonist and antagonist effects were studied in the absence and presence of 5×10 7 mol/L 3,3′,5-triiodo-L-thyronine, which induced submaximal β-galactosidase activity. Naphthalene, 1,2,3,4,5,6,7,8-octachloronaphthalene and all of the Halowax mixtures (Halowax 1000, 1001, 1013, 1014 and 1099) showed no agonist or antagonist activity on TRβ at the concentrations tested (up to 10 2 g/L). The lighter PCN congeners, namely 1-chloronaphthalene, 2-chloronaphthalene, 1,4-dichloronaphthalene and 1,2,3,4-tetrachloronaphthalene showed no agonist activity but showed significant antagonist activity on TRβ. The 20% relative inhibitory concentrations of these PCNs were less than 9.13 × 10 3 g/L. Thus, bioaccumulation of these lighter PCN congeners may disrupt the thyroid hormone system and inhibit TR-mediated cellular responses. Studies in the future should investigate the possible associations between the presence PCNs and adverse health outcomes.
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