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Search Results: 1 - 10 of 587081 matches for " Senena Corbalán-García "
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Structural characterization of the C2 domains of classical isozymes of protein kinase C and novel protein kinase Cε by using infrared spectroscopy
Senena Corbalán-García,Josefa García-García,M. Susana Sánchez-Carrillo,Juan C. Gómez-Fernández
Spectroscopy: An International Journal , 2003, DOI: 10.1155/2003/361563
Abstract: The amide I regions in the original infrared spectra of PKCα-C2 in the Ca2
Phosphatidylinositol 4,5-Bisphosphate Decreases the Concentration of Ca2+, Phosphatidylserine and Diacylglycerol Required for Protein Kinase C α to Reach Maximum Activity
Antonio L. Egea-Jiménez, ángel Pérez-Lara, Senena Corbalán-García, Juan C. Gómez-Fernández
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069041
Abstract: The C2 domain of PKCα possesses two different binding sites, one for Ca2+ and phosphatidylserine and a second one that binds PIP2 with very high affinity. The enzymatic activity of PKCα was studied by activating it with large unilamellar lipid vesicles, varying the concentration of Ca2+ and the contents of dioleylglycerol (DOG), phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphadidylserine (POPS) in these model membranes. The results showed that PIP2 increased the Vmax of PKCα and, when the PIP2 concentration was 5 mol% of the total lipid in the membrane, the addition of 2 mol% of DOG did not increase the activity. In addition PIP2 decreases K0.5 of Ca2+ more than 3-fold, that of DOG almost 5-fold and that of POPS by a half. The K0.5 values of PIP2 amounted to only 0.11 μM in the presence of DOG and 0.39 in its absence, which is within the expected physiological range for the inner monolayer of a mammalian plasma membrane. As a consequence, PKCα may be expected to operate near its maximum capacity even in the absence of a cell signal producing diacylglycerol. Nevertheless, we have shown that the presence of DOG may also help, since the K0.5 for PIP2 notably decreases in its presence. Taken together, these results underline the great importance of PIP2 in the activation of PKCα and demonstrate that in its presence, the most important cell signal for triggering the activity of this enzyme is the increase in the concentration of cytoplasmic Ca2+.
Phosphatidylinositol-4,5-Bisphosphate Enhances Anionic Lipid Demixing by the C2 Domain of PKCα
Antonio L. Egea-Jiménez, Ana M. Fernández-Martínez, ángel Pérez-Lara, Ana de Godos, Senena Corbalán-García, Juan C. Gómez-Fernández
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095973
Abstract: The C2 domain of PKCα (C2α) induces fluorescence self-quenching of NBD-PS in the presence of Ca2+, which is interpreted as the demixing of phosphatidylserine from a mixture of this phospholipid with phosphatidylcholine. Self-quenching of NBD-PS was considerably increased when phosphatidylinositol-4,5-bisphosphate (PIP2) was present in the membrane. When PIP2 was the labeled phospholipid, in the form of TopFluor-PIP2, fluorescence self-quenching induced by the C2 domain was also observed, but this was dependent on the presence of phosphatidylserine. An independent indication of the phospholipid demixing effect given by the C2α domain was obtained by using 2H-NMR, since a shift of the transition temperature of deuterated phosphatidylcholine was observed as a consequence of the addition of the C2α domain, but only in the presence of PIP2. The demixing induced by the C2α domain may have a physiological significance since it means that the binding of PKCα to membranes is accompanied by the formation of domains enriched in activating lipids, like phosphatidylserine and PIP2. The formation of these domains may enhance the activation of the enzyme when it binds to membranes containing phosphatidylserine and PIP2.
Iconografía de Santa Waldesca y Santa Toscana, monjas de la Orden de San Juan de Jerusalén, en el Monasterio de Santa María de Sijena
Rincón-García, Wifredo
Archivo Espa?ol de Arte , 2009,
Abstract: For centuries, the cult of two saints belonging to the Order of Saint John of Jerusalem, Saint Waldesca or Ubaldesca and Saint Toscana was celebrated in the monastery of Santa María de Sijena. The author offers an approach to their iconography in this monastery. A lo largo de los siglos, en el monasterio de Santa María de Sijena, de la Orden de San Juan de Jerusalén, se tributó culto a dos santas de esta orden, Santa Waldesca o Ubaldesca y Santa Toscana. En este trabajo hacemos una aproximación a la iconografía de las mismas que hubo en ese monasterio.
LA SOCIALIZACIóN DE LA LECTURA: HACIA UN NUEVO CONCEPTO DE LIBRO, DE AUTOR Y DE LECTOR
José Antonio Cordón-García
Nuances : Estudos sobre Educa??o , 2012,
Abstract: Las tecnologías de la información han transformado las tipologías documentales a lo largo de los últimos diez a os, dando lugar a la aparición de medios y formatos nuevos. Los cambios experimentados por obras de referencia y revistas científicas han tenido su continuidad en los libros electrónicos que van consolidando un mercado cada vez mas amplio lingüística y geográficamente. Los cambios no afectan únicamente al soporte sino que también se han modificado las formas de lectura y las practicas y recepción de la misma. Fruto de todo ello es la aparición de un nuevo concepto de libro, más abierto, colaborativo y multimedia, de nuevas formas de lectura, socializadas y en red, y de nuevos lectores, participativos y proclives a la integración reticular de los contenidos que generan. Las bibliotecas, por otra parte, se han involucrado en todo este proceso ampliando las redes de intercambio y de comunicación de obras y dando acceso a miles de libros antes inaccesibles, propiciando el préstamo de los mismos y la difusión de los nuevos dispositivos de lectura.
El campus virtual como recurso útil: un estudio de estudiantes universitarios de carreras humanísticas [The virtual learning platform as a useful resource: a research among university students of humanistic degrees]
Carmen Luján-García
Ensayos : Revista de la Facultad de Educacion de Albacete , 2012,
Abstract: Resumen: Este artículo, realizado con estudiantes universitarios de dos carreras humanísticas en la Universidad de Las Palmas de Gran Canaria: Filología Inglesa y Geografía, investiga el grado de familiaridad y utilidad del campus virtual en el mundo académico. Los resultados demuestran que es una herramienta útil, aunque percibida más como un apoyo a la ense anza presencial que con validez en sí misma. La variable género revela que los hombres valoran mejor esta herramienta, mientras que los informantes de geografía perciben más positivamente el campus virtual que los de filología inglesa. Abstract:This paper presents the results of a study carried out among undergraduate students of English Language and Literature and Geography at the University of Las Palmas de Gran Canaria to investigate their degree of familiarity with and the general usefulness of the virtual learning platform in Higher Education. The results show that whilst this is indeed a useful tool, it is used to best effect when seen as a supportive resource for regular education. The variation in responses from men and women reveals that men are more familiar with and value this tool more highly than women. It was also found that the Geography Undergraduates have a more positive view of virtual learning platforms than English Language and Literature Undergraduates.
Modelo geoestadístico y geotécnico de la generación de emanaciones de hidrocarburos en el fondo marino de la Sonda de Campeche, México
Galván-García, E;Auvinet-Guichard, G;
Ingeniería, investigación y tecnología , 2011,
Abstract: this article introduces a model of the formation of hydrocarbon leaking in the seabed of campo cantarell in sonda de campeche, mexico. the analysis was carried out appealing to geostatistics and geotechnics. using geostatistics, the thickness of the stratum of soft soil that constitutes the marine bottom was estimated and the spatial variation of the physical and mechanical characteristics of the soil was assessed. it was found that soil shear strength behaves like a "white noise" spatial process. it was possible to define a boundary subdividing the clay stratum in two sublayers, one of soft and another of very soft consistency. a finite element geomechanical model was used to simulate the behavior of the sea bottom clayey stratum under the effect of a subpressure which induces failure of this stratum and leads to the generation of hydrocarbon leaking. the model has an explanatory value and allows defining risk zones for the oil facilities, which coincide with the areas of minor thickness of the clayey stratum.
Adaptación de lentes de contacto rígidas permeables al gas en un caso de glaucoma congénito
Palomo-álvarez,C.; Martín-García,B.;
Archivos de la Sociedad Espa?ola de Oftalmología , 2008, DOI: 10.4321/S0365-66912008000600008
Abstract: case report: a 27-year-old woman with congenital glaucoma with high myopia, low visual acuity and nystagmus in both eyes, was referred for contact lens fitting. we fitted her with aspherical rigid gas permeable (rgp) contact lenses with high transmissibility, which she wore on a daily basis. her visual acuity improved with the wearing of these lenses, which remained comfortable whilst being worn for 10 hours a day. discussion: contact lenses were fitted according to her corneal topography. gas permeable contact lenses were chosen as first choice and with proper fitting and vigilant follow-up they may be worn safely on a daily basis.
Critical Phenomena in Gravitational Collapse
Gundlach Carsten,Martín-García José M.
Living Reviews in Relativity , 2007,
Abstract: As first discovered by Choptuik, the black hole threshold in the space of initial data for general relativity shows both surprising structure and surprising simplicity. Universality, power-law scaling of the black hole mass, and scale echoing have given rise to the term “critical phenomena”. They are explained by the existence of exact solutions which are attractors within the black hole threshold, that is, attractors of codimension one in phase space, and which are typically self-similar. Critical phenomena give a natural route from smooth initial data to arbitrarily large curvatures visible from infinity, and are therefore likely to be relevant for cosmic censorship, quantum gravity, astrophysics, and our general understanding of the dynamics of general relativity.
Adaptación de lentes de contacto rígidas permeables al gas en un caso de glaucoma congénito Rigid gas permeable contact lenses fitted in a case of congenital glaucoma
C. Palomo-álvarez,B. Martín-García
Archivos de la Sociedad Espa?ola de Oftalmología , 2008,
Abstract: Caso clínico: Mujer de 27 a os tratada de glaucoma congénito con alta miopía, baja AV y nistagmus en ambos ojos, fue referida para adaptar lentes de contacto. Se adaptan lentes de contacto rígidas permeables a los gases (LC RPG) asféricas y de alta transmisibilidad en uso diario. La paciente mejoró la AV con confort durante 10 horas al día de porte. Discusión: La adaptación de lentes de contacto se realizó teniendo en cuenta la topografía corneal de la paciente. Consideramos las lentes de contacto permeables al gas como las lentes de primera elección para estos pacientes, que con una adecuada adaptación y seguimientos pueden utilizar con seguridad lentes de contacto RPG en uso diario. Case report: A 27-year-old woman with congenital glaucoma with high myopia, low visual acuity and nystagmus in both eyes, was referred for contact lens fitting. We fitted her with aspherical rigid gas permeable (RGP) contact lenses with high transmissibility, which she wore on a daily basis. Her visual acuity improved with the wearing of these lenses, which remained comfortable whilst being worn for 10 hours a day. Discussion: Contact lenses were fitted according to her corneal topography. Gas permeable contact lenses were chosen as first choice and with proper fitting and vigilant follow-up they may be worn safely on a daily basis.
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