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Search Results: 1 - 10 of 461991 matches for " Semjonow A "
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Schwierigkeiten bei der Interpretation des prostataspezifischen Antigens
Semjonow A
Journal für Urologie und Urogyn?kologie , 2002,
PSA - haben wir dazugelernt?
Semjonow A,Albrecht W
Journal für Urologie und Urogyn?kologie , 2007,
Hammerer P,B?rgermann C,Semjonow A,Sieverding M
Journal für Urologie und Urogyn?kologie , 2007,
HIS-based electronic documentation can significantly reduce the time from biopsy to final report for prostate tumours and supports quality management as well as clinical research
Bernhard Breil, Axel Semjonow, Martin Dugas
BMC Medical Informatics and Decision Making , 2009, DOI: 10.1186/1472-6947-9-5
Abstract: We designed electronic forms for histological prostate biopsy reports in our hospital information system (HIS). These forms are created by urologists and sent electronically to pathologists. Pathological findings are entered into the system and sent back to the urologists. We assessed time from biopsy to final report (TBF) and compared pre-implementation phase (paper-based forms) and post-implementation phase. In addition we analysed completeness of the electronic data.We compared 87 paper-based with 86 electronic cases. Using electronic forms within the HIS decreases time span from biopsy to final report by more than one day per patient (p < 0.0001). Beyond the optimized workflow we observed a good acceptance because physicians were already familiar with the HIS. The possibility to use these routine data for quality management and research purposes is an additional important advantage of the electronic system.Electronic documentation can significantly reduce the time from biopsy to final report of prostate biopsy results and generates a reliable basis for quality management and research purposes.Assessing advantages and disadvantages of electronic documentation is important to improve hospital information systems. Paper-based documentation in clinical routine is still very common because of the time needed to fill in electronic forms [1] and reluctance to change the documentation routine [2]. On the one hand users are satisfied with the use of routine electronic data [3], on the other hand the subjective opinion whether electronic forms are faster differs [2].A recent study concerning ambulatory care in the United States shows that although "Electronic health records have the potential to improve the delivery of health care services [...] electronic systems had been adopted by only a small minority of U.S. physicians" and only "four percent of physicians reported having an extensive, fully functional electronic records system, and 13% reported having a basic system
Трансцендентальные основы понимания (И. Кант и неокантианство)
Remezowa I. I.,Semjonow W. E.
Kantovskij Sbornik , 2009, DOI: 10.5922/0207-6918-2009-2-15
HIS-based Kaplan-Meier plots - a single source approach for documenting and reusing routine survival information
Bernhard Breil, Axel Semjonow, Carsten Müller-Tidow, Fleur Fritz, Martin Dugas
BMC Medical Informatics and Decision Making , 2011, DOI: 10.1186/1472-6947-11-11
Abstract: We analysed the current follow-up process of oncological patients in two departments (urology, haematology) with respect to different documentation forms. We developed a concept for comprehensive survival documentation based on a generic data model and implemented a follow-up form within the HIS of the University Hospital Muenster which is suitable for a secondary use of these data. We designed a query to extract the relevant data from the HIS and implemented Kaplan-Meier plots based on these data. To re-use this data sufficient data quality is needed. We measured completeness of forms with respect to all tumour cases in the clinic and completeness of documented items per form as incomplete information can bias results of the survival analysis.Based on the form analysis we discovered differences and concordances between both departments. We identified 52 attributes from which 13 were common (e.g. procedures and diagnosis dates) and were used for the generic data model. The electronic follow-up form was integrated in the clinical workflow. Survival data was also retrospectively entered in order to perform survival and quality analyses on a comprehensive data set. Physicians are now able to generate timely Kaplan-Meier plots on current data. We analysed 1029 follow-up forms of 965 patients with survival information between 1992 and 2010. Completeness of forms was 60.2%, completeness of items ranges between 94.3% and 98.5%. Median overall survival time was 16.4 years; median event-free survival time was 7.7 years.It is feasible to integrate survival information into routine HIS documentation such that Kaplan-Meier plots can be generated directly and in a timely manner.Accurate survival or outcome information is important for many clinical studies, clinical routine and epidemiology. The standard method for estimating survival is the Kaplan-Meier plot (KM-plot) [1] with high relevance in medical research. Particularly in oncology the Kaplan-Meier technique is used to com
Clinical map document based on XML (cMDX): document architecture with mapping feature for reporting and analysing prostate cancer in radical prostatectomy specimens
Okyaz Eminaga, Reemt Hinkelammert, Axel Semjonow, Joerg Neumann, Mahmoud Abbas, Thomas Koepke, Olaf Bettendorf, Elke Eltze, Martin Dugas
BMC Medical Informatics and Decision Making , 2010, DOI: 10.1186/1472-6947-10-71
Abstract: The document architecture of cMDX was designed according to Open Packaging Conventions by separating the whole data into template data and patient data. Analogue custom XML elements were considered to harmonize the graphical representation (e.g. tumour extension) with the textual data (e.g. histological patterns). The graphical documentation was based on the four-layer visualization model that forms the interaction between different custom XML elements. Sensible personal data were encrypted with a 256-bit cryptographic algorithm to avoid misuse. In order to assess the clinical value, we retrospectively analysed the tumour extension in 255 patients after radical prostatectomy.The pathology report with cMDX can represent pathological findings of the prostate in schematic styles. Such reports can be integrated into the hospital information system. "cMDX" documents can be converted into different data formats like text, graphics and PDF. Supplementary tools like cMDX Editor and an analyser tool were implemented. The graphical analysis of 255 prostatectomy specimens showed that PCa were mostly localized in the peripheral zone (Mean: 73% ± 25). 54% of PCa showed a multifocal growth pattern.cMDX can be used for routine histopathological reporting of radical prostatectomy specimens and provide data for scientific analysis.Prostate Cancer (PCa) is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths in Germany [1]. As therapeutic approach, many patients choose total removal of the prostatic gland (radical prostatectomy). Pathology reports of radical prostatectomy specimens include clinically relevant information as well as clinically essential information derived from the macroscopic examination and microscopic evaluation, which play a supporting role in clinical decision making and prognostic evaluation of PCa [2,3]. Consequently, diverse standardized sectioning and documentation protocols of radical prostatectomy specimens are described
Genome-Wide Investigation of Multifocal and Unifocal Prostate Cancer — Are They Genetically Different?
Chinyere Ibeawuchi,Hartmut Schmidt,Reinhard Voss,Ulf Titze,Mahmoud Abbas,Joerg Neumann,Elke Eltze,Agnes Marije Hoogland,Guido Jenster,Burkhard Brandt,Axel Semjonow
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140611816
Abstract: Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investigate prostate cancer heterogeneity, the genetic profiles of multifocal and unifocal prostate cancers were compared. Here, we report observations deduced from tumor-tumor comparison of copy number alteration data of both focal categories. Forty-one fresh frozen prostate cancer foci from 14 multifocal prostate cancers and eight unifocal prostate cancers were subjected to copy number variation analysis with the Affymetrix SNP 6.0 microarray tool. With the investigated cases, tumors obtained from a single prostate exhibited different genetic profiles of variable degrees. Further comparison identified no distinct genetic pattern or signatures specific to multifocal or unifocal prostate cancer. Our findings suggest that samples obtained from multiple sites of a single unifocal prostate cancer show as much genetic heterogeneity and variability as separate tumors obtained from a single multifocal prostate cancer.
The Spread of Infectious Disease on Network Using Neutrosophic Algebraic Structure  [PDF]
A. Zubairu, A. A. Ibrahim
Open Journal of Discrete Mathematics (OJDM) , 2017, DOI: 10.4236/ojdm.2017.72009
Abstract: Network theory and its associated techniques has tremendous impact in various discipline and research, from computer, engineering, architecture, humanities, social science to system biology. However in recent years epidemiology can be said to utilizes these potentials of network theory more than any other discipline. Graph which has been considered as the processor in network theory has a close relationship with epidemiology that dated as far back as early 1900 [1]. This is because the earliest models of infectious disease transfer were in a form of compartment which defines a graph even though adequate knowledge of mathematical computation and mechanistic behavior is scarce. This paper introduces a new type of disease propagation on network utilizing the potentials of neutrosophic algebraic group structures and graph theory.
A Comparative Investigation of Lead Sulfate and Lead Oxide Sulfate Study of Morphology and Thermal Decomposition  [PDF]
S. A. A. Sajadi
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.22024
Abstract: The compound lead oxide sulfate PbSO4.PbO was prepared in our laboratory. The Thermal behavior of PbSO4 was studied using techniques of Thermogravimetry under air atmosphere from 25 to 1200°C. The identity of both compounds was confirmed by XRD technique. Results obtained using both techniques support same decomposition stages for this compound. The electron microscopic investigations are made by SEM and TEM. The compound is characterized by XRD and the purity was determined by analytical Methods. Also a series of thermogravimetric analysis is made and the ideal condition is determined to convert this compound to pure lead oxide.
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