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Search Results: 1 - 10 of 325284 matches for " Seifi S "
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Serum IL-6 level and associated factors: hemodialysis patients
Seifi S, Mokhtari A
Tehran University Medical Journal , 2008,
Abstract: "nBackground: The annual amount of mortality in ESRD exceeds the expectation and represents the recent evidences of the inflammation as its etiology. The etiology of inflammation is not clearly known. Chronic inflammation is a dominant occurrence of ESRD which increases the risk of atherosclerosis, malnutrition and peripheral vascular disease. Inflammatory responses are orchestrated by cytokines. Some of the proinflammatory cytokines like IL-6 have a crucial role in this phenomenon. The IL-6 and its receptor activity is up regulated in ESRD patients and the increased level of IL-6 predicts cardiovascular mortality and morbidity in normal and CRF patients. This study devotes itself to determining the serum level of IL-6 and factors affecting it in patients undergoing chronic hemodialysis in Imam Khomeini Hospital which can represent the Iranian Society. By identifying factors affecting the serum level of IL-6 and high-risk patients we can provide treatment possibilities, a decrease in mortality and an improvement in its prognosis. "n"nMethods: In this study 42 patients in Imam Dialysis Center were chosen and their serum IL-6 levels were measured at 2 times at three month interval and at the same time blood sample analysis were done for the following: Alb CPR, Ca, P, PTH, TIBC, Ferritin, TG, Chol, LDL, HDL, Uric Acid, Hb, WBC and urea."n"nResults: The mean serum level of IL-6 in hemodialysis patients was 6.35±4.47pg/ml (minimum: 0.55, maximum: 18.25) with the normal range of 1.3±3.2pg/ml."n"nConclusions: The IL-6 level was higher than normal range in the 52% of the patients. The serum IL-6 level had a significant correlations with CPR, Ferritin, TIBC, WBC and their serum IL-6 level was significantly higher in patients with hypertension, but no significant correlation was observed between other parameters and IL-6
HER2/neu and αSMA Expression in Oral Squamous Cell Carcinoma
Seifi S.,Shafaie Sh.
Journal of Dentistry , 2011,
Abstract: Statement of Problem: Squamous cell carcinoma (SCC) is the most common cancer of the mouth, but its pathogenesis is unknown. HER2/neu is a protoncogene with homologue sequence with EGF. αSMA is a smooth muscle specific actin which indicates the existence of myofibroblasts in the oral cancer stroma. Purpose: This study aimed to measure the frequency of Her2/neu and (alpha) αSMA in oral SCC. Materials and Method: For this study, 18 paraffinized blocks of OSCC were immunostained with Anti HER2/neu, Anti (Alpha) SMA. Percentage and degree of the epithelial cells staining and percentage staining of myofibroblasts were considered. The results of the study were analyzed using kappa and X2.Results: From 18 cases of OSCC, 3 and 12 cases were positive with HER2/neu and αSMA, respectively. In the normal oral mucosa, one case was positive (Score 2) with HER2/neu but αSMA positive myofibroblasts were not seen in the stroma of OSCC. A significant difference was seen in αSMA expression in OSCC and the normal oral mucosa ( p =0.002). No significant difference was found in HER2/neu expression in OSCC and normal mucosa ( p >0.05).Conclusion: The results of this study suggest that αSMA has an effective role in pathogenesis and aggressive behavior of OSCC but HER2/neu has no main role in this type of oral cancer.
Incidence and risk factors of Mycoplasma synoviae infection in broiler breeder farms of Iran
S Seifi,M R Shirzad
Veterinary World , 2012,
Abstract: Mycoplasma synoviae (MS) is an important pathogen of poultry worldwide, causing respiratory tract infection and infectious synovitis in chickens and turkeys. The aim of this study was to determine the incidence and risk factors (age, size of flock, locale, sex and strain) of Mycoplasma synoviae in broiler breeder farms in Iran. The study was based on Rapid Serum Plate Agglutination (SPA) and enzyme linked immunosorbent assay (ELISA) tests. The prevalence was highest (44%) in winter and lowest (34%) in summer. Ross, Cobb, Arian, Hubbard and Arbor Acres strains had 40%, 44%, 32%, 27% and 45% infection, respectively. The prevalence was recorded highest in above 60 weeks of age (47.8%), but at 10-20 weeks it was lowest (14.2%). No significant difference was seen in flocks up to 30,000 population (41.9%), 30,000-40,000 (52%) and upper 40,000 (57%). The prevalence of Mycoplasmosis in foothills was significantly (p<0.05) higher (41%) than coastal area (34.5%). The results showed that occurrence of MS have a significant relationship with the age and zone of sampling. [Vet. World 2012; 5(5.000): 265-268]
Computational Modeling of Electro-Elasto-Capillary Phenomena in Dielectric Elastomers
Saman Seifi,Harold S. Park
Physics , 2015,
Abstract: We present a new finite deformation, dynamic finite element model that incorporates surface tension to capture elastocapillary effects on the electromechanical deformation of dielectric elastomers. We demonstrate the significant effect that surface tension can have on the deformation of dielectric elastomers through three numerical examples: (1) surface tension effects on the deformation of single finite elements with homogeneous and inhomogeneous boundary conditions; (2) surface tension effects on instabilities in constrained dielectric elastomer films, and (3) surface tension effects on bursting drops in solid dielectrics. Generally, we find that surface tension creates a barrier to instability nucleation. Specifically, we find in agreement with recent experimental studies of constrained dielectric elastomer films a transition in the surface instability mechanism depending on the elastocapillary length. The present results indicate that the proposed methodology may be beneficial in studying the electromechanical deformation and instabilities for dielectric elastomers in the presence of surface tension.
Seroprevalence and Risk Factors of Mycoplasma gallisepticum Infection in Iranian Broiler Breeder Farms
S. Seifi,M.R. Shirzad
International Journal of Animal and Veterinary Advances , 2012,
Abstract: This study was aimed to determine the risk factors (age, size of flock, locale, sex and strain) and seroprevalence of Mycoplasma gallisepticum (MG) in Iranian broiler breeder farms. In addition Correlation between seroprevalence in breeder with chronic respiratory disease in their progeny was analyzed. The study was conducted from May 2002 to October 2008 that was based on rapid Serum Plate Agglutination (SPA) and enzyme linked immunosorbent assay (ELISA) tests. To find a correlation between MG in breeders with airsaculitis in their progeny, data from broiler slaughterhouses were registered. According to the results, the highest (21.4%) and lowest (0%) prevalence of MG infection was found in 2003, 2008 respectively (p<0.05). The prevalence was highest (18.5%) in winter and lowest (6.8%) in summer. Ross, Cobb, Arian, Hubbard and Arbor Acres had 23.2, 8, 11.4, 14 and 6.9, respectively infection. The prevalence was recorded highest at 10-20 weeks of age (28%), but in above 60 weeks it was lowest (3.4%). MG infection was higher (56.21%) in female than in male (43.79%). No significant difference was seen in flocks up to 30,000 population (11.7%), 30,000- 40,000 (19%) and upper 40,000 (23%). The prevalence of mycoplamosis in foothills was relatively higher (9.4%) than coastal area (7.2%), however not significantly different. The correlation between MG in breeder and chronic respiratory disease in broiler wasn’t significant (respectively p = 0.743, p = 0.103) according to this, vertical infection couldn’t be an important cause of condemnation for broiler in slaughterhouse.
"Erythropoietin Utilization Evaluation And Two Brand Products Comparison, Eprex and Eposim "
H. Khalili,S. Dashti,S. Seifi,M. Hadjibabaie
Tehran University Medical Journal , 2006,
Abstract: Background and Aim: Anemia is one of the common problems in patients with chronic renal impairment. The most common cause of anemia in this patients is a decreased in erythropoietin hormone excretion, however other common cause include low life of red blood cells, loss of blood during dialysis, frequent blood sampling, uremia, iron, vitamin B12 and folic acid deficiency. Until introduction of erythropoietin in 1982, blood transfusion was an alternative for correction and maintaining hematocrit in normal range in dialyze patients. In current date, any dialyzed patient take rh-erythropoietin . Materials and Methods: The goal of this study is to evaluate erythropoietin utilization and comparing the effectiveness of the commercial product in the Iranian drugs market. The study was performed at nephrology and dialyze ward of Immam Khomeini hospital in a one year period. Results and Conclusion: Of the 30 patients' subject of study, 13 patients received eprex and 17 received epocim. Average dose of erythropoietin 2000IU was three times per week. The average plasma hemoglobin and hematocrit of patients prior to the treatment were 9.38 g/dl and 28% respectively. Increase in the hemoglobin and hematocrit in the group who received eprex was significantly higher than epocim group (p=0.001 and p=0.026 respectively). The incidents of side effects including hypertension, headache, pain at injection site, and influenza-like in eposim group were considerably higher than eprex.
The effect of plant density and shoot pruning on growth and yield of two greenhouse bell pepper cultivars
S. Seifi,S.H. Nemati,M. Shoor,B. Abedi
Journal of Science and Technology of Greenhouse Culture , 2012,
Abstract: In order to investigate the effects of plant density and pruning on yield characteristics and growth of two bell pepper cultivars, a 2×3×2 factorial experiment was conducted in a complete randomized block design with three replications and three factors of plant density (2.5, 3 and 3.5 plants per m2), shoot pruning at two levels (without pruning and training plants with 3 main stems) and two bell pepper cultivars (Tomson and Maratos), in greenhouse of Ferdowsi University of Mashhad, Iran. The results showed that the effect of shoot pruning on yield per m2, yield per plant, fruit weight, number of fruits per plant and plant weight was significant (P<0.01). The effect of cultivar on plant height, shoot diameter and plant weight was significant (P<0.01), and also the amount of these parameters for Tomson cultivar was higher than Maratos cultivar. Plant density had a significant effect on total yield, average fruit weight, plant height, shoot diameter and plant weight. Plant density of 3.5 plants per m2 produced the highest yield (10.80 kg/m2) and 2.5 plants per m2 showed the lowest yield (6.95 kg/m2). Average fruit weight decreased with increasing plant density, such that 2.5 plants per m2 produced the highest fruit weight (109.8 g). Plant weight and shoot diameter decreased with increasing plant density, while plant height increased with higher plant density. Pruning decreased total yield, yield per plant, plant weight and number of fruits per plant, but it increased fruit weight. The results of this experiment showed that pruning of bell pepper plants caused an increase in fruit weight and improved fruit quality.
The relationship between pro-hepcidin and serum biochemical parameters in chronic hemodialysis patients: a study on 54 patients
Abbasi Larki R,Seifi S,Lesan Pezeshki M
Tehran University Medical Journal , 2011,
Abstract: "nBackground: Prohepcidin, a liver-derived peptide with antimicrobial properties, is regulated by factors such as iron load and inflammation. Hepcidin is a central player in iron homeostasis. It downregulates the iron exporter ferroportin, thereby inhibiting iron absorption, release and recycling. Thus, prohepcidin increases the possibility of iron-limited erythropoiesis and development of anemia. In end-stage renal disease (ESRD), plasma hepcidin levels are elevated, which may contribute to iron deficiency in these patients. This study was undertaken to investigate the relationship between prohepcidin and serum biochemical parameters related to anemia and inflammation in the aforesaid patients."n "nMethods: Fifty-four stable patients with uremia who were on chronic hemodialysis were enrolled in the study. The patients were withheld from intravenous iron two weeks prior to laboratory measurements. Later, (total) prohepcidin was measured by ELISA method as were other parameters including serum iron, TIBC, TSAT, Hct, ferritin, albumin, CRP, ESR, cholesterol and triglyceride."n "nResults: Serum prohepcidin levels were higher than normal values in the patients, but they were not correlated to the serum iron, TIBC, TSAT, Hct, ferritin, albumin, cholesterol and triglyceride (p>0.05). No significant association were also found with ESR (p=0.97, r= -0.005) or CRP (p=0.053, r =0.26)."n "nConclusion: Serum prohepcidin level was higher in chronic hemodialysis patients but it was not predictive of iron status or inflammatory conditions in these patients. Confirmation of these results may necessitate studies with larger sample sizes or measurement of the biologically active form of hepcidin.
The association of uric acid levels with presence of coronary artery disease (CAD) and need for revascularization in renal transplant candidates
Eslami M,Mehrpooya M,Broumand B,Seifi S
Tehran University Medical Journal , 2009,
Abstract: "nBackground: Uric acid as a final product of purine metabolism has a role of risk factor for cardiovascular disease with less clear mechanism in general population. The aim of this study was Assessing and finding association between uric acid levels and CAD as a risk factor in renal transplant candidates and if we can predict need to revascularization according to uric acid level as an important measure. "nMethods: This is a cross-sectional study that has been studied since April 2007 up to December 2008, in imam Khomeini and pars hospitals in Tehran. Inclusion criteria were patients with ESRD, more than 40 years who were candidates for renal transplantations. They underwent coronary angiography without regarding clinical cardiac symptom or results of noninvasive tests (for avoiding referral bias) and simultaneous analysis of serum uric acid level and results of this two producers were analyzed. Excluding criteria were patients who didn't tend to coronary angiography, those who hadn't adequate artery access, or potential co morbidity so that angiography was impossible and life expectancy less than 6 month. "nResults: 56 (24 females and 32 males) were constituted. 89.3% (50) of patients had coronary artery disease. The average of uric acid level was significantly different in patients with and without CAD [7.62±1.07mg/dl and 5.95±1.29mg/dl respectively] (p=0.0024). Moreover, there was statistically significant difference in serum uric level between patients who were candidate for revascularization and the others [7.89±0.79mg/dl and 6.2±1.27mg/dl respectively] (p<0.001). "nConclusion: It seems that serum uric acid can be considered as a cardiovascular risk factor in renal transplant candidates and also as a predictor for related treatment.
Relationship Between ADPKD and Post-Renal Transplant Diabetes Mellitus
S. Seifi,A. Soleimani,M. Lesan Pezeshki,B. Einollahi
Tehran University Medical Journal , 2006,
Abstract: Background: Autosomal-dominant polycystic kidney disease (ADPKD), a common hereditary disease, is characterized by the progressive development and enlargement of multiple cysts in both kidneys, and typically resulting in end stage renal disease (ESRD) by the fifth decade of life. Post-transplant diabetes mellitus (PTDM), a common complication after transplantation with an incidence rate of 2.5-20%, is associated with poor graft and patient survival. In few studies, PTDM has been more frequent in ADPKD transplanted patients. In the present study, we investigated whether there is any association between PTDM and ADPKD in our patients. Methods: In this prospective study, 140 non-diabetic and nonsmoker successfully transplanted patients (27 ADPKD and 113 non ADPKD patients) were enrolled during three years. Both groups were matched for age, sex, body mass index (BMI), duration of renal replacement therapy before transplantation and also immunosuppressive protocols after transplant. Post-transplant diabetes mellitus was defined as Clinical Practice Guidelines advocated by Canadian Diabetes Association. All patients were followed for 12 months. Results: PTDM occurred in 11.1% of ADPKD patients and in 13.1% of control group which was statistically insignificant (P > 0.05). The development of PTDM in ADPKD group was not related to sex, age, and hypertension, duration of renal replacement therapy before transplantation, BMI and serum creatinine levels (P > 0.05). Conclusion: Post-transplant diabetes mellitus appears not to be associated with autosomal-dominant polycystic kidney disease as an etiology of end stage renal disease.
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