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Search Results: 1 - 10 of 1095 matches for " Seema Saini "
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FORMULATION AND EVALUATION OF FEXOFENADINE HYDROCHLORIDE TRANSDERMAL PATCH
HeenaChaudhary,A.C Rana,Seema Saini,Gurpreet Singh
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: To treat allergic disorders on long term therapy needs plasma concentration of drug in better manner. This was achieved by formulating the drug in controlled release pattern. Fexofenadine hydrochloride is almost completely absorbed from the gastro-intestinal tract following oral administration,but bioavailability is reported to be only about 45% due to hepatic first-pass metabolism. The present study aims to prepare Transdermal patch of Fexofenadine hydrochloride. Preparation of transdermal patches of Fexofenadine hydrochloride using polymers: Hydroxypropyl methyl cellulose, Ethyl cellulose plasticized with Glycerol. The patches were evaluated for various parameters like Thickness, Water-Vapor Permeability, Tensile Strength, Drug Content,Diffusion and Dissolution studies. Prepared patches exhibited Zero Order Kinetics and the permeation profile was matrix diffusion type.In-vitrorelease study of Fexofenadine hydrochloride transdermal patch shown release of drug 79 % at 24 h and also follows zero order kinetics release pattern.
FAST DISSOLVING FILMS: A NOVEL APPROACH TO ORAL DRUG DELIVERY
Aggarwal Jyoti,Singh Gurpreet,Saini Seema,Rana A.C
International Research Journal of Pharmacy , 2011,
Abstract: Amongst the plethora of avenues explored for rapid drug releasing products, oral strip technology (OST) is gaining much attention. Dissolvable oral thin films (OTFs) evolved over the past few years from the confection and oral care markets in the form of breath strips and became a novel and widely accepted form by consumers. Fast-dissolving oral films are solid dosage forms, which disintegrate or dissolve within 1 min when placed in the mouth without drinking water or chewing. These drug delivery systems allow the medication to bypass the first pass metabolism thereby making the medication more bioavailable. The sublingual and buccal delivery of a drug via thin film has the potential to improve the onset of action, lower the dosing and eliminate patient’s fear of chocking. Formulation of oral films involves the application of both aesthetic and performance characteristics such as plasticized hydrocolloids, active pharmaceutical ingredient, taste masking agent being laminated by solvent casting or hot melt extrusion. Solvent casting being the most preferred offers great uniformity of thickness and films have fine gloss and better physical properties. Oral strips are evaluated for various attributes such as thickness, folding endurance, disintegration and dissolution time. This review describes about the formulation methodology, evaluation parameters and the future aspects of oral fast dissolving films.
EFFECT OF CHEMICAL PENETRATION ENHANCERS ON SKIN PERMEATION: A REVIEW
Chaudhary Heena,A.C Rana,Seema Saini,Gurpreet Singh
International Research Journal of Pharmacy , 2011,
Abstract: Transdermal drug delivery has attracted considerable attention over the past 2-3 decades in regard of its many potential advantages. Skin penetration enhancers have been used to improve bioavailability and increase the range of drugs to be administered by topical and transdermal route. Therefore, skin penetration enhancers are frequently used in the field of transdermal drug delivery in order to reversibly reduce the barrier function of the stratum corneum, the outermost layer of the skin. The mechanism of action of penetration enhancers are used as an aid in potential clinical applications. Chemical penetration enhancers are present in a large number of transdermal, dermatological, and cosmetic products to aid dermal absorption of curatives and aesthetics. This review presents a critical account of the most commonly used chemical penetration enhancers (fatty acids and surfactants), and some newer classes of chemical enhancers (terpenes, polymers, monoolein, oxazolidinones), with emphasis on their efficacy, mechanism of action, and skin irritation potential. This review also discusses the recently developed methods for the screening and evaluation of chemical penetration enhancers, and addresses the continuing problems in the rational selection of a chemical penetration enhancer for a specific drug to be delivered via the transdermal route.
INDUSTRIAL PROCESS VALIDATION OF TABLET DOSAGE FORM: AN OVERVIEW
Gupta Surbhi,Saini Seema,Singh Gurpreet,Rana A.C.
International Research Journal of Pharmacy , 2012,
Abstract: In pharmaceutical organizations, validation is a fundamental segment that supports a company commitment to quality assurance. Validation is a tool of quality assurance which provides confirmation of the quality in equipment systems, manufacturing processes, software and testing methods. Validation assures that products with pre-determined quality characteristics and attributes can be reproduced consistently/reproducibly within the established limits of the manufacturing process operation at the manufacturing site. Validation of the individual steps of the manufacturing processes is called the process validation. Different dosage forms have different validation protocols. Here this article concentrates on the process validation of tablet dosage form, protocol preparation and regulatory basis for process validation in industry. It gives in detail the validation of each step of the manufacturing process of tablets through wet granulation.
PENETRATION ENHANCERS: A NOVEL STRATEGY FOR ENHANCING TRANSDERMAL DRUG DELIVERY
Singla Vikas,Saini Seema,Singh Gurpreet,Rana A.C
International Research Journal of Pharmacy , 2011,
Abstract: Skin penetration enhancers have been used to improve bioavailability and increase the range of drugs to be administered by topical and transdermal route. Enhancement in skin penetration via modification of the stratum corneum by hydration, or via use of chemical enhancers acting on the structure of the stratum corneum lipids and keratin, partitioning and solubility effects. The mechanism of action of penetration enhancers are used as an aid in potential clinical applications. Synthetic chemicals generally used for this purposes are rapidly losing their value in transdermal patches due to reports of their absorption into the systemic circulation and subsequent possible toxic effect upon long term application. Terpenes are included in the list of Generally Recognized as Safe (GRAS) substances and have low irritancy potential. In this review, we have discussed the chemical penetration as well as natural penetration enhancement technology for transdermal drug delivery as well as the probable mechanisms of action.
EMULGEL: A COMPREHENSIVE REVIEW ON THE RECENT ADVANCES IN TOPICAL DRUG DELIVERY
Joshi Baibhav,Singh Gurpreet,Rana A.C,Saini Seema
International Research Journal of Pharmacy , 2011,
Abstract: Emulgel has emerged as a promising drug delivery system for the delivery of hydrophobic drugs. When gel and emulsion are used in combined form they are referred as Emulgel. Emulsion in gel have emerged as one of the most interesting topical drug delivery system as it have dual release control system i.e. emulsion and gel. Gels are relatively newer class of dosage form created by entrapment of large amount of aqueous or hydro alcoholic liquid in a network of colloidal solid particles which may consist of inorganic substances or organic polymers of natural or synthetic origin. In recent years there has been great interest in the use of novel polymers with complex function such as emulsifiers and thickeners. The gelling capacity of these compounds allows the formulation of stable emulsion and creams by decreasing surface and interfacial tension at the same time increasing the viscosity of aqueous phase. In spite of many advantages of gels a major limitation is in the delivery of hydrophobic drug. So to overcome this limitation an emulsion based approach is being used so that even a hydrophobic moiety can enjoy the unique property of gel.
AN OVERVIEW: ROLE OF PROCESS VALIDATION IN TABLETS
Chawla Nirmaljot Singh,Rana A C,Saini Seema,Singh Gurpreet
International Research Journal of Pharmacy , 2012,
Abstract: The purpose of this work is to present an introduction and general overview on process validation of pharmaceutical manufacturing process especially tablet manufacturing process. Validation is the documented act of demonstrating that a procedure, process, and activity will consistently lead to the expected results. This type of validation is based on the physics of compression. It often includes the qualification of systems and equipment. It is a requirement for good manufacturing practices and other regulatory requirements. A properly designed system will provide a high degree of assurance that every step, process, and change has been properly evaluated before its implementation. Testing a sample of a final product is not considered sufficient evidence that every product within a batch meets the required specification. Three consecutive batches of tablets shall be taken up for process validation. Based on the result of these three batches the conclusion is drawn and Batch Manufacturing Record can be written once the validation process is complete.
BIODEGRADABLE MICROSPHERES: A REVIEW
Kaur Dupinder,Saini Seema,Singh Gurpreet,Rana A.C
International Research Journal of Pharmacy , 2012,
Abstract: Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. The range of techniques for the preparation of microspheres offers a variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. Of the many polymeric drug delivery systems, biodegradable polymers have been used widely as drug delivery systems because of their biocompatibility and biodegradability. The majority of biodegradable polymers have been used in the form of microparticles, from which the incorporated drug is released to the environment in a controlled manner. They can be employed to deliver medication in a rate-controlled and sometimes targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. This review discusses characteristics and degradation behaviors of biodegradable polymers which are currently used in drug delivery.
INDUSTRIAL PROCESS VALIDATION OF SOLID DOSAGE FORMS: A REVIEW
Singh Harsimranjit,A.C Rana,Seema Saini,Gurpreet Singh
International Research Journal of Pharmacy , 2012,
Abstract: Validation is one of the important steps in achieving and maintaining the quality of the final product. If each step of production process is validated we can assure that the final product is of the best quality. Validation of the individual steps of the processes is called the process validation. Different dosage forms have different validation protocols. Here this article concentrates on the process validation of solid dosage forms, protocol preparation and regulatory basis for process validation with special emphasis on tablets in industry. It gives in detail the validation of each step of the manufacturing process through dry granulation.
A Study of Environmental Awareness of Student Teachers and Teachers in Relation of Their Emotional Intelligence  [PDF]
Seema Sharma
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.28021
Abstract: The study aimed at finding out the relationship between environmental awareness and emotional intelligence of student teachers and teachers. The sample of the study consisted of 200 student teachers (100 male and 100 female) and also of 100 teachers (50 male and 50 female). The sample was taken from 15 self-financed B.Ed. colleges of Ghaziabad District of CCS University, Meerut (UP). Environmental awareness measure scale by Dr. P. K. Jha and emotional intelligence inventory by Dr. S. K. Mangal and Mrs. Shubhra Mangal was used for assessing the environmental awareness and emotional intelligence of student teachers and teachers. Data was analyzed by using mean, SD, t-test and by Pearson Product Moment Correlation Technique. The results showed that there was no significant difference between male and female student teachers and teachers regarding environmental awareness and emotional intelligence. The results also showed that the environmental awareness of male and female student teachers was also found to be slightly positively but not significantly correlated with emotional intelligence. The environmental awareness of male teachers was found to be moderately, positively and significantly correlated with emotional intelligence. On the other hand the environmental awareness of female teachers was found to be slightly positively but not significantly correlated with emotional intelligence.
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