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Search Results: 1 - 10 of 301259 matches for " Sebastian J. Markmiller "
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Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis
Yeliz Boglev,Andrew P. Badrock,Andrew J. Trotter,Qian Du,Elsbeth J. Richardson,Adam C. Parslow,Sebastian J. Markmiller,Nathan E. Hall,Tanya A. de Jong-Curtain,Annie Y. Ng,Heather Verkade,Elke A. Ober,Holly A. Field,Donghun Shin,Chong H. Shin,Katherine M. Hannan,Ross D. Hannan,Richard B. Pearson,Seok-Hyung Kim,Kevin C. Ess,Graham J. Lieschke,Didier Y. R. Stainier,Joan K. Heath
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003279
Abstract: Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel zebrafish mutant, titania (ttis450), which harbours a recessive lethal mutation in pwp2h, a gene encoding a protein component of the small subunit processome. The biochemical impacts of this lesion are decreased production of mature 18S rRNA molecules, activation of Tp53, and impaired ribosome biogenesis. In ttis450, the growth of the endodermal organs, eyes, brain, and craniofacial structures is severely arrested and autophagy is up-regulated, allowing intestinal epithelial cells to evade cell death. Inhibiting autophagy in ttis450 larvae markedly reduces their lifespan. Somewhat surprisingly, autophagy induction in ttis450 larvae is independent of the state of the Tor pathway and proceeds unabated in Tp53-mutant larvae. These data demonstrate that autophagy is a survival mechanism invoked in response to ribosomal stress. This response may be of relevance to therapeutic strategies aimed at killing cancer cells by targeting ribosome biogenesis. In certain contexts, these treatments may promote autophagy and contribute to cancer cells evading cell death.
Ten Simple Rules for Providing a Scientific Web Resource
Sebastian J. Schultheiss
PLOS Computational Biology , 2011, DOI: 10.1371/journal.pcbi.1001126
Abstract:
Meaning of Life and Death in the Poetry of John Paul II
A.J. Sebastian
Journal of Alternative Perspectives in the Social Sciences , 2010,
Abstract: John Paul II will ever be remembered in the pages of history as a Poet who admitted the ‘dark pages’ in the Church’s history with the same courage with which he had vindicated the rights of the Church. He asked forgiveness for violence used during the Inquisition, the cooperation of Christians with dictatorships, and the anti-Semitic prejudice that prevented from taking stand against the Nazi slaughterof the Jews (Accattoli, 2001, p. 12).
Voicing Slum-subaltern in Slumdog Millionaire
A.J. Sebastian
Journal of Alternative Perspectives in the Social Sciences , 2009,
Abstract: According to a United Nations report, populationgrowth and urbanization are veritably creating a planet ofslums, which is expected to double by 2030.The slums in thecities of Africa and Asia are growing by more than a millionpeople every week. The report states that the growth of cities will be the single largest influence on development in the21st century (Ibidem).It is my endeavour in this article to examine slumsubaltern with reference to the fiction and the film SlumdogMillionaire. Based on Vikas Swarup’s Q & A, Danny Boylehas aptly brought out a celluloid sensation portrayingslum-subaltern.
Poor-Rich Divide in Aravind Adiga’s The White Tiger
A.J. Sebastian
Journal of Alternative Perspectives in the Social Sciences , 2009,
Abstract: Aravind Adiga’s The White Tiger, which was awarded theMan Booker Prize in 2008, is singular in its fictionalized portrayal of the relationship between Balram Halwai and his master Mr Ashok. The story exposes the poor-rich divide that surrounds India in the backdrop of economic prosperity, in the wake of the IT revolution. As Michael Portillo commented the novel “shocked and entertained in equal measure” (Portillo, 2008). Written in the epistolary form, the novel is a seven-part letter to the Chinese Premier, Wen Jiabao, from Balram alias Ashok Sharma, a self-styled ‘Thinking Man / And an entrepreneur’ (TWT, 2008, p. 3). Balram the killer, metamorphoses into his master’s replica after his heinous crime. By crime and cunning, in the name of the social injustice due to existing rich-poor divide in India, Balram rules his entrepreneurial world. This paper attempts to trace the great poor-rich divide manifested through The White Tiger, having dangerous consequences, if unresolved.
Stable causality of Black Saturns
Sebastian J. Szybka
Physics , 2011, DOI: 10.1007/JHEP05(2011)052
Abstract: We prove that the Black Saturns are stably causal on the closure of the domain of outer communications.
BEACH 2014 Theory Summary
Sebastian J?ger
Physics , 2015, DOI: 10.1088/1742-6596/556/1/012077
Abstract: I summarize key aspects of the quest for physics beyond the Standard Model in flavour physics as discussed at the BEACH 2014 conference in Birmingham.
Chaotic self-similar wave maps coupled to gravity
Sebastian J. Szybka
Physics , 2003, DOI: 10.1103/PhysRevD.69.084014
Abstract: We continue our studies of spherically symmetric self-similar solutions in the SU(2) sigma model coupled to gravity. For some values of the coupling constant we present numerical evidence for the chaotic solution and the fractal threshold behavior. We explain this phenomenon in terms of horseshoe-like dynamics and heteroclinic intersections.
On gravitational interactions between two bodies
Sebastian J. Szybka
Physics , 2014,
Abstract: Many physicists, following Einstein, believe that the ultimate aim of theoretical physics is to find a unified theory of all interactions which would not depend on any free dimensionless constant, i.e., a dimensionless constant that is only empirically determinable. We do not know if such a theory exists. Moreover, if it exists, there seems to be no reason for it to be comprehensible for the human mind. On the other hand, as pointed out in Wigner's famous paper, human mathematics is unbelievably successful in natural science. This seeming paradox may be mitigated by assuming that the mathematical structure of physical reality has many `layers'. As time goes by, physicists discover new theories that correspond to the physical reality on the deeper and deeper level. In this essay, I will take a narrow approach and discuss the mathematical structure behind a single physical phenomenon - gravitational interaction between two bodies. The main aim of this essay is to put some recent developments of this topic in a broader context. For the author it is an exercise - to investigate history of his scientific topic in depth.
On light propagation in Swiss-Cheese cosmologies
Sebastian J. Szybka
Physics , 2010, DOI: 10.1103/PhysRevD.84.044011
Abstract: We study the effect of inhomogeneities on light propagation. The Sachs equations are solved numerically in the Swiss-Cheese models with inhomogeneities modelled by the Lemaitre-Tolman solutions. Our results imply that, within the models we study, inhomogeneities may partially mimic the accelerated expansion of the Universe provided the light propagates through regions with lower than the average density. The effect of inhomogeneities is small and full randomization of the photons' trajectories reduces it to an insignificant level.
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