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Search Results: 1 - 10 of 403549 matches for " Sean M Clemenza "
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Puma predation on radiocollared and uncollared bighorn sheep
Sean M Clemenza, Esther S Rubin, Christine K Johnson, Randall A Botta, Walter M Boyce
BMC Research Notes , 2009, DOI: 10.1186/1756-0500-2-230
Abstract: Three pumas killed 23 bighorn sheep over the course of the study, but they did not preferentially prey on marked (radiocollared) versus unmarked bighorn sheep. Predation occurred primarily during crepuscular and nighttime hours, and 22 kill sites were identified by the occurrence of 2 or more consecutive puma GPS locations (a cluster) within 200 m of each other at 1900, 0000, and 0600 h.We tested the "conspicuous individual hypothesis" and found that there was no difference in puma predation upon radiocollared and uncollared bighorn sheep. Pumas tended to move long distances before and after kills, but their movement patterns immediately post-kill were much more restricted. Researchers can exploit this behaviour to identify puma kill sites and investigate prey selection by designing studies that detect puma locations that are spatially clustered between dusk and dawn.Pumas (Puma concolor) are known predators of bighorn sheep (Ovis canadensis) in North America, but puma behaviour and movements associated with these predation events are poorly understood. Ross et al. [1] found predation on Rocky Mountain bighorn sheep to be an individual behaviour in Alberta, and Logan and Sweanor [2] and Ernest et al. [3] also presented evidence for differences in the frequency that individual pumas killed desert bighorn sheep in the southwestern United States. Although these studies identified individual pumas that selectively killed bighorn sheep, they left important questions unanswered. During ongoing studies of pumas and endangered bighorn sheep in the Peninsular Ranges of California, we radiocollared 3 pumas (1 female and her 2 offspring) who subsequently each killed multiple bighorn sheep (total ≥ 23). This gave us the opportunity to critically evaluate whether or not pumas selectively preyed on radiocollared versus uncollared bighorn sheep (because marked animals are more conspicuous), and to examine movement patterns at and around bighorn sheep kill sites.The Peninsular Rang
Induced Transcriptional Expression of Bacillus subtilis Amino Acid Permease yvbW in Response to Leucine Limitation  [PDF]
Sean M. Rollins
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.48053

T box sequences have been identified upstream of a large number of uncharacterized genes such as transporters in bacterial genomes. Expression of each T box family gene is induced by limitation for a specific amino acid. T box family genes contain an untranslated leader region containing a factor-independent transcriptional terminator upstream of the structural genes. The anticodon of uncharged tRNA base-pairs with the leader mRNA at a codon referred to as the specifier sequence, inducing formation of an alternative antiterminator structure, allowing expression of the structural genes. There are several additional conserved primary sequence and secondary structural elements. Analysis of these elements can be used to predict the identity of the specifier codon and the amino acid signal. Bacillus subtilis hypothetical amino acid permease, yvbW, was analyzed as an example of this type of transcriptional regulatory prediction suggesting expression in response to leucine limitation. Expression was induced up to 130-fold in response to leucine limitation, utilizing a yvbW-lacZ transcriptional fusion. These data suggest that hypothetical amino acid permease YvbW may participate in leucine metabolism. A yvbW knockout strain was generated, although the substrate specificity for the putative amino acid permease was not identified.

Mouse models of sarcomas: critical tools in our understanding of the pathobiology
Sean M Post
Clinical Sarcoma Research , 2012, DOI: 10.1186/2045-3329-2-20
Abstract: Sarcomas are a rare form of cancer with less than 15,000 new cases diagnosed each year in the United States. Though rare, sarcomas are highly debilitating malignancies as they are often associated with significant morbidity and mortality. Sarcomas are biologically very heterogeneous as evidenced by the fact that these cancers arise from a plethora of different tissues and cell types. They are classically defined by their tissue of origin and are additionally stratified by their histopathology or patient’s age at diagnosis [1,2]. While these classifications have proven useful, modern biological and clinical techniques have the ability to further stratify sarcomas based on their genetic profile [1,3,4]. Cytogenetic and karyotype analyses have revealed two divergent genetic profiles in sarcomas. The first and most simple genetic profile is the observation of translocation events in sarcomas with an otherwise normal diploid karyotype. On the other hand, most sarcomas display a more complex genetic phenotype, suggesting genomic instability plays an important role in many sarcomas.Much of our current knowledge regarding sarcoma biology has been ascertained through experimentation using high dose irradiation, viral infections, in vitro cell line studies, and xenografts models. One of the earliest animal studies investigated the impact of the Rous sarcoma virus on the development of soft tissue sarcomas [5]. Our knowledge regarding radiation-induced sarcomagenesis largely stems from the observation of women occupationally exposed to radium and animal models subjected to high dose radiation developed sarcomas [6,7]. While the plight of these patients and the subsequent animal experiments led to the identification of a cause and effect for some sarcomas, these observations were unable to identify the molecular events responsible for sarcomagenesis.To more accurately investigate the genetic and molecular changes manifested in sarcomas, scientists began using patient derived sa
The Cosmological Constant
Carroll Sean M.
Living Reviews in Relativity , 2001,
Abstract: This is a review of the physics and cosmology of the cosmological constant. Focusing on recent developments, I present a pedagogical overview of cosmology in the presence of a cosmological constant, observational constraints on its magnitude, and the physics of a small (and potentially nonzero) vacuum energy.
Integral Time and the Varieties of Post-Mortem Survival
Sean M. Kelly
Integral Review , 2008,
Abstract: While the question of survival of bodily death is usually approached byfocusing on the mind/body relation (and often with the idea of the soul as a special kindof substance), this paper explores the issue in the context of our understanding of time.The argument of the paper is woven around the central intuition of time as an “everlivingpresent.” The development of this intuition allows for a more integral or “complexholistic”theory of time, the soul, and the question of survival. Following the introductorymatter, the first section proposes a re-interpretation of Nietzsche’s doctrine of eternalrecurrence in terms of moments and lives as “eternally occurring.” The next section is atreatment of Julian Barbour’s neo-Machian model of instants of time as configurations inthe n-dimensional phase-space he calls “Platonia.” While rejecting his claim to have doneaway with time, I do find his model suggestive of the idea of moments and lives aseternally occurring. The following section begins with Fechner’s visionary ideas of thenature of the soul and its survival of bodily death, with particular attention to the notionof holonic inclusion and the central analogy of the transition from perception to memory.I turn next to Whitehead’s equally holonic notions of prehension and the concrescence ofactual occasions. From his epochal theory of time and certain ambiguities in hisreflections on the “divine antinomies,” we are brought to the threshold of a potentiallymore integral or “complex-holistic” theory of time and survival, which is treated in thelast section. This section draws from my earlier work on Hegel, Jung, and Edgar Morin,as well as from key insights of Jean Gebser, for an interpretation of Sri Aurobindo’sinspired but cryptic description of the “Supramental Time Vision.” This interpretationleads to an alternative understanding of reincarnation—and to the possibility of itsreconciliation with the once-only view of life and its corresponding version ofimmortality—along with the idea of a holonic scale of selves leading from individualpersonality as we normally experience it, through a kind of angelic self (a reinterpreted“Jivatma”), and ultimately to the Godhead as the Absolute Self. Of greater moment thansuch a speculative ontology, however, is the integral or complex-holistic way of thinkingand imagining that is called for by this kind of inquiry.
Challenges to the European Administrative Elite in the New Millennium = Yeni Milenyumda Avrupa'n n dari Elitinin Kar la t Zorluklar
Sean M. COX
Dogus University Journal , 2001,
Abstract: At the dawn of the new millenium, the European continent faces some of its greatest challenges in decades, from the economic to the social and political. The task of addressing and meeting these challenges falls mostly on the shoulders of Europe's administrative elite - those who have the educational, technical and legal capabilities to solve the problematic issues facing Europe today. This study examines the role of administrative elites in European government and society, and the identification of several challenges that can be addressed by these same elites.
The Politics of Russia’s Financial - Industrial Group = Rusya'n n Finansal Sanayi Grubunun Siyaseti
Sean M. COX
Dogus University Journal , 2000,
Abstract: With the collapse of the Soviet Union, the subsequent privatization of state industries and the Soviet banking system led to the creation of numerous financial-industrial groups (FIGs). Initially limited in the scope of their operations, FIGs have expanded their holdings and political influence dramatically over the past five years. A small number of FIGs have created vast empires centered around investment banks and various industries, and control a significant portion of the Russian economy. Led by the so-called "oligarchs," these organizations have exercised considerable political influence, especially following the re-election of Boris Yeltsin in 1996.
Radio observations of colliding winds in massive stars
Sean M. Dougherty
Physics , 2009,
Abstract: This brief review describes radio observations of colliding winds in massive stars starting with the first direct observational support for the colliding-wind model advanced in the early 1990's to explain non-thermal radio and thermal X-ray emission in some massive stars. Studies of the well-studied and highly-eccentric WR+O star system WR140 are described along with recent observations of O-star systems. Also discussed is the binary nature of almost all massive stars that exhibit non-thermal behavior and some strategies for finding new systems.
Is Our Universe Natural?
Sean M. Carroll
Physics , 2005, DOI: 10.1038/nature04804
Abstract: It goes without saying that we are stuck with the universe we have. Nevertheless, we would like to go beyond simply describing our observed universe, and try to understand why it is that way rather than some other way. Physicists and cosmologists have been exploring increasingly ambitious ideas that attempt to explain why certain features of our universe aren't as surprising as they might first appear.
What if Time Really Exists?
Sean M. Carroll
Physics , 2008,
Abstract: Despite the obvious utility of the concept, it has often been argued that time does not exist. I take the opposite perspective: let's imagine that time does exist, and the universe is described by a quantum state obeying ordinary time-dependent quantum mechanics. Reconciling this simple picture with the known facts about our universe turns out to be a non-trivial task, but by taking it seriously we can infer deep facts about the fundamental nature of reality. The arrow of time finds a plausible explanation in a "Heraclitean universe," described by a quantum state eternally evolving in an infinite-dimensional Hilbert space.
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