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IN-VITRO RELEASE CHARACTERIZATION OF KETOROLAC TROMETHAMINE LOADED MATRIX TABLETS
Sayed Koushik Ahamed, Sujan Banik and Mohammad Salim Hossain*
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: ABSTRACT: The present investigation highlighted the formulation and release characterization of Ketorolac Tromethamine loaded matrix tablet. Various formulations of tablets were prepared by direct compression method along with Kollidon SR and Hydroxy Propyl Methyl Cellulose (HPMC) as release retardant polymers. Each of the formulated tablets contains 50mg Ketorolac Tromethamine. The evaluation involved physical properties studies (weight variation, thickness, length, width, hardness, friability, and drug content) of tablets and in vitro release kinetics assessment. The USP paddle method was operated at 50 rpm selected to perform the dissolution test and 900 ml phosphate buffer of pH 7.4 was used as dissolution medium. The drug release from each formulation was analyzed by using release kinetics theories. All formulations followed Higuchi release kinetics. When the release data was plotted into Korsemeyer-Peppas equation, then it was confirmed that F-1 to F-5 exhibited fickian type drug release whereas F-6 exhibited non-Fickian type drug release. The in-vitro release studies revealed that the formulation F-4 can be taken as an ideal or optimized formulation of sustained release tablets. Furthermore, the dissolution of the formulation-4 was performed in SLS (1%, 1.5%, and 2%) medium, which was observed gradually decreasing release rate as concentration of SLS medium increased.
A COMPARATIVE QUALITY CONTROL STUDY ON CONVENTIONAL IBUPROFEN TABLETS AVAILABLE IN BANGLADESHI PHARMA MARKET
Syed Masudur Rahman Dewan,Ashraful Alam,Sayed Koushik Ahamed
International Research Journal of Pharmacy , 2013,
Abstract: The quality of a pharmaceutical product is essential to ensure the safety of the patients. Different parameters of quality control of pharmaceutical products can guarantee the quality and bioavailability and optimal therapeutic activity. Therefore, the present study was undertaken with the aim of assuring the quality and the therapeutic activity of ibuprofen tablets available in the Bangladeshi drug market. Different quality control parameters, i.e., the variation of weight, friability, content uniformity, disintegration time and dissolution profiles were assessed in vitro. To demonstrate the differences between the products, the difference (f1) and similarity (f2) data were analyzed. The results showed that all products fulfill the given specification selected by Pharmacopeia (USP-NF).
A STUDY ON CYTOTOXIC AND ANTHELMINTIC ACTIVITIES OF CRUDE EXTRACTS OF LEAVES OF CLERODENDRUM VISCOSUM
Islam Md. Shamsul,Moghal Md. Mizanur Rahman,Ahamed Sayed Koushik,Ahmed Jamiuddin
International Research Journal of Pharmacy , 2013,
Abstract: This study describes the biological investigations of Clerodendrum viscosum – a plant belonging to the family Verbenaceae. The leaf of Clerodendrum viscosum was extracted with methanol and water. The crude extract of methanol of Clerodendrum viscosum was screened for cytotoxic activity using brine shrimp lethality bioassay. A reputed cytotoxic agent vincristine sulphate was used as a positive control. From the result of the brine shrimp lethality bioassay it can be well predicted that methanol extract possess cytotoxic principles (with LC50 3.696 μg/ml) comparison with positive control vincristine sulphate (with LC50 0.773 μg /ml). Both methanolic and aqueous extracts from the leaves of Clerodendrum viscosum were investigated for their anthelmintic activity against Pheretima posthuma and five concentrations (10, 20, 30, 40 and 50 mg/ml) of each extracts were studied in activity, which involved the determination of time of paralysis and time of death of the worm. Both the extracts exhibited significant anthelmintic activity at highest concentration of 50 mg/ml. Albendazole in 20mg/ml concentration extract was used as standard reference and saline solution as control. All the extracts showed significant anthelmintic activity in dose dependent manner.
DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF RAMIPRIL AND EVALUATION OF POLYMER EFFECT ON IN-VITRO RELEASE PATTERN
M. Ahmed, S. Koushik Ahamed, Syed Masudur Rahman Dewan, Md. Mizanur Rahman Moghal*
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: ABSTRACT: The objective of the current study was to design an oral sustained release matrix tablet of Ramipril and to evaluate the effect of polymer on release pattern of the drug. Tablets were prepared by direct compression method using Methocel (Hydroxy Propyl Methyl Cellulose) K100MCR and Methocel (Hydroxy Propyl Methyl Cellulose) K4MCR, as matrix forming polymer. Dissolution studies were carried out in 500 ml phosphate buffer (pH 6.5) for 8 hours. The release mechanism was explored with zero order, first order, Higuchi equation and Korsmeyer's equation. The drug release followed Higuchi equation. It was found that the release of drug from matrix tablet decrease with the increasing of percentage of polymer. The two high viscosity polymers (Methocel K4MCR and Methocel K100MCR) were found suitable for the study.
Fixed Interest Player v/s Floating Interest Player: Tug of War  [PDF]
Naseem Ahamed
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.54055
Abstract: Swaps have been one of the most widely used derivatives since 1970s and for good reasons. Interest rate swap is a mutual agreement between two parties to pay each other the differential amount of up and above the fixed v/s LIBOR. This paper tries to answer the long standing question of what should have been the range around which the fixed rate should have hovered with respect to fluctuating LIBOR over the years to attain break-even and not to be worse off. This paper analyses for the difference in the average LIBOR of various periods (1 month, 3 months, 6 months and 12 months) with respect to different maturity dates (5 years, 10 years, 15 years, 20 years and 23 years). It looks for the presence of structural change in the trend of LIBOR beginning from 1990 to 2013. This paper will draw the attraction of academic as well as market participants. Fixed rate player refers to the party which agrees to pay the existing floating rate (LIBOR) in the market in exchange of an agreed upon fixed rate from the counter party and vice-versa.
Case Report on Acute Psychosis Due to Anti-NMDAR Encephalitis  [PDF]
Shabana Ahamed, Harin Karunajeewa
Open Journal of Internal Medicine (OJIM) , 2014, DOI: 10.4236/ojim.2014.41005
Abstract: A 32-year-old female with depression on treatment, was presented with acute psychosis, behavioural symptoms, autonomic instability and a prodromal illness. This occurred on a background of a strong family history of schizophrenia. Despite escalating doses of anti-psychotics, she failed to improve. Her CSF showed a lymphocytic pleocytosis and confirmed the presence of anti-NMDAR antibodies. Following treatment with immunotherapy and excision of her underlying ovarian tumour, she showed a dramatic and seemingly full recovery of her psychotic symptoms. She was weaned off all medications with no residual symptoms. Clinician awareness is important to treat this uncommon but potentially reversible condition.
A Comparative Study on the Milling Speed for the Synthesis of Nano-Structured Al 6063 Alloy Powder by Mechanical Alloying  [PDF]
Hafeez Ahamed, V. Senthil Kumar
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.106038
Abstract: The present article reports on characterization studies performed on amorphized nanostructured Al 6063 alloy powder synthesized by mechanical alloying (MA). The as-milled powder was characterized by X-ray diffraction (XRD) for investigating the development of crystallite nature and determining the different phases of the materials present, scanning electron microscope (SEM) was used for in depth morphological study and High Resolution-transmission electron microscope (HR-TEM) was employed to ensure the development of a nano-structured nature of the Al 6063 matrix. In the present work alloyed powder was milled for 20 h and 40 h at 300 rpm; and 20 h at 700 rpm in a hardened stainless steel medium. Using Williamson-Hall equation; crystallite size, lattice strain and lattice parameter of Al 6063 nanostructure alloy powder was estimated with broadening of XRD peaks. XRD results showed that the crystallite size of Al 6063 alloy powder reached 32 and 53 nm after 20 h at 700 rpm and 40 h at 300 rpm respectively.
Ground Penetrating Radar (GPR) Investigations for Architectural Heritage Preservation: The Case of Habib Sakakini Palace, Cairo, Egypt  [PDF]
Sayed Hemeda
Open Journal of Geology (OJG) , 2012, DOI: 10.4236/ojg.2012.23019
Abstract: A comprehensive Ground Penetration Radar (GPR) investigations and hazard assessment for the rehabilitation and strengthening of Habib Sakakini’s Palace in Cairo is presented herein, which is considered one of the most significant architectural heritage sites in Egypt. The palace located on an ancient water pond at the eastern side of Egyptian gulf besiding Sultan Bebris Al-Bondoqdary mosque is a place also called “Prince Qraja al-Turkumany pond”. That pond had been filled down by Habib Sakakini at 1892 to construct his famous palace in 1897. The integrated geophysical survey of the palace allowed the identification of several targets of potential archaeological and geotechnical engineering interest buried in fill and silty clay in the depth range between 100 - 700 cm. the methodological development focused on Multi-Fold (MF) Ground Penetrating Radar (GPR) imaging and subsurface characterization based on integrated velocity and attenuation analysis. Eight hundred sqm of Ground penetration Radar (GPR) profiling have been conducted to monitor the subsurface conditions. 600 meters are made in the surrounding area of the Palace and 200 sqm at the basement. The aim is to monitor the soil conditions beneath and around the Palace and to identify potential geological discontinuities, or the presence of faults and cavities. A suitable single and dual antenna are used (500 - 100 MHZ) is used to penetrate the desired depth of 7 meters (ASTM D6432). The GPR is used also detect the water table. At the building basement the GPR is used to identify the foundation thickness and soil-basement interface. As well as the inspection of cracks in some supporting columns, piers and masonry walls. The GPR also was used to investigate the floors and ceilings conditions and structural mapping. The results were validated by the geotechnical and structural surveys. All these results together with the seismic hazard analysis will be used for the complete analysis of the palace in the framework of the rehabilitation and strengthening works foreseen in a second stage.
Geotechnical Characterization of Sakakini’s Palace Stones and Other Construction Materials, Cairo-Egypt  [PDF]
Sayed Hemeda
Geomaterials (GM) , 2013, DOI: 10.4236/gm.2013.31005
Abstract:

The understanding of the geotechnical problems and failure mechanisms of stone structures of Sakakini palace (1897 after century) entails a comprehensive study on the mechanical behaviour of the stones and other construction materials. In addition to micro analysis, geological and geomorphologic interests, several investigations on stone deterioration and engineering geology were performed, First phase included more sophisticated techniques, which provided additional information on particular aspects of site deterioration and it included laser induced breakdown spectroscopy (LIBs), electron probe micro analysis, micro XRD and XRF analyses, scanning electron microscope analysis coupled with EDX probing, transmission electron microscopy and grain size distribution analysis, permeability and pore size distribution of stone, mortars, core binders and other construction materials. Second phase included the determination of mechanical properties of building stones, such as compressive strength, modulus of elasticity, tensile strength, and shear strength. To arrive at reliable values for these properties, a suitable number of samples should be extracted, prepared for testing, and properly tested. The test results are then analyzed to establish the investigated stone properties. The testing program includes extracting seven cylindrical cores from the basement stone walls of Sakakini’s mansion in down townCairo. The cores are extracted using rotary cylindrical diamond blade coring machine. The top and bottom surfaces of every core were prepared to be flat circular surfaces perpendicular to the vertical axis of the core. Because the palace is museum and attractive places for the tourists, core sampling could be carried out only at a limited number of locations under official permission. For the purpose, cylindrical specimens with a diameter of 42 - 44 mm and height of 90 - 100 mm, prepared by the use of a core drilling machine and some collected blocks from the archaeological site under investtigation were taken to determine the bulk structure, physical, short and long-term mechanical properties of the stone and other construction materials in the laboratory. A number of specimens prepared from these blocks were employed for testing. Furthermore, limitation

Palm Vein Authentication Based on the Coset Decomposition Method  [PDF]
Mohamed Sayed
Journal of Information Security (JIS) , 2015, DOI: 10.4236/jis.2015.63020
Abstract: The palm vein authentication technology is extremely safe, accurate and reliable as it uses the vascular patterns contained within the body to confirm personal identification. The pattern of veins in the palm is complex and unique to each individual. Its non-contact function gives it a healthful advantage over other biometric technologies. This paper presents an algebraic method for personal authentication and identification using internal contactless palm vein images. We use MATLAB image processing toolbox to enhance the palm vein images and employ coset decomposition concept to store and identify the encoded palm vein feature vectors. Experimental evidence shows the validation and influence of the proposed approach.
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