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Protective Effect of Dendrosomal Curcumin Combination on Colon Cancer in Rat
Sarbolouki MN,Alizadeh AM,Khaniki M,Azizian S
Tehran University Medical Journal , 2012,
Abstract: Background: Cancer is a multistep process that develops very rapidly after its onset. Previous studies have confirmed antitumor effects of curcumin (1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; diferuloylmethane) that can potentially prevent colon cancer development with low side-effects. Different methods have been performed to increase the efficiency and effectiveness of curcumin among which dendrosome, a nanoparticle created by Sarbolouki et al. was used in this study. The present study was undertaken to evaluate the effects of dendrosomal curcumin on rat colon cancer. Methods: In this study which was performed in Cancer Research Center of Tehran University of Medical Sciences in 2010 year, forty rats were equally divided into control, curcumin and curcumin-dendrosome groups. Animals received azoxymethane (15 mg/kg s.c.), a carcinogen, once a week for two weeks. Curcumin (0.2%) and curcumin-dendrosome were administered to the respective animals 2 weeks before the first and 14 weeks after the last azoxymethane injections. Eventually, colorectal specimens from tumoral and adjacent non-tumoral mucosal tissues were fixed in 10% formaldehyde, and passaged and embedded in paraffin. Histopathological and immunohistochemical studies were performed on the specimens. Results: The mean number of lesions, nuclear/cytoplasmic ratio, epithelial stratification, loss of nuclear polarity, goblet depletion, structural abnormality and beta-catenin expression were higher in the control group compared to curcumin and curcumin-dendrosome groups. These parameters had significantly decreased in the dendrosomal curcumin group (P<0.05). Conclusion: The present study shows that dendrosome can be used as a suitable nanoparticle to increase curcumin efficiency in the prevention or treatment of colon cancer.
Analyzing of DNA behavior in passing through micro-structures based on the Fokker-Planck equation and the entropic barrier model
N Maleki-Jirsaraei,A Fatemi,MN Sarbolouki,SH Rouhani
Iranian Journal of Physics Research , 2009,
Abstract: We considered the motion of DNA molecules through a hexagonal array under uniform electric fields as a Fokker-Planck process which is affected by the entropic barriers and we have simulated this motion by computer. We solved the Fokker-Planck equation with numerical simulation of the Brownian dynamics by the Euler method. For different DNA molecules, under different physical conditions, the mean value of velocity, variance, and < x2 > have been calculated, and the results have been compared with the Phase Diagram of our previous results. In the light of this comparison we could find the physics of the DNA behavior in different regimes. It is observed that in regime-1 (small DNA molecules under weak Electric force) we have a pure diffusion process, in regime-3 (large DNA molecules under high Electric field) the entropic barrier model is the dominated physics, and in regime-2 (medium DNA molecules under medium and relative high Electric fields), which is a more complicated regime we have a drifted diffusion phenomenon.
Effects of processing on soybean nutrients and potential impact on consumer health: An overview
MN Lokuruka
African Journal of Food, Agriculture, Nutrition and Development , 2011,
Abstract: Production of soybeans and consumption of soy products is increasing worldwide mainly due to acclaimed health benefits. Processing can alter soybean sensory appeal, nutritive value and potentially affect consumer health. This review of the literature examines these issues. Despite potential changes in nutritive value during processing, soy foods processing below 100oC for short periods, may not adversely affectnutritive value. However, heat inactivation of trypsin inhibitors, denaturation of soybean globulins and haemagglutenins, increases soy protein bioavailability. Excessive heating can impair nutritive value by making lysine unavailable, as serine, cystine and cysteine are converted to a dehydroprotein intermediate that reacts with lysine to form lysinoalanine. Tryptophan and methionine are also lost duringexcessive heating. The acylation reaction catalyzed by alkali, generates lysinoalanine, an unavailable and potentially toxic compound. In rats, ingestion of lysinoalanine results in diarrhoea, pancreatic hyperplasia, and loss of hair. At levels present in foods, protein-bound lysinoalanine does not cause nephrotoxicity in humans. Heat treatments at alkaline pH result in destruction of arginine, which is converted to ornithine, urea, citrulline and ammonia, while cysteine is converted into dehydroalanine. Serine, threonine and lysine are also reduced at alkaline pH. Theseconditions may be present during alkali refining of soy oil. Carbohydrates with free reducing groups react with carbonyl groups on proteins as part of the Maillard reaction. Heat treatments at alkaline pH and above 200oC cause isomerization of amino acids, leading to formation of racemic mixtures of L and D forms. Since Disomers have reduced bioavailability and some including D-proline are reported to be toxic, racemization of an essential amino acid reduces its nutritional value. Changes in lipids include oxidation, loss of lipid-soluble vitamins and change of fatty acids from cis to trans isomers. Autoxidation of unsaturated fatty acids initiates free radicalformation leading to destruction of unsaturated fatty acids, with potential reduction of essential fatty acid content. Oxidized lipid-protein interaction products are important precursors of atherosclerotic plaques in vivo. Carotenoids are lost on bleaching, thereby reducing Vitamin A potential. Vitamin E is lost during oil refining. Roasting and toasting have no effect on soy isoflavones, but organic solvents remove them, while fermentation increases their bioavailability. Dehulling reduces total mineral content but most soy minerals follow protein or meal, while sodium and potassium are lost in wash water. To minimize adverse changes, minimal washing, fermentation, reduction of hydrogenation temperature and thermal processing below 100oC for short periods, are recommended.
Cancer Care in sub-Saharan Africa – Urgent Need for Population–based Cancer Registries
MN Okobia
Ethiopian Journal of Health Development , 2003,
Abstract: Background: The incidence of malignant diseases is increasing globally, particularly in the developing countries as shown by recent cancer statistics from the World Health Organization Reports. It is anticipated that with increase in life expectancy consequent upon improved standard of living and increasing industrialization, the burden of cancer in sub-Saharan Africa is likely to increase in the new millennium. Objective: This article is designed to review the existing literature on cancer statistics in sub-Saharan Africa and assess the need for population-based cancer registries to enhance cancer care and prevention within the region. Design: Relevant literature on cancer statistics in sub-Saharan Africa and the developed Western countries were obtained from the Internet and local libraries. Information obtained from this search formed the basis of this review. Results: There are few cancer registries in sub-Saharan Africa and most of them are hospital-based. Data from these registries indicate some consistency in the pattern of malignant diseases in most countries within the region with slight local variation. Carcinoma of the prostate, liver, Non-Hodgkin's lymphoma and colon and rectal tumors are the top four malignant diseases in the Ibadan cancer registry while Kaposi's sarcoma, liver and oesophageal cancers are the most common in some registries in East Africa. Conclusion: Cancer statistics from the developing countries are inadequate due to lack of functional population-based cancer registries. It is recommended that functional population-based cancer registries be established in various countries within the region to facilitate the formulation of appropriate policies for improved cancer care and prevention. [Ethiop.J.Health Dev. 2003;17(2):89-98]
Military labour mobilisation in colonial Lesotho during World War II: 1940-1943
MN Ntobeni
Scientia Militaria: South African Journal of Military Studies , 2008,
Abstract: In 1940, Great Britain's wartime exploitation of the human and material resources of its colonial empire was extended to colonial Lesotho (then known as Basutoland). The aim of this article, therefore, is to trace the four-year military labour mobilisation process in that colony, with special attention to the timing, number and procedures of the recruitment campaigns that were launched, the reasons for Basotho men's willingness or resistance to enlist, and the overall implications for Lesotho of large-scale absenteeism of able-bodied men as migrant and military labour. Scientia Militaria: South African Journal of Military Studies Vol. 36 (2) 2008: pp. 36-59
Parental access to minors' health records in the South African health care context: concerns and recommendations
MN Slabbert
Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad , 2004,
Abstract: Privacy and confidentiality have long been recognized as essential elements of the doctor-patient relationship. Patients should feel free to disclose the most intimate and private medical facts about themselves to their physicians in order to facilitate optimal patient care. Medical records, whether and-written or electronic, also play an important role in other contexts, such as medical research, health care management and financial audit. In South Africa there is little consistency in approaches to patient confidentiality. There are also no national standards or policies on patient confidentiality, apart from specific ethical rules, some ad hoc statutory provisions and general constitutional provisions not directly related to the intricacies of the doctor-patient relationship. A closer look at the relevant statutory provisions reveal the existence of conflicting standards, most notably in respect of parental access to a minors' health records. The purpose of this paper is to examine the discrepancies and contradictory provisions relating to the access to and disclosure of health information, in particular parental access to health records of minors. In the final instance, some recommendations will be suggested.
Essential drugs in primary health centres of north central Nigeria; where is Bamako initiative?
MN Sambo
Nigerian Journal of Clinical Practice , 2008,
Abstract: To assess the availability of essential drugs and the perceptions of clients on drugs situation in the primary health centres of Tafa Local Government Area, north central Nigeria. Checklist consisting ofminimum drugs expected in a generic primary health centre developed by the National Primary Health Care Development Agency (NPHCDA) was adopted and used to assess drugs availability, while FocusGroupDiscussionswere conducted to determine the perceptions of clients on drugs situation in the health centres. Results showthat, all the 3 primary health centres in Tafa LGAdo not implement Bamako initiative (BI) and none was operating Drug Revolving Fund (DRF) system. Out of the minimum recommended score of 54 points for the availability and adequacy of drugs and consumables, NewWuse primary health centre in the LGA headquarters scored highest points of 19,while New Bwari and Iku primary health centres scored 13 points each.All these are far below the minimum requirement. Similarly, the results of the FGDs confirmed poor vailability of drugs and clients dissatisfactionswith the drugs situation in the primary health centres. This study has revealed that despite Bamako Initiatives put in place in late 80s essentials drugs are stillmirages inmany of the primary health care facilities in the study area. It is therefore recommended that, any effort aimed at reforming or repositioning primary health care must take into account resuscitating Bamako Initiative by ensuring functional DRF systemin all the primary care facilities.
Legal issues relating to the use of surrogate mothers in the practice of assisted conception
MN Slabbert
South African Journal of Bioethics and Law , 2012,
Abstract: The statutory regulation of surrogate motherhood in the Children’s Act 38 of 2005 is fraught with practical, legal and ethical problems. Healthcare professionals specialising in assisted conception are often confronted with practical scenarios for which the Children’s Act does not provide clear answers. The purpose of this article is to briefly examine some of these questions against the background of the relevant legislation and recent case law.
A model for the integration of primary healthcare services in the province of KwaZulu-Natal, South Africa
MN Sibiya
International Journal of Integrated Care , 2010,
Abstract:
Parental access to minors' health records in the South African health care context: concerns and recommendations
MN Slabbert
Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad , 2004,
Abstract: Privacy and confidentiality have long been recognized as essential elements of the doctor-patient relationship. Patients should feel free to disclose the most intimate and private medical facts about themselves to their physicians in order to facilitate optimal patient care. Medical records, whether hand-written or electronic, also play an important role in other contexts, such as medical research, health care management and financial audit. In South Africa there is little consistency in approaches to patient confidentiality. There are also no national standards or policies on patient confidentiality, apart from specific ethical rules, some ad hoc statutory provisions and general constitutional provisions not directly related to the intricacies of the doctor-patient relationship. A closer look at the relevant statutory provisions reveal the existence of conflicting standards, most notably in respect of parental access to a minors' health records. The purpose of this paper is to examine the discrepancies and contradictory provisions relating to the access to and disclosure of health information, in particular parental access to health records of minors. In the final instance, some recommendations will be suggested.
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