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Search Results: 1 - 10 of 6215 matches for " Sarah Pagni "
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The Epidemiology and Clinical Manifestations of Dysexecutive Syndrome in Parkinson’s Disease
Cristina Pagni
Frontiers in Neurology , 2012, DOI: 10.3389/fneur.2012.00159
Abstract: This mini-review summarizes the evidence of the cognitive and behavioral features of dysexecutive syndrome in Parkinson’s disease (PD). Deficits in response inhibition, set-shifting, mental flexibility, and strategy have been frequently described from the earliest stages of PD, although there are inconsistencies in study findings due to the complexity of the executive function (EF) construct and methodological limitations. Behavioral disorders of PD, e.g., apathy, distractibility, perseverative behavior, and impulse-control disorders, may be viewed as the other side of dysexecutive syndrome. Despite the interrelationship between the cognitive and behavioral domains, some reports reveal that the two syndromes may be dissociated, suggesting that both aspects must be clinically assessed. EFs are widely associated with the prefrontal areas, although dysexecutive syndrome may be observed in patients with damage to other brain regions. EFs drive numerous abilities essential to daily life, such as prospective remembering and language comprehension, which may be impaired in PD subjects. Considering the impact of dysexecutive syndrome on independence and quality of life, early detection of executive impairment is crucial in the management of PD.
JACOP: A simple and robust method for the automated classification of protein sequences with modular architecture
Peter Sperisen, Marco Pagni
BMC Bioinformatics , 2005, DOI: 10.1186/1471-2105-6-216
Abstract: Here we present a novel approach, which is based on random sampling of sub-sequences (probes) out of a set of input sequences. The probes are compared to the input sequences, after a normalisation step; the results are used to partition the input sequences into homogeneous groups of proteins. In addition, this method provides information on diagnostic parts of the proteins. The performance of this method is challenged by two data sets. The first one contains the sequences of prokaryotic lyases that could be arranged as a multiple sequence alignment. The second one contains all proteins from Swiss-Prot Release 36 with at least one Src homology 2 (SH2) domain – a classical example for proteins with modular architecture.The outcome of our method is robust, highly reproducible as shown using bootstrap and resampling validation procedures. The results are essentially coherent with the biology. This method depends solely on well-established publicly available software and algorithms.Whole-genome sequencing projects are currently producing an enormous amount of new sequences. As a consequence, protein sequence databases are rapidly increasing in size, thus resulting in severe practical consequences. For example, a simple database search can now yield hundreds of matches. An automated but sensible grouping of those proteins appears as an indispensable solution to analyse such an output in a timely manner.Proteins are often described as the assembly of several structural/functional units called domains. Isolation of the domain sub-sequences renders a multiple alignment possible, from which domain descriptors are built based on efficient methods for remote homology detection (PSSM [1], generalised profiles [2], hidden Markov models (HMM) [3]). This led to the thriving development of protein-domain databases such as PROSITE [4], Pfam [5], Blocks [6], PRINTS [7], IDENTIFY [8], ProDom [9], Domo [10], SMART [11] and ADDA [12]. Classification of domain sub-sequences is relatively
Da polêmica sobre a pós-modernidade aos 'desafios' lyotardianos à Filosofia da Educa??o
Pagni, Pedro Angelo;
Educa??o e Pesquisa , 2006, DOI: 10.1590/S1517-97022006000300010
Abstract: the relations between postmodernity and education have been the object of countless researches, and also of some controversy within the philosophy of education, starting with the very conception of postmodernity and extending to the philosophical positions it engenders. in almost every research and controversy, jean-fran?ois lyotard's the postmodern condition figures as an important reference, although his subsequent works are seldom mentioned, thereby leaving part of his philosophical legacy outside such discussions and, in particular, of his resulting contributions to education. in view of the current state of these studies, the present article seeks to develop an interpretation of the lyotardian thought more strongly focused on the analysis of the works he published after his controversial book, with the purpose of placing his philosophical project beyond a landmark of postmodernity, and of discussing his contributions to the current philosophy of education. such interpretation rescues a philosophical project that places before today's philosophy of education "challenges" concerning the move of its epistemological problems to the sphere of aesthetics, nurtured by a thinking capable of illuminating the complex and obscure face of education, its inhuman shadow, and the constitutive contention of teaching, inapprehensible by language and communication. we thus hope that such project can be understood not for the controversy it brings to the philosophy of education, but for the current challenges put to the latter as a rewriting of modernity.
Entre a escola e a vida: desafios da ética de si para a experiência formativa
Pedro Angelo Pagni
Poiésis , 2011,
Abstract: This essay aims to analyze the relationship between life and school. In opposition totheoretical perspectives longed for a possible reconciliation between life and school, we look for toshow to existing tension between these two spheres, making an analysis of the themes of theexperience with birth, death and the difference, and highlight that this reflection invites the subjectsof the educational practice to an ethical attitude of care for the other, for oneself and so that theother one takes care of the care of the self. Having the thoughts of Arendt’s and Foucault’s asreference, we understand that life goes beyond school knowledge and practices, offering us what wethink about educational practice and making the subjects of that practice learn how to placethemselves between life and school, looking for new senses for themselves and resistance to theexistent while they transform themselves. Thus, we wait to offer the educators some life problemsthat pervade the educational practice, reverberate in their experience and make them think aboutwhat they have left.
Os elos entre a filosofia e a educa o no pensamento de Theodor W. Adorno The links between philosophy and education in Theodor W. Adorno's thoughts
Pedro Angelo Pagni
Pro-Posi??es , 2012, DOI: 10.1590/s0103-73072012000300009
Abstract: Este artigo aborda as rela es entre a filosofia e a educa o no pensamento de Theodor Adorno. A partir da reflex o elaborada pelo frankfurtiano acerca da rela o entre teoria e práxis, procuramos compreender o papel político conferido às suas concep es de filosofia e de forma o humana e discutir os seus limites e possibilidades no presente. Para tanto, elegemos como objeto de análise as conferências pronunciadas pelo autor e os artigos que escreveu sobre o assunto, entre 1959 e 1969, com o objetivo de recuperar os possíveis nexos teóricos entre filosofia e educa o em sua obra e o significado que seu pensamento crítico e sua concep o de educa o política assumiram nesse contexto; e de discutir sua eventual atualidade. Pretendemos, assim, reconstituir a reflex o de Adorno sobre o tema, compreendendo o seu significado em seu projeto filosófico, de modo a vislumbrar a face filosófica educacional de seu pensamento crítico. This article discusses the relationship between philosophy and education in Theodor Adorno's ideas. From the reflection about the relation between theory and praxis in his thoughts, we seek to understand the political role within his conceptions of philosophy and human formation and discuss limits and possibilities in the present. To this end, we selected for our object of analysis the conferences given by the author and articles he wrote on the subject, between 1959 and 1969, so as to recover the possible nexus between philosophy and theoretical education in his work, the meaning that his critical thinking and his conception of political education has taken in this context and to discuss how relevant this is nowadays. We therefore intend to reconstitute Adorno's reflection on the topicand understand its meaning in his philosophical project in order to see the educational philosophical aspect in his critical thinking.
La cuestión social en la Argentina, 1890-1910. Una visión desde la saga de Josecito el memorioso
Fernando Cesaretti,Florencia Pagni
Mundo agrario , 2003,
Fernando De Azevevedo Educador Do Corpo: 1916-1933
Pedro Angelo Pagni
Nuances : Estudos sobre Educa??o , 2009,
Abstract: Fernando De Azevevedo Educador Do Corpo: 1916-1933
Cytogenetic study of women with premature ovarian failure
Pagni, Denise;Melaragno, Maria Isabel;
Genetics and Molecular Biology , 1998, DOI: 10.1590/S1415-47571998000200016
Abstract: etiology of premature ovarian failure (pof) is unclear in most patients. since some cases are related to x-chromosome abnormalities, cytogenetical studies were conducted in patients with pof. lymphocyte cultures from eleven patients were compared to cultures from age-matched controls. all individuals presented normal karyotypes. frequencies of aneuploid and structural chromosome aberrations did not differ between the groups. the x chromosome was more frequently involved in aneuploidy and in premature centromere division in both groups.
Cytogenetic study of women with premature ovarian failure
Pagni Denise,Melaragno Maria Isabel
Genetics and Molecular Biology , 1998,
Abstract: Etiology of premature ovarian failure (POF) is unclear in most patients. Since some cases are related to X-chromosome abnormalities, cytogenetical studies were conducted in patients with POF. Lymphocyte cultures from eleven patients were compared to cultures from age-matched controls. All individuals presented normal karyotypes. Frequencies of aneuploid and structural chromosome aberrations did not differ between the groups. The X chromosome was more frequently involved in aneuploidy and in premature centromere division in both groups.
HitKeeper, a generic software package for hit list management
J?rg Hau, Michael Muller, Marco Pagni
Source Code for Biology and Medicine , 2007, DOI: 10.1186/1751-0473-2-2
Abstract: We present HitKeeper, a software package that controls the fully automatic handling of multiple biological databases and of hit list calculations on a large scale. The software implements an asynchronous update system that introduces updates and computes hits as soon as new data become available. A query interface enables the user to search sequences by specifying constraints, such as retrieving sequences that contain specific motifs, or a defined arrangement of motifs ("metamotifs"), or filtering based on the taxonomic classification of a sequence.The software provides a generic and modular framework to handle the redundancy and incremental updates of biological databases, and an original query language. It is published under the terms and conditions of version 2 of the GNU Public License and available at http://hitkeeper.sourceforge.net webcite.The automated annotation of protein or DNA sequences is performed using a rather heterogeneous collection of motif predictors, which include regular expressions, generalized profiles, hidden Markov models and neural networks. Since the search for hits by a motif on a sequence is expensive in terms of processing time, the lists of hits obtained by comparing collections of motifs with collections of sequences are usually stored and distributed as dedicated databases. InterPro [1] is a canonical example of such a public resource that, by definition, covers only publicly available sequences and motifs.However, biological research is often carried out using sequences and motifs that are derived from public, as well as private, sources. There is a clear need to incorporate both sources of data into the same workflow; however, since the software used to generate, manage and keep the public data up-to-date is usually not available, it is difficult to reproduce and maintain similar hit lists locally.Further issues that complicate matters are the update frequency of public databases, which can lead to an almost continuous data flow,
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