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Search Results: 1 - 10 of 6218 matches for " Sarah Atherton "
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Acanthodasys caribbeanensis sp. n., a new species of Thaumastodermatidae (Gastrotricha, Macrodasyida) from Belize and Panama
Rick Hochberg,Sarah Atherton
ZooKeys , 2010, DOI: 10.3897/zookeys.61.552
Abstract: We describe one new species of Acanthodasys (Gastrotricha, Macrodasyida, Thaumastodermatidae) collected from sublittoral sites around Carrie Bow Cay, Belize and Isla Colón in the Bocas del Toro archipelago, Panama. Though eight species of Acanthodasys are currently recognized, no species has yet been reported from the Caribbean. Acanthodasys caribbeanensis sp. n. is characterized by the lack of lateral adhesive tubes, the presence of ventrolateral adhesive tubes, and with cuticular armature in the form of both spineless and spined scales. The spineless scales are not elliptical as in other species of Acanthodasys, but are instead variable in shape and closely resemble the spineless scales of species of Diplodasys. Spined scales bear uniancres up to 50 μm long and are the largest reported in the genus. Uniancres are arranged dorsally around the mouth rim and distributed in five distinguishable columns. Adult size varies from 325–625 μm long.
Acanthodasys paurocactus sp. n., a new species of Thaumastodermatidae (Gastrotricha, Macrodasyida) with multiple scale types from Capron Shoal, Florida
Sarah Atherton,Rick Hochberg
ZooKeys , 2012, DOI: 10.3897/zookeys.190.2975
Abstract: A new species of Acanthodasys (Gastrotricha, Macrodasyida, Thaumastodermatidae) is described from sublittoral sediments off the Atlantic coast of Florida. Acanthodasys paurocactus sp. n. is a relatively small species (to 450 mm long) with a strap-shaped outline, a series of anterior, lateral, and ventrolateral adhesive tubes, paired caudal pedicles with posterior adhesive tubes, and a morphologically diverse cuticle. The cuticle contains both spined and unspined scales. Unspined scales are present in two general shapes: lanceolate and eye shaped, with some transitional shapes. All scales have a thickened rim and depressed central region; some scales of both shapes bear either one or more central bumps, a parallel ridge, or a perpendicular ridge that gives the appearance of a cross-shaped pattern under transmitted light. Spined scales are somewhat quadrangular in shape and bear uniancres to 15 mm long with a cross-shaped sectional profile. The new species is now one of five described species to possess both spined and spineless scales, and only one of two species to possess two types of spineless scales (the second species is an incompletely described specimen from Norway).
A new species of sublittoral marine gastrotrich, Lepidodasys ligni sp. n. (Macrodasyida, Lepidodasyidae), from the Atlantic coast of Florida
Rick Hochberg,Sarah Atherton,Vladimir Gross
ZooKeys , 2013, DOI: 10.3897/zookeys.289.4764
Abstract: A new species of Lepidodasys is described from sublittoral sandy sediments off the Atlantic coast of Florida. Lepidodasys ligni sp. n. is a small species (≤ 450 μm) with a crossed-helical pattern of small, non-keeled, non-imbricated scales on the dorsal and lateral body surfaces, two columns of ventral, interciliary scales that form a herringbone pattern, and a series of anterior, lateral, dorsal and posterior adhesive tubes. Similar to L. castoroides from the Faroe Islands, the new species possesses a caudal constriction that demarcates the posterior end containing the caudal organ. The frontal organ lies within the posterior constriction, which is heavily invested with somatic circular muscles. These muscles are also present throughout the trunk and represent a novel condition for species of Lepidodasys, which were previously considered to lack somatic circular muscles. Posterior of the caudal constriction is a large, barrel-shaped caudal organ that is wrapped in a series of interdigitating, spindle-shaped, incomplete circular muscle fibers. The caudal organ contains a sclerotized central canal, but the absence of distal cuticular endpieces distinguishes the new species from its morphologically similar congener, L. castoroides.
Climate Change Impacts on the Extreme Rainfall for Selected Sites in North Western England  [PDF]
Mawada Abdellatif, William Atherton, Rafid Alkhaddar
Open Journal of Modern Hydrology (OJMH) , 2012, DOI: 10.4236/ojmh.2012.23007
Abstract: Impact and adaptation assessments of climate change often require more detailed information of future extreme rainfall events at higher resolution in space and/or time, which is usually, projected using the Global Climate Model (GCM) for different emissions of greenhouse concentration. In this paper, future rainfall in the North West region of England has been generated from the outputs of the HadCM3 Global Climate Model through downscaling , employing a hybrid Generalised Linear Model (GLM) together with an Artificial Neural Network (ANN). Using two emission scenarios (A1FI and B1), the hybrid downscaling model was proven to have the capability to successfully simulate future rainfall. A combined peaks-over-threshold (POT)-Generalised Pareto Distribution approach was then used to model the extreme rainfall and then assess changes to seasonal trends over the region at a daily scale until the end of the 21st century. In general, extreme rainfall is predicted to be more frequent in winter seasons for both high (A1FI) and low (B1) scenarios, however for summer seasons, the region is predicted to experience some increase in extreme rainfall under the high scenario and a drop under the low scenario. The variation in intensity of extreme rainfall was found to be based on location,season, future period, return period as well as the emission scenario used.
A Systematic Approach to Implementing Monogenic Genomic Medicine: Genotype-Driven Diagnosis of Genetic Diseases
Sarah Elizabeth Soden, Carol Jean Saunders, Darrell Lee Dinwiddie, Neil Andrew Miller, Andrea Michelle Atherton, Noor Abu Alnadi, J. Steve Leeder, Laurie Denise Smith, and Stephen Francis Kingsmore
Journal of Genomes and Exomes , 2012, DOI: 10.4137/JGE.S10091
Abstract: Genomic medicine is an emerging paradigm for disease diagnosis and management that incorporates individual genome sequence information based on and identified by next-generation sequencing. Here we report on the initial experience in implementing genomic medicine for inherited diseases in a large children’s hospital. In two families, next-generation sequencing identified molecular diagnoses that had not been disclosed by years of traditional diagnostic tests. Two sisters with progressive ataxia were found to have a mutation in aprataxin gene (APTX c.717G > A, p.Trp239X) and were treated with oral Coenzyme Q10. Two brothers with intellectual disability, dysmorphic features, doughy skin, and truncal obesity were found to have autosomal recessive cutis laxa caused by mutations in pyrroline-5-carboxylate reductase, type 1 (PYCR1 c.120_121delCA). Pediatric genomic medicine appears to enable early diagnosis of inherited diseases that feature clinical or genetic heterogeneity and it may allow for targeted treatment. We discuss several bottlenecks to improving care though genomic medicine, as well as potential solutions.
Wie führt eine Inkontinenz-Operation zur Kontinenz? Vergleich der Kolposuspension mit der TVT-Operation
Atherton MJ,Stanton SL
Speculum - Zeitschrift für Gyn?kologie und Geburtshilfe , 2000,
Abstract: Die urodynamischen und Blasenhalsparameter von 36 Frauen, die sich einer prim ren TVT-Operation oder Kolposuspension unterzogen haben, wurden verglichen, um einen überblick über die Kontinenzmechanismen dieser beiden Verfahren zu gewinnen. Dazu geh rte auch die Beurteilung, ob sich das TVT-Band (tension-free vaginal tape) im Laufe der Zeit strafft. Alle Frauen wurden pr operativ sowie ein und 6 Monate nach dem chirurgischen Eingriff einer klinischen Untersuchung, einer transperinealen Sonographie des Blasenhalses und einem Urethradruckprofil unterzogen. Eine Subtraktionszystometrie wurde pr operativ und 6 Monate postoperativ durchgeführt. Die Kolposuspension führt eine gr ere Blasenhalsanhebung herbei als die TVT-Operation. Der Erfolg beider Verfahren l t jedoch im Laufe der Zeit nach. Aufgrund dessen ist im Laufe der Zeit auch eine Straffung des spannungsfreien Vaginalbandes unwahrscheinlich. Die TVT-Operation tr gt zur Verbesserung der Drucktransmission in der Urethramitte bei, w hrend die Kolposuspension die Drucktransmission des Blasenhalses/der proximalen Urethra und in der Urethramitte verbessert. Der Kontinenzbereich für die TVT-Operation liegt wahrscheinlich in der Urethramitte und für die Kolposuspension im Blasenhals/in der proximalen Urethra, obwohl auch Ver nderungen in der Urethramitte eine Rolle spielen k nnen. Die Auswirkung einer TVT-Operation auf die Entleerungsparameter ist mit einer Kolposuspension vergleichbar.
Chronic Heart Failure: We Are Fighting the Battle, but Are We Winning the War?
John J. Atherton
Scientifica , 2012, DOI: 10.6064/2012/279731
Chronic Heart Failure: We Are Fighting the Battle, but Are We Winning the War?
John J. Atherton
Scientifica , 2012, DOI: 10.6064/2012/279731
Abstract: Heart failure represents an end-stage phenotype of a number of cardiovascular diseases and is generally associated with a poor prognosis. A number of organized battles fought over the last two to three decades have resulted in considerable advances in treatment including the use of drugs that interfere with neurohormonal activation and device-based therapies such as implantable cardioverter defibrillators and cardiac resynchronization therapy. Despite this, the prevalence of heart failure continues to rise related to both the aging population and better survival in patients with cardiovascular disease. Registries have identified treatment gaps and variation in the application of evidenced-based practice, including the use of echocardiography and prescribing of disease-modifying drugs. Quality initiatives often coupled with multidisciplinary, heart failure disease management promote self-care and minimize variation in the application of evidenced-based practice leading to better long-term clinical outcomes. However, to address the rising prevalence of heart failure and win the war, we must also turn our attention to disease prevention. A combined approach is required that includes public health measures applied at a population level and screening strategies to identify individuals at high risk of developing heart failure in the future. 1. Introduction Heart failure is a clinical syndrome that represents the end-stage phenotype of a number of different cardiovascular diseases. However, regardless of the underlying cause, the prognosis is generally poor once a patient develops symptoms or signs of heart failure. There has been considerable progress in management including the use of drugs that interfere with neurohormonal activation, device therapy in selected patients, and multidisciplinary disease management. This at least partly explains the reductions in heart failure mortality seen in population-based studies over the last two decades; however, the overall epidemiological impact has been modest. This paper will provide an overview of the epidemiology of heart failure and outline our continued efforts to fight the battle focusing on management strategies that have been shown to modify disease progression. I will then consider whether or not we are winning the war and suggest that efforts to minimize variation in care should continue coupled with increasing emphasis on heart failure prevention. 2. Epidemiology of Heart Failure Heart failure is one of the few cardiovascular diseases whose prevalence continues to rise, largely related to the aging
Stationary and non-stationary fluid flow of a Bose-Einstein condensate through a penetrable barrier
P. Engels,C. Atherton
Physics , 2007, DOI: 10.1103/PhysRevLett.99.160405
Abstract: We experimentally study the fluid flow induced by a broad, penetrable barrier moving through an elongated dilute gaseous Bose-Einstein condensate. The barrier is created by a laser beam swept through the condensate, and the resulting dipole potential can be either attractive or repulsive. We examine both cases and find regimes of stable and unstable fluid flow: At slow speeds of the barrier, the fluid flow is stationary due to the superfluidity of the condensate. At intermediate speeds, we observe a non-stationary regime in which the condensate gets filled with dark solitons. At faster speeds, soliton formation completely ceases and a remarkable absence of excitation in the condensate is seen again.
Year 7 Pupils' Views of the Future
Ken Roberts,Graeme Atherton,Richard Remedios
Child Development Research , 2011, DOI: 10.1155/2011/502314
Abstract: This paper reports findings from a study among 610 Year 7 (typically age 12) pupils at 27 nonselective secondary schools in three English regions: Cornwall and Devon, London, and Greater Manchester. Data was gathered in workshops, each with 15–25 pupils, who completed questionnaires and performed individual tasks, all related to their vocational and educational aims, their ideas on what counted as success, and the main influences on their forward thinking, then discussed their answers and results. The discussions were tape recorded. Most pupils expressed robust occupational aims, and most said that they wanted to go to university. Family class did not predict levels of educational or occupational aims, but was related to the importance attached to “the job that I want to do” in the pupils' forward thinking. SAT scores did predict levels of occupational aspiration, ideas on what counted as success, and by whom and what the pupils were most influenced. These findings are interpreted to challenge the view, on which a raft of current policies are based, that social class disparities in educational and labour market outcomes are due to the intergenerational transmission of low aspirations in lower-class families and neighbourhoods. The paper concludes with an alternative model of status transmission processes in which attainments during secondary education are posited as the key intervening variable. 1. Introduction Most research into young people’s future hopes, aims, and intentions has concentrated on those approaching or at the end of compulsory education. This was true in the 1950s and remains the case today (as, e.g., in [1–5]). Currently, this research is being conducted and read in a UK policy context where governments are: (i) seeking to increase participation in higher education; (ii) know that many young people who appear (from GCSE results) eminently capable at age 16 fail to reach A-levels then university (see [6]), and (iii) the “wastage” is known to be related to young people’s social class origins [7–9]. One view, on which a number of current policy initiatives are based, is that the wastage is due to a “poverty of aspiration” which is transmitted to young people through their families and neighbourhoods [10, 11]. This implies that a propensity to quit education prematurely is laid early in life. Hence, attention is currently being paid to the future aims and hopes not only of the 14–18-year-old but also younger pupils, including those making the transition from primary into secondary education. Many sociologists have long questioned the
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