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Search Results: 1 - 10 of 7226 matches for " Sara Salinas "
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An Update on Canine Adenovirus Type 2 and Its Vectors
Thierry Bru,Sara Salinas,Eric J. Kremer
Viruses , 2010, DOI: 10.3390/v2092134
Abstract: Adenovirus vectors have significant potential for long- or short-term gene transfer. Preclinical and clinical studies using human derived adenoviruses (HAd) have demonstrated the feasibility of flexible hybrid vector designs, robust expression and induction of protective immunity. However, clinical use of HAd vectors can, under some conditions, be limited by pre-existing vector immunity. Pre-existing humoral and cellular anti-capsid immunity limits the efficacy and duration of transgene expression and is poorly circumvented by injections of larger doses and immuno-suppressing drugs. This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation of early region 1 (E1)-deleted to helper-dependent (HD) CAV-2 vectors. We also summarize the essential characteristics concerning their interaction with the anti-HAd memory immune responses in humans, the preferential transduction of neurons, and its high level of retrograde axonal transport in the central and peripheral nervous system. CAV-2 vectors are particularly interesting tools to study the pathophysiology and potential treatment of neurodegenerative diseases, as anti-tumoral and anti-viral vaccines, tracer of synaptic junctions, oncolytic virus and as a platform to generate chimeric vectors.
The molecular mechanism of axonal transport of tetanus toxin in vivo and in vitro
Bilsland Lynsey,Salinas Sara,Schiavo Giampietro
BMC Proceedings , 2008,
Estudio palinológico del género Macroptilium (Benth) Urb. (Leguminosae) en México y Centroamérica
Torres-Colín, Leticia;Fuentes-Soriano, Sara;Delgado-Salinas, Alfonso;
Acta botánica mexicana , 2010,
Abstract: the pollen morphology of eight macroptilium species occurring in mexico and central america is described by means of light and scanning microscopy. in this region, members of the genus have pollen grains 3-colporate, medium-sized, with polar shapes from prolate-spheroidal, suboblate to oblate-spheroidal. differences in ectoaperture (length, apex shape and membrane), ornamentation, margo, and the outline in polar side identify two pollen types: type i. pollen with small colpi (brevicolpate), margo thickened, apex of the ectoaperture round, membrane granular, polar outline convex angular, exine tectate or semitectate, apocolpium punctate or rugulate, and mesocolpium microreticulate or rugulate. species of section microcochle, including m. gibbosifolium, m. pedatum, and m. supinum are characterized by this pollen type. type ii. pollen with long colpi (longicolpate) margo non-thickened, apex of the ectoaperture acute, membrane granular, pollen outline circular to semi-angular, exine tectate or semitectate, apocolpium punctate to foveolate, and mesocolpium microreticulate to foveolate. species of section macroptilium comprising, m. atropurpureum, m. erythroloma, m. gracile, m. lathyroides, and m. longipedunculatum are distinguished by this pollen type. palynological descriptions of five species of macroptilium are provided for the first time.
Incontinencia urinaria de esfuerzo asociada a obstrucción del tracto urinario inferior en el cistocele
Salinas,Jesús; Prieto,Sara; Adot,José María; Virseda,Miguel; Silmi,ángel;
Archivos Espa?oles de Urología (Ed. impresa) , 2007, DOI: 10.4321/S0004-06142007000500008
Abstract: objectives: the association of stress urinary incontinence secondary to urethral hypermobility and lower urinary tract obstruction in the same patient with cystocele is rare, and even represents a contradiction. the objective of our work is to treat to define the characteristics that identify this entity, in comparison with isolated stress urinary incontinence or lower urinary tract obstruction in patients with cystocele. methods: we performed a retrospective study in 1168 cases of cystocele in which urodynamic studies were performed. all patients underwent history and neurological and uro-gynecologycal physical examination. the urodynamic study included uroflowmetry, cystomanometry, voiding pressure/flow tests and voiding cystourethrograms. all data were collected in an excel 2000 database and statistical analysis was performed with the spss software. results: a- general data: 25 cases qualified for the study in group i (isolated stress urinary incontinence with urethral hypermobility); 24 cases in group ii (lower urinary tract obstruction); and 14 cases in group iii (astress urinary incontinence associated with lower urinary tract obstruction). the proportion of each group in the whole group of cystoceles corresponded to a 4/1/0.05 ratio respectively. mean age was 58.4 years for group i, 68.2 for group ii and 71.2 for group iii. a statistically significant lower age was demonstrated for group i (p <0.0005). b-the symptom "sensation of vaginal lump" was less frequent in group i (32%). a significant difference was demonstrated (p = 0.02). c- group i showed a lower increase of daily voiding frequency (32%), p = 0.02. d- group i showed less night-time voiding frequency (1 episode)(p <0.04).e-urinary incontinence with cough was less frequent in group i (84%) (p = 0.0004). f- group i had more bladder capacity (243.6 ml) (p <0.05).g-group i showed less urethral resistances (ura = 37.9 cm h2o) (p = 0.01). h- w80-w20 was higher in group i: 1.3 w/m2 (p <0.05). i-the symptom
Afectación de la contractilidad del detrusor en la hiperreflexia vesical
Salinas,Jesús; Pelaquin,Humberto; Prieto,Sara; Dambros,Miriam; Viudez,Isabel; Virseda,Miguel; Silmi,ángel;
Archivos Espa?oles de Urología (Ed. impresa) , 2008, DOI: 10.4321/S0004-06142008000500006
Abstract: objectives: classically, it was understood detrusor contractility was affected in bladder areflexia but not in hyperreflexia. we aim to demonstrate that there is some detrusor contractility affectation in bladder hyperreflexias, although it may seem paradoxical at first sight. methods: neuro-urologic study was performed in a series of 68 consecutive patients with bladder hyperreflexia (neurogenic detrusor hyperactivity), referred to the unit of functional urology for urodynamic evaluation. all patients underwent clinical history, post void residual determination, cystomanometry, voiding pressure-flow test, videourodynamics and selective emg of the periurethral sphincter. detrusor contractile potency was measured with w 80-20. terminology follows the ics standard. data processing was performed using the statistical software spss 12.0. results: this series includes 14 males (58.8%) and 28 females (41.2%), of all ages (adults more frequent). 88.2% of the cases had acquired neurological diseases (trauma 30.9%; medical 33.8%; degenerative 35.3%), and 11.8% congenital neurological diseases (myelodysplasia). most frequent type of neurological lesion was detrusor-sphincter dyssynergia: 59 cases (79.4%); 22 patients (32.4%) had undergone previous treatment of their vesicourethral dysfunction. the amplitude of detrusor involuntary contractions was wider in detrusor-bladder neck dyssynergia. detrusor isotonic contractility (w 80-20) was significantly affected, mainly in neurological lesions of traumatic nature and less in degenerative lesions (p = 0.01). conclusions: we demonstrated that bladder contractility is affected in bladder hyperreflexias (neurogenic detrusor hyperactivity), more important in traumatic lesions without relationship with the type of neurological associated lesion, which could be related to a bladder structural change, or with a change in the central neurological tracts (without requirement of presence of dyssynergia).
Leticia Torres-Colín,Sara Fuentes-Soriano,Alfonso Delgado-Salinas
Acta botánica mexicana , 2010,
Abstract: Se describe la morfología del polen de ocho especies del género Macroptilium con distribución en México y Centroamérica, a partir de granos acetolizados y observados bajo microscopio de luz y microscopio electrónico de barrido. En esta región geográfica los miembros del género tienen granos de polen tricolporados, prolado-esferoidales, suboblados a rara vez oblado-esferoidales, de tama o generalmente mediano. De acuerdo con las diferencias en las ectoaberturas (longitud, forma del ápice y membrana), ornamentación de la exina, engrosamiento del margo y contorno en vista polar se distinguen dos tipos polínicos: Tipo I. Polen con colpos cortos (brevicolpos), margo engrosado, ápice de la ectoabertura redondeado, membrana granular, contorno angular convexo, exina tectada o semitectada, punctada a rugulada en el apocolpio y microrreticulada a rugulada en el mesocolpio; característico de la sección Microcochle, representada por M. gibbosifolium, M. pedatum y M. supinum. Tipo II. Polen con colpos largos (longicolpos), margo no engrosado, ápice de la ectoabertura agudo, membrana granular, contorno circular a semiangular, exina tectada a semitectada, psilada, punctada, foveolada a microrreticulada en el apocolpio y microrreticulada a foveolada en el mesocolpio; este tipo distingue a las especies de la sección Macroptilium, incluyendo a M. atropurpureum, M. erythroloma, M. gracile, M. lathyroides y M. longipedunculatum. Por primera vez se proveen descripciones palinológicas para cinco especies del género.
CAR-Associated Vesicular Transport of an Adenovirus in Motor Neuron Axons
Sara Salinas,Lynsey G. Bilsland,Daniel Henaff,Anne E. Weston,Anne Keriel,Giampietro Schiavo ,Eric J. Kremer
PLOS Pathogens , 2009, DOI: 10.1371/journal.ppat.1000442
Abstract: Axonal transport is responsible for the movement of signals and cargo between nerve termini and cell bodies. Pathogens also exploit this pathway to enter and exit the central nervous system. In this study, we characterised the binding, endocytosis and axonal transport of an adenovirus (CAV-2) that preferentially infects neurons. Using biochemical, cell biology, genetic, ultrastructural and live-cell imaging approaches, we show that interaction with the neuronal membrane correlates with coxsackievirus and adenovirus receptor (CAR) surface expression, followed by endocytosis involving clathrin. In axons, long-range CAV-2 motility was bidirectional with a bias for retrograde transport in nonacidic Rab7-positive organelles. Unexpectedly, we found that CAR was associated with CAV-2 vesicles that also transported cargo as functionally distinct as tetanus toxin, neurotrophins, and their receptors. These results suggest that a single axonal transport carrier is capable of transporting functionally distinct cargoes that target different membrane compartments in the soma. We propose that CAV-2 transport is dictated by an innate trafficking of CAR, suggesting an unsuspected function for this adhesion protein during neuronal homeostasis.
Avances en el Manejo Nutricional de Oso Andino (Tremarctos ornatus)
Alexandra Salinas-Salinas
Memorias de la Conferencia Interna en Medicina y Aprovechamiento de Fauna Silvestre, Exótica y no Convencional , 2009,
Abstract: El oso andino o de anteojos (Tremarctos ornatus, Cuvier, 1825) único representante de la familia Ursidae en Sudamérica, es el mamífero más grande de los ecosistemas que habita, ya que puede llegar a medir hasta 2m de altura y pesar 175Kg...
Homotopy Perturbation Method for Solving Moving Boundary and Isoperimetric Problems  [PDF]
Sara Ghaderi
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.35062
Abstract: In this paper, homotopy perturbation method is applied to solve moving boundary and isoperimetric problems. This method does not depend upon a small parameter in the equation. homotopy is constructed with an imbedding parameter p, which is considered as a “small parameter”. Finally, we use combined homotopy perturbation method and Green’s function method for solving second order problems. Some examples are given to illustrate the effectiveness of methods. The results show that these methods provides a powerful mathematical tools for solving problems.
Creativity at the Crossroad Creative Education as Moral Education?  [PDF]
Sara Nosari
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B015

The man’s action, thanks to its creative capacities, gave a new order to the reality: the “created reality” does not present simply a different order, but is an authentic transformation. Which criteria had directed this transformation? Which will be the criteria of future transformation? The paper presents two possible ideas about creativity and argues in favor of a creative action educated and directed by an ethical criteria.

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