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匹配条件: “Sara Moosavi” ,找到相关结果约5816条。
Formulation and evaluation of buccoadhesive tablets of clotrimazole
Reza Tahvilian,Sara Moosavi
Asian Journal of Pharmaceutics , 2010,
Abstract: The buccoadhesive tablet is one of delivery systems that can be used for different drugs in order to improve the efficacy of drugs in patients. Hydrophilic polymers are using to prepare these types of tablets with appropriate adhesion and stability in order to deliver the drug for a period of time and also in a specific place in month. The purpose of the study was to formulate and evaluate mucoadhesive buccal tablets of clotrimazole. The tablets were evaluated for weight variation, hardness, friability, disintegration, content uniformity, surface pH, mucoadhesive strength, swelling index and in vitro drug release.Increasing hydroxypropylmethylcellulose (HPMC) concentration resulted in decreasing the swelling index and increasing surface pH. The surface pH of all tablets was found to be satisfactory, close to neutral pH; hence, no irritation would observe with these tablets. The maximum bioadhesive strength was observed in tablets formulated with high content of HPMC. Lower release rates were observed by increasing the content of HPMC in the formulation The in vitro release results demonstrated that drug is released by non-Fickian diffusion mechanism with zero-order kinetics.
Journal of Research in Medical Sciences , 2000,
Abstract: Introduction. Endodontic implants are used to ratain teeth with periodontal bone resorption and/or short roots. The implants are placed from inside of root canal passing the apex into the periapical bone. Teeth with horizontal root fracture. Clinically mobile teeth, teeth with periodontal bone resorption, teeth with reduced root / crown ratio. Anatomic considerations around the root apex. Methods: After case selection, twenty five endodontic implants were placed in selected teeth. The cromcobalt and/or titanium implants were placed using Frank";s method. Results. After three years of radiographic evaluation, 3 of the cases failed and the rest of the samples were completely normal. The success rate was 88 percent. Discussion. Endodontic implants allow us to treat teeth with mobility due to root fracture, bone resorption, of reduced crown / root ratio. The success rate in this investigation was 88 percent which was comparable to 91 percent success rate in the similar research. Regarding the success rate of investigations of endo implants, this method is a acceptable preventive treatment to retain mobile teeth.
Computing With Contextual Numbers
Vahid Moosavi
Computer Science , 2014,
Abstract: Self Organizing Map (SOM) has been applied into several classical modeling tasks including clustering, classification, function approximation and visualization of high dimensional spaces. The final products of a trained SOM are a set of ordered (low dimensional) indices and their associated high dimensional weight vectors. While in the above-mentioned applications, the final high dimensional weight vectors play the primary role in the computational steps, from a certain perspective, one can interpret SOM as a nonparametric encoder, in which the final low dimensional indices of the trained SOM are pointer to the high dimensional space. We showed how using a one-dimensional SOM, which is not common in usual applications of SOM, one can develop a nonparametric mapping from a high dimensional space to a continuous one-dimensional numerical field. These numerical values, called contextual numbers, are ordered in a way that in a given context, similar numbers refer to similar high dimensional states. Further, as these numbers can be treated similarly to usual continuous numbers, they can be replaced with their corresponding high dimensional states within any data driven modeling problem. As a potential application, we showed how using contextual numbers could be used for the problem of high dimensional spatiotemporal dynamics.
Effect of Surface Roughness and Materials Composition  [PDF]
Maryam Gharechahi, Horieh Moosavi, Maryam Forghani
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.324056
Abstract: In the mouth, biofilm formation occurs on all soft and hard surfaces. Microbial colonization on such surfaces is always preceded by the formation of a pellicle. The physicochemical surface properties of a pellicle are largely dependent on the physical and chemical nature of the underlying surface. Thus, the surface structure and composition of the underlying surface will influence on the initial bacterial adhesion. The aim of this review is to evaluate the influence of the surface roughness and the restorative material composition on the adhesion process of oral bacteria. Both in vitro and in vivo studies underline the importance of both variables in dental plaque formation. Rough surfaces will promote plaque formation and maturation. Candida species are found on acrylic dentures, but dentures coating and soaking of dentures in disinfectant solutions may be an effective method to prevent biofilm formation. Biofilms on gold and amalgam are thick, but with low viability. Glass-ionomer cement collects a thin biofilm with a low viability. Biofilms on composites cause surface deterioration, which enhances biofilm formation. Biofilms on ceramics are thin and highly viable.
H Kalantari,M Moosavi
Jundishapur Journal of Natural Pharmaceutical Products , 2010,
Abstract: T-2 toxin is a member of the fungal metabolites known as trichothecene mycotoxin. The major attribute of T-2 toxin is that it inhibit protein synthesis which is followed by a secondary disruption of DNA and RNA synthesis. T-2 toxin affects the actively dividing cells such as those lining the gastrointestinal tract, skin, lymphoid and erythroid cells. It can decrease antibody levels, immunoglobolines and certain other humoral factors. In addition, in this review article acute and chronic effects on health, toxicokinetics, regulatory matters related to its use as a potential warfare and treatment strategies that may be undertaken will be briefly covered.
The effect of Hadron mass on the energy distribution function of Hadron
SM Moosavi Nejad,AN Khorramian
Iranian Journal of Physics Research , 2011,
Abstract: In the Hadronic interactions, the point which is less considered is the mass effect of interacting Hadrons on the energy distribution function of outgoing Hadrons. In this article we present a method to incorporate these mass effects which leads us to improve one of the basic formulas in QCD. In the end, we will show how these mass effects improve our previous results.
The effect of rebonding and liner type on microleakage of Class V amalgam restorations
Moosavi H.,Sadeghi S.
Journal of Dental Medicine , 2008,
Abstract: Background and Aim: Application of varnish and dentin bonding agents can effectively reduce microleakage under amalgam restorations. Also rebonding may show some effects on microleakage and its complications. The aim of this study was to evaluate the effect of liner/ adhesives on microleakage of Class V amalgam restoration with or without rebonding. Materials and Methods: In this in vitro study Class V cavities were prepared on sixty sound human maxillary premolars with the gingival floor 1mm below the CEJ. Cases were divided into six groups of ten teeth each. Specimens in group 1 and 2 were lined with Copalite and Scotchbond Multi-Purpose (SBMP) respectively. In the third group (control) no liner was applied. The teeth were then restored with spherical amalgam. Specimens in group 4 to 6 received the same treatments but after filling, the interfaces of restorations and teeth were etched with 37% phosphoric acid gel, rinsed and dried. Adhesive resin of SBMP was applied over amalgam and tooth margins and polymerized (rebonding). Specimens were thermocycled, exposed to dye and sectioned. Microleakage was graded (0-3) using a stereomicroscope at X40 magnification. Data were analyzed with Kruskal-Wallis, Mann-Whitney and Wilcoxon pair wise statistical tests. P<0.05 was considered as the limit of significance. Results: The groups lined with SBMP showed the lowest and the groups without liner the highest microleakage (p= 0.001). Significant difference was observed in microleakage mean rank of enamel and dentin margins (p=0.048). Rebonding with resin did not improve the seal (p> 0.05). Conclusion: Based on the results of this study, total etch adhesive system had significant effect on microleakage of Class V amalgam restorations especially in cervical margin. Rebonding did not show a significant effect on microleakage.
"Effect of multiple factors on success rate of high dose radioiodine therapy (>150μCi/gr) in 164 patients with hyperthyroidism "
"Zakavi SR,Moosavi Z "
Iranian Journal of Nuclear Medicine , 2000,
Abstract: Background: Radiodine therapy (RIT) for hyperthyroidism is increasingly used as a therapy of choice in most of the patients. Effect of multiple factors on the result of therapy was noted. This study tries to analyze the effect of multiple factors on success rate of RIT. Methods and patients: One hundred and sixty four hyperthyroid patients referred for RIT therapy from 1996-99, were studied. Thyroid examination and 24 hrs RAIU were performed in all patients and 150-255 μCi/gr of 131I was administered. Follow up of the patients, including thyroid examination and thyroid values measurements were done at 2-6 months after treatment. The patients were divided in two groups: those who responded to radioiodine (group 1) and those who did not (group 2). Results: Two to six months after RIT, seventy one percent of the patients were in group 1 and 29% in group 2. No difference was noted in the mean age [45.7 yrs vs 47.2 yrs] (P=0.42), total Iodine dose [15.4 mCi vs 17.2] (P=0.2), Iodine dose per gram of thyroid weight [189.3 μCi/gr vs 192.6 μCi/gr] (P=0.06) and female/male ratio [65/21 vs 30/5] (P=0.32) between two groups. The mean thyroid weight was 59.1 gr in group 1 and 55.2 gr in group 2. Using logistic regression, the only significant effective factor in success of therapy was thyroid weight (R=0.172, P=0.03). With inceasing thyroid weight, success rate of Iodine therapy was decreased. Conclusion: With high dose (>150 μCi/gr) RIT, only thyroid weight negatively affects the result of the therapy and the other factors have no significant role.
"The optimal time of discountinuing Methimazole before radioiodine therapy "
"Moosavi Z,Zakavi SR "
Iranian Journal of Nuclear Medicine , 2001,
Abstract: Hyperthyroidism is a common disease and one of the best methods for its treatment is radioiodine therapy. Treatment with antithyroid drugs brings patients to euthyroidism before radioiodine therapy. Antithyroid drugs should be discontinued before radioiodine therapy to increase thyroid uptake. The purpose of this study was to determine the optimal time of methimazole (MTZ) discontinuation. One hundred eighty four patients, who were referred for radioiodine therapy were classified in 3 groups according to the duration of MTZ discontinuation before thyroid uptake (RAIU) measurement. Group 1, 2 and 3 were patients who discontinued MTZ (48-72 hrs), (72-120 hrs) and more than 120 hrs before RAIU measurement, respectively. Mean thyroid uptake in group 1, 2 and 3 was (64±15.1%), (60.1±14.1%) and (59.3±12.8), respectively. No significant difference was noted in thyroid uptake between these groups (F=1.83, P<0.16). This study shows that 48-72 hrs of MTZ discontinuation before radioiodine therapy is enough and longer term abstention is not associated with higher uptake.
Effect of Adenosine 5-Triphosphate on Cell Cycle of Human Acute Myeloid Leukemia KG1 Cells during S Phase
M.A Moosavi
Qom University of Medical Sciences Journal , 2012,
Abstract: Background and Objectives: Adenosine 5 -triphosphate (ATP) not only is the current energy source of all cells but also plays critical role in triggering signaling pathways leading to apoptosis or differentiation. In recent years many investigations have reported anti-cancer activity of ATP on different cell lines. Also several mechanisms have been proposed for its mechanism of action and it appears that the mechanism depends on the cell type. In the present study the effects of ATP on human leukemia KG1 cell line as an experimental model of AML and mechanistic approach was studied. Methods: KG1 cells were cultured and treated with different concentrations of the ATP (50-1000μM) for various time intervals (24-72 hours). The Effect of ATP on cell proliferation was studied by MTT assay. Apoptosis was studied by flowcytometery, fluorescent microscopy and DNA fragmentation assay. Cell cycle was analyzed using flowcytometery. The effects of ATPγS (un-degradable agonist of ATP) and degradable products of ATP such as AMP, ADP and adenosine were studied to evaluate its mechanism of action. Data were analyzed by student-t-test (p<0.05). Results: ATP inhibited growth and induced S-phase cell cycle arrest at 24 h to 72 h in concentration between 100-1000μm (p<0.05) along with apoptosis. In addition, results showed that these effects of ATP on KG1 cell line were made through P2X7 receptors. Conclusion: Because current AML therapy methods based on chemotherapy are not so effective and have side effects, according to the results of present study ATP can be used as an effective compound alone or in combination of other drugs to treat of AML.

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