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Search Results: 1 - 10 of 5669 matches for " Sara Khodahemmati "
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Expressions of the Cell Cycle Relative Proteins in Esophageal Cancer Tissues  [PDF]
Sara Khodahemmati, Jintao Li, Hongwei Liu, Maliha Ghaffar, Yangjunqi Wang, Zhixiang Zhou, Yi Zeng
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.911071
Abstract: The aim of the research is to investigate the expression of the cell cycle relative proteins (P53, P16, Cyclin D1, and Ki67) in Esophageal Cancer (EC) patients of the Chaoshan area, China. In China, Chaoshan has the high incidence of EC. Different areas have shown different rate for expression of these proteins in EC. We investigated the expression of p53, p16, cyclinD1, and ki67 for the first time in Chaoshan. In this research, DNA was extracted from formalin fixed and paraffin embedded tissues of esophageal cancer (EC) patients. The expression level of proteins cycle was detected by using immunohistochemistry (IHC). And the data was checked by χ2 test or Fisher’s exact test of SPSS17.0. The positive immunohistochemical staining of p53, p16, cyclinD1, and ki67 were observed in 65.7% 39.2%, 69.1%, and 83.5% specimens respectively. There was a positive correlation between p53 positive staining and p16, cyclinD1, ki67 staining at p < 0.05. CyclinD1 has the high correlation with ki67 at p < 0.05. A significant inverse correlation was considered between the expression of p16 and cyclinD1 and there was no correlation observed between p16 and ki67. In Conclusion, this study demonstrated the high expression of p53, Cyclin D1 and Ki67 and low expression of P16 and the association of these cell cycle relative proteins in esophageal cancer are new data in Chaoshan area of China. Geographical distribution of EC on the molecular basis is revealed in this research.
HPV18 E6 and E7 Intratumour Heterogeneity in Esophageal Cancer  [PDF]
Sara Khodahemmati, Maliha Gaffar, Jintao Li, Yangjunqi Wang, Xiaoli Wang, Zhixiang Zhou, Yi Zeng
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.105029

The development of esophageal cancer accompanied by the presence of human papillomavirus (HPV) DNA into the host genome. By evaluating the expression of this virus for tumor cell origin and also their cell grows and migrations, we examined esophageal cancer clonality in the context of intra-tumor heterogeneity. In this research, we have checked the expression of HPV18 E6 and E7 in different single cell clones by the manual cell picking method in the HPV positive esophageal cancer (EC109), EC109 cell line used as a negative control, and Hela cell line used as the positive control. Quantitative real-time PCR (QRT-PCR) was run to detect the expression levels of HPV E6 and E7, Cell Counting Kit-8 (CCK-8) assay was used to examine cell proliferation, invasion assays performed using Costar chambers and wounding assay to study cell migrations in vitro. We investigated the intra-tumor heterogeneity of HPV E6 and E7 in esophageal cancer and the evaluation of the growth and migrations at the clonal level, using 10 single cell clones. In particular clones, C7 & C10 displayed a highly variable expression in both HPV E6 and E7 and weak in four clones (C1, C3, C4, and C9) consequently, the cell invasion, proliferation, and migration increase with increasing the level of HPV expression and inverse. In conclusion, the resulting based on single cell cloning showed the relationship between HPV and cell growth and migration in esophageal cancer. Future study in HPV DNA integration needed to explore the mains specific integration site of HPV DNA in esophageal cancer and molecular monitoring of the HPV for future prevention researches and also effective therapeutic strategies.

Homotopy Perturbation Method for Solving Moving Boundary and Isoperimetric Problems  [PDF]
Sara Ghaderi
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.35062
Abstract: In this paper, homotopy perturbation method is applied to solve moving boundary and isoperimetric problems. This method does not depend upon a small parameter in the equation. homotopy is constructed with an imbedding parameter p, which is considered as a “small parameter”. Finally, we use combined homotopy perturbation method and Green’s function method for solving second order problems. Some examples are given to illustrate the effectiveness of methods. The results show that these methods provides a powerful mathematical tools for solving problems.
Creativity at the Crossroad Creative Education as Moral Education?  [PDF]
Sara Nosari
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B015

The man’s action, thanks to its creative capacities, gave a new order to the reality: the “created reality” does not present simply a different order, but is an authentic transformation. Which criteria had directed this transformation? Which will be the criteria of future transformation? The paper presents two possible ideas about creativity and argues in favor of a creative action educated and directed by an ethical criteria.

Using Figurative Language to Assess the Stage of Acceptance of Learning Disability as a Springboard for Treatment of Students with Learning Disabilities  [PDF]
Sara Givon
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.46054

In order to examine the emotional and cognitive processes experienced by adolescents with learning disabilities (LD), twenty tenth grade Israeli students were studied over three years. Data gathered through in-depth interviews underwent an axial-coding process, and a grounded theory model was constructed. The findings revealed various coping styles adopted by students throughout the process of accepting the disability. Participants were asked to use figurative language to describe their method of coping with the disability. Participants’ choice of phrase, metaphor or image characterized the phase of their acceptance as well as their coping style. This can be served as an effective tool of detection. Identifying the stage of students’ acceptance and their coping style may promote optimal treatment for students with LD.

Response Surface Optimization of a Solvent Free Production of cis-9, trans-11 and trans-10, cis-12 Isomers of Conjugated Linoleic Acid Using High Linoleic Sunflower Oil  [PDF]
Sara Koohikamali
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.86047
Abstract: The most dominant and beneficial conjugated linoleic acids isomers (CLAs) with miscellaneous biological tasks are 9c11t-C18:2 and 10t12c-C18:2. The problem with most of the commercial CLA produced by non-optimized conventional approaches is the heterogeneity of their isomers and undesirable toxic by-products. In this study, optimization of the isomerization of the fatty acid methyl esters of the high linoleic sunflower oil was investigated through response surface methodology (RSM). The reaction temperature, the concentration of PEG400 and NaOCH3 had positive influence on the total conjugated linoleic acid methyl esters (CLAME) production as response. However, the effect of the polyethylene glycol 400 (PEG400) concentration was more significant on response than those of other factors (p < 0.05). The reaction time and the interactions between the factors had no significant effect on response (p ≥ 0.05). The optimum point for the maximum response of 72.90% (i.e., based on the mass percentage of total fatty acid methyl esters mixture) was at 5% w/w NaOCH3, 1.06% w/w PEG400 and temperature of 140°C.
Implementation of an open-source customizable minimization program for allocation of patients to parallel groups in clinical trials  [PDF]
Mahmoud Saghaei, Sara Saghaei
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.411090
Abstract: Current minimization programs do not permit full control over different aspects of minimization algorithm such as distance or probability measures and may not allow for unequal allocation ratios. This article describes the implementation of “MinimPy” an open-source minimization program in Python programming language, which provides full customizetion of minimization features. MinimPy supports naive and biased coin minimization together with various new and classic distance measures. Data syncing is provided to facilitate minimization of multicenter trial over the network. MinimPy can easily be modified to fit special needs of clinical trials and in particular change it to a pure web application, though it currently supports network syncing of data in multi-center trials using network repositories.
Variational Iterative Method Applied to Variational Problems with Moving Boundaries  [PDF]
Fateme Ghomanjani, Sara Ghaderi
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.35061
Abstract: In this paper, He’s variational iterative method has been applied to give exact solution of the Euler Lagrange equation which arises from the variational problems with moving boundaries and isoperimetric problems. In this method, general Lagrange multipliers are introduced to construct correction functional for the variational problems. The initial approximations can be freely chosen with possible unknown constant, which can be determined by imposing the boundary conditions. Illustrative examples have been presented to demonstrate the efficiency and applicability of the variational iterative method.
Facile Synthesis and Characterization of Nanoporous NiO with Folic Acid as Photodegredation Catalyst for Congo Red  [PDF]
Faezeh Farzaneh, Sara Haghshenas
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.310102
Abstract: In this study nanoporous NiO was prepared using Ni(CH3COO)2,4H2O, folic acid and water as starting material, template and solvent respectively, by sol gel method followed by calcination at 400℃. The solid product was characterized by X-ray diffraction (XRD), nitrogen adsorption-desorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM) Fourier transform infrared (FT-IR) and photoluminescence (PL) techniques. The particle size of the nanoparticles estimated by XRD was in good agreement with the particle size obtained by TEM analysis (4-5nm). It was also found that the prepared nanoporous NiO show very good activity for photodegredation of dye organic pollutants such as Congo red (91%) during 1.5 hours.
Drilling Operation and Formation Damage  [PDF]
Hooman Fallah, Sara Sheydai
Open Journal of Fluid Dynamics (OJFD) , 2013, DOI: 10.4236/ojfd.2013.32005

Transport of particle suspensions in oil reservoirs is an essential phenomenon in many oil industry processes. Solid and liquid particles dispersed in the drilling fluid (mud) are trapped by the rock (porous medium) and permeability decline takes place during drilling fluid invasion into reservoir resulting in formation damage. The formation damage due to mud filtration is explained by erosion of external filter cake. Nevertheless, the stabilization is observed in core floods, which demonstrates internal erosion. A new mathematical model for detachment of particles is based on mechanical equilibrium of a particle positioned on the internal cake or matrix surface in the pore space. In the current work the analytical solution obtained to mud filtration with one particle capture mechanism with damage stabilization. The particle torque equilibrium is determined by the dimensionless ratio between the drag and normal forces acting on the particle. The maximum retention function of the dimensionless ratio closes system of governing equations for colloid transport through porous medium.

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