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Search Results: 1 - 10 of 5667 matches for " Sara Chinetti "
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Recombinant Chromosome 4 from a Familial Pericentric Inversion: Prenatal and Adulthood Wolf-Hirschhorn Phenotypes
Francesca Malvestiti,Francesco Benedicenti,Simona De Toffol,Sara Chinetti,Adelheid H?ller,Beatrice Grimi,Gertrud Fichtel,Monica Braghetto,Cristina Agrati,Eleonora Bonaparte,Federico Maggi,Giuseppe Simoni,Francesca Romana Grati
Case Reports in Genetics , 2013, DOI: 10.1155/2013/306098
Abstract: Pericentric inversion of chromosome 4 can give rise to recombinant chromosomes by duplication or deletion of 4p. We report on a familial case of Wolf-Hirschhorn Syndrome characterized by GTG-banding karyotypes, FISH, and array CGH analysis, caused by a recombinant chromosome 4 with terminal 4p16.3 deletion and terminal 4q35.2 duplication. This is an aneusomy due to a recombination which occurred during the meiosis of heterozygote carrier of cryptic pericentric inversion. We also describe the adulthood and prenatal phenotypes associated with the recombinant chromosome 4. 1. Introduction Wolf-Hirschhorn Syndrome (WHS) results from partial deletion of the distal short arm of chromosome 4 (4p16.3). The clinical features are variable, with increasing severity depending on the extent of the deletion, although the minimal diagnostic criteria should include the association of typical facial appearance, growth delay, mental retardation, and seizures [1]. Considering that small and large 4p16.3 deletions are associated with mild and severe WHS phenotype, respectively, Zollino et al. [1] have suggested a WHS classification in three categories based on the clinical presentation, all sharing the minimal diagnostic criteria: “mild” form (deletions < 3.5?Mb) refers to patients with a mild mental retardation (MR), possible fluent language, and usually independent walking by the age of 2-3 years; “classical” form (deletions 5–18?Mb) is characterized by major malformations, severe psychomotor delay (PMD), delay or absence of speech, and late walking; “severe” one (deletions > 22–25?Mb) has severe PMD and MR, facial anomalies, severe scoliosis, and psychotic behaviour. At a molecular level, two WHS critical regions (WHSCRs) have been identified: the WHSCR region, which is 165?Kb in size and it is located at about 2?Mb from the telomere between the markers D4S166 and D4S3327 [2], and the WHSCR-2 region which embraces a 300–600?Kb interval between the loci D4S3327 and D4S168 and it is mapped distal to WHSCR at about 1,9?Mb from the telomere [1]. Most of the 4p16 deletions involved in WHS occur de novo, but in 10%–15% of cases the derivative chromosome 4 originate from chromosomal rearrangements in one of the parents. Four different rearrangements are reported [1]: (1) isolated 4p deletion (70% of patients); (2) unbalanced translocation (22%); (3) inverted duplication associated with terminal 4p deletion (6%); (4) recombinant chromosome 4, rec(4), consisting of unbalanced pericentric inversion with a large 4q segment duplicated on the deleted 4p (2%). Herein we describe a
PPARs/RXRs in Cardiovascular Physiology and Disease
Brian N. Finck,Giulia Chinetti,Bart Staels
PPAR Research , 2008, DOI: 10.1155/2008/173780
Abstract:
Homotopy Perturbation Method for Solving Moving Boundary and Isoperimetric Problems  [PDF]
Sara Ghaderi
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.35062
Abstract: In this paper, homotopy perturbation method is applied to solve moving boundary and isoperimetric problems. This method does not depend upon a small parameter in the equation. homotopy is constructed with an imbedding parameter p, which is considered as a “small parameter”. Finally, we use combined homotopy perturbation method and Green’s function method for solving second order problems. Some examples are given to illustrate the effectiveness of methods. The results show that these methods provides a powerful mathematical tools for solving problems.
Creativity at the Crossroad Creative Education as Moral Education?  [PDF]
Sara Nosari
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B015
Abstract:

The man’s action, thanks to its creative capacities, gave a new order to the reality: the “created reality” does not present simply a different order, but is an authentic transformation. Which criteria had directed this transformation? Which will be the criteria of future transformation? The paper presents two possible ideas about creativity and argues in favor of a creative action educated and directed by an ethical criteria.

Using Figurative Language to Assess the Stage of Acceptance of Learning Disability as a Springboard for Treatment of Students with Learning Disabilities  [PDF]
Sara Givon
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.46054
Abstract:

In order to examine the emotional and cognitive processes experienced by adolescents with learning disabilities (LD), twenty tenth grade Israeli students were studied over three years. Data gathered through in-depth interviews underwent an axial-coding process, and a grounded theory model was constructed. The findings revealed various coping styles adopted by students throughout the process of accepting the disability. Participants were asked to use figurative language to describe their method of coping with the disability. Participants’ choice of phrase, metaphor or image characterized the phase of their acceptance as well as their coping style. This can be served as an effective tool of detection. Identifying the stage of students’ acceptance and their coping style may promote optimal treatment for students with LD.

Response Surface Optimization of a Solvent Free Production of cis-9, trans-11 and trans-10, cis-12 Isomers of Conjugated Linoleic Acid Using High Linoleic Sunflower Oil  [PDF]
Sara Koohikamali
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.86047
Abstract: The most dominant and beneficial conjugated linoleic acids isomers (CLAs) with miscellaneous biological tasks are 9c11t-C18:2 and 10t12c-C18:2. The problem with most of the commercial CLA produced by non-optimized conventional approaches is the heterogeneity of their isomers and undesirable toxic by-products. In this study, optimization of the isomerization of the fatty acid methyl esters of the high linoleic sunflower oil was investigated through response surface methodology (RSM). The reaction temperature, the concentration of PEG400 and NaOCH3 had positive influence on the total conjugated linoleic acid methyl esters (CLAME) production as response. However, the effect of the polyethylene glycol 400 (PEG400) concentration was more significant on response than those of other factors (p < 0.05). The reaction time and the interactions between the factors had no significant effect on response (p ≥ 0.05). The optimum point for the maximum response of 72.90% (i.e., based on the mass percentage of total fatty acid methyl esters mixture) was at 5% w/w NaOCH3, 1.06% w/w PEG400 and temperature of 140°C.
Implementation of an open-source customizable minimization program for allocation of patients to parallel groups in clinical trials  [PDF]
Mahmoud Saghaei, Sara Saghaei
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.411090
Abstract: Current minimization programs do not permit full control over different aspects of minimization algorithm such as distance or probability measures and may not allow for unequal allocation ratios. This article describes the implementation of “MinimPy” an open-source minimization program in Python programming language, which provides full customizetion of minimization features. MinimPy supports naive and biased coin minimization together with various new and classic distance measures. Data syncing is provided to facilitate minimization of multicenter trial over the network. MinimPy can easily be modified to fit special needs of clinical trials and in particular change it to a pure web application, though it currently supports network syncing of data in multi-center trials using network repositories.
Variational Iterative Method Applied to Variational Problems with Moving Boundaries  [PDF]
Fateme Ghomanjani, Sara Ghaderi
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.35061
Abstract: In this paper, He’s variational iterative method has been applied to give exact solution of the Euler Lagrange equation which arises from the variational problems with moving boundaries and isoperimetric problems. In this method, general Lagrange multipliers are introduced to construct correction functional for the variational problems. The initial approximations can be freely chosen with possible unknown constant, which can be determined by imposing the boundary conditions. Illustrative examples have been presented to demonstrate the efficiency and applicability of the variational iterative method.
Facile Synthesis and Characterization of Nanoporous NiO with Folic Acid as Photodegredation Catalyst for Congo Red  [PDF]
Faezeh Farzaneh, Sara Haghshenas
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.310102
Abstract: In this study nanoporous NiO was prepared using Ni(CH3COO)2,4H2O, folic acid and water as starting material, template and solvent respectively, by sol gel method followed by calcination at 400℃. The solid product was characterized by X-ray diffraction (XRD), nitrogen adsorption-desorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM) Fourier transform infrared (FT-IR) and photoluminescence (PL) techniques. The particle size of the nanoparticles estimated by XRD was in good agreement with the particle size obtained by TEM analysis (4-5nm). It was also found that the prepared nanoporous NiO show very good activity for photodegredation of dye organic pollutants such as Congo red (91%) during 1.5 hours.
Drilling Operation and Formation Damage  [PDF]
Hooman Fallah, Sara Sheydai
Open Journal of Fluid Dynamics (OJFD) , 2013, DOI: 10.4236/ojfd.2013.32005
Abstract:

Transport of particle suspensions in oil reservoirs is an essential phenomenon in many oil industry processes. Solid and liquid particles dispersed in the drilling fluid (mud) are trapped by the rock (porous medium) and permeability decline takes place during drilling fluid invasion into reservoir resulting in formation damage. The formation damage due to mud filtration is explained by erosion of external filter cake. Nevertheless, the stabilization is observed in core floods, which demonstrates internal erosion. A new mathematical model for detachment of particles is based on mechanical equilibrium of a particle positioned on the internal cake or matrix surface in the pore space. In the current work the analytical solution obtained to mud filtration with one particle capture mechanism with damage stabilization. The particle torque equilibrium is determined by the dimensionless ratio between the drag and normal forces acting on the particle. The maximum retention function of the dimensionless ratio closes system of governing equations for colloid transport through porous medium.

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