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Search Results: 1 - 10 of 984 matches for " Sanjeev Galande "
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THE BLOOM SYNDROME PROTEIN BLM IS SELECTIVELY CLEAVED DURING APOPTOTIC CELL DEATH
Oliver Bischof,Sanjeev Galande,Terumi Kohwi-Shigematsu,Judith Campisi
The Scientific World Journal , 2001, DOI: 10.1100/tsw.2001.157
Abstract:
Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner
Dimple Notani,Kamalvishnu P. Gottimukkala,Ranveer S. Jayani,Amita S. Limaye,Madhujit V. Damle,Sameet Mehta,Prabhat Kumar Purbey,Jomon Joseph,Sanjeev Galande
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1000296
Abstract: In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear accumulation of β-catenin, which then associates with the lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) to activate target genes. Wnt/β -catenin signalling is essential for T cell development and differentiation. Here we show that special AT-rich binding protein 1 (SATB1), the T lineage-enriched chromatin organizer and global regulator, interacts with β-catenin and recruits it to SATB1's genomic binding sites. Gene expression profiling revealed that the genes repressed by SATB1 are upregulated upon Wnt signalling. Competition between SATB1 and TCF affects the transcription of TCF-regulated genes upon β-catenin signalling. GATA-3 is a T helper type 2 (TH2) specific transcription factor that regulates production of TH2 cytokines and functions as TH2 lineage determinant. SATB1 positively regulated GATA-3 and siRNA-mediated knockdown of SATB1 downregulated GATA-3 expression in differentiating human CD4+ T cells, suggesting that SATB1 influences TH2 lineage commitment by reprogramming gene expression. In the presence of Dickkopf 1 (Dkk1), an inhibitor of Wnt signalling, GATA-3 is downregulated and the expression of signature TH2 cytokines such as IL-4, IL-10, and IL-13 is reduced, indicating that Wnt signalling is essential for TH2 differentiation. Knockdown of β-catenin also produced similar results, confirming the role of Wnt/β-catenin signalling in TH2 differentiation. Furthermore, chromatin immunoprecipitation analysis revealed that SATB1 recruits β-catenin and p300 acetyltransferase on GATA-3 promoter in differentiating TH2 cells in a Wnt-dependent manner. SATB1 coordinates TH2 lineage commitment by reprogramming gene expression. The SATB1:β-catenin complex activates a number of SATB1 regulated genes, and hence this study has potential to find novel Wnt responsive genes. These results demonstrate that SATB1 orchestrates TH2 lineage commitment by mediating Wnt/β-catenin signalling. This report identifies a new global transcription factor involved in β-catenin signalling that may play a major role in dictating the functional outcomes of this signalling pathway during development, differentiation, and tumorigenesis.
Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner
Dimple Notani,Kamalvishnu P. Gottimukkala,Ranveer S. Jayani,Amita S. Limaye,Madhujit V. Damle,Sameet Mehta,Prabhat Kumar Purbey,Jomon Joseph,Sanjeev Galande
PLOS Biology , 2010, DOI: 10.1371/journal.pbio.1000296
Abstract: In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear accumulation of β-catenin, which then associates with the lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) to activate target genes. Wnt/β -catenin signalling is essential for T cell development and differentiation. Here we show that special AT-rich binding protein 1 (SATB1), the T lineage-enriched chromatin organizer and global regulator, interacts with β-catenin and recruits it to SATB1's genomic binding sites. Gene expression profiling revealed that the genes repressed by SATB1 are upregulated upon Wnt signalling. Competition between SATB1 and TCF affects the transcription of TCF-regulated genes upon β-catenin signalling. GATA-3 is a T helper type 2 (TH2) specific transcription factor that regulates production of TH2 cytokines and functions as TH2 lineage determinant. SATB1 positively regulated GATA-3 and siRNA-mediated knockdown of SATB1 downregulated GATA-3 expression in differentiating human CD4+ T cells, suggesting that SATB1 influences TH2 lineage commitment by reprogramming gene expression. In the presence of Dickkopf 1 (Dkk1), an inhibitor of Wnt signalling, GATA-3 is downregulated and the expression of signature TH2 cytokines such as IL-4, IL-10, and IL-13 is reduced, indicating that Wnt signalling is essential for TH2 differentiation. Knockdown of β-catenin also produced similar results, confirming the role of Wnt/β-catenin signalling in TH2 differentiation. Furthermore, chromatin immunoprecipitation analysis revealed that SATB1 recruits β-catenin and p300 acetyltransferase on GATA-3 promoter in differentiating TH2 cells in a Wnt-dependent manner. SATB1 coordinates TH2 lineage commitment by reprogramming gene expression. The SATB1:β-catenin complex activates a number of SATB1 regulated genes, and hence this study has potential to find novel Wnt responsive genes. These results demonstrate that SATB1 orchestrates TH2 lineage commitment by mediating Wnt/β-catenin signalling. This report identifies a new global transcription factor involved in β-catenin signalling that may play a major role in dictating the functional outcomes of this signalling pathway during development, differentiation, and tumorigenesis.
US versus Taiwan Healthcare System Reforms: What Can India Learn from Them?  [PDF]
Ajit Kumar, Sanjeev Maskara, Sanjeev Maskara
American Journal of Industrial and Business Management (AJIBM) , 2015, DOI: 10.4236/ajibm.2015.510062
Abstract: India has been famous for producing excellent clinicians who have served the entire world. More-over, India has been one of the medical tourism destinations for international patients. Yet, unfortunately, healthcare facilities and resources for Indian citizen are not up to the standard com-pared to other countries. In recent years, the Indian healthcare system has received wide attention by the various stakeholders, such as patients, healthcare providers, health insurance companies, Information and Communication Technology companies, the government, and investors. The government of India has taken a number of initiatives in order to streamline the healthcare system of India. As many others have reformed their healthcare system, it is good to learn from their success and failure. In this paper, we discuss healthcare reforms in the USA and Taiwan. We find that, despite a number of healthcare reforms, the USA is somewhat struggling, whereas Taiwan is relatively successful in streamlining their healthcare system. Also, we explore a possible reason (Optimizing Big Coefficient or New Reality theory) for this gap. Afterwards, we highlight ongoing healthcare reform in India, including what India can learn from the USA and Taiwan.
The In-Terrorem Value of Science: Bisphenol-A Litigation and an Empirical Assessment of Science as a Collective Litigation Tool  [PDF]
Suman Kakar, Sanjeev Sirpal
Beijing Law Review (BLR) , 2011, DOI: 10.4236/blr.2011.22006
Abstract: This paper examines the role that science plays as a tool in collective litigation to substantiate claims. Scientific data and expert testimony are often included to buttress a claim and the admissibility of such evidence is often a conse-quence of the extant evidentiary rules and their application. The article will focus on the multidistrict litigation con-cerning Bisphenol-A (“BPA”) as a case study of the phenomena of scientific tailoring of evidence and its admissibility. BPA is a compound included in the synthesis of plastics and is found in food containers, plastic bottles, and ep-oxy-based coatings used to avert the rusting process of food containers. There is a negligible amount of BPA in several food and beverage products. Several countries along with the US Food and Drug Administration (FDA) and Environ-mental Protection Agency (EPA) have marshaled scientific studies that demonstrate the lack of any definable negative health effect attributable to an exposure to trace amounts of BPA. Notwithstanding the conclusions of these scientific inquiries, opponents have asserted that BPA exposure results in an alteration of embryonic hormone levels, thereby impacting their development and later reproductive function. This article will address these issues in addition to the salient question of what role science plays as a tool for collective litigation.
Model of Real Time Architecture for Data Placement in Wireless Sensor Networks  [PDF]
Sanjeev GUPTA, Mayank DAVE
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.2010.21008
Abstract: Wireless sensor network (WSN) technology has promised fine grain monitoring in time and space as well as at a lower cost than is currently possible. These sensor networks are required to provide a robust service in hostile environments. Therefore the issue of real-time and reliable data delivery is extremely important for taking effective decisions in WSN. In this paper the architecture for reliable and real time approach by using sensor clusters has been proposed for storage management. Instead of storing information in an individual cluster head as suggested in some approaches, storing of information of all clusters, inside the cell is recommended within the corresponding base station. For data dissemination and action we have used Action and Relay Stations (ARS). We have developed programming model for formal specification and verification of our architecture.
8 MeV Electron Induced Changes in Structural and Thermal Properties of Lexan Polycarbonate  [PDF]
K. Hareesh, Ganesh Sanjeev
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.211224
Abstract: Lexan polycarbonate films were irradiated by 8MeV electron beam at different fluences and characterized using X-ray Diffractogram (XRD), UV-Visible spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). The structural parameters such as degree of crystallinity and crystallite size were found to decrease after irradiation due to chain-scission. he UV-Visible spectroscopic study show the formation of chromophore groups upon irradiation and was reduced at larger wavelength. FTIR Study shows the carbonate linkage was found to be the radiation-sensitive linkage and benzene ring does not undergo any changes after irradiation. The DSC studies showed a decrease in glass transition temperature and heat of fusion after irradiation due to chain-scission which indicates polymer was moving towards more disordered state. Thermal decomposition temperature of Lexan polycarbonate increases upon irradiation.
Playing Around with “Kaleidagraph” Program for Determination of pKa Values of Mono, Di and Tri Basic Acids in a Physical-Organic Chemistry Laboratory  [PDF]
Vandanapu Jagannadham, Rachuru Sanjeev
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.33060
Abstract: A simple and easy laboratory protocol for the determination of the pKa of mono, di and tri-basic weak acids is described in this paper by using arbitrarily simulated data as a function of pH. An equation compatible to Kaleidagraph program is derived and used in the program to determine the pKa. The present protocol for the determination of the pKa is useful in teaching chemistry experiments in a Physical-Organic Chemistry Laboratory.
Buffer Management in the Sliding-Window (SW) Packet Switch for Priority Switching  [PDF]
Alvaro Munoz, Sanjeev Kumar
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2014, DOI: 10.4236/ijcns.2014.77027
Abstract:

Switch and router architectures employing a shared buffer are known to provide high throughput, low delay, and high memory utilization. Superior performance of a shared-memory switch compared to switches employing other buffer strategies can be achieved by carefully implementing a buffer-management scheme. A buffer-sharing policy should allow all of the output interfaces to have fair and robust access to buffer resources. The sliding-window (SW) packet switch is a novel architecture that uses an array of parallel memory modules that are logically shared by all input and output lines to store and process data packets. The innovative aspects of the SW architecture are the approach to accomplishing parallel operation and the simplicity of the control functions. The implementation of a buffer-management scheme in a SW packet switch is dependent on how the buffer space is organized into output queues. This paper presents an efficient SW buffer-management scheme that regulates the sharing of the buffer space. We compare the proposed scheme with previous work under bursty traffic conditions. Also, we explain how the proposed buffer-management scheme can provide quality-of-service (QoS) to different traffic classes.

Denial of Service Due to Direct and Indirect ARP Storm Attacks in LAN Environment  [PDF]
Sanjeev Kumar, Orifiel Gomez
Journal of Information Security (JIS) , 2010, DOI: 10.4236/jis.2010.12010
Abstract: ARP-based Distributed Denial of Service (DDoS) attacks due to ARP-storms can happen in local area networks where many computer systems are infected by worms such as Code Red or by DDoS agents. In ARP attack, the DDoS agents constantly send a barrage of ARP requests to the gateway, or to a victim computer within the same sub-network, and tie up the resource of attacked gateway or host. In this paper, we set to measure the impact of ARP-attack on resource exhaustion of computers in a local area network. Based on attack experiments, we measure the exhaustion of processing and memory resources of a victim computer and also other computers, which are located on the same network as the victim computer. Interestingly enough, it is observed that an ARP-attack not only exhausts resource of the victim computer but also significantly exhausts processing resource of other non-victim computers, which happen to be located on the same local area network as the victim computer.
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