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Search Results: 1 - 10 of 3543 matches for " Sang Youl Rhee "
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Blood lead is significantly associated with metabolic syndrome in Korean adults: an analysis based on the Korea National Health and Nutrition Examination Survey (KNHANES), 2008
Sang Youl Rhee, You-Cheol Hwang, Jeong-taek Woo, Dong Hyun Sinn, Sang Ouk Chin, Suk Chon, Young Seol Kim
Cardiovascular Diabetology , 2013, DOI: 10.1186/1475-2840-12-9
Abstract: We analyzed MS status and whole blood lead, mercury, cadmium, manganese, and creatinine-adjusted urine arsenic concentrations in 1,405 subjects, ? 20 years of age, who were registered for the Korea National Health and Nutrition Examination Survey, 2008.Various demographic and biochemical parameters were associated with MS and blood heavy metal status. After adjusting for these variables, lead was the only heavy metal that was significantly associated with MS. Lead concentrations in subjects with MS were significantly higher than those in subjects without MS (p?=?0.015). The prevalence of MS and a moderate/high risk for cardiovascular disease, as determined by Framingham risk score, also increased significantly according to the logarithmic transformation of the lead quartile (p?
Investigation of Responsiveness to Thyrotropin-Releasing Hormone in Growth Hormone-Producing Pituitary Adenomas
Sang Ouk Chin,Sang Youl Rhee,Suk Chon,You-Cheol Hwang,In-Kyung Jeong,Seungjoon Oh,Sung-Woon Kim
International Journal of Endocrinology , 2013, DOI: 10.1155/2013/159858
Abstract: Objective. The aim of this study was to investigate how the paradoxical response of GH secretion to TRH changes according to tumor volumes. Methods. Patients with newly diagnosed acromegaly were classified as either TRH responders or nonresponders according to the results of a TRH stimulation test (TST), and their clinical characteristics were compared according to responsiveness to TRH and tumor volumes. Results. A total of 41 acromegalic patients who underwent the TST were included in this study. Between TRH responders and nonresponders, basal GH, IGF-I levels, peak GH levels, and tumor volume were not significantly different, but the between-group difference of GH levels remained near significant over the entire TST time. during the TST were significantly different according to the responsiveness to TRH. Peak GH levels and during the TST showed significantly positive correlations with tumor volume with higher levels in macroadenomas than in microadenomas. GH levels over the entire TST time also remained significantly higher in macroadenomas than in microadenomas. Conclusion. Our data demonstrated that the paradoxical response of GH secretion to TRH in GH-producing pituitary adenomas was not inversely correlated with tumor volumes. 1. Introduction Abnormal responsiveness of growth hormone- (GH-) producing pituitary adenomas to hypothalamic hormones has been previously described [1]. This paradoxical response of GH to thyrotropin-releasing hormone (TRH) in GH-producing pituitary adenomas was first reported in 1972 [2, 3] and observed in 50~75% of untreated acromegalic patients [4]. However, this response is not specific to acromegaly and was also found in various pathologic conditions such as severe hepatic failure [2], chronic renal failure [5], diabetes mellitus [6], and anorexia nervosa [7]. There have been many studies of the predictive value of the paradoxical response for treatment outcome and prognosis in acromegaly [4, 8–10]. However, the detailed mechanism of the paradoxical response of GH to TRH in acromegaly remains unknown despite a number of possible hypotheses: local production of TRH by adenoma cells [11, 12], TRH-induced release of GH [13], TRH production by anterior pituitary gland [14], and inappropriate expression of TRH receptors at tumor cells [15]. Moreover, only a few studies have attempted to observe how the pattern of paradoxical response changes according to tumor volume [10, 16]. The aim of this study was to investigate how the paradoxical response of GH secretion to TRH changes according to tumor volume in acromegalic
Development of an HbA1c-Based Conversion Equation for Estimating Glycated Albumin in a Korean Population with a Wide Range of Glucose Intolerance
Chang Hee Jung, You-Cheol Hwang, Kwang Joon Kim, Bong Soo Cha, Cheol-Young Park, Won Seon Jeon, Jae Hyeon Kim, Sang-Man Jin, Sang Youl Rhee, Jeong-taek Woo, Byung-Wan Lee
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095729
Abstract: Background Compared to the golden standard glycation index of HbA1c, glycated albumin (GA) has potentials for assessing insulin secretory dysfunction and glycemic fluctuation as well as predicting diabetic vascular complications. However, the reference ranges of GA and a conversion equation need to be clearly defined. We designed this study to determine the reference ranges in patients with normal glucose tolerance (NGT) based on conventional measures of glycemic status and to devise a conversion equation for calculating HbA1c and GA in a Korean population. Methodology/Principal Findings In this multicenter, retrospective, cross-sectional study, we recruited antidiabetic drug-na?ve patients with available glycemic variables including HbA1c, GA, and fasting plasma glucose regardless of glucose status. For the reference interval of serum GA, 5th to 95th percentile value of GA in subjects with NGT was adopted. The conversion equation between HbA1c and GA was devised using an estimating regression model with unknown break-points method. The reference range for GA was 9.0–14.0% in 2043 subjects. The 95th percentile responding values for FPG, and HbA1c were approximately 5.49 mmol/l, and 5.6%, respectively. The significant glycemic turning points were 5.868% HbA1c and 12.2% GA. The proposed conversion equation for below and above the turning point were GA (%) = 6.960+0.8963 × HbA1c (%) and GA (%) = ?9.609+3.720 × HbA1c (%), respectively. Conclusions/Significance These results should be helpful in future studies on the clinical implications of high GA relative to HbA1c and the clinical implementation of diabetes management.
A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism
Jin Kyung Hwang,Joo Hee Cho,So Young Park,Jung Il Son,Uk Jo,Sang Ouk Chin,Yun Jung Lee,Moon Chan Choi,Sang Youl Rhee,Eui Jong Kim,Suk Chon
Case Reports in Endocrinology , 2013, DOI: 10.1155/2013/816236
Abstract: Sarcoidosis is a chronic multisystemic inflammatory disease of unknown etiology, which is characterized by noncaseating granulomatous inflammation of the involved organs. It is known that neurosarcoidosis involving the nervous system occurs in about 5% of patients with sarcoidosis. However, neurosarcoidosis without systemic involvement is extremely rare. We present a case of suspicious neurosarcoidosis affecting the pituitary gland, which was manifested as chronic uncontrolled headache, panhypopituitarism, central diabetes insipidus, and hypercalcemia. Though the biopsy at the pituitary lesion was not performed due to the high risk of surgical complication, treatment was needed urgently and we started steroid therapy. After steroid therapy, we observed the immediate symptom relief with improved hypercalcemia. According to the follow-up examination, no recurrent symptom was seen, and resolution of the pituitary lesion with improving panhypopituitarism was noted. 1. Introduction Sarcoidosis is a noncaseating granulomatous disease that can affect any system of the body [1]. Neurosarcoidosis involves the nervous system and occurs in less than 5% of patients with systemic sarcoidosis. Isolated neurosarcoidosis without systemic involvement is extremely rare [2]. We describe a case of possible neurosarcoidosis of the pituitary gland without any other systemic involvement. The patient presented with panhypopituitarism, central diabetes insipidus, and hypercalcemia. Sellar magnetic resonance imaging (MRI) showed an infiltrating mass of the pituitary gland with invasion of stalk and cavernous sinus. Steroid therapy resulted in the resolution of the pituitary lesion on sellar MRI and all symptoms. 2. Case Presentation A 39-year-old man presented to our clinic with nausea and headache. He reported that these symptoms had waxed and waned for five years and were aggravated for three weeks before admission. His medical history revealed that he had been diagnosed with a pituitary microadenoma at the age of thirty four with symptoms of polyuria, polydipsia, and severe headache. Initial sellar MRI showed a pituitary microadenoma with stalk deviation and thickening (Figure 1(a)). An anterior pituitary function test revealed minimal elevation of prolactin (20.2?ng/mL) with no other significant abnormalities. He began to take lisuride hydrogen maleate, which decreased his serum prolactin level. Although intranasal vasopressin therapy significantly relieved the polyuria and polydipsia, his headache did not subside, and, thus, intermittent low-dose steroid therapy was
Sarcopenia Is Independently Associated with Cardiovascular Disease in Older Korean Adults: The Korea National Health and Nutrition Examination Survey (KNHANES) from 2009
Sang Ouk Chin, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, In-Kyung Jeong, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Jeong-taek Woo, Sung-Woon Kim, Jin-Woo Kim, Young Seol Kim, Hong-Yup Ahn
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060119
Abstract: Background The association between sarcopenia and cardiovascular disease (CVD) in elderly people has not been adequately assessed. The aim of this study was to investigate whether CVD is more prevalent in subjects with sarcopenia independent of other well-established cardiovascular risk factors in older Korean adults. Method This study utilized the representative Korean population data from the Korea National Health and Nutrition Examination Survey (KNHANES) which was conducted in 2009. Subjects older than 65 years of age with appendicular skeletal muscle mass (ASM) determined by dual energy X-ray absorptiometry were selected. The prevalence of sarcopenia in the older Korean adults was investigated, and it was determined whether sarcopenia is associated with CVD independent of other well-known risk factors. Results 1,578 subjects aged 65 years and older with the data for ASM were selected, and the overall prevalence of sarcopenia was 30.3% in men and 29.3% in women. Most of the risk factors for CVD such as age, waist circumference, body mass index, fasting plasma glucose and total cholesterol showed significant negative correlations with the ratio between appendicular skeletal muscle mass and body weight. Multiple logistic regression analysis demonstrated that sarcopenia was associated with CVD independent of other well-documented risk factors, renal function and medications (OR, 1.768; 95% CI, 1.075–2.909, P = 0.025). Conclusions Sarcopenia was associated with the presence of CVD independent of other cardiovascular risk factors after adjusting renal function and medications.
BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets
Jaehwi Lee,Man Hee Rhee,Eunji Kim,Jae Youl Cho
Mediators of Inflammation , 2012, DOI: 10.1155/2012/416036
Abstract: BAY 11-7082 (BAY) is an inhibitor of κB kinase (IKK) that has pharmacological activities that include anticancer, neuroprotective, and anti-inflammatory effects. In this study, BAY-pharmacological target pathways were further characterized to determine how this compound simultaneously suppresses various responses. Primary and cancerous (RAW264.7 cells) macrophages were activated by lipopolysaccharide, a ligand of toll-like receptor 4. As reported previously, BAY strongly suppressed the production of nitric oxide, prostaglandin E2, and tumor necrosis factor-α and reduced the translocation of p65, major subunit of nuclear factor-κB, and its upstream signaling events such as phosphorylation of IκBα, IKK, and Akt. In addition, BAY also suppressed the translocation and activation of activator protein-1, interferon regulatory factor-3, and signal transducer and activator of transcription-1 by inhibiting the phosphorylation or activation of extracellular signal-related kinase, p38, TANK-binding protein, and Janus kinase-2. These data strongly suggest that BAY is an inhibitor with multiple targets and could serve as a lead compound in developing strong anti-inflammatory drugs with multiple targets in inflammatory responses.
Applying Lipson's state models to marked graph diagrams of surface-links
Yewon Joung,Seiichi Kamada,Sang Youl Lee
Mathematics , 2014,
Abstract: A. S. Lipson constructed two state models yielding the same classical link invariant obtained from the Kauffman polynomial $F(a,z)$. In this paper, we apply Lipson's state models to marked graph diagrams of surface-links, and observe when they induce surface-link invariants.
Crossing number of an alternating knot and canonical genus of its Whitehead double
Hee Jeong Jang,Sang Youl Lee
Mathematics , 2014,
Abstract: A conjecture proposed by J. Tripp in 2002 states that the crossing number of any knot coincides with the canonical genus of its Whitehead double. In the meantime, it has been established that this conjecture is true for a large class of alternating knots including $(2, n)$ torus knots, $2$-bridge knots, algebraic alternating knots, and alternating pretzel knots. In this paper, we prove that the conjecture is not true for any alternating $3$-braid knot which is the connected sum of two torus knots of type $(2, m)$ and $(2, n)$. This results in a new modified conjecture that the crossing number of any prime knot coincides with the canonical genus of its Whitehead double. We also give a new large class of prime alternating knots satisfying the conjecture, including all prime alternating $3$-braid knots.
Computations of quandle cocyle invariants of surface-links using marked graph diagrams
Seiichi Kamada,Jieon Kim,Sang Youl Lee
Mathematics , 2015,
Abstract: By using the cohomology theory of quandles, quandle cocycle invariants and shadow quandle cocycle invariants are defined for oriented links and surface-links via broken surface diagrams. By using symmetric quandles, symmetric quandle cocycle invariants are also defined for unoriented links and surface-links via broken surface diagrams. A marked graph diagram is a link diagram possibly with $4$-valent vertices equipped with markers. S. J. Lomonaco, Jr. and K. Yoshikawa introduced a method of describing surface-links by using marked graph diagrams. In this paper, we give interpretations of these quandle cocycle invariants in terms of marked graph diagrams, and introduce a method of computing them from marked graph diagrams.
The canonical genus for Whitehead doubles of a family of alternating knots
Hee Jeong Jang,Sang Youl Lee
Mathematics , 2011,
Abstract: For any given integer $r \geq 1$ and a quasitoric braid $\beta_r=(\sigma_r^{-\epsilon} \sigma_{r-1}^{\epsilon}...$ $ \sigma_{1}^{(-1)^{r}\epsilon})^3$ with $\epsilon=\pm 1$, we prove that the maximum degree in $z$ of the HOMFLYPT polynomial $P_{W_2(\hat\beta_r)}(v,z)$ of the doubled link $W_2(\hat\beta_r)$ of the closure $\hat\beta_r$ is equal to $6r-1$. As an application, we give a family $\mathcal K^3$ of alternating knots, including $(2,n)$ torus knots, 2-bridge knots and alternating pretzel knots as its subfamilies, such that the minimal crossing number of any alternating knot in $\mathcal K^3$ coincides with the canonical genus of its Whitehead double. Consequently, we give a new family $\mathcal K^3$ of alternating knots for which Tripp's conjecture holds.
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