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Search Results: 1 - 10 of 1860 matches for " Sandeep Kishore "
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A Student-Led Campaign to Help Tackle Neglected Tropical Diseases
Sandeep P Kishore ,Prabhjot S Dhadialla
PLOS Medicine , 2007, DOI: 10.1371/journal.pmed.0040241
Better outcome after pediatric resuscitation is still a dilemma
Sahu Sandeep,Kishore Kamal,Lata Indu
Journal of Emergencies, Trauma and Shock , 2010,
Abstract: Pediatric cardiac arrest is not a single problem. Although most episodes of pediatric cardiac arrest occur as complications and progression of respiratory failure and shock. Sudden cardiac arrest may result from abrupt and unexpected arrhythmias. With a better-tailored therapy, we can optimize the outcome. In the hospital, cardiac arrest often develops as a progression of respiratory failure and shock. Typically half or more of pediatric victims of in-hospital arrest have pre-existing respiratory failure and one-third or more have shock, although these figures vary somewhat among reporting hospitals. When in-hospital respiratory arrest or failure is treated before the development of cardiac arrest, survival ranges from 60% to 97%. Bradyarrthmia, asystole or pulseless electric activity (PEA) were recorded as an initial rhythm in half or more of the recent reports of in-hospital cardiac arrest, with survival to hospital discharge ranging from 22% to 40%. Data allowing characterization of out of hospital pediatric arrest are limited, although existing data support the long-held belief that as with hospitalized children, cardiac arrest most often occurs as a progression of respiratory failure or shock to cardiac arrest with bradyasystole rhythm. Although VF (Ventricular fibrillation, is a very rapid, uncoordinated, ineffective series of contractions throughout the lower chambers of the heart. Unless stopped, these chaotic impulses are fatal) and VT (Ventricular tachycardia is a rapid heartbeat that originates in one of the ventricles of the heart. To be classified as tachycardia, the heart rate is usually at least 100 beats per minute) are not common out-of-cardiac arrest in children, they are more likely to be present with sudden, witnessed collapse, particularly among adolescents. Pre-hospital care till the late 1980s was mainly concerned with adult care, and the initial focus for pediatric resuscitation was provision of oxygen and ventilation, with initial rhythm at the time of emergency medical services arrival being infrequently recorded. In the 1987 series, pre-hospital pediatric cardiac arrest demonstrated asystole in 80%, PEA in 10.5% and VF or VT in 9.6%. Only 29% arrests were witnessed, however, and death in many victims was caused by sudden infant death syndrome.
The Global Health Crisis and Our Nation's Research Universities
Sandeep P. Kishore ,Gloria Tavera,Peter J. Hotez
PLOS Neglected Tropical Diseases , 2010, DOI: 10.1371/journal.pntd.0000635
Comparative Performance of Private and Public Healthcare Systems in Low- and Middle-Income Countries: A Systematic Review
Sanjay Basu ,Jason Andrews,Sandeep Kishore,Rajesh Panjabi,David Stuckler
PLOS Medicine , 2012, DOI: 10.1371/journal.pmed.1001244
Abstract: Introduction Private sector healthcare delivery in low- and middle-income countries is sometimes argued to be more efficient, accountable, and sustainable than public sector delivery. Conversely, the public sector is often regarded as providing more equitable and evidence-based care. We performed a systematic review of research studies investigating the performance of private and public sector delivery in low- and middle-income countries. Methods and Findings Peer-reviewed studies including case studies, meta-analyses, reviews, and case-control analyses, as well as reports published by non-governmental organizations and international agencies, were systematically collected through large database searches, filtered through methodological inclusion criteria, and organized into six World Health Organization health system themes: accessibility and responsiveness; quality; outcomes; accountability, transparency, and regulation; fairness and equity; and efficiency. Of 1,178 potentially relevant unique citations, data were obtained from 102 articles describing studies conducted in low- and middle-income countries. Comparative cohort and cross-sectional studies suggested that providers in the private sector more frequently violated medical standards of practice and had poorer patient outcomes, but had greater reported timeliness and hospitality to patients. Reported efficiency tended to be lower in the private than in the public sector, resulting in part from perverse incentives for unnecessary testing and treatment. Public sector services experienced more limited availability of equipment, medications, and trained healthcare workers. When the definition of “private sector” included unlicensed and uncertified providers such as drug shop owners, most patients appeared to access care in the private sector; however, when unlicensed healthcare providers were excluded from the analysis, the majority of people accessed public sector care. “Competitive dynamics” for funding appeared between the two sectors, such that public funds and personnel were redirected to private sector development, followed by reductions in public sector service budgets and staff. Conclusions Studies evaluated in this systematic review do not support the claim that the private sector is usually more efficient, accountable, or medically effective than the public sector; however, the public sector appears frequently to lack timeliness and hospitality towards patients. Please see later in the article for the Editors' Summary
Enabling access to new WHO essential medicines: the case for nicotine replacement therapies
Sandeep P Kishore, Asaf Bitton, Alejandro Cravioto, Derek Yach
Globalization and Health , 2010, DOI: 10.1186/1744-8603-6-22
Abstract: Tobacco use kills 5.4 million people annually. Even if no children started smoking in the future, 8.3 million people will die annually of tobacco-related diseases by 2030. Unless tobacco cessation and control vastly improves, the death toll from tobacco this century will easily reach an estimated 1 billion deaths [1]. In this paper, we discuss the benefits and challenges of enabling access to pharmacotherapies [nicotine replacement therapies (NRTs)] to treat nicotine dependence and bolster tobacco cessation in low and middle income countries (LMIC).In March 2009, NRTs (specifically, nicotine gums and patches) were added to the Model List of Essential Medicines by the World Health Organization (WHO) [2]. Essential medicines are defined as those that satisfy the priority health care needs of the population, and the Essential Medicines List (EML) is used by over 160 governments as a guide for determining which medicines should be made available to their citizens at low cost (http://www.who.int/medicines/en/ webcite and Figure 1). The addition of a medicine to the international EML directly encourages individual nations to add the drug to their national EML and to internal drug registries. This is an important logistical step. Many countries (e.g. South Africa) restrict drug importations to medicines on national EML and registries. Similarly, several foundations and major charities base their medicine supply on the WHO EML. Medicines not on the international or national EML are often not available or are simply unaffordable in LMIC.In this context, we argue that in light of the increasing global burden of tobacco dependence and the clinical utility of NRT, these new WHO essential medicines can and should be available more widely. Let us be clear at the outset. We do not argue that every smoker in a given population should use NRT to quit. Rather, we posit that a nicotine-dependent individual in a low resource country should have the opportunity to affordably access the
Management of unusual case of self-inflicted penetrating craniocerebral injury by a nail
Kishore Kamal,Sahu Sandeep,Bharti Pradeep,Dahiya Subhash
Journal of Emergencies, Trauma and Shock , 2010,
Abstract: During war, sharp high-speed missiles have been driven inside the brain; however, in civilian practice it is rare to see such episodes. An approximately 10-cm long nail was driven inside the brain in an attempt to commit suicide by a schizophrenic patient. The case is being reported for its rarity in civilian practice and as a case of clinical interest. After investigating the patient by plain X-rays and a CT scan, he was operated by a neurosurgical team and the nail was successfully removed. In post-operative phase, patient was given medical and psychiatric care along with psychological counseling. The patient made good uneventful recovery in the post-operative phase.
A novel way of managing shearing of epidural catheter during tunnelling
Kishore Kamal,Sahu Sandeep,Singh Manish,Agarwal Anil
Indian Journal of Anaesthesia , 2010,
Molecular Motors—Self-Organization of Cytoskeletal Network  [PDF]
Kishore Dutta
Yangtze Medicine (YM) , 2017, DOI: 10.4236/ym.2017.14021
Abstract: Molecular motors play an important role in the organization of cytoskeletal filament networks. These nanometer-sized natural molecular machines opened up a new frontier of nano-technology. This article describes biomolecular nano-machines, their internal structures, and dynamical interactions between molecular motors and their molecular tracks which reorganize a network of long protein filaments, particularly during cell division to form cytoskeleton of daughter cells. Towards the end, the article also takes up some still-to-be resolved matters and prospects for future developments in this exciting multidisciplinary area of science.
The Silent Epidemic of Exclusive University Licensing Policies on Compounds for Neglected Diseases and Beyond
Connie E. Chen,C. Taylor Gilliland,Jay Purcell,Sandeep P. Kishore
PLOS Neglected Tropical Diseases , 2010, DOI: 10.1371/journal.pntd.0000570
Misalignment between perceptions and actual global burden of disease: evidence from the US population
Karen R. Siegel,Andrea B. Feigl,Sandeep P. Kishore,David Stuckler
Global Health Action , 2011, DOI: 10.3402/gha.v4i0.6339
Abstract: Significant funding of health programs in low-income countries comes from external sources, mainly private donors and national development agencies of high-income countries. How these external funds are allocated remains a subject of ongoing debate, as studies have revealed that external funding may misalign with the underlying disease burden. One determinant of the priorities set by both private donors and development agencies is the perceptions of populations living in high-income countries about which diseases are legitimate for global health intervention. While research has been conducted on the priorities expressed by recipient communities, relatively less has been done to assess those of the donating country. To investigate people's beliefs about the disease burden in high-income countries, we compared publicly available data from U.S. surveys of people's perceptions of the leading causes of death in developing countries against measures of the actual disease burden from the World Health Organization. We found little correlation between the U.S. public's perception and the actual disease burden, measured as either mortality or disability-adjusted life years. While there is potential for reverse causality, so that donor programs drive public perceptions, these findings suggest that increasing the general population's awareness of the true global disease burden could help better align global health funding with population health needs.
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