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Search Results: 1 - 10 of 2185 matches for " Sandeep Arora "
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Cutaneous reactions in nuclear, biological and chemical warfare
Arora Sandeep
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract: Nuclear, biological and chemical warfare have in recent times been responsible for an increasing number of otherwise rare dermatoses. Many nations are now maintaining overt and clandestine stockpiles of such arsenal. With increasing terrorist threats, these agents of mass destruction pose a risk to the civilian population. Nuclear and chemical attacks manifest immediately while biological attacks manifest later. Chemical and biological attacks pose a significant risk to the attending medical personnel. The large scale of anticipated casualties in the event of such an occurrence would need the expertise of all physicians, including dermatologists, both military and civilian. Dermatologists are uniquely qualified in this respect. This article aims at presenting a review of the cutaneous manifestations in nuclear, chemical and biological warfare and their management.
Reiter′s disease in a six-year-old girl
Arora Sandeep,Arora Gulhima
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract: Reiter′s syndrome has characteristically been described in young males and presents with a triad of urethritis, conjunctivitis and arthritis. Reiter′s syndrome has been known to affect children, although they usually do not manifest with the typical triad. Only a few such cases have been reported and these have described males predominantly. A case of a six-year-old girl who presented with watery diarrhea, redness of eyes and joint pains followed by skin involvement is reported. She was managed with topical salicylic acid and hydrocortisone, and oral aspirin and showed complete resolution of her clinical features in three weeks.
Formulation and In Vitro Evaluation of Ufasomes for Dermal Administration of Methotrexate
Arvind Sharma,Sandeep Arora
ISRN Pharmaceutics , 2012, DOI: 10.5402/2012/873653
Abstract:
Formulation and In Vitro Evaluation of Ufasomes for Dermal Administration of Methotrexate
Arvind Sharma,Sandeep Arora
ISRN Pharmaceutics , 2012, DOI: 10.5402/2012/873653
Abstract: Dermal drug delivery system that is required to localizes methotrexate (MTX) in the synovial joint is needed to treat inflammation in rheumatoid arthritis (RA). The present investigation aims at exploring the potential of fatty acid vesicles for the topical delivery of methotrexate. Vesicles were prepared by film hydration method using oleic acid as a fatty acid principal component. Developed vesicles were characterized for size, size distribution, shape, in vitro release, pH dependent, and storage stability. Interaction between MTX and oleic acid was investigated using differential scanning calorimetry. The MTX amount permeated through rat skin was three- to fourfold higher using oleic acid compared to those from plain drug solution or carbopol gel. At the end of the skin permeation assay using ufasomes, up to 50% of the administered dose was found in the skin. These results suggest that methotrexate encapsulated in oleic acid vesicles may be of value for the topical administration of MTX in the treatment of psoriasis. 1. Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology and complex multifactorial pathogenesis. It is characterized by progressive and irreversible damage of the synovial-lined joints, resulting in the loss of joint space, bone, and a decrease in joint function and deformity [1]. RA is usually treated first with a nonsteroidal antiinflammatory drug (NSAID). However, current RA treatment favors early use of slow acting disease modifying anti-rheumatic drugs (DMARDs) because DMARDs have the potential to prevent or reduce joint damage. Therefore, they are used early in the treatment of RA and usually no later than 3 months after the commencement of NSAID treatment [2, 3]. Methotrexate (MTX) is one of the most frequently used DMARDs in the treatment of RA. Although the exact mechanism of action is still unclear, the efficacy of MTX is related to its cytotoxic and anti-inflammatory effects [4]. When administered in low weekly oral doses, MTX effectively suppresses inflammation in RA [5]. However, systemic toxicity effects such as stomatitis, nausea, bone marrowdepression, and liver toxicity can limit the oral use of this drug [6]. To reduce these effects, clinical studies have been done with topical methotrexate [7, 8]. A major problem in topical administration of methotrexate is that the drug is hydrosoluble and is mostly in the dissociated form at physiological pH: its capacity for passive diffusion is thus limited. One of the possibilities for increasing the penetration of drugs through the skin is
Finite Element Modeling and Design of Rectangular Patch Antenna with Different Feeding Techniques  [PDF]
Rajat Arora, Ajay Kumar, Saleem Khan, Sandeep Arya
Open Journal of Antennas and Propagation (OJAPr) , 2013, DOI: 10.4236/ojapr.2013.12004
Abstract: The finite element modeling of three dimensional structures is important for researchers especially in the field of antennas and other domains of electromagnetic waves. This paper presents a finite element calculations and numerical analysis for the microstrip patch antennas. In this paper, two different designs have been modelled and analyzed and both designs are based on the rectangular patches. The feeding point of one design is inside the patch while the other design contains feeding point outside the patch is T shaped. The computational analysis showed some interesting results for radiation pattern and far field domain. For these designs, the characteristic impedance taken is 50 Ω and the operating frequency domain is 1.4 to 1.7 GHz. The microstrip patch antennas are encapsulated in the inert spherical atmosphere of 20 mm thickness containing air inside it.
Role of the Parasight-F test in the diagnosis of complicated Plasmodium falciparum malarial infection
Arora, Sandeep;Gaiha, Manorama;Arora, Anju;
Brazilian Journal of Infectious Diseases , 2003, DOI: 10.1590/S1413-86702003000500008
Abstract: an evaluation was made of the diagnostic efficacy and utility of the parasight-f test in diagnosing plasmodium falciparum malaria, compared with conventional microscopy, particularly in severe and complicated cases. this study was designed as a prospective, case control hospital-based study. febrile patients suspected to be suffering from malaria were selected randomly and were subjected to peripheral smear examinations (thick and thin) and parasight-f tests till the required number of at least 30 cases of p. falciparum infection were identified, including at least 15 complicated cases. in addition 20 cases of p. vivax malarial infection as well as 20 healthy age and sex-matched individuals were taken as two control groups. the outcome measure was the number of cases with positive parasight-f test results compared with conventional microscopy. thirty-two patients with p. falciparum malaria were identified, with 15 severe and complicated cases. peripheral smears were positive in 29 (91%) of these, while parasight-f test was positive in 31 out of 32 (97%) cases. parasites were detected only by bone marrow examination in one case. diagnostic sensitivity and specificity of peripheral smears for detecting falciparum infection were 90.6% and 100% respectively while that of the parasight-f test were 96.8% and 100%, respectively (p>.05). the parasight-f test has high sensitivity and specificity in diagnosing p. falciparum malarial infection, comparable to or even higher than microscopy exams, particularly in severe and complicated cases, with additional advantages of speed, simplicity and objectivity.
Relapsing linear acantholytic dermatosis in a four-year-old boy
Arora Sandeep,Arora Gulhima,Ranjan P
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract: Linear acantholytic dermatoses are a spectrum of cutaneous disorders that form a subset of linear dermatoses with distinct clinical features and histopathologically show acantholysis. The lesions may be zosteriform or follow the lines of Blaschko. This report describes a four-year-old boy who, on a follow up of two years, exhibited a relapsing acantholytic dermatosis along the lines of Blaschko. Histopathology of a representative lesion revealed epidermal acantholysis with multiple acantholytic keratinocytes with in the prickle cell layer and an absence of corp ronds and grains, consistent with features of Hailey-Hailey disease. This, to our knowledge, is the third case of relapsing linear acantholytic dermatosis reported.
Hand foot and mouth disease: Emerging epidemics
Arora Sandeep,Arora Gulhima,Tewari Vanmalini
Indian Journal of Dermatology, Venereology and Leprology , 2008,
Abstract:
Role of the Parasight-F test in the diagnosis of complicated Plasmodium falciparum malarial infection
Arora Sandeep,Gaiha Manorama,Arora Anju
Brazilian Journal of Infectious Diseases , 2003,
Abstract: An evaluation was made of the diagnostic efficacy and utility of the Parasight-F test in diagnosing Plasmodium falciparum malaria, compared with conventional microscopy, particularly in severe and complicated cases. This study was designed as a prospective, case control hospital-based study. Febrile patients suspected to be suffering from malaria were selected randomly and were subjected to peripheral smear examinations (thick and thin) and Parasight-F tests till the required number of at least 30 cases of P. falciparum infection were identified, including at least 15 complicated cases. In addition 20 cases of P. vivax malarial infection as well as 20 healthy age and sex-matched individuals were taken as two control groups. The outcome measure was the number of cases with positive Parasight-F test results compared with conventional microscopy. Thirty-two patients with P. falciparum malaria were identified, with 15 severe and complicated cases. Peripheral smears were positive in 29 (91%) of these, while parasight-F test was positive in 31 out of 32 (97%) cases. Parasites were detected only by bone marrow examination in one case. Diagnostic sensitivity and specificity of peripheral smears for detecting falciparum infection were 90.6% and 100% respectively while that of the Parasight-F test were 96.8% and 100%, respectively (P>.05). The Parasight-F test has high sensitivity and specificity in diagnosing P. falciparum malarial infection, comparable to or even higher than microscopy exams, particularly in severe and complicated cases, with additional advantages of speed, simplicity and objectivity.
Therapeutic Effect of Ficus lacor Aerial Roots of Various Fractions on Adjuvant-Induced Arthritic Rats
Rakesh K. Sindhu,Sandeep Arora
ISRN Pharmacology , 2013, DOI: 10.1155/2013/634106
Abstract: The present study was carried out to evaluate antiarthritic potential and phytochemical screening of various extracts of Ficus lacor aerial roots. The antiarthritic activity was evaluated by adjuvant-induced arthritis at the dose of 50 and 100?mg/kg body weight and the standard drug used was indomethacin. The extracts administered in higher doses reduced the lesions to a greater extent showing a dose-dependent decrease in lesions comparable with standard drug indomethacin. The extracts of FLPE and FLET showed significant increase in body weight as compared to arthritic control group as well as an increase in liver weight, a decrease in liver weight, and an increase in spleen weight in arthritis control. The extracts of FLPE and FLET showed significant decrease in WBC count, increase in hemoglobin contents, and RBC count as compared to control group. FLEA and FLCF were not able to produce a significant effect. There was significant reduction in production of IL-1 and TNF-α level between model group and control group in serum. In conclusion, we demonstrate that, at 100?mg/kg body weight, doses of FLPE and PLET extracts were highly effective in preventing and suppressing the development of adjuvant-induced arthritis. 1. Introduction Inflammation is common and essential protective response to the harmful stimuli such as infectious agents, antigen-antibody reactions, thermal, chemical, and physical agents, and ischemia [1]. It is caused by a variety of stimuli including physical damage, ultraviolet irradiation, microbial invasion, and immune reactions. The classical key features of inflammation are redness, warmth, swelling, and pain. Inflammation cascades can lead to the development of diseases such as arthritis, chronic asthma, multiple sclerosis, inflammatory bowel disease, and psoriasis. Many of these diseases are debilitating and are becoming increasingly common in our aging society. Rheumatoid arthritis and osteoarthritis are the major inflammatory diseases affecting people worldwide [2]. Rheumatoid arthritis is an inflammatory condition that usually affects multiple joints. It affects 0.3%–1.0% of the general population and is more prevalent among women in the developed countries. Persistent inflammation leads to joint destruction, but the disease can be controlled with drugs. Osteoarthritis, which is characterized by loss of joint cartilage that leads to pain and loss of function primarily in the knees and hips, affects 9.6% of men and 18% of women aged more than 60 years. Increases in life expectancy and aging populations are expected to make
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