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Search Results: 1 - 10 of 6490 matches for " Samuel Deutsch "
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The future is genome-wide
Samuel Deutsch, Alexandre Reymond
Genome Biology , 2006, DOI: 10.1186/gb-2006-7-8-324
Abstract: More than 1,700 human geneticists from 59 countries congregated in Amsterdam in May for this year's meeting of the European Society of Human Genetics, which mainly focused on the use of post-genome analysis tools to dissect the causes of and mechanisms governing complex traits. Many of the exciting studies presented were based on two technologies: array-based methods for genome-wide genotyping or technologies for high-density comparative genome hybridization (CGH). A highlight of the meeting was the keynote lecture by Nobel laureate Sydney Brenner (Salk Institute for Biological Studies, La Jolla, USA) on 'humanity's genes', which focused on the challenges we face in transforming the information from the human genome into concrete benefits for our societies.This year has seen the success of several whole-genome association studies using genotyping for single-nucleotide polymorphisms (SNPs) to identify genes responsible for some common complex phenotypes for both discrete and quantitative traits. A plenary lecture by Kari Stefansson (deCODE Genetics, Reykjavik, Iceland) highlighted the tremendous potential of this approach. Several examples were discussed in which new genes have recently been identified using a combination of linkage and association analysis approaches. One example is a locus on human chromosome 8p12 that confers susceptibility to schizophrenia. Although nucleotide variation around the NRG1 gene has been known to be associated with schizophrenia for the past 4 years, the mechanism of action of the associated SNPs, located in noncoding regions 53 to the gene, has remained unclear. Recent evidence strongly suggests that these variants might influence the level of NRG1 expression. Stefansson suggested that many SNPs involved in the etiology of complex phenotypes are likely to affect gene expression or splicing, and that these variants are under strong selective pressure. A second, more recent, example presented by Stefansson concerns the genetics of myoc
The Seeking Solutions Approach: Solving Challenging Business Problems with Local Open Innovation
Christophe Deutsch
Technology Innovation Management Review , 2013,
Abstract: How can small and medium-sized enterprises try open innovation and increase their level of collaboration with local partners? This article describes a possible solution: the Seeking Solutions approach. The Seeking Solutions process consists of four steps: a call for problems, problem selection, problem broadcast, and a collaborative event. This approach has been successfully used for the Quebec Seeks Solutions events in 2010 and 2012 with concrete results and real impacts. By mixing open innovation and collaboration, the Seeking Solutions approach has introduced a new concept: local open innovation.
The Elevation to Area Relationship of Lake Behnke
Kaitlin Deutsch
Undergraduate Journal of Mathematical Modeling : One + Two , 2012, DOI: 10.5038/2326-3652.4.2.5
Abstract: The objective of this project was to determine the area-to-depth relationship in Lake Behnke, which acts as the principal stormwater drainage basin for the University of South Florida campus in Tampa, Florida. Data previously collected in a stormwater management study by Jeffery Earhart illustrated a linear correlation between the lake's area and depth; however, that study was conducted in 1998, and this present work serves to double check that correlation. We analyzed a bathymetric map of Lake Behnke that displayed several contour lines indicating depth and approximated the area inside each closed curve with a contour integral. The resulting relationship between area and elevation was determined to be more parabolic than linear.
Is primary biliary cirrhosis a risk factor for hepatic and extrahepatic malignancies?
Melanie Deutsch
Annals of Gastroenterology , 2009,
Abstract: Primary biliary cirrhosis (PBC) represents a classical cause of liver cirrhosis but clear data about the true risk of the development of hepatocellular carcinoma (HCC) are still lacking.Data are based especially on epidemiologic studies from different geographical areas and, since PBC is a relatively rare disease with a very slow natural course, the true incidence of HCC is not well known. However, most of the studies agree that patients with cirrhotic stage PBC are at increased risk and they should be included in a surveillance program.On the other hand, some authors suggested during the 1970s and early 1980s that PBC patients are at increased risk for development of extrahepatic cancer, especially breast cancer.These findings could not be confirmed in more recent larger studies and finally no higher risk of developing extrahepatic cancer has been documented in these patients.
Status and Future Prospects in Searches for New Interactions in Neutron and Nuclear Beta-decay, Muon- and Pion-decay
Jules Deutsch
Physics , 1999,
Abstract: The interest, the status and the perspectives of various experiments in neutron and nuclear beta-decay, muon-decay and pion-decays are discussed. The talk is segmented into a discussion of the decay-rates and of the energy-spectra and correlations. The impact on various scenarios of "new physics" is briefly mentioned; left-right symmetric models are discussed in more detail and the informations gained from the considered experiments is compared to those from other sources.
Return of the Ether: Conjecture That Can Explain Photon and Electron Two-Slit Interference
Sid Deutsch
Physics , 1998,
Abstract: The ether can "explain" certain questionable "quantum realities" in which single, isolated photons form a diffraction pattern in a two-slit apparatus; and, similarly, single, isolated electrons form a diffraction pattern in the equivalent of a two-slit apparatus. The notion that every large object, such as the earth, carries its own ether, is not considered.
Quantum Theory of Probability and Decisions
David Deutsch
Physics , 1999, DOI: 10.1098/rspa.1999.0443
Abstract: The probabilistic predictions of quantum theory are conventionally obtained from a special probabilistic axiom. But that is unnecessary because all the practical consequences of such predictions follow from the remaining, non-probabilistic, axioms of quantum theory, together with the non-probabilistic part of classical decision theory.
The Structure of the Multiverse
David Deutsch
Physics , 2001,
Abstract: The structure of the multiverse is determined by information flow.
Qubit Field Theory
David Deutsch
Physics , 2004,
Abstract: The canonical commutation relations of quantum field theory require all pairs of observables located in spacelike-separated regions to commute. In the theory as it is currently constituted, this implies that the information-carrying capacity of a finite volume of space is infinite. Yet Bekenstein's bound gives us strong reason to believe that it is finite. A class of quantum field theories is presented in which observables localised in spacelike-separated regions do not necessarily commute, but which nevertheless has no physical pathologies.
Constructor Theory
David Deutsch
Physics , 2012,
Abstract: Constructor theory seeks to express all fundamental scientific theories in terms of a dichotomy between possible and impossible physical transformations - those that can be caused to happen and those that cannot. This is a departure from the prevailing conception of fundamental physics which is to predict what will happen from initial conditions and laws of motion. Several converging motivations for expecting constructor theory to be a fundamental branch of physics are discussed. Some principles of the theory are suggested and its potential for solving various problems and achieving various unifications is explored. These include providing a theory of information underlying classical and quantum information; generalising the theory of computation to include all physical transformations; unifying formal statements of conservation laws with the stronger operational ones (such as the ruling-out of perpetual motion machines); expressing the principles of testability and of the computability of nature (currently deemed methodological and metaphysical respectively) as laws of physics; allowing exact statements of emergent laws (such as the second law of thermodynamics); and expressing certain apparently anthropocentric attributes such as knowledge in physical terms.
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