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Search Results: 1 - 10 of 41372 matches for " Samuel Barros Ferreira Jr. "
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Dose-Response Met-RANTES Treatment of Experimental Periodontitis: A Narrow Edge between the Disease Severity Attenuation and Infection Control
Carlos Eduardo Repeke,Samuel Barros Ferreira Jr.,Andreia Espindola Vieira,Elcia Maria Silveira,Mario Julio Avila-Campos,Jo?o Santana da Silva,Carlos Ferreira Santos,Ana Paula Campanelli,Ana Paula Favaro Trombone,Gustavo Pompermaier Garlet
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0022526
Abstract: Chemokines and chemokine receptors have been implicated in the selective migration of leukocyte subsets to periodontal tissues, which consequently influences the disease outcome. Among these chemoattractants, the chemokines CCL3, CCL4 and CCL5 and its receptors, CCR1 and CCR5, have been associated with increased disease severity in mice and humans. Therefore, in this study we investigated the modulation of experimental periodontitis outcome by the treatment with a specific antagonist of CCR1 and 5 receptors, called met-RANTES. C57Bl/6 mice was orally infected with Aggregatibacter actinomycetemcomitans and treated with 0.05, 0.1, 0.5, 1.5 and 5 mg doses of met-RANTES on alternate days, and evaluated by morphometric, cellular, enzymatic and molecular methods. At 0.5 mg up to 5 mg doses, a strong reduction in the alveolar bone loss and inflammatory cell migration were observed. Interestingly, 5 mg dose treatment resulted in the maximum inhibition of inflammatory cell migration, but resulted in a similar inhibition of bone loss when compared with the lower doses, and also resulted in increased bacterial load and CRP response. When 0.5 and 5 mg therapy regimens were compared it was observed that both therapeutic protocols were able to downregulate the levels of pro-inflammatory, Th1-type and osteoclastogenic cytokines, and CD3+ and F4/80+ cells migration to periodontal tissues, but the high dose modulates host response in a more pronounced and unspecific and excessive way, interfering also with the production of antimicrobial mediators such as MPO, iNOS and IgG, and with GR1+ and CD19+ cells migration. Our results demonstrate a thin line between beneficial immunoregulation and impaired host defense during experimental periodontitis, and the determination of the exact equilibrium point is mandatory for the improvement of immune-targeted therapy of periodontitis.
Thermomechanical Behavior Modeling of a Cr-Ni-Mo-Mn-N Austenitic Stainless Steel  [PDF]
Rafael P. Ferreira, Eden S. Silva, Carmem C. F. Nascimento, Samuel F. Rodrigues, Clodualdo Aranas Jr., Valdemar S. Leal, Gedeon S. Reis
Materials Sciences and Applications (MSA) , 2016, DOI: 10.4236/msa.2016.712062
Abstract: The analytical approach and the thermomechanical behavior of a Cr-Ni-Mo-Mn-N austenitic stainless steel were characterized based on the parameters of work hardening (h), dynamic recovery (r) and dynamic recrystallization (n, t0.5), considering constitutive equations (σ, ε) and deformation conditions expressed according to the Zener-Hollomon parameter (Z). The results indicated that the curves were affected by the deformation conditions and that the stress levels increased with Z under high work hardening rates. The σc/σp ratio was relatively high in the first part of the curves, indicating that softening was promoted by intense dynamic recovery (DRV). This was corroborated by the high values of r and average stacking fault energy, γsfe = 66.86 mJ/m2, which facilitated the thermally activated mechanisms, increasing the effectiveness of DRV and delaying the onset of dynamic recrystallization (DRX). The second part of the curves indicates that there was a delay in the kinetics of dynamic softening, with a higher value of t0.5 and lower values of the Avrami exponent (n) due to the competing DRV-DRX mechanisms, and steady state stress (σss) was achieved under higher rates of deformation.
Incidência de les?es nos jogadores de futebol masculino sub-21 durante os Jogos Regionais de Sert?ozinho-SP de 2006
Selistre, Luiz Fernando Approbato;Taube, Oswaldo Luiz Stamato;Ferreira, Luciano Maia Alves;Barros Jr, Edson Alves;
Revista Brasileira de Medicina do Esporte , 2009, DOI: 10.1590/S1517-86922009000600006
Abstract: soccer is one of the most popular and practiced sports in the world. it is a sport in which athletes are submitted to many types and effort intensities. this sport has changed over the years, and instead of emphasizing technique, currently the physical components are more favored, increasing hence the injury risk. objective: the aim of this study was to perform an epidemiological survey of sub-21 male soccer player's injuries in the regional games 2006. methods: this study was of epidemiological descriptive and analytical type, with a transversal design. all games of the modality were followed, and the injuries found were registered by their prevalence and classification. injuries were classified according to their profile and anatomical segment and according to athletes' position as well. results: the highest prevalence of injuries was found in the lower extremities 127 (74.7%), and muscular injuries were the most frequent 64 (37.6%). midfielders were the most affected players 72 (42.4%). the most frequent injury type in goalkeepers and defenders were contusions with 7 (63.6%) and 11 (50%), respectively. strikers, outside midfielders and midfielders showed mostly muscular injuries, with 11 (36.7%), 12 (34.3%) and 33 (45.8%), respectively. conclusions: in conclusion, this study demonstrated higher incidence of injuries in lower extremities in sub-21 soccer players, being muscular injuries the most common ones. the results also suggest that injuries are directly related with the characteristics of each athlete's position.
In vitro assessment of solvent evaporation from commercial adhesive systems compared to experimental systems
Nihi, Fabio Mitugui;Fabre, Hebert Samuel Carafa;Garcia, Georges;Fernandes, Karen Barros Parron;Ferreira, Flaviana Bombarda de Andrade;Wang, Linda;
Brazilian Dental Journal , 2009, DOI: 10.1590/S0103-64402009000500007
Abstract: solvents should be properly evaporated after application to dental substrates. the aim of this study was to assess the evaporation of commercial, experimental and neat solvents. the tested null hypotheses were that there are no differences in solvent evaporation regardless of its formulation and over time. evaporation from commercial adhesive systems (scotchbond multipurpose primer, scotchbond multipurpose adhesive, prime & bond nt, multi bond, excite, single bond 2, adhese primer, adhese bond, xeno iii a and xeno iii b) and experimental primers (35% hema plus 65% acetone or ethanol or water v/v) were compared to neat solvents (acetone, ethanol and water). samples (10 μl) of these products were dripped into glass containers placed on a digital precision balance. evaporation was assessed at 0, 5, 10, 15, 30, 60, 120, 300 and 600 s times to calculate mass loss. data were analyzed statistically by anova and bonferroni's correction (a=0.05). acetone-based products exhibited a remarkable capacity to evaporate spontaneously over time. neat acetone evaporated significantly more than the hema-mixtures and the commercial formulations (p<0.05). the incorporation of monomers and other ingredients in the commercial formulations seem to reduce the evaporation capacity. solvent evaporation was time and material-dependent.
A rela o de valores de potenciais consumidores de cursos de gradua o
Samuel Carvalho De Benedicto,Aline Michelli Penido da Sil,Luiz Henrique de Barros Vilas Boas,Candido Ferreira da Silva Filho
Revista Gest?o Universitária na América Latina : Revista GUAL , 2012, DOI: http://dx.doi.org/10.5007/1983-4535.2012v5n2p174
Abstract: Nowadays, the Higher Learning Institutions (IES) face great competitivity, they search a new positioning on market. The understanding of the consumer profile enables the development of positioning strategies for new products/services. Thus, it is necessary to understand the variables which need to be improved in order to make the corporate image of the organization and the satisfaction of the entrant and students with the offered education services better. This work was intended to identify the relationship of the values of potential consumers of undergraduate courses when of the choice of an IES. In-depth interviews utilizing the qualitative technique laddering, were performed which make use of the theoretical presupposed ones of the mean and purpose chains. A hierarquical value map (MHV) was constructed, which allows to identify the dominant chains which influence the consumer’s behavior in his purchasing decision. The results show the consumers’ concern about the IES which present a set of essential attributes which allow a place in the labor market and reach a range of personal aspirations. The clients/consumers investigated long for IES which possess: recognition of the society, qualified professors; high quality teaching; practical classes in specialized laboratories. Such attributes lead to diverse desirable consequences to the consumers of the education services in higher learning: the broadening of the knowledge of the student; the increase of the chances to get a job; the safety in profession practice; the conquest of the so-dreamt financial independence. Such attributes and consequences are linked to several values such as pleasure, safety, self-fulfillment, happiness, solidarity and independence/liberty.
Doen?a veno-linfática: altera??es linfocintilográficas nas úlceras venosas
Silva, José Humberto;Perez, Maria del Carmen Janeiro;Barros Jr., Newton de;Castiglioni, Mário Luiz Vieira;Novo, Neil Ferreira;Miranda Jr., Fausto;
Jornal Vascular Brasileiro , 2009, DOI: 10.1590/S1677-54492009000100006
Abstract: background: the lymphatic system plays a relevant role in any type of peripheral edema. lymphoscintigraphy is currently considered the primary test in the diagnosis of lymphatic disease of the lower limbs. although there is an association between lymphatic edema and chronic venous ulcers, the physiopathology of such changes remains uncertain. objective: to assess qualitative lymphoscintigraphic findings in patients with chronic venous ulcers of the lower limbs. methods: forty patients with unilateral chronic venous ulcer or scar were submitted to bilateral lymphoscintigraphy of the lower limbs. the sample was comprised of 25 women and 15 men, with a mean age of 53.7 years (28 to 79) and mean ulcer duration of 71.5 months (3 to 240 months). lymphoscintigraphic parameters were qualitatively compared among three groups of lower limbs previously classified according to the clinical, etiologic, anatomic and pathologic classification (ceap): i, limbs without clinical signs of venous disease or with telangiectasias and/or reticular veins (classes 0 and 1); ii, limbs with varicose veins, edema and/or skin and subcutaneous alterations (classes 2, 3 and 4); iii, lower limbs with ulcer and/or ulcer scars (classes 5 and 6). results: there was a significant difference (p < 0.001) in the comparison of lymphoscintigraphic findings of the lower limbs with (group iii - classes 5 and 6) and without ulcers/scars (groups i and ii - classes 0, 1, 2, 3 and 4). there was also a significant difference (p < 0.001) in the comparison of groups according to the clinical ceap classification: lymphoscintigraphic abnormalities were present in 72.5% in group iii (classes 5 and 6), in 30.8% in group ii (classes 2, 3 and 4), and in 7.1% in group i (classes 0 and 1). there was a statistically significant difference between group iii and the other groups with regard to radiotracer retention, inguinal adenomegaly and dermal reflux. there was no significance as to the parameters popliteal lymph node and
Biochemical and biological evaluation of gyroxin isolated from Crotalus durissus terrificus venom
Barros, LC;Soares, AM;Costa, FL;Rodrigues, VM;Fuly, AL;Giglio, JR;Gallacci, M;Thomazini-Santos, IA;Barraviera, SRCS;Barraviera, B;Ferreira Junior, RS;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2011, DOI: 10.1590/S1678-91992011000100004
Abstract: gyroxin, a thrombin-like enzyme isolated from crotalus durissus terrificus venom and capable of converting fibrinogen into fibrin, presents coagulant and neurotoxic activities. the aim of the present study was to evaluate such coagulant and toxic properties. gyroxin was isolated using only two chromatographic steps - namely gel filtration (sephadex g-75) and affinity (benzamidine sepharose 6b) - resulting in a sample of high purity, as evaluated by rp-hplc c2/c18 and electrophoretic analysis that showed a molecular mass of 30 kda. gyroxin hydrolyzed specific chromogenic substrates, which caused it to be classified as a serine proteinase and thrombin-like enzyme. it was stable from ph 5.5 to 8.5 and inhibited by mn2+, cu2+, pmsf and benzamidine. human plasma coagulation was more efficient at ph 6.0. an in vivo toxicity test showed that only behavioral alterations occurred, with no barrel rotation. gyroxin was not able to block neuromuscular contraction in vitro, which suggests that its action, at the studied concentrations, has no effect on the peripheral nervous system.
Tunneling probability for the birth of an asymptotically DeSitter universe
J. Acacio de Barros,E. V. Corrêa Silva,G. A. Monerat,G. Oliveira-Neto,L. G. Ferreira Filho,P. Romildo Jr
Physics , 2006, DOI: 10.1103/PhysRevD.75.104004
Abstract: In the present work, we quantize a closed Friedmann-Robertson-Walker model in the presence of a positive cosmological constant and radiation. It gives rise to a Wheeler-DeWitt equation for the scale factor which has the form of a Schr\"{o}dinger equation for a potential with a barrier. We solve it numerically and determine the tunneling probability for the birth of a asymptotically DeSitter, inflationary universe, initially, as a function of the mean energy of the initial wave-function. Then, we verify that the tunneling probability increases with the cosmological constant, for a fixed value of the mean energy of the initial wave-function. Our treatment of the problem is more general than previous ones, based on the WKB approximation. That is the case because we take into account the fact that the scale factor ($a$) cannot be smaller than zero. It means that, one has to introduce an infinity potential wall at $a = 0$, which forces any wave-packet to be zero there. That condition introduces new results, in comparison with previous works.
Sec??o da aorta descendente por traumatismo fechado do tórax: tratamento cirúrgico com sucesso
Gregori Jr, Francisco;Takeda, Roberto;Moure, Osney;Silva, Samuel S;Isper, José;Aquino, Walace K;Ferreira, Thelma E;Mocelin, Amilcar;Sah?o, Eduardo;Goulart, Marcos P;
Revista Brasileira de Cirurgia Cardiovascular , 1988, DOI: 10.1590/S0102-76381988000300010
Abstract: the case of a 33 year-old woman victim of an automobile accident whith a descending aorta transection due to thoracic blunt trauma surgically treated in described. the early diagnosis and treatment were responsible for the excellent postoperative results.
Space-time and hadrons
Barros, Jr., C. C.;
Brazilian Journal of Physics , 2007, DOI: 10.1590/S0103-97332007000100007
Abstract: the hadronic structure is investigated in terms of a recently proposed theory which considers the effect of the strong interaction in the space-time description. from the equations, the masses of the particles may be calculated, and quark confinement appears as a natural result, without the need of confining potentials. some properties of the considered particles, such as the topponium size, are also estimated.
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