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Search Results: 1 - 10 of 1803 matches for " Samir Eid "
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Role of vitamin-E on rat liver-amiodarone: An ultrastructural study
Zaki Mohamed Samir,Eid Refaat
Saudi Journal of Gastroenterology , 2009,
Abstract: Background/Aim: Amiodarone, a class III antiarrhythmic drug, has been found to be effective in the management of patients with life-threatening ventricular arrhythmias. The aim of this study was to test whether the co administration of vitamin-E with amiodarone can reduce amiodarone-induced liver damage. Materials and Methods: Twelve male albino rats were divided into three groups (ml vegetable oil/day by oral gavages daily for 2 weeks and were used as control group. The rats of the second group received 5.4 mg amiodarone/100 gm rat dissolved in vegetable oil daily by oral gavages for 2 weeks. In the third group, the rats received 5.4 mg amiodarone and 5 mg vitamin-E/100 gram rat dissolved in 2 ml vegetable oil by oral gavages daily for 2 weeks. Two weeks after treatment, the rats were sacrificed and liver specimens were immediately taken and processed for transmission electron microscopic examinations. Results : Sections from the rat liver receiving amiodarone examined by electron microscopy showed disrupted hepatocytes with increased vacuolations. Degenerated organelles and disrupted nuclei were observed. The microvilli of bile canaliculi were disrupted and the hepatocytes showed increased lipid contents. Both endothelial cells and Kupffer cells were damaged. Phospholipids inside the mitochondria showed a loss of cristae. Sections from the liver of rats received amiodarone and vitamin-E showed lesser effects, especially in depositions of phospholipids in the mitochondria and the whole organelles and the nucleus showed minor damage in comparison to the previous group. Conclusion: Milder hepatotoxic effects are seen in rats administered amiodarone and vitamin E simultaneously suggesting that vitamin-E may play a role in amelioration of the effects of amiodarone.
A Thiazole Analogue Exhibits an Anti-Proliferative Effect in Different Human Carcinoma Cell Lines and Its Mechanism Based on Molecular Modeling  [PDF]
Hatem K. Amin, Amr M. El-Araby, Sameh Eid, Tamer Nasr, Samir Bondock, Ola Leheta, Moustafa E. Dawoud
Advances in Biological Chemistry (ABC) , 2017, DOI: 10.4236/abc.2017.71005
Abstract: Purpose: Aim of this study is to assess the anti-proliferative effect of the thiazole analogue (5-acetyl-4-methyl-2-(3-pyridyl) thiazole) with different human carcinoma cell lines and to postulate its possible mechanism of action using molecular modeling. Methods: Three different human carcinoma cell lines were used namely hepatocyte carcinoma (HEPG2), breast adenocarcinoma (MCF7) and colon cancer (HCT116). Molecular docking simulations for tested thiazole analogue and its virtual analogues against the cytochrome P-450 2A6 enzyme and mutated SOD were performed. Results: Cell lines cytotoxicity revealed that the tested thiazole analogue exerts a significant anti-proliferative activity in all the used human carcinoma cell lines with a pronounced anti-proliferative effect in liver carcinoma cell line HEPG2 (IC50 = 23.8 μg/ml) whereas the anti-proliferative effect in colon carcinoma and breast cancer cell lines was poor with IC50 = 50 μg/ml and IC50 > 50 μg/ml respectively. The postulated mechanism of action revealed the high affinity to inhibit SOD and CYP2A6 enzymes in the liver. Conclusion: The thiazole analogue (5-acetyl-4-methyl-2-(3-pyridyl)thiazole) is a potential liver specific anticancer agent capable of interfering with both apoptotic signaling pathway and the free radical processing in liver which leads to more studies on liver cancer from different perspective rather than the apoptotic signaling pathway.
Kidney Manifestations of Inflammatory Bowel Diseases  [PDF]
Kawthar Braysh, Alice Gerges Geagea, Charbel Matar, Manfredi Rizzo, Assaad Eid, Liliane Massaad-Massade, Samir Mallat, Abdo Jurjus
Open Journal of Gastroenterology (OJGas) , 2018, DOI: 10.4236/ojgas.2018.85020
Abstract: Inflammatory bowel disease (IBD) is profoundly associated with extraintestinal manifestations (EIM) that can involve almost every organ in our body. Although the exact etiology of IBD is still poorly understood, it is generally characterized by an overly aggressive inflammatory response in the intestinal mucosa. Renal damage is one of the manifestations encountered in Crohn’s disease (CD) and ulcerative colitis (UC) and it accounts for 4% - 23% of IBD patients. The common renal complications of IBD include: glomerulonephritis, tubulointerstitial nephritis, nephrolithiasis, amyloidosis and iatrogenic complications of IBD treatment. Several hypotheses have emerged to explain the pathogenic mechanisms underlying the prevalence of IBD-induced kidney injuries. The present work aims to elucidate the pathological principles that drive secondary renal injury in individuals with IBD and highlight the currently used therapeutic strategies for evaluating, monitoring and treating kidney complications-related IBD.
The Impact of Neutrophil to Lymphocytic Ratio (NLR) as a Predictor of Treatment Outcomes in Rectal Carcinomas: A Retrospective Cohort Study  [PDF]
Samir Eid, Hoda Hasan, Doaa Abdel-Aleem, Amal Rayan
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.109064
Abstract: Background and aim: The prognostic role of neutrophil to lymphocyte ratio (NLR) has been shown in many solid tumors included in a recent meta-analysis of one hundred studies. We aimed to evaluate the prognostic value of neutrophil to lymphocyte ratio in treatment outcomes; response and survival of patients with different stages of rectal cancers. Patients and methods: All patients with pathologically confirmed cancer rectum presented to our department during the period from January 2012 to the end of 2014 were included in this retrospective study, these recruited patients were evaluated through their files to determine different objectives of our study. Results: The median overall survival was 31 ± 4.676 months while disease free survival was 40 ± 2.346 for the whole study group; neutrophil to lymphocyte ratio was negatively correlated with overall survival with r = 0.743, P < 0.001, also with disease free survival with r = 0.717, P < 0.0001. Neutrophil to lymphocyte ratio was positively correlated with the number of positive lymph nodes dissected to total number of lymph nodes dissected ratio with r = +0.254, P =
Copy-Move Forgeries Detection and Localization Using Two Levels of Keypoints Extraction  [PDF]
Soad Samir, Eid Emary, Khaled Elsayed, Hoda Onsi
Journal of Computer and Communications (JCC) , 2019, DOI: 10.4236/jcc.2019.79001
Abstract: Copy-move offense is considerably used to conceal or hide several data in the digital image for specific aim, and onto this offense some portion of the genuine image is reduplicated and pasted in the same image. Therefore, Copy-Move forgery is a very significant problem and active research area to check the confirmation of the image. In this paper, a system for Copy Move Forgery detection is proposed. The proposed system is composed of two stages: one is called the detection stages and the second is called the refine detection stage. The detection stage is executed using Speeded-Up Robust Feature (SURF) and Binary Robust Invariant Scalable Keypoints (BRISK) for feature detection and in the refine detection stage, image registration using non-linear transformation is used to enhance detection efficiency. Initially, the genuine image is picked, and then both SURF and BRISK feature extractions are used in parallel to detect the interest keypoints. This gives an appropriate number of interest points and gives the assurance for finding the majority of the manipulated regions. RANSAC is employed to find the superior group of matches to differentiate the manipulated parts. Then, non-linear transformation between the best-matched sets from both extraction features is used as an optimization to get the best-matched set and detect the copied regions. A number of numerical experiments performed using many benchmark datasets such as, the CASIA v2.0, MICC-220, MICC-F600 and MICC-F2000 datasets. With the proposed algorithm, an overall average detection accuracy of 95.33% is obtained for evaluation carried out with the aforementioned databases. Forgery detection achieved True Positive Rate of 97.4% for tampered images with object translation, different degree of rotation and enlargement. Thus, results from different datasets have been set, proving that the proposed algorithm can individuate the altered areas, with high reliability and dealing with multiple cloning.
ESR Dosimetric Study on Gamma Induced Radicals in DL-Ornithine Hydrochloride  [PDF]
Sayeda Eid
Open Journal of Polymer Chemistry (OJPChem) , 2013, DOI: 10.4236/ojpchem.2013.31005
Abstract:

DL-ornithine hydrochloride rods (3 ×10 mm) were studied to be a radiation sensitive material for EPR dosimetry. The rods have specified EPR signal developed under irradiation and its intensity increases with the increase in absorbed dose. The intensity also affected by the concentration of DL-ornithine in the rods. The prepared rods can be used in the dose range from 0.5 - 50 kGy. The obtained number of free radicals per 100 eV (G value) was found to be 0.3551 ± 0.0333. The hyperfine (hf) coupling constant is 2.325 mT at g-factor 2.033. The rods have the advantage of negligible humidity effects during irradiation. The pre and post- irradiation stability was found to be satisfactory.

A New Full-NT-Step Infeasible Interior-Point Algorithm for SDP Based on a Specific Kernel Function  [PDF]
Samir Bouali, Samir Kabbaj
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.39150
Abstract: In this paper, we propose a new infeasible interior-point algorithm with full NesterovTodd (NT) steps for semidefinite programming (SDP). The main iteration consists of a feasibility step and several centrality steps. We used a specific kernel function to induce the feasibility step. The analysis is more simplified. The iteration bound coincides with the currently best known bound for infeasible interior-point methods.
Anti-Metastatic and Anti-Tumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling and Reduction of Nitric Oxide Production
Yusra Al Dhaheri, Samir Attoub, Kholoud Arafat, Synan AbuQamar, Jean Viallet, Alaaeldin Saleh, Hala Al Agha, Ali Eid, Rabah Iratni
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068808
Abstract: Background We have recently reported that Origanum majorana exhibits anticancer activity by promoting cell cycle arrest and apoptosis of the metastatic MDA-MB-231 breast cancer cell line. Here, we extended our study by investigating the effect of O. majorana on the migration, invasion and tumor growth of these cells. Results We demonstrate that non-cytotoxic concentrations of O. majorana significantly inhibited the migration and invasion of the MDA-MB-231 cells as shown by wound-healing and matrigel invasion assays. We also show that O. majorana induce homotypic aggregation of MDA-MB-231 associated with an upregulation of E-cadherin protein and promoter activity. Furthermore, we show that O. majorana decrease the adhesion of MDA-MB-231 to HUVECs and inhibits transendothelial migration of MDA-MB-231 through TNF-α-activated HUVECs. Gelatin zymography assay shows that O. majorana suppresses the activities of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9). ELISA, RT-PCR and Western blot results revealed that O. majorana decreases the expression of MMP-2, MMP-9, urokinase plasminogen activator receptor (uPAR), ICAM-1 and VEGF. Further investigation revealed that O. majorana suppresses the phosphorylation of IκB, downregulates the nuclear level of NFκB and reduces Nitric Oxide (NO) production in MDA-MB-231 cells. Most importantly, by using chick embryo tumor growth assay, we also show that O. majorana promotes inhibition of tumor growth and metastasis in vivo. Conclusion Our findings identify Origanum majorana as a promising chemopreventive and therapeutic candidate that modulate breast cancer growth and metastasis.
Mitotic Arrest and Apoptosis in Breast Cancer Cells Induced by Origanum majorana Extract: Upregulation of TNF-α and Downregulation of Survivin and Mutant p53
Yusra Al Dhaheri, Ali Eid, Synan AbuQamar, Samir Attoub, Mohammad Khasawneh, Ghenima Aiche, Soleiman Hisaindee, Rabah Iratni
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056649
Abstract: Background In the present study, we investigated the effect of Origanum majorana ethanolic extract on the survival of the highly proliferative and invasive triple-negative p53 mutant breast cancer cell line MDA-MB-231. Results We found that O. majorana extract (OME) was able to inhibit the viability of the MDA-MB-231 cells in a time- and concentration-dependent manner. The effect of OME on cellular viability was further confirmed by the inhibition of colony growth. We showed, depending on the concentration used, that OME elicited different effects on the MDA-MB 231 cells. Concentrations of 150 and 300 μg/mL induced an accumulation of apoptotic–resistant population of cells arrested in mitotis and overexpressing the cyclin-dependent kinase inhibitor, p21 and the inhibitor of apoptosis, survivin. On the other hand, higher concentrations of OME (450 and 600 μg/mL) triggered a massive apoptosis through the extrinsic pathway, including the activation of tumor necrosis factor-α (TNF-α), caspase 8, caspase 3, and cleavage of PARP, downregulation of survivin as well as depletion of the mutant p53 in MDA-MB-231 cells. Furthermore, OME induced an upregulation of γ-H2AX, a marker of double strand DNA breaks and an overall histone H3 and H4 hyperacetylation. Conclusion Our findings provide strong evidence that O. majorana may be a promising chemopreventive and therapeutic candidate against cancer especially for highly invasive triple negative p53 mutant breast cancer; thus validating its complementary and alternative medicinal use.
Investigation of Dyed Film Based on Quinaldine Red Dyed Poly(Vinyl Alcohol) and Poly(Vinyl Butyral) for High Dose Dosimetry Applications  [PDF]
Wafaa B. Beshir, Sayeda Eid
Open Journal of Polymer Chemistry (OJPChem) , 2012, DOI: 10.4236/ojpchem.2012.23015
Abstract: Dyed polymer films, prepared by a simple technique of casting aqueous solutions of poly(vinyl alcohol) PVA or poly(vinyl butyral) PVB containing quinaldine red (QR) on a horizontal glass plate, are useful as routine high-dose dosimeters. These flexible plastic film dosimeters are bleached when exposed to gamma rays. The response of these dosimeters depends on the concentration of QR and the polymer material. The radiation chemical yield (G-value) of both PVA and PVB dyed films was calculated and was found to increase with increasing dye concentration. The effect of relative humidity during irradiation as well as pre- and post-irradiation storage, on the response of the films is examined. These films are not affected by humidity change in the intermediate range of 10% - 50%.
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