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Search Results: 1 - 10 of 553 matches for " Samar Kassim "
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Profile Hidden Markov Model for Detection and Prediction of Hepatitis C Virus Mutation
Mohamed El Nahas,Samar Kassim,Nabila Shikoun
International Journal of Computer Science Issues , 2012,
Abstract: Hepatitis C virus (HCV) is a widely spread disease all over the world. HCV has very high mutation rate that makes it resistant to antibodies. Modeling HCV to identify the virus mutation process is essential to its detection and predicting its evolution. This paper presents a model of HCV based on profile hidden Markov model (PHMM) architecture. An iterative model learning procedure is proposed and applied to both full-length sequence of virus and its very high variation (mutation) zone called NS5A. A pilot study on HCV dataset of type 4 is conducted which is of special concern in Egypt
Model Based Framework for Estimating Mutation Rate of Hepatitis C Virus in Egypt
Nabila Shikoun,Mohamed El Nahas,Samar Kassim
Computer Science , 2013,
Abstract: Hepatitis C virus (HCV) is a widely spread disease all over the world. HCV has very high mutation rate that makes it resistant to antibodies. Modeling HCV to identify the virus mutation process is essential to its detection and predicting its evolution. This paper presents a model based framework for estimating mutation rate of HCV in two steps. Firstly profile hidden Markov model (PHMM) architecture was builder to select the sequences which represents sequence per year. Secondly mutation rate was calculated by using pair-wise distance method between sequences. A pilot study is conducted on NS5B zone of HCV dataset of genotype 4 subtype a (HCV4a) in Egypt.
A Comparison of the Effects of Epidural Anesthesia, Lumbar Paravertebral Block and General Anesthesia in Percutaneous Nephrolithotomy
Md. Eman Elbealy,Md. Doaa Rashwan,Md. Samaa A. Kassim,Md. Samar Abbas
Journal of Medical Sciences , 2008,
Abstract: The present study evaluated the effects of lumbar epidural anesthesia (E) vs lumbar paravertebral block (P) and general anesthesia (G) with respect to intraoperative mean arterial blood pressure, heart rate, postoperative pain intensity, analgesic requirements and postoperative complications in patients undergoing percutaneous nephrolithotomy. The study included 57 patients undergoing percutaneous nephrolithotomy, patients were randomly allocated into three groups. Paravertebral group (P) (n = 18), Epidural group (E) (n = 19), General group (G) (n = 20), non invasive mean arterial blood pressure, intraoperative heart rate, the severity of postoperative pain for 24 h using (VAS), number of patients require analgesia, incidence of side effects: nausea, vomiting, urine retention were evaluated in all patients. Three patients were excluded from the study (2 in P group and 1 in E group) because of technical failure. Intraoperative mean arterial blood pressure was significantly lower in E group compared to P and G groups (p<0.05). Intraoperative heart rate shows no significant difference between P, E and G groups. The severity of postoperative pain were significantly less in P group compared to E and G groups (p<0.05), number of patients requiring postoperative analgesia was significantly lower in P group compared to E and G groups (p<0.05). Number of patients having postoperative nausea and vomiting was significantly higher in G group than in the P group and E group (p<0.05). Lumbar paravertebral block with bupivacain 0.5% was associated with more intraoperative hemodynamic stability, reduced postoperative pain and significantly decreased the postoperative analgesic requirements than epidural anesthesia and general anesthesia in patients undergoing percutaneous nephrolithotomy without increasing the incidence of PONV.
Disparity between Ideals and Reality in Curriculum Construction: The Case of the Lebanese English Language Curriculum  [PDF]
Kassim Ali Shaaban
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.412A2005
Abstract: This paper describes the disparity between the principles, guidelines, suggested themes, organization, methodology, classroom activities, and assessment outlined in the thematic, content-based English language curriculum adopted by the Lebanese government in 1997 and the classroom realities and other contextual factors that have hampered its proper implementation. The paper shows that the curriculum is designed in line with international ESL/EFL standards as it has clear goals, objectives, and performance indicators as well as sound perspectives on instruction, material selection and adaptation, and evaluation guidelines. These perspectives are based on widely accepted theoretical views in language acquisition and best practices in English language education. However, the content-based curriculum normally demands a high level of language proficiency and content and pedagogical knowledge from teachers, and it is highly dependent on the availability of adequate resources and ongoing professional development programs. The educational context in Lebanon still suffers the effects of the 1975-1990 civil war in these areas, which has made the implementation fraught with all sorts of problems.
Molecular Docking Investigation of New Inhibitors of Falciparum vivax  [PDF]
Kassim Adebambo, Sinthusan Gunaratnam
Computational Molecular Bioscience (CMB) , 2018, DOI: 10.4236/cmb.2018.82002
Abstract: Despite the vigorous research and development, as of 2017, there is currently no widely available antimalarial vaccine. An effective, commercially available vaccine would be a huge game changer; however, it seems like there is still a long way to go until that target is reached. Therefore, the purpose of this study was to use molecular docking technique to identify new inhibitors for a novel antimalarial target with the overall aim of finding hit compounds which could be further optimized to become potential drug candidates. The docking protocol AutoDockVina was used alongside the molecular visualisation software UCSF Chimera to dock 100 naphthoquinones (labelled TM1-100) and 66 aryl diketones (labelled TM101-166) with the chosen target, Plasmodium vivax N-myristoyltransferase (PvNMT). Each docking session yielded the best 9 binding modes between the ligand and target. The hydrogen bond interactions of all binding modes were analysed, and the top six target molecules (TM) were short listed as the possible hit compounds (TM40, TM65, TM66, TM81, TM94 and TM165). These compounds displayed more than six hydrogen bonds under 3 angstroms over the 9 binding modes. Using Lipinski’s rule of 5, the potential hit compounds were further analysed to determine the drug-likeness and all were found to obey the parameters. Following the same method used to dock the ligands, twelve FDA approved antimalarial drugs were also docked with PvNMT for comparison purposes. Apart from proguanil, the other eleven antimalarial drugs displayed fewer hydrogen bonds under 3 angstroms over the 9 binding modes compared to all six of the potential hit compounds. This study discovered six compounds which displayed stronger interactions with the target protein compared to majority of the FDA approved drugs. The results of this investigation gave us new molecules that could be further investigated for the designing of novel drug-like compounds for the treatment of Malaria.
Emerging Business Trends in the Microelectronics Industry  [PDF]
Samar K. Saha
Open Journal of Business and Management (OJBM) , 2016, DOI: 10.4236/ojbm.2016.41012
Abstract: This paper describes the emerging trends in the major business segments of the integrated circuit industry. As the integrated circuit technology approaches its ultimate scaling limit, the different segments of the industry are evolving continuously by adopting new business strategies to gain competitive advantage: the manufacturing is persistently releasing next generation technologies, dedicated foundries are transitioning to complete product development solution providers, fabless companies are adopting innovative business strategies, integrated device manufacturers are transitioning to fab-lite, and the assembly and test is developing scaled packages. This paper discusses the evolution of these major business segments in the microelectronics industry.
Transitioning Semiconductor Companies Enabling Smart Environments and Integrated Ecosystems  [PDF]
Samar K. Saha
Open Journal of Business and Management (OJBM) , 2018, DOI: 10.4236/ojbm.2018.62031
This paper discusses the business opportunities to the semiconductor companies transitioning from “pure-play” compute-focused chip providers only to complete solution providers enabling smart environments and integrated ecosystems. The semiconductor industry has led to the foundation of the Internet and Information age. The Internet enables connecting smart devices or “things” to be operated without human interactions creating Internet of Things (IoT). The IoT-enabled smart devices are being integrated into a single ecosystem with a shared user interface for healthcare, security, energy saving, automation, autonomous vehicles, telecommunications, computers, entertainment, and so on. Thus, the IoT offers semiconductor companies great business opportunities to provide IoT-enabling components for interoperability as well as system integration and software support. In this paper, the key IoT-enabling technologies and role of semiconductor companies transitioning from component suppliers only to complete IoT solution providers enabling smart environments and integrated ecosystems are discussed.
Engineering, Project, and Production Management: Lessons
Kassim Gidado
Journal of Engineering, Project, and Production Management , 2013,
Abstract: This Journal always faces the challenge of bringing together the three disciplines in a common pool of management research. This edition provides at least a paper in each of the disciplines. Although each paper has a clearly defined focus in a specific discipline, the contribution of knowledge by each seems relevant to all three disciplines. This reinforces the need to further integrate the managerial aspects of the three disciplines for mutual benefits.
The Professional Medical Journal , 2002,
Abstract: OBJECTIVES: To determine the impact of mode of delivery on perinatal maternal outcome in breech presentation.To scrutinize the causes of increasing incidence of caesarean section in breech presentation. DESIGN: Prospective study.PERIOD: The study was conducted in Department of Obstetrics and Gynaecology Unit I (PMC) Allied HospitalFaisalabad and completed in two years. SUBJECTS & METHODS: This study includes 5022 patients admitted inantenatal and labour ward, out of them 255 were with breech presentation, who were analyzed in detail with help ofproforma. Final out come regarding mother and fetus was compared in both groups of vaginal and abdominal delivery.Ante-partum deaths and congenital anomalies were excluded. RESULTS: 103 (39.6%) patients were delivered bycaesarean section much higher than Vertex (12%), 154 were delivered vaginally. Perinatal outcome was slightly higherin vaginal group. While maternal morbidity was significantly low in those delivered vaginally. CONCLUSION: Weconcluded that with goods antenatal care vaginal breech deliveries at term are relatively safe if selected on basis of setprotocol and rising incidence of caesarean section in breech presentation can be reduced.
Birth centenary of Sir Harold Ridley (10th July 1906 - 25th May 2001)
Basak Samar
Indian Journal of Ophthalmology , 2006,
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