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Search Results: 1 - 10 of 120380 matches for " Sam T. Mathew "
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Rationale and Role of High Loading Dose Clopidogrel in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention  [PDF]
Sam T. Mathew, Gayathri Devi S, Prasanth V. V, Vinod B
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.34066
Abstract: Antiplatelet therapy, which reduces platelet activation and aggregation, is the corner stone of treatment for patients undergoing percutaneous coronary intervention (PCI). Clopidogrel is an established oral antiplatelet medication of thienopyridine class, which inhibits blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Many studies have revealed that high loading dose clopidogrel in patients undergoing PCI. This review article investigates the rationale and role of high loading dose clopidogrel in patients undergoing PCI.
Prasanth V.V,Mitesh P Modi,Sam T. Mathew
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: In the field of modified release, this review covers the detail aspect of a novel pulsatile drug delivery systems (PDDS) by oral administration that aims to release drugs on a programmed pattern at specific time and specific site as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. In particular, the recent literature reports on a variety of pulsatile release systems intended for the oral route, which have been recognised as potentially beneficial to the chronotherapy of widespread diseases. Asthma, peptic or deodenal ulcer, diabetes, neurological disorder, hypertension, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia these kind of diseases are promising by pulsatile drug delivery. Technically, This system is designed for chronopharmacotherapy which is based on circadian rhythm and beneficial for the drugs having chronopharmacological behavior where night time dosing is required and for the drugs having high first-pass effect and specific site of absorption in gastrointestinal tract. This controlled–release system can maintain the drug concentration within the therapeutic window with a single dose, which lowers the systemic drug level and also preserves medication that rapidly destroyed by the body. Pulsatile drug delivery system is time related or site-specific related to drug released at the desired site within the intestinal tract (e.g., the colon). Pulsatile drug delivery systems are formulated when zero order drug release is not desired. Based on these premises, the aim of this review is to outline the rational and prominent design strategies behind oral pulsatile delivery. Capsular systems, osmotic systems, soluble or erodible polymer coating and rupturable membranes etc. are summarized in this pulse article. Various marketed technologies on pulsatile drug delivery like OROS, PULSINCAP, GEOCLOCK, SODAS, CODAS, etc., were launched by pharmaceutical companies.
Prasanth V V,Akashmoy Chakraborty*,Sam T Mathew,G Parthasarathy
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: Salbutamol sulphate (SS) loaded alginate microspheres were prepared by ionotropic gelation method with calcium chloride, barium chloride, aluminium sulphate and magnesium aluminium silicate. A total of 16 formulations were prepared and formulations A1, A2, A3, B1, B2, B3, C1, C2, C3, D1, D2 and D3 were dried in hot air oven and A4, B4, C4 and D4 dried at room temperature. The particle size of the hot air oven dried microspheres varied between 0.782±0.02 and 0.985±0.03 μm and for air dried between 0.99±0.04 and 1.22±0.06μm.The drug content of the hot air oven dried microspheres varied between 77.28±2.8 and 96.18±1.1 mg and for air dried it shows between 82.98±3.2 and 98.34±1.7 mg. The release data were analyzed on the basis of Korsmeyer-Peppas equation and Higuchi kinetics. The release rates k and n of each model were calculated by linear regression analysis. Coefficients of correlation (r2) were used to evaluate the accuracy of the fit. During and at the end of the accelerated stability study, the tested microspheres showed almost similar drug content and drug release as observed at the beginning of the study.
Efficacy and Safety of COX-2 Inhibitors in the Clinical Management of Arthritis: Mini Review
Sam T. Mathew,Gayathri Devi S,V. V. Prasanth,B. Vinod
ISRN Pharmacology , 2011, DOI: 10.5402/2011/480291
Abstract: In the clinical management of arthritis, the choice of nonsteroidal anti inflammatory drug (NSAID) remains confusing and controversial. A common practice on the choice of NSAID in clinical management of arthritis is the risk benefit ratio. The main objective of this review is to addresses the main arguments for the pharmacological and clinical use of COX-2 inhibitors in relation to nonselective NSAIDs for the clinical management of arthritis. This review concluded that, both NSAIDs and COX-2 inhibitors are equally effective and are associated with increased risk of GI, renal, and CV, adverse effects. Complete understanding of the patient's comorbid conditions and concomitant medications, coupled with precise monitoring during the treatment, may help to decrease the threat of adverse effects induced by nonselective NSAIDs and selective COX-2 inhibitors. 1. Introduction Arthritis is a complex disorder that comprises more than hundred distinct conditions involving damage to the joints of the body. Many mediators are known to be involved in the pathophysiology and progression of arthritis. These include cartilage-degrading enzymes, cytokines, leukotrienes (LTs), and prostaglandins (PGs). LTs and PGs are produced by the activity of three enzymes–5-lipoxygenase, cyclooxygenase (COX)-1 and COX-2–as part of the arachidonic acid (AA) pathway. PGs have various physiological and pathophysiological effects. PGs produced by COX-1 isoenzyme exert house-keeping functions, including gastric mucosal defense and renal homeostasis, whereas COX-2 synthesizes detrimental PGs which are responsible for inflammation and pain. The activity of COX-2 leads to production of a narrower spectrum of PGs, specifically PGE2 and PGI2. The vasodilatory properties of these two molecules increase mucus production and reduce acid and pepsin levels in the stomach, thereby protecting the integrity of the gastrointestinal (GI) mucosa [1–4]. The ultimate goal for arthritis treatment is the modification of disease progression, in combination with anti-inflammatory and analgesic efficacy [5–7]. Traditional nonselective, nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used to relieve the pain and inflammation due to osteoarthritis and rheumatoid arthritis. These drugs possess potent anti-inflammatory, analgesic, and antipyretic activity and are among the most widely used drugs worldwide and represent a mainstay in the treatment of acute and chronic pain [8]. However, numerous reported adverse drug reactions, case-control, and postmarketing surveillance studies have revealed that
Modeling And Closed Loop Control Of Bldc Motor Using A Single Current Sensor
International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering , 2013,
Abstract: For closed loop current control of BLDC motor, the motor phase currents are measured using current sensors. These sensors are bulky, heavy and expensive. Also the use of different current sensors can cause undesirable imbalance in phase currents as well as torque fluctuations due to differences in current sensor sensitivities. These drawbacks can be avoided by using a single current sensor placed on the DC link. Here an algorithm is presented to obtain the phase current values from the DC link current. The proposed and conventional systems were simulated using MATLAB/Simulink, to compare their performance.
A Small Genomic Region Containing Several Loci Required for Gastrulation in Drosophila
Sam J. Mathew,Stephen Kerridge,Maria Leptin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007437
Abstract: Genetic screens in Drosophila designed to search for loci involved in gastrulation have identified four regions of the genome that are required zygotically for the formation of the ventral furrow. For three of these, the genes responsible for the mutant phenotypes have been found. We now describe a genetic characterization of the fourth region, which encompasses the cytogenetic interval 24C3-25B, and the mapping of genes involved in gastrulation in this region. We have determined the precise breakpoints of several existing deficiencies and have generated new deficiencies. Our results show that the region contains at least three different loci associated with gastrulation effects. One maternal effect gene involved in ventral furrow formation maps at 24F but could not be identified. For a second maternal effect gene which is required for germ band extension, we identify a candidate gene, CG31660, which encodes a G protein coupled receptor. Finally, one gene acts zygotically in ventral furrow formation and we identify it as Traf4.
Veeva Mathew,Sam Thomas,Joseph I Injodey
Economic Review : Journal of Economics and Business , 2012,
Abstract: Brand equity has been and will be an area of interest for marketing managers. All marketing efforts are directed toward the development ofbrand equity. Therefore efforts are taken among the researchers, to understand the concept of brand equity as deep as possible.This paper attempts to understand the interrelationships among key formative indicators of brand equity, using beliefattitude- intention hierarchy of effects. The formative indicators include brand credibility, brand commitment, and loyalty intentions. Using Sequential Chi-square Difference Test in Structural Equations Modelling, the researchers identified the mediating role of brand commitment and loyalty intentions, in the formation of brand equity.
Strong correlation effects in single-wall carbon nanotubes
Sam T. Carr
Physics , 2008, DOI: 10.1142/S0217979208049455
Abstract: We present an overview of strong correlations in single-wall carbon nanotubes, and an introduction to the techniques used to study them theoretically. We concentrate on zigzag nanotubes, although universality dictates that much ofthe theory can also be applied to armchair or chiral nanotubes. We show how interaction effects lead to exotic low energy properties and discuss future directions for studies on correlation effects in nanotubes.
A Wideband Microstrip-Line-FED Isosceles Trapezoidal Dielectric Resonator Antenna with Modified Ground Plane
C. Gopakumar;K. T. Mathew
PIER C , 2010, DOI: 10.2528/PIERC10080804
Abstract: A microstrip-line-fed Isosceles Trapezoidal Dielectric Resonator Antenna (ITDRA) with a parasitic strip and modified ground plane is introduced. It is proved by simulation and experiment that the antenna's resonant frequency can be lowered and the bandwidth can be increased considerably by introducing a slot and optimizing its position and dimensions in the ground plane. The proposed antenna is a wide band antenna with a 2:1 VSWR bandwidth of 21.5% centered at 2.51GHz and exhibits good radiation characteristics and moderate gain in the entire operating band. The antenna covers important application bands viz. ISM: Bluetooth/WLAN 2.4/Wibree (802.11 b/g/n)/ZigBee, WiBro and DMB. The wideband response in the relatively lower frequency range which includes the above mentioned application bands are not much seen anywhere in literature. Details of the design along with experimental and simulation results are presented and discussed.
Neuroprotective and immune effects of active forms of vitamin D3 and docosahexaenoic acid in Alzheimer disease patients
Milan Fiala,Mathew T. Mizwicki
Functional Foods in Health and Disease , 2011,
Abstract: ABSTRACT:Neurodegenerative diseases, in particular Alzheimer disease (AD), afflict an increasing proportion of the older population with aging. Decreased exposure to sunlight and decreased consumption of fish, fruits, and vegetables, are two epidemiological factors that appear to be related to the pandemic of AD. In addition to replacing simple with complex carbohydrates and avoiding saturated fat, two nutritional components, vitamin D (acting through the endogenous hormonal form 1 ,25 dihydroxyvitamin D, 1,25D) and docosahexaenoic acid (DHA) (acting through the docosanoid lipidic modulators resolvins and neuroprotectins) have high potential for prevention of Alzheimer disease. 1,25D is a neuroprotective, it acts both directly and indirectly in neurons by improving the clearance of amyloid-beta by macrophages/microglia. Resolvins and neuroprotectins inhibit amyloidogenic processing of amyloid-precursor protein, inflammatory cytokines, and apoptosis. It is likely that the increased consumption of vitamin D and fish oil could prevent neurodegeneration in some subjects by maintaining adequate endocrine, paracrine, and/or autocrine production of 1,25D and the DHA-derived lipidic modulators. Before firm recommendations of the dosage can be proposed, however, the in vivo effects of vitamin D3 and DHA supplementation should be investigated by prospective studies.
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