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Search Results: 1 - 10 of 1830 matches for " Salvatore Rubino "
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Plankton Resting Stages in the Marine Sediments of the Bay of Vlor? (Albania)
Fernando Rubino,Salvatore Moscatello,Manuela Belmonte,Gianmarco Ingrosso,Genuario Belmonte
International Journal of Ecology , 2013, DOI: 10.1155/2013/101682
Abstract: In the frame of the INTERREG III CISM project, sediment cores were collected at 2 stations in the Gulf of Vlor? to study the plankton resting stage assemblages. A total of 87 morphotypes were identified and produced by Dinophyta, Ciliophora, Rotifera, and Crustacea. In 22 cases, the cyst belonged to a species absent from the plankton of the same period. The most abundant resting stages were those produced by Scrippsiella species (Dinophyta). Some calcareous cysts were identified as fossil species associated with Pleistocene to Pliocene sediment, although they were also found in surface sediments and some of them successfully germinated, thus proving their modern status. Total abundance generally decreased with sediment depth at station 40, while station 45 showed distinct maxima at 3 and 8?cm below the sediment surface. The depth of peak abundance in the sediment varied with species. This paper presents the first study of the plankton resting stages in the Bay of Vlor?. The study confirmed the utility of this type of investigation for a more correct evaluation of species diversity. In addition, the varying distribution with sediment depth suggests that this field could be of some importance in determining the history of species assemblages. 1. Introduction Resting stages produced by plankton organisms in temperate seas accumulate in the bottom sediments of confined coastal areas [1]. Their assemblages represent reservoirs of biodiversity which sustain the high resilience of plankton communities, providing recruits of propagules at each return of favourable conditions, in accordance with the so-called Supply Vertical Ecology model [2]. The existence of benthic stages in the life cycles of holoplankton provides a new key for understanding the role of life cycles in the pelagic-benthic relationship in coastal waters [3, 4]. Consequently, assessments of biodiversity at marine sites should take account of the unexpressed fraction of the plankton community contained in the bottom sediments by performing integrated sampling programs [5, 6]. Despite the proven importance of resting stage banks in coastal marine ecology, the issue of “resting versus active” plankters has commonly been considered for single taxa and only rarely from the whole-community point of view. This is probably due to the great complexity (compositional, functional, and distributional) of resting stage banks. Indeed, it has been demonstrated that at any given moment the species assemblages in bottom sediments (as resting stages) are quite different from the species detectable in the water
Rituximab ameliorated severe hearing loss in Cogan's syndrome: a case report
Jelka G Orsoni, Bruno Laganà, Pierangela Rubino, Laura Zavota, Salvatore Bacciu, Paolo Mora
Orphanet Journal of Rare Diseases , 2010, DOI: 10.1186/1750-1172-5-18
Abstract: a 25-year-old Italian woman was referred with conjunctival hyperaemia, interstitial keratitis, moderate bilateral sensorineural hearing loss accompanied by tinnitus, dizziness, nausea and vertigo, poorly responsive to oral and topical steroidal therapy. Diagnosis of typical CS was made. The administration of a combined immunosuppressive treatment resolved ocular inflammation, dizziness, nausea, and vertigo but gave little results in controlling progressive hearing loss. A noticeable improvement in hearing function was documented by pure tone audiometry after infusion of Rituximab.in CS, hearing function is often the most difficult parameter to control with therapy. A positive effect of Rituximab on was observed in our case. The drug also allowed to significantly reduce the number of adjuvant immunosuppressive medications.Rituximab is a chimeric human-mouse monoclonal antibody against lymphocyte CD20 surface antigen, and treatment induces depletion of B lymphocytes by various mechanisms. These antibodies are thought to act in vivo mostly through activation of antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, although direct growth inhibition and/or induction of apoptosis may also take place [1]. Rituximab is presently approved for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis. Here is the first report of the use of this drug in a case of severe Cogan's syndrome (CS).A 25-year-old Italian woman developed severe bilateral sensorineural hearing loss over the course of 12 months from her first acute inflammatory episode characterized by conjunctival hyperaemia, interstitial keratitis and tinnitus. Before the admission, the patient had already experienced a 3-week regimen of oral prednisone (50 mg/day at regressive dosage) and dexametasone eye-drops with poor response. After the patient had been screened for a possible infectious origin of her symptoms and all other known causes of interstitial keratitis had been exclu
Effects of crp deletion in Salmonella enterica serotype Gallinarum
Valentina Rosu, Mark S Chadfield, Antonella Santona, Jens P Christensen, Line E Thomsen, Salvatore Rubino, John E Olsen
Acta Veterinaria Scandinavica , 2007, DOI: 10.1186/1751-0147-49-14
Abstract: Mutants were constructed in S. Gallinarum by P22 transduction from Salmonella Typhimurium (S. Typhimurium) with deletion of the crp gene. The effect was characterized by measuring biochemical properties and by testing of invasion in a chicken loop model and by challenge of six-day-old chickens. Further, birds were immunized with the deleted strain and challenged with the wild type isolate.The crp deletions caused complete attenuation of S. Gallinarum. This was shown by ileal loop experiments not to be due to significantly reduced invasion. Strains with such deletions may have vaccine potential, since oral inoculatoin with S. Gallinarum Δcrp completely protected against challenge with the same dose of wild type S. Gallinarum ten days post immunization. Interestingly, the mutations did not cause the same biochemical and growth changes to the two biotypes of S. Gallinarum. All biochemical effects but not virulence could be complemented by providing an intact crp-gene from S. Typhimurium on the plasmid pSD110.Transduction of a Tn10 disrupted crp gene from S. Typhimurium caused attenuation in S. Gallinarum and mutated strains are possible candidates for live vaccines against fowl typhoid.The avian host specific serotype Salmonella enterica serotype Gallinarum consists of two biovars, gallinarum and pullorum (S. Gallinarum and S. Pullorum) [1]. They are considered the causative agents of two distinct diseases, fowl typhoid and pullorum disease, which occur especially in countries with less developed poultry industries [2]. While many western countries have succeeded with elimination of the diseases by test and slaughter, developing countries are often left with only the strategy of prophylactic treatment with antibiotics. To avoid this use of antibiotics, development of safe and effective vaccines is a priority.The gene crp encodes the cAMP receptor protein (CRP), which regulates transcription of a magnitude of operons concerned with transport of sugars and catabolic func
Corpos, cadeiras, colares: Charlotte Perriand e Lina Bo Bardi
Rubino, Silvana;
Cadernos Pagu , 2010, DOI: 10.1590/S0104-83332010000100013
Abstract: the article explores the crossroads of the trajectories of two professional women linked to the production of space: the italian architect lina bo bardi, who worked in brazil, and the french designer charlotte perriand. the article begins by comparing two photographs and then investigates the performance of these two well-known professionals, their moments of exclusion, disqualification as well as success throughout their careers. as they both had long and diversified careers, we capture two moments when they produced the emblematic chairs, that they exhibited using their own bodies, albeit in a quite anonymous way, as an ergonometric measure.
Experience with an extended-release opioid formulation designed to reduce abuse liability in a community-based pain management clinic
Rubino D
International Journal of General Medicine , 2011, DOI: http://dx.doi.org/10.2147/IJGM.S23042
Abstract: ience with an extended-release opioid formulation designed to reduce abuse liability in a community-based pain management clinic Review (2819) Total Article Views Authors: Rubino D Published Date September 2011 Volume 2011:4 Pages 617 - 626 DOI: http://dx.doi.org/10.2147/IJGM.S23042 Daniel Rubino Pain Center of Devon, Devon, PA, USA Context: With the growing public health concern over rising rates of opioid abuse, physicians have a responsibility to incorporate safeguards into their practice to minimize the potential for opioid misuse, abuse, and diversion. Patient-specific treatment regimens should include steps to monitor treatment success with regard to optimal pain management as well as inappropriate use of opioids and other substances. Opioid formulations designed to be less attractive for abuse are also being developed. While future studies are needed to determine the impact of such formulations in addressing the issue of opioid misuse in the community as a whole, the experience of practitioners who have utilized these formulations can highlight the practical steps to incorporate such formulations into the everyday patient-care setting. Purpose: The purpose of this report is to describe experience in managing patients with chronic, moderate-to-severe pain using morphine sulfate and naltrexone hydrochloride extended-release capsules (MS-sNT) (EMBEDA , King Pharmaceuticals Inc, Bristol, TN, which was acquired by Pfizer Inc, New York, in March 2011), a formulation designed with features to deter abuse/misuse, in a community-based pain management clinic. Case presentations: Case reports demonstrating a clinical management plan for assessment, initial interview procedures, explanation/discussion of proposed therapies, patients' treatment goals, conversion to MS-sNT, and titration and treatment outcomes are provided. Results: The management approach yielded successful outcomes including pain relief, improved quality of life, treatment satisfaction, and patient acceptance of a formulation designed to deter abuse/misuse. Discussion: The cases presented demonstrate that the communication accompanying complete pretreatment assessment, goal-setting and expectations, and attention to individual patient needs can enable optimization of pain-related outcomes, resulting in improved quality of life for patients and fostering patient acceptance of formulations designed to help address opioid abuse/misuse issues in the community at large.
Experience with an extended-release opioid formulation designed to reduce abuse liability in a community-based pain management clinic
Rubino D
International Journal of General Medicine , 2011,
Abstract: Daniel Rubino Pain Center of Devon, Devon, PA, USA Context: With the growing public health concern over rising rates of opioid abuse, physicians have a responsibility to incorporate safeguards into their practice to minimize the potential for opioid misuse, abuse, and diversion. Patient-specific treatment regimens should include steps to monitor treatment success with regard to optimal pain management as well as inappropriate use of opioids and other substances. Opioid formulations designed to be less attractive for abuse are also being developed. While future studies are needed to determine the impact of such formulations in addressing the issue of opioid misuse in the community as a whole, the experience of practitioners who have utilized these formulations can highlight the practical steps to incorporate such formulations into the everyday patient-care setting. Purpose: The purpose of this report is to describe experience in managing patients with chronic, moderate-to-severe pain using morphine sulfate and naltrexone hydrochloride extended-release capsules (MS-sNT) (EMBEDA , King Pharmaceuticals Inc, Bristol, TN, which was acquired by Pfizer Inc, New York, in March 2011), a formulation designed with features to deter abuse/misuse, in a community-based pain management clinic. Case presentations: Case reports demonstrating a clinical management plan for assessment, initial interview procedures, explanation/discussion of proposed therapies, patients' treatment goals, conversion to MS-sNT, and titration and treatment outcomes are provided. Results: The management approach yielded successful outcomes including pain relief, improved quality of life, treatment satisfaction, and patient acceptance of a formulation designed to deter abuse/misuse. Discussion: The cases presented demonstrate that the communication accompanying complete pretreatment assessment, goal-setting and expectations, and attention to individual patient needs can enable optimization of pain-related outcomes, resulting in improved quality of life for patients and fostering patient acceptance of formulations designed to help address opioid abuse/misuse issues in the community at large. Keywords: morphine abuse, universal precautions, drug abuse
La governance locale inglese e la governance europea: un confronto possibile?
Francesco Rubino
Espa?o Jurídico : Journal of Law , 2011,
Abstract: Voglio in questo lavoro trattare l'argomento della governance inglesa locale e della Europa, constatando in che misura si può stabilire confronti ed utilizzazione di ogni esperienza. Parole-chiavi: Governanza. Democrazia. Pottere Locale.
Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice
Amber Farooqui, Alberto J Leon, Yanchang Lei, Pusheng Wang, Jianyun Huang, Raquel Tenorio, Wei Dong, Salvatore Rubino, Jie Lin, Guishuang Li, Zhen Zhao, David J Kelvin
Virology Journal , 2012, DOI: 10.1186/1743-422x-9-104
Abstract: This study presents the heterogeneous virulence of clinically similar strains of pandemic 2009 influenza virus in human alveolar adenocarcinoma cells and mice. The viruses were obtained from patients who were admitted in a local hospital in China with a similar course of infection and recovered. The A/Nanchang/8002/2009 and A/Nanchang/8011/2009 viruses showed efficient replication and high lethality in mice while infection with A/Nanchang/8008/2009 was not lethal with impaired viral replication, minimal pathology and modest proinflammatory activity in lungs. Sequence analysis displayed prominent differences between polymerase subunits (PB2 and PA) of viral genomes that might correlate with their different phenotypic behavior.The study confirms that biological heterogeneity, linked with the extent of viral replication, exists among pandemic H1N1 strains that may serve as a benchmark for future investigations on influenza pathogenesis.
Revisiting a Celebrated Bakerian Lecture  [PDF]
Salvatore Ganci
Optics and Photonics Journal (OPJ) , 2019, DOI: 10.4236/opj.2019.94005
Abstract: This paper revisits the optical contributions of Thomas Young to the theory of diffraction and, in particular, some experiments presented in his celebrated “Bakerian Lecture” of 1803. The major input to re-analyze some of Young’s experiments came by a recent paper appeared on an instructional and pedagogical journal. Diffraction experiments of Thomas Young are here revisited with particular reference to the coherence requirements of the white light source to see and measure diffraction fringes by pins, and in general to consider the difficulties in working in a “camera obscura”. If at the beginning of the nineteenth century, the experiments of Optics in a darkroom were considered “simple”, however they needed rooms about 7 meters long, completely darkened out, with a window mostly exposed to south, a darkened window and a small hole practiced on a dark sheet applied to a hole in the window shutter. Often a heliostat should be placed outside and a mirror inside the room to direct the cone of sunlight. Thomas Young worked only with a mirror interior to the darkened room in order to have a cone of light horizontally directed and moving the mirror at each observation. Today, these requirements are not easy to implement. However, only a single measure by Thomas Young will be repeated under his own conditions with a “reduced darkroom” using internally blackened cardboard tubes.
Corporate Intranet Security: Packet-Level Protocols for Preventing Leakage of Sensitive Information and Assuring Authorized Network Traffic  [PDF]
Boris S. Verkhovsky, Roberto D. Rubino
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2012, DOI: 10.4236/ijcns.2012.55033
Abstract: Securing large corporate communication networks has become an increasingly difficult task. Sensitive information routinely leaves the company network boundaries and falls into the hands of unauthorized users. New techniques are required in order to classify packets based on user identity in addition to the traditional source and destination host addresses. This paper introduces Gaussian cryptographic techniques and protocols to assist network administrators in the complex task of identifying the originators of data packets on a network and more easily policing their behavior. The paper provides numerical examples that illustrate certain basic ideas.
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