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Search Results: 1 - 10 of 71 matches for " Salata "
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Applications of nanoparticles in biology and medicine
OV Salata
Journal of Nanobiotechnology , 2004, DOI: 10.1186/1477-3155-2-3
Abstract: Nanotechnology [1] is enabling technology that deals with nano-meter sized objects. It is expected that nanotechnology will be developed at several levels: materials, devices and systems. The nanomaterials level is the most advanced at present, both in scientific knowledge and in commercial applications. A decade ago, nanoparticles were studied because of their size-dependent physical and chemical properties [2]. Now they have entered a commercial exploration period [3,4].Living organisms are built of cells that are typically 10 μm across. However, the cell parts are much smaller and are in the sub-micron size domain. Even smaller are the proteins with a typical size of just 5 nm, which is comparable with the dimensions of smallest manmade nanoparticles. This simple size comparison gives an idea of using nanoparticles as very small probes that would allow us to spy at the cellular machinery without introducing too much interference [5]. Understanding of biological processes on the nanoscale level is a strong driving force behind development of nanotechnology [6].Out of plethora of size-dependant physical properties available to someone who is interested in the practical side of nanomaterials, optical [7] and magnetic [8] effects are the most used for biological applications.The aim of this review is firstly to give reader a historic prospective of nanomaterial application to biology and medicine, secondly to try to overview the most recent developments in this field, and finally to discuss the hard road to commercialisation. Hybrid bionanomaterials can also be applied to build novel electronic, optoelectronics and memory devices (see for example [9,10]). Nevertheless, this will not be discussed here and will be a subject of a separate article.A list of some of the applications of nanomaterials to biology or medicine is given below:- Fluorescent biological labels [11-13]- Drug and gene delivery [14,15]- Bio detection of pathogens [16]- Detection of proteins [17]- Pro
Nanotechnology in Therapeutics: hydrogels and beyond
OV Salata
Journal of Nanobiotechnology , 2007, DOI: 10.1186/1477-3155-5-5
Abstract: The very first chapter of this section overviews the "concepts of medical chronobiology, chronopharmacology and chronotherapeutics" as the basis for applications of drug delivery technology" and is dealing with the drug delivery matching to the biological rhythms. Can a doctor who takes decisions on the drug dosage by monitoring patient's progress be replaced by an automated system (see Chapter 2, dedicated to the "Feedback Control in Drug delivery")? Four diseases are analysed in this context and only in the simplest single input case of glucose control in diabetes a feedback control seems to be feasible at present. One of the major non-technical hurdles in this field is the acceptance of the technology by both clinicians and patients.The advances in drug delivery for nanoparticles are discussed in the third chapter of this thrilling volume. The main reason for creating nanoparticles is to improve solubility and bioavailability of drugs. It is a well known phenomenon that nanoparticles can be taken much faster across the cell membranes. There are also opportunities here to create a targeted drug delivery. Routes of nanoparticle preparation are described, followed by the discussion of the requirements to their physical and chemical properties for effective delivery.Molecular recognition is one of the central concepts in biology and is of great importance for the creation of active synthetic nanomaterials. In the Chapter 4 ("Synthetic Ligand-Receptor Interactions in Delivery Systems") the authors are describing what is involved in the design of a synthetic receptor (as opposed to designing a ligand, which is a more common pharmaceutical problem). The next chapter is entitled "Nanoscale Analysis of Mucus-Carrier Interactions for Improved Drug Absorption". It describes the structure of the mucous layer on the molecular level and discusses the interaction of this layer with synthetic polymers.The final sixth chapter of the "intelligent therapeutics" part is dedicated to
Toxoplasma gondii IN TRIAL ANIMALS TOXOPLASMOSE EM ANIMAIS DE EXPERIMENTA O
Ednir Salata
Pesquisa Agropecuária Tropical , 2007, DOI: 10.5216/pat.v17i1.2498
Abstract: Toxoplasmosis is a zoonosis wide world spread, caused by Toxoplasma gondii. This study points out, among other topics, historical aspects about the description of the disease, the evolutionary cycle of zoonotic agent, techniques for diagnosis and also prophylactic and therapeutic steps directed to experimentation animals. A toxoplasmose é uma zoonose mundialmente difundida, causada pelo parasito Toxoplasma gondii. Este artigo revisa, desde aspectos históricos sobre a descri o da doen a, o ciclo evolutivo do agente causal, até técnicas de diagnóstico e medidas profiláticas e terapêuticas dirigidas para animais de experimenta o.
The Inner Man and his Deed: Jerzy Grotowski and the legacy of Adam Mickiewicz and polish romanticism
Kris Salata
Revista Brasileira de Estudos da Presen?a , 2013,
Abstract: This article locates Grotowski in a concrete cultural milieu of Polish Romanticism and of the lifework of the Romantic poet Adam Mickiewicz. The bulk of my focus goes towards the notion of the deed and the act of doing that dematerialises the work of art turning it into an inner process – all features of Mickiewicz’s and Grotowski’s projects.
Uma nova classe média no Brasil da última década?: o debate a partir da perspectiva sociológica
Celi Scalon,André Salata
Sociedade e Estado , 2012, DOI: 10.1590/s0102-69922012000200009
Abstract: Este artigo analisa o surgimento de uma nova classe média, como vem sendo proposto pelos economistas brasileiros, à luz da perspectiva sociológica dos Estudos de Classe. Para tanto, recupera o debate da Economia, que se baseia na renda para definir classes, assim como o da Sociologia da Estratifica o, de acordo com seus diferentes marcos teóricos. Usando dados das PNADs 2002 e 2009, apresenta o argumento de que as mudan as na estrutura de classes n o foram significativas a ponto de apoiar a ideia de uma nova classe, nem houve um crescimento na classe média tradicional. The article analyses, from the perspective of class studies in Sociology, the argument of Brazilian economists about the emergence of a new middle class. To achieve this task, the paper brings the debate conducted in economics, in which class is defined by income, as well as the debate of the Sociology of Stratification, according to its different theoretical frameworks. Using data from PNADs 2002 and 2009, it argues that the changes in the classes structure were not significant to support the idea of existence of a new class, neither that there was a growth in the traditional middle class.
Isoformas de Prolactina no Fluido Folicular de Pacientes Submetidas a FIV
Rom?o Gustavo Salata
Revista Brasileira de Ginecologia e Obstetrícia , 2000,
Abstract:
Impact of Chronic Pelvic Pain on Female Sexual Function  [PDF]
Adriana Peterson Mariano Salata Rom?o, Ricardo Gorayeb, Gustavo Salata Rom?o, Omero Benedicto Poli-Neto, Antonio Alberto Nogueira
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.43031
Abstract:

The objective of the present study was to determine the prevalence of sexual dysfunction and depression in women with chronic pelvic pain (CPP). A case-control study was conducted on 66 women, 36 of them with CPP and 30 without this diagnosis. Depression was evaluated using the Beck Depression Inventory (BDI) and sexual dysfunction was evaluated using the Female Sexual Function Index (FSFI). Data were analyzed statistically by the Mann-Whitney test, Fisher exact test, chisquare test, and Spearman correlation test. Regarding sociodemographic data, no significant differences were detected between populations with respect to the variables studied (age, schooling, number of children, income, salary, and marital status), indicating group homogeneity and thus increasing the reliability of the data. A cut-off of 26.55 points was used to calculate the total score for sexual function. In the group of women with CPP, 94.4% were at high risk for sexual dysfunction. Comparison of FSFI scores showed that the domains of sexual function, such as orgasm, lubrication and pain differed significantly between women with and without CPPP. Correlations were detected between the following items: orgasm × age (r = -0.01904), orgasm × number of children (r =-0. 00947), orgasm × body mass index (BMI) (r =-0.00 955), relationship × age (r = 0.03952), income × relationship (r =-0.014680), relationship × number of children (r =-0.03623), depression × relationship (r =-0.16091), desire × age (r = -0.45255), desire × number of children (r = -0.01824), lubrication × excitement (r = 0.04198), and lubrication × BMI (r = -0.01608). The prevalence of depression detected in the present study was 38.9% among women with pain and 3.3% among control women. It was observed that women with CPP suffer a negative interference regarding sexual function compared to controls. Thus, it can be seen that a specific approach related to sexuality is extremely important within the context of women with CPP. Depression was clearly associated with CPP and therefore an interdisciplinary approach is fundamental in order to solve this problem.

The Impact of Chronic Pelvic Pain in Women  [PDF]
Adriana P. M. S. Rom?o, Ricardo Gorayeb, Gustavo Salata Rom?o, Omero Benedicto Poli-Neto, Antonio Alberto Nogueira
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.410076
Abstract:

Chronic pelvic pain (CPP) is a prevalent condition with a significant impact on the personal, social, professional and marital life of women. It is a complex condition that may have no specific causal diagnosis or may be associated with multiple diagnoses, frequently involving treatment failure. The definition of health care strategies fundamentally depends on the way women live with this condition. Thus, the objective of the present study is to learn how women with CPP experience their diagnosis and the meaning they attribute to it. A qualitative study was conducted by interviewing a focus group of 11 women. The content of the interviews was recorded and fully transcribed, and the speeches were interpreted by Bardin’s content analysis. The topics most frequently dealt with in the interview were diagnosis, beginning of pain, worsening and improving factors, marital and interpersonal relationships, interference with daily activities, association with emotional aspects, and perspectives for the future. It could be perceived how much these women need to be better heard and how much the association between psychic and physical questions must be visualized by the professionals who provide care for them. The approach used by professionals from different areas, when properly structured, can minimize the problem of the division of a sick person into separate parts. Psychological care is very important, especially in relation to the discovery of more effective strategies for living with pain.

View and review on viral oncology research
Valeria Bergonzini, Cristiano Salata, Arianna Calistri, Cristina Parolin, Giorgio Palù
Infectious Agents and Cancer , 2010, DOI: 10.1186/1750-9378-5-11
Abstract: The first evidence of tumor viral aetiology dates back to 1907 when Ciuffo and co-workers showed that human warts could be transmitted by cell-free filtrates derived from lesions [1]. Seventy years later, papillomaviruses were linked to human cancer. In 1908, Ellermann and Bang, reported that also leukemia could be transferred to healthy chicken by a cell-free filtrate of cells obtained form affected birds [2]. Moreover, in 1911, Rous and colleagues showed that the spindle cell sarcoma could be transmitted to healthy chickens using filtered cell-free tumor extracts [3]. This study led to the identification of the first oncogenic virus: the Rous sarcoma virus (RSV). Over the next four decades after the discovery of RSV new tumor viruses were identified. In particular, in 1935, Rous and Beard demonstrated that the cottontail rabbit papillomavirus (CRPV), discovered few years earlier [2], was able to induce skin carcinomas in domestic cottontail rabbit [4]. Moreover, in 1951, studies by Gross and co-workers led to the identification of the first mouse leukemia virus (murine leukemia virus) [5], later confirmed by Moloney and others [6-8], and in 1953 of a mouse virus that induced a variety of solid tumors (mouse polyomavirus) [9]. As far as primates is concerned, in 1962, Eddy, Hilleman, and co-workers showed the tumorigenic potential of simian virus 40 (SV40) [10,11] while, interestingly, Trentin and colleagues reported, for the first time, that viruses could be linked to cancer development also in humans, at least under experimental conditions. Indeed, these authors showed that specific human adenoviruses are tumorigenic in experimentally infected animals [12]. Starting from then, studies were focused on connection among viruses and human cancer. In 1965, Epstein, Barr, and colleagues were able to visualize by electron microscopy herpesvirus-like particles in a cell line, established from Burkitt's lymphoma (BL) [13]. This virus resulted to be biologically and antige
Modelo de apoio à decis?o de roteamento na distribui??o física de produtos perecíveis
Salata Jr, Fábio Roberto;Yoshizaki, Hugo T.Y;
Produ??o , 1993, DOI: 10.1590/S0103-65131993000100005
Abstract: this work describes the effort to construct a decision support model for fleet routing in the distribution of a food industry. the sweep algorithm was employed, obtaining better results than the previous approch. on the other hand, the model helped to segregate distribution channel operations of sales and physical sistribution. a set of productivity indicators was also developed to allow better managerial control of that activity.
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