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A Comparative Study Between Sabril (Vigabatrin) and ACTH in Treatment of Infantile Spasms
S Amir Salari,M Ghofrani
Iranian Journal of Pediatrics , 2002,
Abstract: Infantile spasms (IS) is an age specific epileptic syndrome. With respect to poor response of IS to conventional anti-epileptic drugs, scientists tend to find new effective drugs. In this study, 50 infants with IS in the age group of 2-24 months, were divided randomly into 2 equal groups, treated with sabril or ACTH and compared for clinical efficacy and drug side effects. After 6 week of treatment is sabril group there was 28% complete remission and 40% reduction in seizure frequencies while in ACTH group there was 40.9% complete remission and 45.5% reduction in seizure frequencies, showing no significant difference between clinical responses in the two groups. Drug side effects were seen in 16% of patients in sabril group and 81.8% of those in ACTH group. These differences were significant from statistical point of view. Unfortunately, it is impossible to evaluate visual field constriction, a probable irreversible side effect of sabril. This justified the use ACTH as the first line of treatment in IS.
Fast prediction of RNA-RNA interaction
Raheleh Salari, Rolf Backofen, S Cenk Sahinalp
Algorithms for Molecular Biology , 2010, DOI: 10.1186/1748-7188-5-5
Abstract: In this paper we present a novel algorithm to accurately predict the minimum free energy structure of RNA-RNA interaction under the most general type of interactions studied in the literature. Moreover, we introduce a fast heuristic method to predict the specific (multiple) binding sites of two interacting RNAs.We verify the performance of our algorithms for joint structure and binding site prediction on a set of known interacting RNA pairs. Experimental results show our algorithms are highly accurate and outperform all competitive approaches.Regulatory non-coding RNAs (ncRNAs) play an important role in gene regulation. Studies on both prokaryotic and eukaryotic cells show that such ncRNAs usually bind to their target mRNA to regulate the translation of corresponding genes. Many regulatory RNAs such as microRNAs and small interfering RNAs (miRNAs/siRNAs) are very short and have full sequence complementarity to the targets. However some of the regulatory antisense RNAs are relatively long and are not fully complementary to their target sequences. They exhibit their regulatory functions by establishing stable joint structures with target mRNA initiated by one or more loop-loop interactions.In this paper we present an efficient method for the RNA-RNA interaction prediction (RIP) problem with multiple binding domains. Alkan et al. [1] proved that RIP, in its general form, is an NP-complete problem and provided algorithms for predicting specific types of interactions and two relatively simple energy models - under which RIP is polynomial time solvable. We focus on the same type of interactions, which to the best of our knowledge, are the most general type of interactions considered in the literature; however the energy model we use is the joint structure energy model recently presented by Chitsaz et al. [2] which is more general than the one used by Alkan et al.In what follows below, we first describe a combinatorial algorithm to compute the minimum free energy joint str
Evaluation of the Influence of Resin Cement Thickness on the bond Strength of FRC Post
Esfahanizadeh GR.,Salari MH.,Zahedi Rad S.
Journal of Dentistry , 2011,
Abstract: Statement of Problem: The increasing popularity and widespread use of fiber posts have changed the procedure of reconstructing endodontically treated teeth. A reinforced composite (FRC) post presents the advantage of having an elasticity modulus similar to the dentin, which reduces the risk of root fracture. Some factors like cement thickness may affect the bond strength of the posts.Purpose: This study aimed to evaluate the influence of resin cement thickness on the bond strength of a FRC post system.Materials and Method: In this experimental study, eighteen single-rooted human teeth were decoronated. (Length: 16 mm) The canals were prepared and the specimens were randomly allocated to two groups (n=9): Group 1, (low cement thickness) in which size 3 FRC posts and group 2 (high cement thickness) in which size 1 FRC posts were cemented. The specimens were sectioned, producing 2 samples (thickness: 4.5mm). For evaluation of the cement thickness, an optical microscope was used. Each sample was evaluated using push-out test and the data were statistically analyzed using T-test.Result: Bond strengths of the 2 groups, low cement thickness and hight cement thickness, did not show a significant different ( p = 0.14).Conclusion: The increase in cement thickness surrounding the FRC post did not impair the bond strength.
Effect of Sodium Bentonite and Comparison of Pellet vs Mash on Performance of Broiler Chickens
S. Salari,H. Kermanshahi,H. Nasiri Moghaddam
International Journal of Poultry Science , 2006,
Abstract: An experiment was conducted to study the effect of Sodium Bentonite (SB) and comparison of feed forms (pellet vs mash) on broiler performance. 320 day-old Cobb strain male broiler chickens were allocated to 8 experimental diets with 4*2 factorial arrangements in a completely randomized design. Treatments were 0, 1, 2 and 3 percent of SB and two forms of diets (pellet and mash). At 49 days of age, chickens that fed pelleted diets, consumed more feeds and showed better weight gain and feed conversion ratio (P< 0.05). Pelleting the diets also significantly increased weight of abdominal fat and decreased thigh percentage (P< 0.05). Chickens fed diets containing 1-2 % SB consumed more feed, had more weight gain and less feed conversion ratio (P< 0.05). Under the conditions of this study, it seems that pelleting the diets and 1-2% of SB, improves performance of broiler chickens.
Channel and Frequency Offset Estimation for MIMO-OFDM Systems
S. Salari,M. Ardebilipour,M. Ahmadian
Journal of Applied Sciences , 2008,
Abstract: In this study, we present a new reduced-complexity scheme for Maximum-Likelihood (ML) estimate of both Carrier-Frequency Offset (CFO) and channel coefficients in multi antenna OFDM transmission, assuming that a training sequence is available. Our scheme is also capable to accommodate any Space-Time Coded (STC) transmission. Moreover, to benchmark the performance of the proposed scheme, the Cramer-Rao Bounds (CRBs) are derived for both CFO and channel estimators. Simulation results show that the proposed scheme achieves almost ideal performance compared with the CRBs in all ranges of Signal-to-Noise Ratios (SNR) for both channel and frequency offset estimates.
Antibacterial effect of Glycyrrhetinic Acid on 55 hospital strains of Staphylococcus Aureus and 32 Actinobacillus Actinomycetemcomitans
Salari MH,Eshraghi S,Noroozi M
DARU : Journal of Pharmaceutical Sciences , 2001,
Abstract: Glycyrrhetinic acid is a major component of a traditional plant called Licorice. This substance has been found to have some pharmacological properties including anti-inflammatory, anti-viral, anti-bacterial, anti-fungal, anti-allergic, anti-carcinogenic and anti-peptic-ulcer. Glycyrrhetinic acid also affects against some parasites such as Trichomonas vaginalis. In this study, 55 hospital strains of Staphylococcus aureus and 32 Actinobacillus actinomycetemcomitans, were isolated from patient’s specimens by culture method. Antibacterial activities of glycyrrhetinic acid against those microorganisms were investigated by determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods. The MIC for S. aureus and A. actinomycetemcomitans were 64 and 8 μg/ml respectively. The MBC for S. aureus and A. actinomycetemcomitans were 64 and 16 μg/ml respectively. It is concluded that Glycyrrhetinic acid is effective against Staphylococcus aureus and Actinobacillus actinomycetemcomitans in appropriate concentrations.
Comparison of Spiritual Intelligence and Mental Health in Addicts and Normal Individuals
S Moallemi,M Raghibi,Z Salari Dargi
Journal of Shahid Sadoughi University of Medical Sciences , 2010,
Abstract: Introduction: Substance abuse is a chronic phenomenon that affects mental and physical health and results in a lot of social, domestic and economic trauma. Methods: The samples included 80 addicts and 80 healthy individuals. The addicts were selected randomly from private and state remedy and rehabilitation centers of Zahedan city. Healthy individuals were matched with addicts in respect to age and sex and also selected randomly. Then, participants were assessed with The Spiritual Intelligence Self‐Report Inventory-24(SISI) and General Health Questionnaire (GHQ). The data was analyzed with Pearson correlation coefficient and t test for independent groups. Results: There were significant differences in SISI scores and GHQ scores. Addicts scored lower in two scales. There was a significant positive correlation between SISI scores and GHQ scores and subscales of GHQ (P< 0.01) in two groups. Substance abuse affects mental and physical health. Individuals with lesser spiritual intelligence levels are more prone to addiction and maybe with higher levels of spiritual intelligence, we can prevent individuals from addiction.
Comparison of Creativity and Self-Confidence of Gifted and Normal High School Students of District Two in Zahedan  [PDF]
Sedighe Salari, Hossein Jenaabadi
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.613171
Abstract: The present study aimed to compare creativity and self-confidence of gifted and normal high school students studying in district two in Zahedan. The casual-comparative method was adapted. The statistical population of the study included all male and female high school students studying in public schools, schools for exceptional talents, martyrs’, non-profit and private schools in Zahedan, district two. According to the statistics, the number of male and female students studying in these schools was 8530 students, among which 368 students were selected. To collect data, Abedi Creativity Test and Moradi’s Inventory of the Level of Self-Confidence (2011) were used. The obtained data were analyzed using independent t-test and MANOVA. The results of multivariate covariance analysis indicated the difference between gifted and normal students considering their creativity. Moreover, there was a significant difference between the level of self-confidence of gifted and normal high school students in Zahedan. Additionally, no significant difference was found between male and female students with regard to their creativity and self-confidence.
The Effect of Oral Ascorbic Acid Pretreatment on Feeding Changes Following Injection in Nucleus Accumbens Shell in Adult Male Rats
Salari S,Abbasnejad M,Badreh F,Esmaeili Mahani S
Tehran University Medical Journal , 2012,
Abstract: Background: Ascorbic acid (AA) is not synthesized in the brain but it is actively transported through blood-brain barrier by SVCT2 cotransporter and it is stored in high concentrations with heterogeneous distribution in areas such as nucleus accumbens shell (AcbSh) in the mammalian brain. Previous studies have shown that Ascorbic acid injection into AcbSh decreases feeding; therefore, in the present study we evaluated the effects of oral Ascorbic acid pretreatment on changes in feeding upon its injection in AcbSh in adult male rats.Methods: Sixty-three adult male rats (220-280 g) were divided into five treatment and five pretreatment groups. The treatment groups included the control (intact) group, sham-operated Ascorbic acid group that received normal saline as vehicle, and three other groups that received different doses of ascorbic acid (10, 50 and 250 μg/rat) by injection into AcbSh for four days. The pretreatment groups received Ascorbic acid (100 mg/kg) for 15 days via gastric gavage before receiving the aforementioned doses in treatment groups into intra nucleus AcbSh. Feeding measurement was repeated every 12 hours by automatic metabolic cage.Results: The results indicated that all injected doses of Ascorbic acid (10, 50 and 250 μg/rat) into nucleus accumbens shell decrease food intake (P<0.05) in rats and oral Ascorbic acid pretreatment had no effects in this regard.Conclusion: Our findings show that ascorbic acid is an effective factor in feeding regulation. Oral pretreatment seems to have no influence on the central effects of ascorbic acid in the nucleus accumbens shell.
Association between diabetes complications and leukocyte counts in Iranian patients
Moradi S, Kerman SRJ, Rohani F, Salari F
Journal of Inflammation Research , 2012, DOI: http://dx.doi.org/10.2147/JIR.S26917
Abstract: ssociation between diabetes complications and leukocyte counts in Iranian patients Original Research (2113) Total Article Views Authors: Moradi S, Kerman SRJ, Rohani F, Salari F Published Date January 2012 Volume 2012:5 Pages 7 - 11 DOI: http://dx.doi.org/10.2147/JIR.S26917 Received: 06 October 2011 Accepted: 22 November 2011 Published: 24 January 2012 Sedigheh Moradi1, Scott Reza Jafarian Kerman2, Farzaneh Rohani1, Fereshteh Salari2 1Endocrine and Metabolism Research Center (Firouzgar), Hemmat Campus, Tehran University of Medical Sciences, Tehran, Iran, 2Scientific Students Research Committee, Tehran University of Medical Sciences, Tehran, Iran Background: The long term complications of diabetes can be fatal. They are also renowned for being an economic burden. Previous studies have demonstrated a relationship between inflammatory markers and complications of diabetes. The objective of this study was to evaluate the relationship between leukocyte counts and these complications. Methods: The study included 184 patients diagnosed with type 2 diabetes. The study was carried out in Iran during 2007 and 2008. Data collected on the subjects were as follows: age, gender, weight, height, blood pressure, smoking history, lipid profile including low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol, triglycerides, and leukocyte count, albuminuria, and retinopathy. Furthermore, information on cardiac history for 100 patients was collected. The subjects were split into two groups according to their leukocyte levels: low (≤7000/mm3) and high (>7000/mm3); and then analyzed by Student's t-test or Mann–Whitney U-test as appropriate. Results: The average leukocyte count in these patients was 7594 ± 1965/mm3. Leukocyte count was significantly different in patients with and without retinopathy and albuminuria (P < 0.0001). According to this analysis, a leukocyte count of 6750/mm3 with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm3 with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication. Conclusion: An elevated leukocyte count even within the normal range was associated with chronic complications in type 2 diabetes.
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