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Search Results: 1 - 10 of 3067 matches for " Sakha Sedigheh Hossein "
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The effect of clofibrate with phototherapy in late pre-term newborns with non-hemolytic jaundice
Sakha Sedigheh Hossein,Gharehbaghi Manizheh,Rahbani Mohammad
Indian Journal of Medical Sciences , 2009,
Abstract: Background : Despite an understanding of the enzymatic pathways leading to bilirubin production and degradation, very few pharmacologic interventions are utilized and the mainstay of treatment remains phototherapy. Aims : To evaluate the efficacy of clofibrate in reducing total serum bilirubin levels in late pre-term neonates with non-hemolytic jaundice. Design and Setting : Double-blind, placebo-controlled, randomized trial; tertiary level neonatal unit. Materials and Methods : A randomized controlled study was carried out in the neonatal ward of Children′s Hospital, Tabriz, Iran, over a 1-year period. Sixty-eight healthy late pre-term infants readmitted with non-hemolytic hyperbilirubinemia were randomized to receive phototherapy and clofibrate (n= 35) or phototherapy and placebo (n= 33). Statistical Analysis Used : Chi-square test and independent sample ′t′ test. Results : There were no significant differences in the weight, gender, modes of delivery and age of neonates between the two groups. Similarly the mean total serum bilirubin (TSB) level at the time of admission was not significantly different between the two groups [mean± SD: 19.72 ± 1.79 (95% confidence interval: 19.12-20.54 mg/dL) vs. 20.05 ± 2.82 (95% confidence interval, 19.54-22.04 mg/dL), P= 0.57]. The mean TSB 48 hours after phototherapy [mean± SD: 8.06± 1.34 (95% confidence interval: 7.94-10.18 mg/dL) vs.10.94 ± 2.87 (95% confidence interval: 9.92-12.16 mg/dL), P= 0.02] and the mean duration of phototherapy [mean± SD: 64.32 ± 12.48 (95% confidence interval: 60-81.6 hours) vs. 87.84 ± 29.76 (95% confidence interval: 79.2-108 hours), P< 0.001] were significantly lower in the clofibrate-treated group. Conclusions : Clofibrate is an effective adjunctive drug in neonatal hyperbilirubinemia, which results in decreased TSB level and reduced duration of phototherapy in late pre-term newborns.
Three-dimensional Brownian diffusion of rod-like macromolecules in the presence of randomly distributed spherical obstacles: Molecular dynamics simulation
Farzaneh Sakha,Hossein Fazli
Physics , 2010, DOI: 10.1063/1.3518978
Abstract: Brownian diffusion of rod-like polymers in the presence of randomly distributed spherical obstacles is studied using molecular dynamics (MD) simulations. It is observed that dependence of the reduced diffusion coefficient of these macromolecules on the available volume fraction can be described reasonably by a power law function. Despite the case of obstructed diffusion of flexible polymers in which reduced diffusion coefficient has a weak dependence on the polymer length, this dependence is noticeably strong in the case of rod-like polymers. Diffusion of these macromolecules in the presence of obstacles is observed that is anomalous at short time scales and normal at long times. Duration time of the anomalous diffusion regime is found that increases very rapidly with increasing both the polymer length and the obstructed volume fraction. Dynamics of diffusion of these polymers is observed that crosses over from Rouse to reptation type with increasing the density of obstacles.
Decorating and Filling of Multi-Walled Carbon Nanotubes with TiO2 Nanoparticles via Wet Chemical Method  [PDF]
Sedigheh Abbasi, Seyed Mojtaba Zebarjad, Seyed Hossein Noie Baghban
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.52030
Abstract:

Multi-walled carbon nanotubes (MWCNTs) have been successfully modified with TiO2 nanoparticles via wet chemical method. For this purpose tetra chloride titanium (TiCl4) was used as titanium source. MWCNTs were exposed at different amount of TiCl4 (0.25 and 0.1 ml) and different soaking times. The modified MWCNTs have been characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). TEM results showed that the MWCNTs were fully decorated with TiO2 at short term immersion. Increasing soaking time caused to fill the MWCNTs with TiO2 nanoparticles. The results showed that the amount of precursor had a significant role on quantity of decoration. The decoration of outer surface of MWCNTs with TiO2 was more noticeable at large amount of TiCl4. XRD results revealed that the crystalline structure of TiO2 on the surface and inner of MWCNTs was rutile. The average size of TiO2 nanoparticles which modified MWCNTs were 20 nm.

Tetrakis(benzylamino)phosphonium chloride
Khodayar Gholivand,Hossein Mostaanzadeh,Sedigheh Farshadian
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536810054401
Abstract: The title salt, [P(NHCH2C6H5)4]+·Cl , crystallizes with the P atom and Cl anion lying on a twofold rotation axis. The P atom has a slightly distorted tetrahedral geometry with two classes of N—P—N angles [101.15 (10) and 100.55 (11)° and 113.07 (9) and 114.83 (8)°] and the environments of sp2-hybridized N atoms are essentially planar (sum of angles = 359.9 and 360.1°). In the crystal, the phosphonium ion interacts with each neighboring chloride ion via two approximately equal N—H...Cl interactions, forming parallel chains along the c axis.
Analysis of von Willebrand factor A domain-related protein (WARP) polymorphism in temperate and tropical Plasmodium vivax field isolates
Saber Gholizadeh, Navid Djadid, Hamid Basseri, Sedigheh Zakeri, Hossein Ladoni
Malaria Journal , 2009, DOI: 10.1186/1475-2875-8-137
Abstract: Clinical isolates were collected from north temperate and southern tropical regions in Iran. Primers have been designed based on P. vivax sequence (ctg_6991) which amplified a fragment of about 1044 bp with no size variation. Direct sequencing of PCR products was used to determine polymorphism and further bioinformatics analysis in P. vivax sexual stage antigen, pvwarp.Amplified pvwarp gene showed 886 bp in size, with no intron. BLAST analysis showed a similarity of 98–100% to P. vivax Sal-I strain; however, Iranian isolates had 2 bp mismatches in 247 and 531 positions that were non-synonymous substitution [T (ACT) to A (GCT) and R (AGA) to S (AGT)] in comparison with the Sal-I sequence.This study presents the first large-scale survey on pvwarp polymorphism in the world, which provides baseline data for developing WARP-based TBV against both temperate and tropical P. vivax isolates.Plasmodium vivax is one of the two most prevalent species of human malaria parasites that occurs throughout the tropics, except in western and central sub-Saharan Africa, where the absence of Duffy factor on the surface of red blood cells largely protects the local populations [1]. In addition, recent studies have suggested that vivax malaria can become lethal in a similar way to severe falciparum malaria [2-5]. To date, the anti-malarial treatment and the vector control measures have not had a significant impact on the transmission of malaria from humans to mosquitoes. Therefore, vaccine-targeting antigens expressed on the surface of the sexual stages of malaria parasites, such as gametocytes, gametes, zygotes and ookinetes, are being considered for the development of a transmission-blocking vaccine (TBV) [6-8], a promising strategy for malaria control. The parasite has to undergo a complex development programme inside the mosquito from gametocyte to sporozoite [9]. So far, several studies have focused on the identification and characterization of TBV targets [10-14]. One of the TBV targ
Cloning, expression and transmission-blocking activity of anti-PvWARP, malaria vaccine candidate, in Anopheles stephensi mysorensis
Saber Gholizadeh, Hamid Basseri, Sedigheh Zakeri, Hossein Ladoni, Navid Djadid
Malaria Journal , 2010, DOI: 10.1186/1475-2875-9-158
Abstract: The PvWARP was expressed in Escherichia coli BL21 using the pET-23a vector and was purified using Ni-NTA affinity chromatography from a soluble fraction. Polyclonal antibody was raised against rPvWARP and transmission blocking activity was carried out in an Anopheles stephensi-P. vivax model.Expression of full length of PvWARP (minus signal peptide) expression showed a 35-kDa protein. The purified protein was recognized by mouse polyclonal antibody directed against rPvWARP. Sera from the animals displayed significantly a blocking activity in the membrane feeding assay of An. stephensi mysorensis.This is the first report on P. vivax WARP expression in E. coli that provides an essential base for development of the malaria TBV against P. vivax. This may greatly assist in malaria elimination, especially in the oriental corner of WHO Eastern Mediterranean Regional Office (WHO/EMRO) including Afghanistan, Iran and Pakistan.Plasmodium vivax is responsible for 25-40% of annual cases of malaria especially in parts of Latin America and Asia [1]. Drug resistance in P. vivax is spreading and vivax malaria has been considered lethal in a similar way to severe falciparum malaria [1-3], challenging the concept that P. vivax malaria as 'benign' [4]. Therefore, the development of new control strategies such as a safe and an effective malaria vaccine is expected to play an important role in controlling P. vivax malaria [5].Based on the life cycle stages, malaria vaccines have focused on candidate target antigens on asexual and sexual stages of the parasite [6]. A transmission-blocking vaccine (TBV) targeting the parasite's sexual stages aims at interfering and/or blocking pathogen development within the vector and halting transmission to the non-infected vertebrate host [7,8]. Most TBV candidate targets have been focused on gametocytes, gametes, zygotes or ookinetes [9]. Li et al., [10] concluded that ookinete micronemal proteins, chitinase 1 (CHT1), circumsporozoite protein/thrombos
The Review on Lifestyle and its Relation with the Pregnancy Outcomes in the Pregnant Women Coming to Educational Hospitals of Tabriz in 2004
Sehhatie Shafai Fahimeh,Sadeghi Khamneh Sedigheh,Hossein Kushavar,Sheybaei Fatemeh
Research Journal of Medical Sciences , 2012,
Abstract: The life style which is called for individual life manner is described as one of the important factors which influence the health. The health and progress of every society to some extent is dependent on the health of women, the pregnancy and child delivering have had significant effect on the women`s health and hygiene and is accounted for national health and important indexes. On the other hand, the life style has had long-term and permanent effect on the health of mother and child. Therefore, this research is done for objective reviewing pregnant women`s life style and its relation with pregnancy outcomes in pregnant women coming to educational centers of Tabriz. This research is cross-sectional study in the form of comparative which in it 385 women coming to AL-Zahra and Taleghani Hospitals studied; they have had a unit characteristics of research case, The procedure was in the aim of choice and with the help of questionnaires containing three parts socio-individual characteristics; life style and the pregnancy outcomes, the data collected and analyzed with the help of computer software SPSS/Win11 and statistic tests ANOVA, correlation and t test. The research results showed that the life style 44.7% of pregnant women studied were middle and 55.3% were good, which only in the field of physical exercise were poor and in the rest cases the situation evaluated in the majority was good and from point view of statistic, the relation between life style and weight of newborn was significant (p = 0.006), with the use of Pearson`s ratio scales it was defined that the relation between physical exercise (from part of life style) and pregnancy age (r = 0.1 and p = 0.046) and relation between nutrition (from part of life style) and the weight of newborn and pregnancy age (in order p = 0.033 and p = 0.005) was significant. Regarding to research findings, there is relation between the life style situation and nutrition with the weight of newborn and also nutrition and physical exercise with pregnant age, for helping to promote women`s health during pregnancy and improving the pregnancy outcomes with education to the style of healthy life (regular exercise, healthy nutrition, not to smoke, suitable caring himself and acceptable social relation) are suggested from hygienic personnel during this period.
Antioxidant, total phenol and flavonoid contents of two Pedicularis L. species from Eastern Azarbaijan, Iran
Laleh Khodaie,Sedigheh Bamdad,Abbas Delazar,Hossein Nazemiyeh
BioImpacts , 2012,
Abstract: Introduction: Pedicularis sibthorpii and P. wilhelmsiana are endemic species mainly found in North-West of Iran. Plants of genus Pedicularis produce some important polyphenols and flavonoids. In the present work, total phenol and flavonoid contents of the mentioned species as well as their antioxidant capacity have been evaluated. Methods: Methanol extract of samples was fractionated by SPE method using an ODS cartridge and their 1H-NMR spectra were recorded. Total phenols and flavonoids of methanol extracts were determined using Folin- Ciocalteu and aluminum chloride methods. For determining antioxidant activity of the extracts and fractions, bleaching of purple colour methanol solution of 1, 1-diphenylpycryl hydrazyl (DPPH) was measured by spectrophotometric assay. Results: Total phenols of Pedicularis sibthorpii and P. wilhelmsiana were in the range of 8-30 mg g-1 and 9-20 mg g-1, respectively. The 40% and 60% fractions of P.sibthorpii and the 20%, 40% and 60% fractions of P. wilhelmsiana showed higher amounts of phenolic compounds. The total flavonoid contents of P. sibthorpii and P. wilhelmsiana were in the range of 0-215 mg g-1 and 0-177 mg g-1, respectively, whereas the 40% and 60% fractions showed higher flavonoid amounts. Antioxidant activity of P. sibthorpii and P. wilhelmsiana were in the range of 0.01-0.7 mg mL-1 and 0.01-1.02 mg mL-1. In the same manner, the 20% and 40% fractions of P. sibthorpii and the 40% and 60% fractions of P. wilhelmsiana had lower RC50 than that of other fractions. Conclusion: Fractions with lower RC50 had higher contents of phenolic and flavonoid compounds. The results of NMR spectra are parallel with these findings and show that it is worth to do phytochemical studies on this.
The Comparison of the Effects of Chlorhexidine Mouthwash Alone and Chlorhexidine Mouthwash Followed By Oral Suctioning on Oral Hygiene of Critically Ill Patients
Hossein Rafiei,Hakimeh Hosseinrezaei,Sedigheh Iranmanesh,Maryam Tajadiny
Turkish Journal of Medical and Surgical Intensive Care Medicine , 2012,
Abstract: Aim: Oral hygiene is one of the main issues in nursing care, being especially important among patients admitted to intensive care units (ICU). The aim of the study was to assess the effect of Chlorhexidine mouthwash alone and 0.2% Chlorhexidine mouthwash followed by oral suctioning on oral hygiene in ICU patients.Material and Methods: In a semi-experimental research design, 90 patients who were admitted to the ICUs were selected. Patients were randomly divided into two groups. In group I, 0.2% chlorhexidine mouthwash alone was applied and in group 2, 0.2% chlorhexidine mouthwash was followed by oral suctioning. These procedures were repeated for 7 consecutive days. The oral hygiene status of patients was assessed by using a Beck checklist on the 1st and 7th days of ICU admission.Results: Oral hygiene scores of group I on the 1st and 7th days were 12.4 and 14.3 respectively. In group II, the scores of the 1st and 7th days were 11.8 and 10.5 respectively. Oral hygiene status of group I was poorer on the 7th day, but in group II oral hygiene had improved on the 7th day of application. Conclusion: We found that using a 0.2% chlorhexidine solution alone is not enough for oral care of patients in the ICU and suctioning of the oral secretions after 0.2% chlorhexidine mouthwash will improve oral hygiene in critically ill patients.
Comparison of serum levels of Tri‐iodothyronine (T3), Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy
Nayereh Khadem,Hossein Ayatollahi,Fatemeh Vahid Roodsari,Sedigheh Ayati
Iranian Journal of Reproductive Medicine , 2012,
Abstract: Background: The physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia.Objective: The aim of this study was comparison of serum levels of Tri‐iodothyronine (T3), Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy. Materials and Methods: In this case‐control study, 40 normal pregnant women and 40 cases of preeclampsia in third trimester of pregnancy were evaluated. They were compared for serum levels of Free T3 (FT3), Free T4 (FT4) and TSH. The data was analyzed by SPSS software with the use of t‐student, Chi‐square, Independent sample T-test and Bivariate correlation test. p≤0.05 was considered statistically significant. Results: The mean age was not statistically different between two groups (p=0.297). No significant difference was observed in terms of parity between two groups (p=0.206). Normal pregnant women were not significantly different from preeclampsia cases in the view of FT3 level (1.38 pg/ml vs. 1.41 pg/ml, p=0.803), FT4 level (0.95 pg/ml vs. 0.96 pg/ml, p=0.834) and TSH level (3.51 μIU/ml vs. 3.10 μIU/ml, p=0.386). Conclusion: The findings of the present study do not support the hypothesis that changes in FT3, FT4 and TSH levels could be possible etiology of preeclampsia
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