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Pericarditis and cardiac tamponade: Urgent condition not only in cardiology
SakaDejan,Kova?evi? Dragan V.,Kora?evi? Goran
Medicinski Pregled , 2011, DOI: 10.2298/mpns1104194s
Abstract: Introduction. Pericarditis is a condition with inflammation of the pericardium; however, most of these conditions are not infective and many of them are not even inflammatory. Pericarditis by its development can be acute, subacute and chronic, and later, recurring or relapsing. Apart from idiopathic, the causes of pericarditis are numerous, very often inflammatory, most frequently caused by viruses, or tumours and neoplasms, diseases of connective tissue, vasculitis, different allergic reactions, radiation, thyroid gland diseases, uraemia, dissection of aorta etc. Clinical picture. Accumulation of fluid in the pericardium in the amount sufficient to cause significant obstruction of blood inflow in chambers can cause cardiac tamponade. If it is not treated immediately, the outcome may be fatal. The most common causes are tumours, viruses or uraemia. Cardiac tamponade should be suspected in patients with a decrease in systemic arterial pressure or presence of hypotension, tachycardia, silent and discreet heart beats, increase in systemic venous pressure (Beck triad). Electrocardiogram may result in tachycardia, QRS complex is of smaller voltage, often of reversed polarity. The amount of effusion is estimated by echocardiography. Conclusion. The cause of pericarditis should always be searched for. On the other hand, during monitoring or treatment of numerous conditions which could be a frequent cause of pericarditis, the presence of pericardial effusion or cardiac tamponade should be suspected and detected in due time. A timely intervention - pericardiocentesis, can prevent the fatal outcome. Besides non-steroid anti-inflammatory medication, many prospective randomized studies propose colchicine as addition to the standard therapy. When opting for the proper treatment for pericarditis always keep in mind the current diagnosis and cause of this condition.
Anthropometric indicators of mass and distribution of adipose tissue in the assessment of cardiovascular and diabetes risk in women
Rastovi? Marina,Srdi?-Gali? Biljana,Stoki? Edita,SakaDejan
Medicinski Pregled , 2013, DOI: 10.2298/mpns1302011r
Abstract: Introduction. From the clinical and epidemiological point of view it is very important to define easily measurable and simple anthropometric parameters of mass and distribution of adipose tissue that will also be good predictors of future complications of obesity. The aim of our study was to correlate anthropometric indicators of mass and distribution of adipose tissue with the risk of developing cardiovascular diseases and diabetes. Material and Methods. The study group consisted of 155 women aged 45.4±13.04y. The anthropometric measurements were performed in order to assess adipose tissue mass and its specific distribution. The 10-year risk of developing cardiovascular diseases was assessed by using two score-systems: Framingham and Prospective Cardiovascular Munster Study, while the 10-year risk of development of diabetes was assessed by QDScore system. Results. According to our results, the waist-to-stature ratio was the best predictor of cardiovascular and diabetes risk (r=0.617-0.780; AUC=0.872). The estimated cut-off value for the waist-to-stature ratio in cardiovascular and diabetes risk prediction was 0.486. Apart from the waist-to-stature ratio, the body mass index, body fat mass, waist circumference and indicators of upper extremity adiposity also correlated strongly with the assessed risk. The anthropometric indicators of lower body adiposity had no significant diagnostic values. Conclusion. The waistto-stature ratio is the best anthropometric indicator of cardiovascular and diabetes risk.
Prophylaxis of infective endocarditis
SakaDejan,Kova?evi? Dragan V.,Sekuli? Slobodan
Medicinski Pregled , 2011, DOI: 10.2298/mpns1106319s
Abstract: Introduction. Infective endocarditis is defined as an infection of the endothelial surface of the heart and heart valves, above all. It is a great challenge for doctors to diagnose infective endocarditis especially in primary health care, because this is a disease in evolution, bearing in mind changes in epidemiological and clinical characteristics, which developed in the last decades. Even today this is a very severe and insidious disease, with poor prognosis and high mortality. Prevention of Infective Endocarditis. Although previous guidelines proposed a limitation to prophylaxis in patients at increased risk of adverse outcome of infective endocarditis, new guidelines recommend the principles of antibiotic prophylaxis when performing procedures at risk of infective endocarditis in patients with predisposing cardiac conditions, and limit its indication to patients at the highest risk of infective endocarditis undergoing the highest risk procedures. Conclusion. Despite the fact that previous guidelines for diagnostics and treatment of infective endocarditis were published only several years ago, the Task Force on Prevention, Diagnosis and Treatment of Infective Endocarditis of the European Society of Cardiology identify infective endocarditis as a clearly evolving disease, with changes in its microbiological profile and higher incidence of health care associated cases which has brought about a need for new recommendations to help health care providers in making clinical decisions including preventive measures and antibiotic prophylaxis. As a novelty, a group of patients at the highest risk of infective endocarditis was defined as well as the type of procedures at risk divided into four categories.
Left ventricular diastolic dysfunction in patients with metabolic syndrome
Penja?kovi? Davor,SakaDejan,Dejanovi? Jovanka,Zec Radovan
Medicinski Pregled , 2012, DOI: 10.2298/mpns1202018p
Abstract: Metabolic syndrome (MetS), which is a cluster of medical disorders, is common and it is associated with increased cardiovascular morbidity and mortality. The aim of this study was to evaluate the relationship between characteristics of metabolic syndrome and the grade of diastolic dysfunction. The study included 72 patients (29 male and 43 female), who had central obesity and at least two of the other four characteristics of metabolic syndrome according to IDF (International Diabetes Federation) criteria. The exclusion criteria were age above 65, impaired systolic function (left ventricular ejection fraction <55%), atrial fibrillation, valvular and pericardial heart disease. Diastolic function was determined according to the criteria of the American Society of Echocardiography. There was a positive correlation between the number of characteristics of metabolic syndrome and the diastolic dysfunction grade (p<0.0001). The positive correlation was found between the grade of diastolic dysfunction and the waist circumference (p<0.0001), arterial hypertension (p<0.001), pared glucose tolerance/diabetes (P=0.0063), and hypertriglyceridemia (p=0.0262). A low level of high-density lipoprotein did not show a statistically significant correlation. The presence of metabolic syndrome is associated with the presence of diastolic dysfunction. The grade of diastolic dysfunction is dependent on the number of coexisting characteristics of metabolic syndrome. Arterial hypertension, central obesity, hyperglycemia and hypertriglyceridemia showed a significant correlation with the degree of diastolic dysfunction.
Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family
SakaDejan,Kora?evi? Goran,Pavlica Tatjana,Sekuli? Slobodan
Vojnosanitetski Pregled , 2012, DOI: 10.2298/vsp1207620s
Abstract: Background. Fabry Disease is a rare, X-chromosomal inherited lysosomal storage disease with a consequent intracellular accumulation of neutral glycosphingolipids in various tissues. This can cause skin and ocular lessions, progressive renal, cardiac or cerebrovascular disorders. If a person in a family has Fabry disease, other family members including even extended relatives, may also be at risk. Case report. We presented three cases pointed out various manifestation of Fabry disease, that illustrate a possible cause for otherwise unexplained cardiac hypertrophy and various rhythm and conduction abnormalities. Conclusion. Although most symptoms begin in childhood, various manifestations often lead to misdiagnosis and clinical diagnosis is frequently delayed for many years, even decades. Enzyme replacement therapy has become available, pointing out the importance of early diagnosis so that treatment can be initiated before irreversible organ damage.
Should we prescribe “vasodilating” beta-blockers in Marfan syndrome to prevent aortic aneurysm and dissection?
Kora?evi? Goran,SakaDejan,Pavlovi? Milan,Ili? Dragana
Vojnosanitetski Pregled , 2012, DOI: 10.2298/vsp1202195k
Abstract: nema
Prevalence of overweight and obesity in adult rural population of the northern part of Ba ka and Banat
Pavlica Tatjana,Bo?i?-Krsti? Verica,Raki? Rada,SakaDejan
Vojnosanitetski Pregled , 2012, DOI: 10.2298/vsp1210833p
Abstract: Background/Aim. Obesity represents one of the frequent health problems in developed countries today. It is related to cardiovascular diseases, diabetes and various cancer forms. The aim of the study was to determine the prevalence of overweight and obesity in adult population of the northern Ba ka and Banat. Methods. On the basis of a multistage stratified random sampling, 4,505 individuals of the age 40.61 ± 11.29 years took part in the study. The study included 46 rural settlements. The overweight and obesity prevalence was obtained using the anthropometric indicators of body mass index (BMI), waist circumference (WC) and the waist to hip ratio (WHR). The correlations among BMI, WC and WHR were determined by the Pearson's correlation coefficient while the multiple regression analysis was used for correlating sociodemographic parameters and the obesity index. Results. A significant positive correlation was found in relation to all anthropometric parameters in both sexes. The data indicated that 66.32% of males and 49.68% of females had an overweight problem. On average, approximately 38.52% of subjects of both sexes were overweight, while 19.48% were obese. The factors that largely contributed to higher values of the obesity index were the age of male subjects and the age, education and origin in females. Ragarding the female subjects, the level of education negatively correlated with the level of nutritional condition. Conclusion. The prevalence values of the overweight and obese subjects, obtained on the basis of the anthropometric parameters, vary. However, regardless methods applied, the percentage of the overweight and obese persons is very high, being among the highest recorded in European populations. The obtained results indicate the necessity of introducing better education programmes and conducting regular health controls among citizens in these regions.
Theory of Asymmetric Electrostatic Force  [PDF]
Katsuoi Saka
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2017, DOI: 10.4236/jemaa.2017.92004
Abstract: Asymmetric Electrostatic Force is a very interesting phenomenon. The intensity of the electrostatic force that acts on a charged asymmetric shaped conductor changes when the direction of the electric field is reversed. The theory of this phenomenon is not clear until today. Therefore this paper will clearly explain the theory of this phenomenon with Gauss’s law. Total ΣES on a closed Gaussian surface around a disk-cylinder shaped charged conductor is the same before and after when the direction of the electric field is reversed. However the distribution of ΣES changes. Many part of total ΣES gather on the front surface of the disk when the electric field is generated. But they transfer to the peripheral side of the cylinder when the direction of the electric field is reversed. This result means that many charges transferred from the surface to the peripheral side. As a result the intensity of the field direction electrostatic force becomes weak.
Characterization of sirodesmins isolated from the phytopathogenic fungus Leptosphaeria maculans
Mitrovi? Petar M.,Or?i? Dejan Z.,Saka? Zvonimir O.,Marjanovi?-Jeromela Ana M.
Journal of the Serbian Chemical Society , 2012, DOI: 10.2298/jsc111231048m
Abstract: Pathogenicity of phytopathogenic fungi is accociated with phytotoxins, especially with their chemical nature and quantity. Sirodesmins are phytotoxins from epipolythiodioxopiperazines group, produced by fungi Leptosphaeria maculans that is a cause of blackleg and stem canker in oilseed rape (Brassica napus L.). The aim of this work was to obtain a detailed chemical profile of sirodesmins in five fungal isolates (four from Vojvodina and one from UK). Sirodesmins showing different phytotoxicity on treated cotyledons of cv. Quinta were separated and detected by thin layer chromatography in all analysed isolates (L.m, C-3, St-5, S-11) except K-113, which did not contain sirodesmin congeners nor exhibited activity. By use of high performance liquid chromatography coupled with tandem mass spectrometer, it was possible to identify total of 10 sirodesmins, together with their precursor - phomamide. It was found that dominant epipolythiodioxopiperazines of investigated L. maculans isolates were sirodesmin PL, sirodesmin C, and their deacetylated derivatives.
Physical Network Approach Applied to Wind Turbine Modeling with Simscape Language  [PDF]
Elhaini Jamila, Saka Abdelmjid
Open Journal of Modelling and Simulation (OJMSi) , 2014, DOI: 10.4236/ojmsi.2014.22010
Abstract: Model-Based Design is an efficient and cost-effective way to develop controls, signal processing, image processing, communications, mechatronics, and other embedded systems. Rather than re-lying on physical prototypes and textual specifications, Model-Based Design uses a system model as an executable specification throughout development. It supports system- and component-level design and simulation, automatic code generation, and continuous test and verification. This paper is focused firstly on the so-called model-based design and aims at presenting an up-to-date state of the art in this important field. Secondly, it develops a model based design for wind energy systems. Mathematical formulations and numerical implementations for different components of wind energy systems are highlighted with Simscape language. Finally, results are derived from simulations.
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