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Search Results: 1 - 10 of 2673 matches for " Saito Ryota "
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Diagnostic efficacy of gadoxetic acid-enhanced MRI for hepatocellular carcinoma and dysplastic nodule
Kazuhiro Saito,Fuminori Moriyasu,Katsutoshi Sugimoto,Ryota Nishio
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i30.3503
Abstract: AIM: To evaluate the relationship between the signal intensity of hepatobiliary phase images on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and histological grade. METHODS: Fifty-nine patients with 82 hepatocellular lesions were evaluated retrospectively. Hepatobiliary phase images on gadoxetic acid-enhanced MRI were classified into 3 groups: low, iso or high. Angiography-assisted computed tomography (CT) findings were also classified into 3 groups: CT during arterial portography, and CT hepatic arteriography: A: iso, iso or low; B: slightly low, iso or low; and C: low, high. We correlated angiography-assisted CT, hepatobiliary phase findings during gadoxetic acid-enhanced MRI and histological grades. Furthermore, correlations between MRI findings and histological grade for each hemodynamic pattern were performed. Correlations among radiological and pathological findings were statistically evaluated using the chi-square test and Fisher’ s exact test. RESULTS: There was a significant correlation between histological grade and hemodynamic pattern (P < 0.05). There was a significant correlation between histological grade and signal intensity in the hepatobiliary phase (P < 0.05) in group A lesions. There was no significant correlation between histological grade and signal intensity in the hepatobiliary phase in group B or C lesions (P > 0.05). CONCLUSION: Signal intensity in the hepatobiliary phase correlated with histological grade in the lesions that maintained portal blood flow, but did not correlate in lesions that showed decreased or defective portal blood flow.
Successful adjuvant bi-weekly gemcitabine chemotherapy for pancreatic cancer without impairing patients’ quality of life
Toyama Yoichi,Yoshida Seiya,Saito Ryota,Kitamura Hiroaki
World Journal of Surgical Oncology , 2013, DOI: 10.1186/1477-7819-11-3
Abstract: Background Although adjuvant gemcitabine (GEM) chemotherapy for pancreatic cancer is standard, the quality of life (QOL) in those patients is still impaired by the standard regimen of GEM. Therefore, we studied whether mild dose-intensity adjuvant chemotherapy with bi-weekly GEM administration could provide a survival benefit with acceptable QOL to the patients with pancreatic cancer. Methods After a phase I trial, an adjuvant bi-weekly 1,000 mg/m2 of GEM chemotherapy was performed in 58 patients with pancreatic cancer for at least 12 courses (Group A). In contrast, 36 patients who declined the adjuvant bi-weekly GEM chemotherapy underwent traditional adjuvant 5FU-based chemotherapy (Group B). Careful periodical follow-ups for side effects of GEM and disease recurrence, and assessment of patients’ QOL using the EORTC QOL questionnaire (QLQ-C30) and pancreatic cancer-specific supplemental module (QLQ-PAN26) were performed. Retrospectively, the degree of side effects, patients’ QOL, compliance rate, disease-free survival (DFS), and overall survival (OS) in Group A were compared with those in Group B. Results No severe side effects (higher than Grade 2 according to the common toxicity criteria of ECOG) were observed, except for patients in Group B, who were switched to the standard GEM chemotherapy. Patients’ QOL was better in Group A than B (fatigue: 48.9 ± 32.1 versus 68.1 ± 36.3, nausea and vomiting: 26.8 ± 20.4 versus 53.7 ± 32.6, diarrhea: 21.0 ± 22.6 versus 53.9 ± 38.5, difficulty gaining weight: 49.5 ± 34.4 versus 67.7 ± 40.5, P < 0.05). Compliance rates in Groups A and B were 93% and 47%. There was a significant difference in the median DFS between both groups (Group A : B =12.5 : 6.6 months, P < 0.001). The median OS of Group A was prolonged markedly compared with Group B (20.2 versus 11.9 months, P < 0.005). For OS between both groups, univariate analysis revealed no statistical difference in 69-year-old or under females, and T1–2 factors, moreover, multivariate analysis indicated three factors, such as bi-weekly adjuvant GEM chemotherapy, T2 or less, and R0. Conclusions Adjuvant chemotherapy with bi-weekly GEM offered not only the advantage of survival benefits but the excellent compliance with acceptable QOL for postoperative pancreatic cancer patients.
An antioxidant resveratrol significantly enhanced replication of hepatitis C virus
Mitsuyasu Nakamura, Hidetsugu Saito, Masanori Ikeda, Ryota Hokari, Nobuyuki Kato, Toshifumi Hibi, Soichiro Miura
World Journal of Gastroenterology , 2010,
Abstract: AIM: To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication.METHODS: We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6. RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses. AXN is also a strong antioxidant. The replication of HCV RNA was assessed by the luciferase reporter assay. An additive effect of antioxidants on antiviral effects of interferon (IFN) and ribavirin (RBV) was investigated.RESULTS: This is the first report to investigate the effect of RVT and AXN on HCV replication. In contrast to other reported viruses, RVT significantly enhanced HCV RNA replication. Vitamin E also enhanced HCV RNA replication as reported previously, although AXN didnot affect replication. IFN and RBV significantly reduced HCV RNA replication, but these effects were dose-dependently hampered and attenuated by the addition of RVT. AXN didnot affect antiviral effects of IFN or RBV.CONCLUSION: These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis C.
Hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor
Yuji Ishii, Ryota Saito, Hideki Marushima, Ryusuke Ito, Taro Sakamoto, Katsuhiko Yanaga
World Journal of Gastroenterology , 2008,
Abstract: AIM: To examine the efficacy of the radial flow bioreactor (RFB) as an extracorporeal bioartificial liver (BAL) and the reconstruction of liver organoids using embryonic pig liver cells.METHODS: We reconstructed the liver organoids using embryonic porcine liver cells in the RFB. We also determined the gestational time window for the optimum growth of embryonic porcine liver cells. Five weeks of gestation was designated as embryonic day (E) 35 and 8 wk of gestation was designated as E56. These cells were cultured for one week before morphological and functional examinations. Moreover, the efficacy of pulsed administration of a high concentration hepatocyte growth factor (HGF) was examined.RESULTS: Both cell growth and function were excellent after harvesting on E35. The pulsed administration of a high concentration of HGF promoted the differentiation and maturation of these fetal hepatic cells. Microscopic examination of organoids in the RFB revealed palisading and showed that bile duct-like structures were well developed, indicating that the organoids were mini livers. Transmission electron microscopy revealed microvilli on the luminal surfaces of bile duct-like structures and junctional complexes, which form the basis of the cytoskeleton of epithelial tissues. Furthermore, strong expression of connexin (Cx) 32, which is the main protein of hepatocyte gap junctions, was observed. With respect to liver function, ammonia detoxification and urea synthesis were shown to be performed effectively.CONCLUSION: Our system can potentially be applied in the fields of BAL and transplantation medicine.
Constructing a Coactivation Model for Explaining Humor Elicitation  [PDF]
Ryota Nomura, Shunichi Maruno
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.25074
Abstract: The present study first aimed to construct a coactivation model that integrates cognitive and motivational variables that determine an individual’s conscious humor experience. It then aimed to test the model’s reliability, validity, and generalizability. As part of the study, 16 (out of 48) four-frame cartoons were randomly presented to 201 (42 male and 159 female) high school students and 302 (185 male and 117 female) undergraduate and graduate students (age range was 15 to 23, M = 18.15, SD = 1.79) who were instructed to rate items related to the variable humor. Using structural equation modeling (SEM), the generalizability of the model to predict the humor experience to a great extent within different population samples was shown. Furthermore, the theoretical prediction of the coactivation model was supported. The results are discussed from the viewpoint of future research that could demonstrate the possible application of the coactivation model.
Rapid Algorithm for Independent Component Analysis  [PDF]
Ryota Yokote, Yasuo Matsuyama
Journal of Signal and Information Processing (JSIP) , 2012, DOI: 10.4236/jsip.2012.33037
Abstract: A class of rapid algorithms for independent component analysis (ICA) is presented. This method utilizes multi-step past information with respect to an existing fixed-point style for increasing the non-Gaussianity. This can be viewed as the addition of a variable-size momentum term. The use of past information comes from the idea of surrogate optimization. There is little additional cost for either software design or runtime execution when past information is included. The speed of the algorithm is evaluated on both simulated and real-world data. The real-world data includes color images and electroencephalograms (EEGs), which are an important source of data on human-computer interactions. From these experiments, it is found that the method we present here, the RapidICA, performs quickly, especially for the demixing of super-Gaussian signals.
Blackening of the Surfaces of Mesopotamian Clay Tablets Due to Manganese Precipitation  [PDF]
Etsuo Uchida, Ryota Watanabe
Archaeological Discovery (AD) , 2014, DOI: 10.4236/ad.2014.24012
Abstract: Blackening was observed on the surfaces of Mesopotamian clay tablets from Umma, Dilbat, Larsa, Ur, Babylon, Uruk, Sippar, and Nippur produced between the Third Dynasty of Ur and the Early Achaemenid Dynasty. Portable X-ray fluorescence analysis revealed that manganese was concentrated on the blackened surfaces. Rod-shaped materials with a length of 100 - 200 nm and a width of 30 nm were observed using a field emission scanning electron microscope. Distinct peaks were not necessarily obtained by micro-X-ray diffractometer analysis, but several samples of the black material showed peaks identifiable as buserite. These results may suggest that blackening on the surfaces of the clay tablets can be ascribed to the activity of manganese-oxidizing microbe. However, the size of the rod-shaped materials is too small compared to common bacteria.
Code Clone Detection Method Based on the Combination of Tree-Based and Token-Based Methods  [PDF]
Ryota Ami, Hirohide Haga
Journal of Software Engineering and Applications (JSEA) , 2017, DOI: 10.4236/jsea.2017.1013051
Abstract: This article proposes the high-speed and high-accuracy code clone detection method based on the combination of tree-based and token-based methods. Existence of duplicated program codes, called code clone, is one of the main factors that reduces the quality and maintainability of software. If one code fragment contains faults (bugs) and they are copied and modified to other locations, it is necessary to correct all of them. But it is not easy to find all code clones in large and complex software. Much research efforts have been done for code clone detection. There are mainly two methods for code clone detection. One is token-based and the other is tree-based method. Token-based method is fast and requires less resources. However it cannot detect all kinds of code clones. Tree-based method can detect all kinds of code clones, but it is slow and requires much computing resources. In this paper combination of these two methods was proposed to improve the efficiency and accuracy of detecting code clones. Firstly some candidates of code clones will be extracted by token-based method that is fast and lightweight. Then selected candidates will be checked more precisely by using tree-based method that can find all kinds of code clones. The prototype system was developed. This system accepts source code and tokenizes it in the first step. Then token-based method is applied to this token sequence to find candidates of code clones. After extracting several candidates, selected source codes will be converted into abstract syntax tree (AST) for applying tree-based method. Some sample source codes were used to evaluate the proposed method. This evaluation proved the improvement of efficiency and precision of code clones detecting.
Localization of D-β-Aspartyl Residue-Containing Proteins in Various Tissues
Ryota Motoie,Noriko Fujii,Shigeru Tsunoda,Kenji Nagata,Tadashi Shimo-oka,Tadatoshi Kinouchi,Norihiko Fujii,Takeshi Saito,Koji Ono
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10051999
Abstract: Prior to the emergence of life, it is believed that only L-amino acids were selected for formation of protein and that D-amino acids were eliminated on the primitive Earth. Whilst homochirality is essential for life, the occurrence of proteins containing D-β-aspartyl (Asp) residues in various tissues from elderly subjects has been reported recently. Here, we demonstrate the presence of a D-β-Asp-containing protein in the cardiac muscle of heart, blood vessels of the lung, chief cells of the stomach, longitudinal and circular muscle of the stomach, small intestine and large intestine. Since the D-β-Asp residue occurs through a succinimide intermediate, this isomer may potentially be generated in proteins more easily than initially thought. Formation of the D-β-Asp residue in proteins may be related to stress.
Possibility of sandwiched liver surgery with molecular targeting drugs, cetuximab and bevacizumab on colon cancer liver metastases: a case report
Yoichi Toyama, Takuro Ushigome, Kazuhiro Watanabe, Hiroaki Kitamura, Shinji Onda, Ryota Saito, Seiya Yoshida, Hidejiro Kawahara, Satoru Yanagisawa, Katsuhiko Yanaga
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-129
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