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Search Results: 1 - 10 of 762 matches for " Saini Savita "
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Anaesthetic management of a patient in prone position-advantage of proseal laryngeal mask airway along with review of literature
Teena Bansal,Savita Saini
Cumhuriyet Medical Journal , 2013,
Abstract: General anaesthesia for surgical procedures requiring prone position consists of induction and tracheal intubation in supine position on a trolley and then the patient is turned prone on the operation table and positioned carefully. Even though this approach is familiar to anaesthesiologists, it is time consuming and requires shift of manpower from other tasks to properly position the patient. Alternative to this technique is to ask the patient to position him/ herself in the prone position on the operating table and then inducing anaesthesia with laryngeal mask airway. The major advantages of laryngeal mask airway in prone position are easy reinsertion, a clear airway provided during the recovery phase from anaesthesia and less sequelae as compared to that commonly accompanying tracheal intubation and accidental tracheal extubation.
Role of Active Principles of Podophyllum hexandrum in Amelioration of Radiation Mediated Lung Injuries by Reactive Oxygen/Nitrogen Species Reduction  [PDF]
Rashmi Saini, Savita Verma, Abhinav Singh, Manju Lata Gupta
CellBio (CellBio) , 2013, DOI: 10.4236/cellbio.2013.23012
Abstract: Radiation induced reactive oxygen/nitrogen species (ROS/RNS) are reported to cause lung injuries such as pneumonitis and fibrosis which may be fatal at times. Current study is designed to analyse the radioprotective efficacy of P. hexandrum active principles (G-002M) on lungs of mice exposed to high dose of gamma irradiation (7 Gy). Cellular profiles and inflammatory cell infiltrates of irradiated bronchoalveolar lavage fluid (BALF) have shown correlations with lung pathology. Cell counts were determined in BALF of control, 7 Gy radiation exposed and radiation with G-002M pretreated mice. ROS/Nitric Oxide (NO) production was measured by 2,7 dichlorodihydrofluorescein diacetate (DCF-DA) and diaminofluorescein diacetate (DAF-2DA) through microscopy and flow cytometry respectively. Immunostaining of inducible nitric oxide synthase (iNOS) in BALF cells and lung sections was also observed microscopically. iNOS ex- pression was observed in lungs by western blotting. BALF was also processed to estimate total protein, LDH, and phospholipids content. Catalase, reduced Glutathione (GSH), Glutathione reductase (GR) and lipid peroxidation were estimated in lung tissues. Pre-administration of G-002M significantly decreased radiation mediated neutrophils count in BALF of irradiated mice. ROS generation, iNOS expression, total protein, LDH and phospholipids were found less affected in G-002M pretreated group in comparison to radiation alone group. Radiation exposure to mice was found apparently leading to parenchymal fibrosis, an architectural distortion of the lung tissue with edema, infiltration of inflammatory blood cells with increased immunolabeling of iNOS. G-002M pretreatment significantly countered radiation mediated increased lipid peroxidation and decreased GR, catalase and GSH in mice. Current study demonstrates possible role of P. hexandrum (G-002M) in minimizing lung damage induced by radiation mediated ROS/RNS generation.
Problem of positioning in a patient with spinal deformities undergoing eye surgery
Saini Savita,Malhotra Naveen,Bolia Sameer
Indian Journal of Ophthalmology , 2002,
Per-Operative Kinking of a Reinforced Endotracheal Tube: An Unforeseen Complication
Geeta Ahlawat,Savita Saini,Karampal Singh,Punam Raghove
Indian Anaesthetists' Forum , 2012,
Abstract: Reinforced tubes are routinely used in Oro-maxillary surgeries. In spite of its advantages, any intra-operative deformity in reinforced tubes can at times lead to occlusion of a patent airway. To change this tube intraoperatively with distorted oral anatomy could be an anaesthetic challenge.
Antioxidant Potential Some Medicinal Plants of Central India  [PDF]
Savita Dixit, Huma Ali
Journal of Cancer Therapy (JCT) , 2010, DOI: 10.4236/jct.2010.12014
Abstract: Cellular damage or oxidative injury arising from free radicals or reactive oxygen species (ROS) now appears the fun-damental mechanism underlying a number of human neurodegenerative disorder, diabetes, inflammation, viral infec-tions, autoimmune pathologies and digestive system disorders. Free radicals are generated through normal metabolism of drugs, environmental chemicals and other xenobiotics as well as endogenous chemicals, especially stress hormones (adrenalin and noradrenalin). Accumulated evidence suggests that ROS can be scavenged through chemoprevention utilizing natural antioxidant compounds present in foods and medicinal plants. In this review, research on the antioxi-dant potential of some medicinal plants of origin of Central India is considered.4CdBw3
Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine Pathway
Abhishek Mandal?,Sushmita Das?,Saptarshi Roy?,Ayan Kumar Ghosh?,Abul Hasan Sardar?,Sudha Verma?,Savita Saini,Ruby Singh?,Kumar Abhishek?,Ajay Kumar
PLOS Neglected Tropical Diseases , 2016, DOI: 10.1371/journal.pntd.0004373
Abstract: The growth and survival of intracellular parasites depends on the availability of extracellular nutrients. Deprivation of nutrients viz glucose or amino acid alters redox balance in mammalian cells as well as some lower organisms. To further understand the relationship, the mechanistic role of L-arginine in regulation of redox mediated survival of Leishmania donovani promastigotes was investigated. L-arginine deprivation from the culture medium was found to inhibit cell growth, reduce proliferation and increase L-arginine uptake. Relative expression of enzymes, involved in L-arginine metabolism, which leads to polyamine and trypanothione biosynthesis, were downregulated causing decreased production of polyamines in L-arginine deprived parasites and cell death. The resultant increase in reactive oxygen species (ROS), due to L-arginine deprivation, correlated with increased NADP+/NADPH ratio, decreased superoxide dismutase (SOD) level, increased lipid peroxidation and reduced thiol content. A deficiency of L-arginine triggered phosphatidyl serine externalization, a change in mitochondrial membrane potential, release of intracellular calcium and cytochrome-c. This finally led to DNA damage in Leishmania promastigotes. In summary, the growth and survival of Leishmania depends on the availability of extracellular L-arginine. In its absence the parasite undergoes ROS mediated, caspase-independent apoptosis-like cell death. Therefore, L-arginine metabolism pathway could be a probable target for controlling the growth of Leishmania parasites and disease pathogenesis.
Vaccines against human papilloma virus and cervical cancer: An overview
Sharma Savita
Indian Journal of Community Medicine , 2008,
Abstract: The paradigm of preventing human papilloma virus (HPV) infection through currently approved vaccines, namely, Gardasil, manufactured by Merck and Co., Inc. (Whitehouse Station, NJ) and Cervarix, manufactured by GlaxoSmithKline (GSK, Philadelphia) holds tremendous promise for the developing countries in decreasing the burden of HPV infection and its sequelae, such as cervical cancer, genital warts and anogenital cancers. Effective screening programs that have reduced the burden of this killer disease in the developed countries are still lacking in India, despite the high incidence of cervical cancer and the implementation of the National Cancer Control Programme since 1975. The recent breakthrough in the global war against cervical cancer will provide new insight for meeting the future challenge of the prevention of cervical cancer in India.
A Novel Technique to Image Annotation using Neural Network
Pankaj Savita
International Journal of Computer Applications and Information Technology , 2013,
Abstract: Automatic annotation of digital pictures is a key technology for managing and retrieving images from large image collection. Traditional image semantics extraction and representation schemes were commonly divided into two categories, namely visual features and text annotations. However, visual feature scheme are difficult to extract and are often semantically inconsistent. On the other hand, the image semantics can be well represented by text annotations. It is also easier to retrieve images according to their annotations. Traditional image annotation techniques are time-consuming and requiring lots of human effort. In this paper we propose Neural Network based a novel approach to the problem of image annotation. These approaches are applied to the Image data set. Our main work is focused on the image annotation by using multilayer perceptron, which exhibits a clear-cut idea on application of multilayer perceptron with special features. MLP Algorithm helps us to discover the concealed relations between image data and annotation data, and annotate image according to such relations. By using this algorithm we can save more memory space, and in case of web applications, transferring of images and download should be fast. This paper reviews 50 image annotation systems using supervised machine learning Techniques to annotate images for image retrieval. Results obtained show that the multi layer perceptron Neural Network classifier outperforms conventional DST Technique.
Towards age/rotation/magnetic activity relation with seismology
Savita Mathur
Physics , 2015, DOI: 10.1051/epjconf/201510105005
Abstract: The knowledge of stellar ages directly impacts the characterization of a planetary system as it puts strong constraints on the moment when the system was born. Unfortunately, the determination of precise stellar ages is a very difficult task. Different methods can be used to do so (based on isochrones or chemical element abundances) but they usually provide large uncertainties. During its evolution a star goes through processes leading to loss of angular momentum but also changes in its magnetic activity. Building rotation, magnetic, age relations would be an asset to infer stellar ages model independently. Several attempts to build empirical relations between rotation and age (namely gyrochronology) were made with a focus on cluster stars where the age determination is easier and for young stars on the main sequence. For field stars, we can now take advantage of high-precision photometric observations where we can perform asteroseismic analyses to improve the accuracy of stellar ages. Furthermore, the variability in the light curves allow us to put strong constraints on the stellar rotation and magnetic activity. By combining these precise measurements, we are on the way of understanding and improving relations between magnetic activity, rotation, and age, in particular at different stages of stellar evolution. I will review the status on gyrochronology relationships based on observations of young cluster stars. Then I will focus on solar-like stars and describe the inferences on stellar ages, rotation, and magnetism that can be provided by high-quality photometric observations such as the ones of the Kepler mission, in particular through asteroseismic analyses.
An algebra of absolutely continuous functions and its multipliers
Savita Bhatnagar
Mathematics , 2005,
Abstract: The aim of this paper is to study the algebra $AC_{p}$ of absolutely continuous functions $f$ on [0,1] satisfying $f(0) = 0, f'\in L^{p} [0, 1]$ and the multipliers of $AC_{p}$.
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