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Search Results: 1 - 10 of 13589 matches for " Saijun FAN "
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Advances in Anti-tumor Activity of Indole-3-carbinol
Chang GE,Saijun FAN
Chinese Journal of Lung Cancer , 2009,
BRCA1: A New Predictive Genomic Marker for Chemotherapy and Radiotherapy of Non-small Cell Lung Cancer
Min LI,Saijun FAN
Chinese Journal of Lung Cancer , 2012, DOI: 10.3779/j.issn.1009-3419.2012.08.06
Abstract: Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors worldwide. Chemotherapy and radiotherapy are the main methods in therapy of NSCLC. The identification and characterization of predictive markers of radio- and chemo-sensitivity will be beneficial with customized treatment of NSCLC patients. This article will review the evidence regarding breast cancer susceptibility gene 1 (BRCA1) as a new predictive marker for chemotherapy and radiotherapy of NSCLC.
Identification and function of coactivator of estrogen receptor: ERIAP
Qinghui Meng,Lixin Zhou,Jianping Cao,Bin Gao,Rongguang Shao,Jiyou Li,Saijun Fan
Science China Life Sciences , 2003, DOI: 10.1360/03yc0062
Abstract: Estrogen receptor (ER), one member of nuclear hormone receptor (NR) family, is an estrogen-dependent transcriptional factor that plays an important role in development, progression and treatment of breast cancer. Transcriptional co-factors (co-activators and co-repressors) are critical for ER to transduce hormone and metabolic signaling to target genes. A number of functional and structural studies have elucidated the precise mechanisms of co-activator interaction with the ligand-inducible activation domain in ER via one and several LXXLL motifs (where X is any amino acid) known as NR-Box. By the yeast two-hybrid system we have identified a novel ER-α interacting protein ERIAP (Estrogen Receptor Interacting and Activating Protein) which contains two consensus LXXLL motifs. ERIAP associated with ER-α in a ligand-dependent manner, as demonstrated by in vivo immunoprecipitation and in vitro GST capture assays. The two NR boxes were essential for ERIAP interaction with ER-α. Furthermore, ERIAP specifically enhanced ligand-mediated ER-α transcriptional activity in a dose-dependent fasion and increased the expression of estrogen-responsive gene pS2. Thus, our present findings indicate that ERIAP funcions as a new coactivator for ER-α transcriptional activity, which may play an important role in development and progression of breast cancer.
Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation
Yue Fu,Yan Wang,Liqing Du,Chang Xu,Jia Cao,Tiqiang Fan,Jianxiang Liu,Xu Su,Saijun Fan,Qiang Liu,Feiyue Fan
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140714105
Abstract: IL-1β, a pro-inflammatory cytokine, has been shown to contribute to radiation injury. Sirt1, an NAD +-dependent class III protein deacetylase, plays an important role in the regulation of the proinflammatory cytokines involved in inflammation-associated diseases. The relationship between Sirt1 and IL-1β, however, has remained elusive. The present study was designed to explore the potential effect of Sirt1 on IL-1β expression induced by radiation and to provide a new target for the development of radiation protection drugs. Our results showed that radiation significantly increased IL-1β mRNA and protein expression and that pretreatment with resveratrol, a Sirt1 activator, inhibited the radiation-induced IL-1β expression in a concentration-dependent manner, whereas the knockdown or inhibition of Sirt1 by nicotinamide significantly enhanced radiation-induced IL-1β expression. This effect can likely be attributed to Sirt1-mediated inhibition of NLRP-3 inflammasome activation because Sirt1 inhibits the transactivation potential of NF-κb by deacetylation, which then suppresses NLRP3 transcription. Taken together, the results demonstrate that Sirt1 exerts anti-inflammatory effects by regulating NLRP3 expression partially through the NF-κb pathway in mesenchymal stem cells. More importantly, our findings suggest that resveratrol is an effective agent in protecting against radiation injury, and we provide a theoretical basis for developing a drug to protect against radiation injury by targeting Sirt1.
The Effects of p38 MAPK Inhibition Combined with G-CSF Administration on the Hematoimmune System in Mice with Irradiation Injury
Deguan Li, Yueying Wang, Hongying Wu, Lu Lu, Xiaochun Wang, Junling Zhang, Heng Zhang, Saijun Fan, Feiyue Fan, Daohong Zhou, Aimin Meng
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062921
Abstract: The acute and residual (or long-term) bone marrow (BM) injury induced by ionizing radiation (IR) is a major clinic concern for patients receiving conventional radiotherapy and victims accidentally exposed to a moderate-to-high dose of IR. In this study, we investigated the effects of the treatment with the p38 inhibitor SB203580 (SB) and/or granulocyte colony-stimulating factor (G-CSF) on the hematoimmune damage induced by IR in a mouse model. Specifically, C57BL/6 mice were exposed to a sublethal dose (6 Gy) of total body irradiation (TBI) and then treated with vehicle, G-CSF, SB, and G-CSF plus SB. G-CSF (1 μg/mouse) was administrated to mice by intraperitoneal (ip) injection twice a day for six successive days; SB (15 mg/kg) by ip injection every other day for 10 days. It was found that the treatment with SB and/or G-CSF significantly enhanced the recovery of various peripheral blood cell counts and the number of BM mononuclear cells 10 and 30 days after the mice were exposed to TBI compared with vehicle treatment. Moreover, SB and/or G-CSF treatment also increased the clonogenic function of BM hematopoietic progenitor cells (HPCs) and the frequency of BM lineage?Sca1+c-kit+ cells (LSK cells) and short-term and long term hematopoietic stem cells (HSCs) 30 days after TBI, in comparison with vehicle treated controls. However, the recovery of peripheral blood B cells and CD4+ and CD8+ T cells was not significantly affected by SB and/or G-CSF treatment. These results suggest that the treatment with SB and/or G-CSF can reduce IR-induced BM injury probably in part via promoting HSC and HPC regeneration.
Ultrasmall Au10-12(SG)10-12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy
Xiao-Dong Zhang,Zhentao Luo,Jie Chen,Xiu Shen,Shasha Song,Yuanming Sun,Saijun Fan,Feiyue Fan,David Tai Leong,Jianping Xie
Physics , 2014, DOI: 10.1002/adma.201400866
Abstract: Radiosensitizers can increase the local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, we report a new class of radiosensitizers that contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10-12(SG)10-12) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.
Imaging cold atoms with shot-noise and diffraction limited holography
J. P. Sobol,Saijun Wu
Physics , 2014, DOI: 10.1088/1367-2630/16/9/093064
Abstract: We theoretically develop and experimentally demonstrate a holographic method for imaging cold atoms at the diffraction and photon shot noise limits. Aided by a double point source reference field, a simple iterative algorithm robustly removes the twin image of an $^{87}$Rb cold atom sample during the image reconstruction. Shot-noise limited phase shift and absorption images are consistently retrieved at various probe detunings, and during the laser cooling process. We consistently resolve less than 2 mrad phase shift ($0.4~\%$ attenuation) of the probe light, outperforming shot-noise limited phase-contrast (absorption) imaging by a factor of 4 or more if the same camera is used without pixel saturation. We discuss the possible extension of this work for precise phase imaging of dense atomic gases, and for off-resonant probing of multiple atoms in optical lattices.
Metabolizable Bi2Se3 Nanoplates: Biodistribution, Toxicity, and Uses for Cancer Radiation Therapy and Imaging
Xiao-Dong Zhang,Jie Chen,Yuho Min,Gyeong Bae Park,Xiu Shen,Sha-Sha Song,Yuan-Ming Sun,Hao Wang,Wei Long,Jianping Xie,Kai Gao,Lianfeng Zhang,Saijun Fan,Feiyue Fan,Unyong Jeong
Physics , 2013, DOI: 10.1002/adfm.201302312
Abstract: Bi, a high atom number element, has a high photoelectric absorption coefficient, and Se element has anticancer activity. Hence, their compound chalcogenide (Bi2Se3) deserves a thorough investigation for biomedical applications. This study reveals that Bi2Se3 nanoplates (54 nm wide) protected with poly(vinylpyrollidone) (PVP) are biocompatible and have low toxicity even at a high dose of 20 mg/kg in mice. This conclusion was made through the studies on the biodistribution and 90-day long term in vivo clearance of the nanoplates. Liver and spleen were dominant organs for the nanoplates accumulation which was mainly due to RES absorption, but 93 % the nanoplates were cleared after 90 days treatment. Concentrations of Bi and Se in tumor tissue continuously increased until 72 h after intraperitoneal injection into mice. Such selective accumulation of Bi was utilized to enhance the contrast of X-ray CT images. The Bi elements concentrated in a tumor led to damage on the tumor cells when exposed to gamma radiation. Growth of the tumor significantly delayed and stopped after 16 days after the tumor was treated with the Bi2Se3 nanoplates and radiation. This work clearly shows that the Bi2Se3 nanoplates may be used for cancer radiation therapy and CT imaging. They deserve further studies for biological and medical applications.
Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy
Xiao-Dong Zhang,Jie Chen,Zhentao Luo,Di Wu,Xiu Shen,Sha-Sha Song,Yuan-Ming Sun,Pei-Xun Liu,Jing Zhao,Shuaidong Huo,Saijun Fan,Feiyue Fan,Xing-Jie Liang,Jianping Xie
Physics , 2013, DOI: 10.1002/adhm.201300189
Abstract: A new type of metabolizable and efficient radiosensitizer for cancer radiotherapy is presented in this study by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH). The new nano-construct (GSH-coated Au25 NCs) inherits attractive features of both the Au core (strong radiosensitizing effect) and GSH shell (good biocompatibility). It can preferentially accumulate in tumor via the improved EPR effect, which leads to strong enhancement for cancer radiotherapy. After the treatment, the small-sized GSH-Au25 NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au25 NCs in the body.
Identification and function of coactivator of estrogen receptor: ERIAP
MENG Qinghui ZHOU Lixin CAO Jianping GAO Bin SHAO Rongguang LI Jiyou FAN Saijun,

中国科学C辑(英文版) , 2003,
Abstract: With one million new cases in the world each year, breast cancer is the most common malig- nancy in women and comprises 18% of all female cancers. The incidence and mortality of breast cancer in China have been significantly increased in the past years. It has been known that several risk factors are associated with breast cancer1], including inherited mutation in the BRCA1 and BRCA2 genes, increasing age, early onset of menstruation, late menopause, never having had chil- dren or havin…
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