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Search Results: 1 - 10 of 42317 matches for " Sai-Wen Tang "
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Full-Length Enrich c-DNA Libraries-Clear Cell-Renal Cell Carcinoma
Sai-Wen Tang,Jung-Yaw Lin
Journal of Oncology , 2012, DOI: 10.1155/2012/680796
Abstract: Clear cell renal cell carcinoma (ccRCC), the most common subtype of RCC, is characterized by high metastasis potential and strong resistance to traditional therapies, resulting in a poor five-year survival rate of patients. Several therapies targeted to VEGF pathway for advanced RCC have been developed, however, it still needs to discover new therapeutic targets for treating RCC. Genome-wide gene expression analyses have been broadly used to identify unknown molecular mechanisms of cancer progression. Recently, we applied the oligo-capping method to construct the full-length cDNA libraries of ccRCC and adjacent normal kidney, and analyzed the gene expression profiles by high-throughput sequencing. This paper presents a review for recent findings on therapeutic potential of MYC pathway and nicotinamide N-methyltransferase for the treatment of RCC. 1. Introduction Renal cell carcinoma (RCC) represents 3% of all human malignancies worldwide with an increasing incidence and accounts for 85% of renal cancers, resulting in close to 78,000 deaths annually [1–5]. The most common subtype, clear cell RCC (ccRCC), which originates from the proximal tubule epithelium, is mostly sporadic, unilateral, and unifocal [6]. RCC cells have a poor response to traditional therapies, such as the chemotherapy, hormonal therapy, and radiation therapy [7–10]. These properties result in a poor prognosis and low five-year survival rate of RCC patients. Surgery remains to be the main therapeutics for treatment of RCC [11]. It has been demonstrated that the activation of hypoxia-inducible factor-α (HIF-α) turns on the genes, such as VEGF and PDGF, which are responsible for the progression of ccRCC, providing potential targets for advanced ccRCC [12]. Gene expression analysis appears to be an important tool for studying cancer pathogenesis and progression. Markers related to tumor proliferation, growth, angiogenesis, and loss of cell adhesion have been evaluated for their potential as prognostic factors. Numerous reports have investigated the differential gene expression profile between normal and tumor tissues using the high-throughput technologies, including cDNA microarray, cDNA subtraction, and serial analysis of gene expression [13–15]. Many studies have applied these methods to analyze the genome-wide changes in ccRCC, providing specific gene expression signature, the potential biomarkers, and prognostic factors [16–21], whereas Lenburg et al. pointed out a diverse gene expression results by microarray method published previously [22]. Recently, two international projects, The
Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses
Tang Sai-Wen,Ducroux Aurelie,Jeang Kuan-Teh,Neuveut Christine
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-92
Abstract: Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert the cell’s autophagic process. Here, we review the interactions between viruses and cells in regards to cellular autophagy. Using findings from hepatitis B virus and human retroviruses, HIV-1 and HTLV-1, we discuss mechanisms used by viruses to usurp cellular autophagy in ways that benefit viral replication.
Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis
Yu-Huei Liu,Meng-Luen Li,Meng-Yu Hsu,Ya-Yueh Pang,I-Ling Chen,Ching-Kuei Chen,Sai-Wen Tang,Hsuan-Yuan Lin,Jung-Yaw Lin
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/935860
Abstract: Aeginetia indica Linn. (Guan-Jen-Huang, GJH), a traditional Chinese herb, has the potential to be an immunomodulatory agent. The purpose of this study was to explore the effect of GJH in the treatment of renal cancer. Concentration-effect curves for the influence of GJH on cellular proliferation showed a biphasic shape. Besides, GJH had a synergistic effect on cytotoxicity when combined with 5-fluorouracil (5-FU)which may be due to the alternation of the chemotherapeutic agent resistance-related genes and due to the synergistic effects on apoptosis. In addition, treatment with GJH extract markedly reduced 786-O cell adherence to human umbilical vein endothelial cells (HUVECs) and decreased 786-O cell migration and invasion. In a xenograft animal model, GJH extract had an inhibitory effect on tumor cell-induced metastasis. Moreover, western blot analysis showed that the expression of intercellular adhesion molecule-1 (ICAM-1) in 786-O cells was significantly decreased by treatment with GJH extract through inactivation of nuclear factor-κB (NF--κB). These results suggest that GJH extract has a synergistic effect on apoptosis induced by chemotherapeutic agents and an inhibitory effect on cell adhesion, migration, and invasion, providing evidence for the use of water-based extracts of GJH as novel alternative therapeutic agents in the treatment of human renal cancer.
Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway
Shih-Chin Wang,Sai-Wen Tang,Sio-Hong Lam,Chung-Chieh Wang,Yu-Huei Liu,Hsuan-Yuan Lin,Shoei-Sheng Lee,Jung-Yaw Lin
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/409823
Abstract: Renal cell carcinoma (RCC) cells are characterized by strong drug resistance and high metastatic incidence. In this study, the effects of ten kinds of Chinese herbs on RCC cell migration and proliferation were examined. Aqueous extract of Paeonia suffruticosa (PS-A) exerted strong inhibitory effects on cancer cell migration, mobility, and invasion. The results of mouse xenograft experiments showed that the treatment of PS-A significantly suppressed tumor growth and pulmonary metastasis. We further found that PS-A markedly decreased expression of VEGF receptor-3 (VEGFR-3) and phosphorylation of FAK in RCC cells. Moreover, the activation of Rac-1, a modulator of cytoskeletal dynamics, was remarkably reduced by PS-A. Additionally, PS-A suppressed polymerization of actin filament as demonstrated by confocal microscopy analysis and decreased the ratio of F-actin to G-actin in RCC cells, suggesting that PS-A inhibits RCC cell migration through modulating VEGFR-3/FAK/Rac-1 pathway to disrupt actin filament polymerization. In conclusion, this research elucidates the effects and molecular mechanism for antimigration of PS-A on RCC cells and suggests PS-A to be a therapeutic or adjuvant strategy for the patients with aggressive RCC.
Influence of IBED Testing Parameters on Cr N Coating Structure

TANG Bin,LIU Dao-Xin,HU Nai-Sai,HE Jia-Wen,

无机材料学报 , 1999,
Abstract: This paper studies the structure of IBED Cr-N coatings with different parameters such as N partial pressure, N ions bombarding energy and N ions/Cr atoms ratio. The results show that the chemical composition and structure of the coatings are mainly determined by N partial pressure. According to N partial pressure increasing, there are an increase of CrN phase and a decrease of Cr and Cr2N phase. The grain orientations of the coatings are affected by bombarding energy. When N ions/Cr atoms ratio changed from 1.45×10-2 to 5.87×10-2, high N ion flux of bombarding will result in acceleration of sputtering away from the coated CrN layer as well as its decomposition. In the mean time Cr2O3 is easy to be produced in the layer.
A Literature Review of Personalized Learning Algorithm  [PDF]
Yin Tang, Wen Wang
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.61009
With the rapid development of the online learning platform, the learning resources are also unprecedentedly rich. The study of personalized learning algorithms meets the need to provide students with the most suitable resources for learning. This paper constitutes a literature review on personalized learning algorithm at home and abroad. The review aims at elaborating the research based on recommendation system and data mining in personalized learning algorithm and look forward to the future research trend.
Clinical features, prognosis, and related factors of severe viral encephalitis in children

HU Wenjing
, YANG Liming, LIAO Hongmei, TANG Jingwen, YANG Sai, WANG Ping, FANG Hongjun

- , 2018, DOI: 10.3969/j.issn.1671-9638.2018.03.012
Abstract: 目的了解重症病毒性脑炎(SVE)患儿的临床特点及预后,探讨影响其预后的相关因素。方法回顾性分析2014年1月—2016年1月湖南省儿童医院神经内科及重症监护病房收治的102例SVE患儿临床资料,根据预后将患儿分为预后良好组[24例,儿童格拉斯哥预后评分量表 (CGOS)评级4~5级]和预后不良组(78例,CGOS评级1~3级) ,比较两组患儿临床资料,分析影响SVE患儿预后的危险因素。结果预后良好组中,痊愈15例,9例有轻度后遗症;预后不良组中,14例死亡,25例留有严重后遗症,39例有中度后遗症。预后良好组患儿发热持续时间、住院时间均短于预后不良组,差异具有统计学意义(均P<0.05)。多因素非条件logistic回归分析显示:惊厥持续状态、呼吸衰竭、发热持续时间长(>5 d)、脑电图重度异常、头颅MRI累及病变超过2处或累及幕下以及应激性高血糖为SVE预后不良因素,其OR值分别为13.468、4.580、2.378、10.196、3.012、6.316。结论SVE严重威胁儿童的生存质量,伴有惊厥持续状态、呼吸衰竭、发热持续时间长、脑电图重度异常、头颅MRI累及病变超过2处或累及幕下以及应激性高血糖是影响儿童SVE预后的危险因素
Floral Organogenesis of Blyxa japonica (Hydrocharitaceae)

TANG Sai-chun,WANG Yu-guo,XIA Nian-he,LIU Yan,WEI Fa-nan,WEN He-qun,
,王玉国,夏念和,刘 演,韦发南,文和群

热带亚热带植物学报 , 2002,
Abstract: 利用扫描电镜首次对水筛Blxa japonica(Miq.)Maxim.ex Asch.et Guerk.]花器官的发生进行了观察。结果显示:萼片原基以轮关方式向心发生;花瓣原基轮状近同时发生,与萼片基基交替排列;雄蕊原基以对萼的形式轮关发生,与花瓣原基轮状近同时发生,与萼片原基交替排列;雄蕊原基以对萼的形式轮状发生,与花瓣原基交替排列;花柱原基在整个花的发育过程中发生较晚,以对瓣的形式轮状发生,与雄蕊原基交替排列。与同科其它属的花比较,水筛的花为两性,辐射对称,胚珠多数,体现了较原始的特征。花各部数目均为3,进化程度居于中间水平。该属花各部轮状发生,子房下位,心皮合生,体现了本科在泽泻亚纲中花部结构进化的特征。
Signal photon flux generated by high-frequency relic gravitational waves
Xin Li,Sai Wang,Hao Wen
Physics , 2015,
Abstract: The power spectrum of primordial tensor perturbations $\mathcal{P}_t$ increases rapidly in high frequency region if the spectral index $n_t>0$. It is shown that the amplitude of relic gravitational wave $h_t$($5\times10^9$Hz) varies from $10^{-36}$ to $10^{-25}$ while $n_t$ varies from $-6.25\times 10^{-3}$ to $0.87$. High frequency gravitational waves detector that is proposed by F.-Y. Li detects gravitational waves through observing the perturbed photon flux that is generated by interaction between the relic gravitational waves and electromagnetic system. It is shown that the perturbative photon flux $N_x^1$($5\times10^9$Hz) varies from $1.40\times10^{-4}\rm s^{-1}$ to $2.85\times10^{7}\rm s^{-1}$ while $n_t$ varies from $-6.25\times 10^{-3}$ to $0.87$. Correspondingly, the ratio of the transverse perturbative photon flux $N_x^1$ to the background photon flux varies from $10^{-28}$ to $10^{-16}$.
Predicting Managerial Coaching Behaviors by the Big-Five Personality Traits  [PDF]
Guohai Chen, Wen Huang, Yuwen Tang
Journal of Human Resource and Sustainability Studies (JHRSS) , 2013, DOI: 10.4236/jhrss.2013.14011
Abstract: The research of this paper aims to construct a Chinese Managerial Coaching Behavior Inventory and examine the correlations of managerial coaching behaviors and the Big-Five personality traits. In Study One, 196 managers from several companies filled out a self-complied Managerial Coaching Behavior Inventory based on Noer’s Triangle Coaching Model and Social Desirability Scale. A Chinese Managerial Coaching Behavior Inventory with 46 items was developed, including three subscales (namely, Accessing, Challenging, and Supporting) with high Cronbach alphas (all > 0.85). In Study Two, this inventory and the NEO Five-Factor Inventory were administered to 175 managers. Analysis showed that scores on the three managerial coaching behaviors Accessing, Challenging, and Supporting were positively related to those on Extraversion, Openness to Experience, Agreeableness, and Conscientiousness, while they were negatively related to Neuroticism. Big-Five personality traits (particularly Extraversion, Openness to Experience, and Conscientiousness) were good predictors of managerial coaching behaviors. Implications for human resource management and enterprise coaching are discussed.
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