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Search Results: 1 - 10 of 665 matches for " Sagnelli Caterina "
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Rituximab-Based Treatment, HCV Replication, and Hepatic Flares
Evangelista Sagnelli,Mariantonietta Pisaturo,Caterina Sagnelli,Nicola Coppola
Clinical and Developmental Immunology , 2012, DOI: 10.1155/2012/945950
Abstract: Rituximab, a chimeric mouse-human monoclonal antibody directed to the CD20 antigen expressed on pre-B lymphocytes and mature lymphocytes, causes a profound B-cell depletion. Due to its peculiar characteristics, this drug has been used to treat oncohaematological diseases, B cell-related autoimmune diseases, rheumatoid arthritis, and, more recently, HCV-associated mixed cryoglobulinaemic vasculitis. Rituximab-based treatment, however, may induce an increased replication of several viruses such as hepatitis B virus, cytomegalovirus, varicella-zoster virus, echovirus, and parvovirus B19. Recent data suggest that rituximab-based chemotherapy induces an increase in HCV expression in hepatic cells, which may become a target for a cell-mediated immune reaction after the withdrawal of treatment and the restoration of the immune control. Only a few small studies have investigated the occurrence of HCV reactivation and an associated hepatic flare in patients with oncohaematological diseases receiving R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). These studies suggest that the hepatic flares are frequently asymptomatic, but life-threatening liver failure occurs in nearly 10% of cases.
Peg-Interferon Plus Ribavirin with or without Boceprevir or Telaprevir for HCV Genotype 1: A Meta-Analysis on the Role of Response Predictors
Nicola Coppola, Mariantonietta Pisaturo, Caterina Sagnelli, Evangelista Sagnelli, Italo F. Angelillo
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094542
Abstract: Background & aim To compare the efficacy of pegylated-interferon (Peg-IFN) α-2a or α-2b and ribavirin given as dual therapy versus triple therapy (Peg-IFN and ribavirin plus boceprevir or telaprevir) in patients with HCV-1 chronic hepatitis na?ve for anti-HCV therapy or relapsers to dual therapy in relation to the presence of constitutional, clinical and virological predictors of treatment response. Methods Included in the meta-analysis were studies meeting these criteria: original data from randomized trials on the efficacy of dual versus triple therapy in therapy-na?ve patients or relapsers; at least one primary outcome clearly defined: sustained virological response in patients with or without rapid virological response (RVR), with genotype 1a or 1b, low or high HCV load, IL28-B CC or non-CC genotype, mild or severe fibrosis; odds ratio estimates of relative risk (RR) and 95% confidence intervals; English language; and published up to the end of June 2013. Results Seven original studies met the inclusion criteria, allowing a meta-analysis on 3,652 patients. Triple therapy was more effective than dual, regardless of IL-28B genotype, HCV sub-genotype, liver fibrosis, and baseline HCV load. In 1,045 patients who achieved RVR, SVR was more frequently achieved with dual therapy (RR = 1.11; p = 0.002) than triple. The same results were achieved when only the therapy-na?ve patients were considered. Conclusions Triple therapy provides a significantly higher SVR rate than dual therapy, but dual therapy obtains a significantly higher SVR rate in patients with RVR. The data stress the clinical importance of a 4-week lead-in phase in direct-acting antiviral-based treatment.
Efficacy of pegylated interferon α-2a and α-2b in patients with genotype 1 chronic hepatitis C: a meta-analysis
Coppola Nicola,Pisaturo Mariantonietta,Tonziello Gilda,Sagnelli Caterina
BMC Infectious Diseases , 2012, DOI: 10.1186/1471-2334-12-357
Abstract: Background Two formulations of Pegylated interferon (Peg-IFN) are on the market for treatment of chronic hepatitis C virus (HCV) infection. The purpose of this meta-analysis was to assess the efficacy of Peg-IFN α-2a versus Peg-IFN α-2b in combination with ribavirin in anti-human immunodeficiency virus (HIV)-negative patients with genotype 1 chronic HCV infection. Methods The following criteria were to be met for inclusion in the meta-analysis: (a) original data from randomized and non-randomized clinical trials; (b) study on the efficacy of conventional doses of Peg-IFN α-2a (180 μg/week) versus Peg-IFN α-2b (1.5 μg/kg of body weight/week), both in combination with ribavirin, in antiviral therapy-na ve HCV-genotype 1 subjects; (c) at least one of these primary outcomes: Rapid Virological Response (RVR); Early Complete Virological Response (EVR); End of Treatment Response (ETR); Sustained Virological Response (SVR); (d) odds ratio estimates of relative risk (RR) and associated 95% confidence intervals (CIs) or at least data enabling them to be computed; (e) English language; and (f) published as a full paper up to December 2011. Results Seven published studies met the inclusion criteria, allowing a meta-analysis on 3,026 patients. Peg-IFN α-2a and Peg-IFN α-2b showed similar rate of RVR (RR = 1.05; 95% CI = 0.87-1.27, p = 0.62) and SVR (RR = 1.08; 95% CI = 0.99-1.18, p = 0.098). Peg-IFN α-2a more frequently than Peg-IFN α-2b achieved EVR (RR = 1.11; 95% CI = 1.02-1.21, p = 0.013) and ETR (RR = 1.22; 95% CI = 1.14-1.31, p < 0.0001). Conclusion The standard schedules of Peg-IFN α-2a and Peg-IFN α-2b, both in combination with ribavirin, can be used indifferently for patients with chronic HCV genotype 1 who are anti- to eliminate HIV-negative and antiviral treatment-na ve.
Liver microRNA hsa-miR-125a-5p in HBV Chronic Infection: Correlation with HBV Replication and Disease Progression
Nicola Coppola, Nicoletta Potenza, Mariantonietta Pisaturo, Nicola Mosca, Gilda Tonziello, Giuseppe Signoriello, Vincenzo Messina, Caterina Sagnelli, Aniello Russo, Evangelista Sagnelli
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065336
Abstract: To study in HBsAg chronic carriers the expression of liver hsa-miR-125a-5p and its correlation with liver HBV-DNA values and clinical presentation, 27 consecutive Caucasian, HBsAg/anti-HBe/HBV-DNA-positive patients who were naive to nucleos(t)ide analogues and interferon therapy and had no marker of HCV, HDV or HIV infection and no history of alcohol intake were enrolled. For each patient, liver HBV DNA and liver hsa-miR-125a-5p were quantified by real-time PCR in relation to β-globin DNA or RNU6B, respectively. Liver fibrosis and necroinflammation were graded by applying Ishak's scoring system. Liver hsa-miR-125a-5p was detected in all patients enrolled and a correlation between its concentration and liver HBV DNA was demonstrated (p<0.0001). Higher liver hsa-miR-125a-5p concentrations were observed in patients with HBV-DNA plasma level >103 IU/ml (p<0.02), in those with HAI >6 (p = 0.02) and those with fibrosis score >2 (p<0.02) than in patients with lower scores. Higher HBV-DNA liver concentrations were found in patients with abnormal AST (p = 0.005) and ALT serum levels (p = 0.05), in those with serum HBV DNA higher than 10E3 IU/mL (p = 0.001) and those with fibrosis score >2 (p = 0.02) than in patients with a lower load. By multivariate logistic regression analysis, liver hsa-miR-125a-5p was identified as an independent predictor of disease progression: O.R. = 4.21, C.I. 95% = 1.08–16.43, p<0.05, for HAI >6; O.R. = 3.12, C.I. 95% = 1.17–8.27, p<0.05, for fibrosis score >2. In conclusion, in HBsAg/anti-HBe-positive patients, the liver hsa-miR-125a-5p level correlated with liver and plasma HBV-DNA values and was associated to a more severe disease progression.
Cannabinoid Receptor 2-63 QQ Variant Is Associated with Persistently Normal Aminotransferase Serum Levels in Chronic Hepatitis C
Nicola Coppola, Rosa Zampino, Caterina Sagnelli, Giulia Bellini, Aldo Marrone, Maria Stanzione, Nicolina Capoluongo, Adriana Boemio, Carmine Minichini, Luigi Elio Adinolfi, Sabatino Maione, Emanuele Miraglia Del Giudice, Evangelista Sagnelli, Francesca Rossi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099450
Abstract: Background and Aim To evaluate in anti-HCV-positive patients the clinical impact of the rs35761398 variant of the CNR2 gene leading to the substitution of Gln (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with Arg (R). Patients and Methods 253 consecutive anti-HCV-/HCV-RNA-positive patients were enrolled, of whom 53 were HCV carriers with persistently normal ALT (PNALT group) and 200 had a history of steadily abnormal serum ALT values (abnormal ALT group). All patients were naive for antiviral therapy and were screened for the CNR2 rs35761398 polymorphism by a TaqMan assay. Results Subjects in the PNALT group, compared with those in the abnormal ALT group were older (58.5±12 vs. 50.7±12.4 years, p = 0.001), more frequently female (66% vs. 42%, p = 0.003), with lower body massindex (BMI) (24.5±3.1 vs. 26.6±4.6, p = 0.003), and more frequently with HCV genotype 2 (43.1% vs 17.7%, p = 0.0002) and CB2-63 QQ variant (34% vs. 11%, p = 0.0001). Considering all 253 patients, no difference in the demographic, biochemical, or virological data was observed between patients in the different CB2-63 variants. The logistic regression analysis identified CB2-63 QQ, HCV genotype 2, older age and lower BMI as independent predictors of PNALT (p<0.00001). Discussion The CB2-63 QQ variant in HCV patients was independently associated with the PNALT status.
The Cognitive Development of Sociology: The Contribution of John Stuart Mill  [PDF]
Caterina Galluccio
Advances in Applied Sociology (AASoci) , 2018, DOI: 10.4236/aasoci.2018.83011
Abstract: One may track the origin of sociology back to the work of individuals such as Auguste Comte among other prominent scholars in the nineteenth century. Comte work of a general way to deal with the investigation of society stands out as one of a major contribution towards the cognitive development of sociology. The development of cognitive sociology can also be attributed to the ancient publications in the sociology of knowledge, sociology of culture, and cognitive and cultural anthropology. Arguably, scholars strive to understand the cognitive processes in order to understand how individuals come up with meanings for various phenomena in the society. John Stuart Mill deserves credit for his profound contribution in as far as the development of the methodology of the social science is concerned. His addition of a psychological perspective was critical to the development of sociology. Mill also incorporated the knowledge of psychology to explain what drives individuals to act in the manner they do while interacting with each other. Other than the deduction of the laws, Mill emphasized on the necessity of using an experiment to understand the personal and interpersonal interaction of individuals. However, other individuals who also made contributions to the development of the discipline of sociology dismissed and criticized his stand on the necessity of conducting experiments and not relying on deductive reasoning. Scholars who were opposed to Mill’s position subscribed to the idea of anti-psychologism. Some of the profound authors and scholars include Karl Marx, Max Weber, Watkins, L. von Mises, Popper, Menger, von Hayek, Boudon, and Elster among others. Popper stands out as one of the scholars who were sternly opposed to Mill’s idea of psychologism, contributing to the reinstatement of the autonomy of sociology and social laws. However, Millian convention and ideologies of integrating the psychologism perspective into sociology was adopted by several scholars from 1970s onwards. The purpose of this work is precisely to offer a more in-depth understanding of John Stuart Mill’s contribution to the cognitive development of sociology.
Trust in the Market: Institutions versus Social Capital  [PDF]
Caterina Galluccio
Open Journal of Political Science (OJPS) , 2018, DOI: 10.4236/ojps.2018.82008
Abstract: The principal objective of this research paper is to gain an in-depth understating on what is the critical driver of trust in the market, whether it is social capital or institutions. Works by several authors such as Robert Putnam, Ostrom, Francis Fukuyama, Douglass North, among others were used as primary sources for the research. It is, however, essential to note that there are no proven theories on what is the primary driver of trust in the market, but it is imperative to study a market to know whether institutions or social capital?are?the primary driver of trust in that particular market. The merits, demerits, and the composition of trust in social capital and institutions are identified in this paper. Generalized trust, values, and norms of reciprocity and cooperation are viewed as the key pillars of social capital and have an undeniable influence on confidence in markets. Trust in institutions, on the other hand, is influenced by the type of institution and institutional change. Organizations are viewed more formally by players in a market and are conceived to be credible; hence one cannot ignore their influence on trust in the market. According to this paper, trust in markets is driven by both social capital and institutions. One cannot solely rely on one and ignore the other. The interdependent relationship existing between institutions and social capital has a significant impact on economic, financial and financing decisions of the players in a market. Developing an even-handed, balanced employment of trust in social capital and trust in institutions could positively influence the socio-economic conditions of any market. In other words, to achieve their primary objective, which is profit maximization, the participants in a market have to learn how to strike a balance in the levels of trust they place on either social capital or institutions.
Methods for Selecting Ethical Investments: Some Sociological Explanations  [PDF]
Caterina Galluccio
Advances in Applied Sociology (AASoci) , 2018, DOI: 10.4236/aasoci.2018.84018
Abstract: Nowadays the need for an ethical and socially responsible approach to finance appears increasingly evident, yet the sphere of ethical finance does not have the success that one could imagine. This work reflects on the possible causes of this lukewarm or just partial response to ethical finance by investors and does so using the paradigm of methodological individualism as an explanatory tool, focusing in particular on the issues of individual responsibility and personal freedom.
Toward a Responsible Capitalism: A Need for Financial Education and Social Finance  [PDF]
Caterina Galluccio
Sociology Mind (SM) , 2018, DOI: 10.4236/sm.2018.82014
Abstract: Ralf Dahrendorf, in his paper After the Crisis: Back to the Protestant Ethic? sought to find the causes that made the society decide to adopt debt-based capitalism while dropping the savings capitalism. He used Max Weber’s pieces to explain how thinking among the members of the society had transformed and how this contributed to the type of capitalism that had dominated the modern world. It is unquestionable that we cannot get into debt indefinitely— says Dahrendorf—but it’s certainly not possible a return to the Protestant ethics. So the key point is in what he calls responsible capitalism that includes the concepts of responsibility and trust and requires that the satisfaction of individual needs falls under a sustainable economic development model. The thesis presented in this paper is that, in order to facilitate the emergence of a new mentality based on responsibility, there should be more economic and social participation that can take place on the one hand, through processes of economic socialization and financial education and, on the other hand, through the selection of alternative financial instruments, particularly the ones which belong to the social finance. The latter includes in the broad sense socially responsible finance and micro-credit and, strictly speaking, the more recent phenomena of crowd funding and social impact investments.
Subjective Well-Being within Organizations: A Sociological Explanation  [PDF]
Caterina Galluccio
Sociology Mind (SM) , 2018, DOI: 10.4236/sm.2018.82008
Abstract: Is subjective well-being within organizations a top-down or a bottom-up process? In other words, who is responsible for it? A number of theories exist and many support the principle of well-being driven by good leadership. This work takes a different tack. It develops a model of well-being where well-being is seen as the final result of a process that involves all the individuals who work in an organization at each level of the hierarchical structure. The paper argues that subjective well-being within organizations cannot be reduced to a psychological question, instead, it is, above all, a sociological, logical and epistemological issue. For this reason, it is suggested that it cannot depend on a single manager or even on a group of them. The argument finds its roots in the theory of methodological individualism; dispersed and tacit knowledge (F. Hayek and M. Polanyi); the fallibility of human nature (K. Popper); bounded rationality (H. Simon); the distribution of power within organizations (M. Crozier).
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